United States Government Publishing Office publisher pbl distributor dst United States National Archives and Records Administration Office of the Federal Register author aut Government Organization text government publication eng FR Regulatory Information 2026_register executive 2026-01-17 article Rules and Regulations D09002ee1dd19c71c D09002ee1dd19c7ef United States Department of Justice originator org United States Government Agency or Subagency United States Drug Enforcement Administration originator org United States Government Agency or Subagency The Drug Enforcement Administration is publishing this final rule to amend its regulations related to "cannabimimetic agents" by including the term's definition, identifying 18 additional substances that meet the definition, and consolidating most existing administration controlled substances code numbers (drug codes) into a single drug code number for substances that meet this definition. The listing for two schedule I "cannabimimetic agents" that are under international control, JWH-018 and AM2201, are moved to the "hallucinogens" paragraph of schedule I but retain their existing drug codes to facilitate quota and international reporting requirements. While this final rule does not change the current and continuing schedule I status for the 18 additional substances meeting the definition of "cannabimimetic agents," these and other substances meeting this definition will be assigned a new administration controlled substances code number once this final rule becomes effective. 91 FR 2297 https://www.govinfo.gov/app/details/FR-2026-01-20/2026-00907 2026-00907 fr20ja26-6 4410-09-P Docket No. DEA-368 https://www.govinfo.gov/app/details/FR-2026-01-20/2026-00907 https://www.govinfo.gov/content/pkg/FR-2026-01-20/html/2026-00907.htm https://www.govinfo.gov/content/pkg/FR-2026-01-20/pdf/2026-00907.pdf Administrative Practice and Procedure Drug Traffic Control Reporting and Recordkeeping Requirements 3 p. 2297 2299 91 FR 2297 Title 21 Part 1308 21 CFR Part 1308 Definition of “Cannabimimetic Agents” and Assignment of an Administration Controlled Substances Code Number for All “Cannabimimetic Agents”; Federal Register Vol. 91, Issue RULE 2026-00907 DEPARTMENT OF JUSTICE Drug Enforcement Administration 2026-02-19 Docket No. DEA-368 4410-09-P 2026-00907 Final rule.

The Drug Enforcement Administration is publishing this final rule to amend its regulations related to "cannabimimetic agents" by including the term's definition, identifying 18 additional substances that meet the definition, and consolidating most existing administration controlled substances code numbers (drug codes) into a single drug code number for substances that meet this definition. The listing for two schedule I "cannabimimetic agents" that are under international control, JWH-018 and AM2201, are moved to the "hallucinogens" paragraph of schedule I but retain their existing drug codes to facilitate quota and international reporting requirements. While this final rule does not change the current and continuing schedule I status for the 18 additional substances meeting the definition of "cannabimimetic agents," these and other substances meeting this definition will be assigned a new administration controlled substances code number once this final rule becomes effective.

This final rule is effective February 19, 2026. Terrence L. Boos, Ph.D., Drug & Chemical Evaluation Section, Diversion Control Division, Drug Enforcement Administration; Telephone: (571) 362-3249. Administrative Practice and Procedure Drug Traffic Control Reporting and Recordkeeping Requirements Definition of Cannabimimetic Agents and Assignment of an Administration Controlled Substances Code Number for all Cannabimimetic Agents, www.incb.org Vol. 91, no. 12 Office of the Federal Register, National Archives and Records Administration 2026-01-20 continuing daily deposited born digital 184 p. Table of Contents: AE 2.7: GS 4.107: AE 2.106: KF70.A2 https://www.govinfo.gov/app/details/FR-2026-01-20 P0b002ee1dd141128 0097-6326 0042-1219 0364-1406 769-004-00000-9 000582072 f:fr20ja26 https://www.govinfo.gov/app/details/FR-2026-01-20 https://www.govinfo.gov/content/pkg/FR-2026-01-20/pdf/FR-2026-01-20.pdf https://www.govinfo.gov/content/pkg/FR-2026-01-20/xml/FR-2026-01-20.xml fdlp 2285 2458 DGPO 2026-01-17 2026-01-17 FR-2026-01-20 machine generated eng FR FR-2026-01-20 91 12