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 <subject>Avian influenza</subject>
 <subject>Disease control</subject>
 <subject>Disease detection or diagnosis</subject>
 <subject>Disease surveillance</subject>
 <subject>Emergency preparedness</subject>
 <subject>Emergency response plans</subject>
 <subject>Emerging infectious diseases</subject>
 <subject>Infectious diseases</subject>
 <subject>Influenza</subject>
 <subject>Pandemic</subject>
 <subject>Program management</subject>
 <subject>Public health</subject>
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 <subject>Risk management</subject>
 <subject>Vaccination</subject>
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 <title>Influenza Pandemic: Efforts Under Way to Address Constraints on Using Antivirals and Vaccines to Forestall a Pandemic</title>
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<abstract>Pandemic influenza poses a threat to public health at a time when
the United Nations&apos; World Health Organization (WHO) has said that
infectious diseases are spreading faster than at any time in	 
history. The last major influenza pandemic occurred from 1918 to 
1919. Estimates of deaths worldwide if a similar pandemic were to
occur have ranged between 30 million and 384 million people.	 
Individual countries and international organizations have	 
developed and begun to implement a strategy for forestalling	 
(that is, containing, delaying, or minimizing the impact of) the 
onset of a pandemic. Antivirals and vaccines may help forestall a
pandemic. GAO was asked to examine (1) constraints upon the use  
of antivirals and vaccines to forestall a pandemic and (2)	 
efforts under way to overcome these constraints. GAO reviewed	 
documents and consulted with officials of the Departments of	 
State and Health and Human Services (HHS), international	 
organizations, and pharmaceutical manufacturers. WHO commented	 
that the report was comprehensive and useful. HHS stressed that  
vaccines and antivirals must be viewed in a larger context. State
and HHS commented that the term &quot;forestall&quot; is ambiguous and	 
misleading. However, GAO has used the word in a way that is	 
consistent with WHO&apos;s use of the term.</abstract>
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 <topic>Avian influenza</topic>
 <topic>Disease control</topic>
 <topic>Disease detection or diagnosis</topic>
 <topic>Disease surveillance</topic>
 <topic>Emergency preparedness</topic>
 <topic>Emergency response plans</topic>
 <topic>Emerging infectious diseases</topic>
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 <topic>Influenza</topic>
 <topic>Pandemic</topic>
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 <topic>Public health</topic>
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 <topic>Vaccination</topic>
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