United States Government Publishing Office publisher pbl distributor dst United States National Archives and Records Administration Office of the Federal Register author aut Government Organization text government publication eng FR Regulatory Information 2026_register executive 2026-07-08 article Proposed Rules D09002ee1e4949c51 D09002ee1e4949caf United States Department of Justice originator org United States Government Agency or Subagency United States Drug Enforcement Administration originator org United States Government Agency or Subagency The Drug Enforcement Administration proposes placing the substance tianeptine (7-[(3-chloro-6,11-dihydro-6-methyl-5,5- dioxidodibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid), including its isomers, esters, ethers, salts, and salts of isomers, esters, and ethers whenever the existence of such isomers, esters, ethers, salts, and salts of isomers, esters, and ethers is possible, in schedule I of the Controlled Substances Act. If finalized, this action would impose the regulatory controls and administrative, civil, and criminal sanctions applicable to schedule I controlled substances on persons who handle (manufacture, distribute, reverse distribute, import, export, engage in research, conduct instructional activities or chemical analysis with, or possess) or propose to handle tianeptine. 91 FR 42150 https://www.govinfo.gov/app/details/FR-2026-07-08/2026-13821 2026-13821 fr08jy26-7 4410-09-P Docket No. DEA1596 https://www.govinfo.gov/app/details/FR-2026-07-08/2026-13821 https://www.govinfo.gov/content/pkg/FR-2026-07-08/html/2026-13821.htm https://www.govinfo.gov/content/pkg/FR-2026-07-08/pdf/2026-13821.pdf Administrative Practice and Procedure Drug Traffic Control Reporting and Recordkeeping Requirements 9 p. 42150 42158 91 FR 42150 Title 21 Part 1308 21 CFR Part 1308 Schedules of Controlled Substances: Placement of Tianeptine in Schedule I; Federal Register Vol. 91, Issue PRORULE 2026-13821 DEPARTMENT OF JUSTICE Drug Enforcement Administration 2026-08-07 Docket No. DEA1596 4410-09-P 2026-13821 Notice of proposed rulemaking.

The Drug Enforcement Administration proposes placing the substance tianeptine (7-[(3-chloro-6,11-dihydro-6-methyl-5,5- dioxidodibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid), including its isomers, esters, ethers, salts, and salts of isomers, esters, and ethers whenever the existence of such isomers, esters, ethers, salts, and salts of isomers, esters, and ethers is possible, in schedule I of the Controlled Substances Act. If finalized, this action would impose the regulatory controls and administrative, civil, and criminal sanctions applicable to schedule I controlled substances on persons who handle (manufacture, distribute, reverse distribute, import, export, engage in research, conduct instructional activities or chemical analysis with, or possess) or propose to handle tianeptine.

Comments must be submitted electronically or postmarked on or before August 7, 2026. The electronic Federal Docket Management System will not accept comments after 11:59 p.m. Eastern Time on the last day of the comment period. Dr. Terrence L. Boos, Drug and Chemical Evaluation Section, Diversion Control Division, Drug Enforcement Administration; Telephone: (571) 362-3249. Administrative Practice and Procedure Drug Traffic Control Reporting and Recordkeeping Requirements Schedules of Controlled Substances Placement of Tianeptine in Schedule I, http://www.regulations.gov https://scifinder.cas.org https://www.aapcc.org/data-system/ https://www.census.gov/data/tables/2021/econ/susb/2021-susb-annual.html https://www.census.gov/naics/reference_files_tools/2022_NAICS_Manual.pdf https://www.fda.gov/consumers/health-fraud-scams/new-gas-station-heroin-tianeptine-product-trend https://www.regulations.gov https://www.sba.gov/sites/default/files/2023-06/Table%20of%20Size%20Standards_Effective%20March%2017%2C%202023%20%282%29.pdf www.regulations.gov Vol. 91, no. 129 Office of the Federal Register, National Archives and Records Administration 2026-07-08 continuing daily deposited born digital 185 p. Table of Contents: AE 2.7: GS 4.107: AE 2.106: KF70.A2 https://www.govinfo.gov/app/details/FR-2026-07-08 P0b002ee1e49377a5 0097-6326 0042-1219 0364-1406 769-004-00000-9 000582072 f:fr08jy26 https://www.govinfo.gov/app/details/FR-2026-07-08 https://www.govinfo.gov/content/pkg/FR-2026-07-08/pdf/FR-2026-07-08.pdf https://www.govinfo.gov/content/pkg/FR-2026-07-08/xml/FR-2026-07-08.xml fdlp 42135 42311 DGPO 2026-07-08 2026-07-08 FR-2026-07-08 machine generated eng FR FR-2026-07-08 91 129