United States Government Publishing Office publisher pbl distributor dst United States National Archives and Records Administration Office of the Federal Register author aut Government Organization text government publication eng FR Regulatory Information 2025_register executive 2025-06-03 article Rules and Regulations D09002ee1d3a51df0 D09002ee1d3a51e6b United States Department of Justice originator org United States Government Agency or Subagency United States Drug Enforcement Administration originator org United States Government Agency or Subagency On March 15, 2024, the Drug Enforcement Administration published a final order placing 1-(2-methyl-4-(3-phenylprop-2-en-1- yl)piperazin-1-yl)butan-1-one (commonly known as 2-methyl AP-237), including its optical and geometric isomers, esters, ethers, salts, and salts of isomers, esters, and ethers whenever the existence of such isomers, esters, ethers, and salts is possible within the specific chemical designation, in schedule I of the Controlled Substances Act. The effective date of that final order was 30 days after publication in the Federal Register. Before the effective date, DEA published another final order that made the instructions for 2-methyl AP-237 in the March 15 final order invalid. This document corrects that error, adding 2- methyl AP-237 and its drug code 9664 for regulatory purposes. 90 FR 23437 https://www.govinfo.gov/app/details/FR-2025-06-03/2025-09989 2025-09989 fr03jn25-11 4410-09-P Docket No. DEA-1245 https://www.govinfo.gov/app/details/FR-2025-06-03/2025-09989 https://www.govinfo.gov/content/pkg/FR-2025-06-03/html/2025-09989.htm https://www.govinfo.gov/content/pkg/FR-2025-06-03/pdf/2025-09989.pdf Administrative Practice and Procedure Drug Traffic Control Reporting and Recordkeeping Requirements 2 p. 23437 23438 90 FR 23437 Title 21 Part 1308 21 CFR Part 1308 Schedules of Controlled Substances: Placement of 2-Methyl AP-237 in Schedule I; Correction; Federal Register Vol. 90, Issue RULE 2025-09989 DEPARTMENT OF JUSTICE Drug Enforcement Administration 2025-06-03 Docket No. DEA-1245 4410-09-P 2025-09989 Correcting amendment.

On March 15, 2024, the Drug Enforcement Administration published a final order placing 1-(2-methyl-4-(3-phenylprop-2-en-1- yl)piperazin-1-yl)butan-1-one (commonly known as 2-methyl AP-237), including its optical and geometric isomers, esters, ethers, salts, and salts of isomers, esters, and ethers whenever the existence of such isomers, esters, ethers, and salts is possible within the specific chemical designation, in schedule I of the Controlled Substances Act. The effective date of that final order was 30 days after publication in the Federal Register. Before the effective date, DEA published another final order that made the instructions for 2-methyl AP-237 in the March 15 final order invalid. This document corrects that error, adding 2- methyl AP-237 and its drug code 9664 for regulatory purposes.

This correcting amendment is effective June 3, 2025, and applicable beginning April 15, 2024. Dr. Terrence L. Boos, Drug and Chemical Evaluation Section, Diversion Control Division, Drug Enforcement Administration; Telephone: (571) 362-3249. Administrative Practice and Procedure Drug Traffic Control Reporting and Recordkeeping Requirements Schedules of Controlled Substances Placement of 2-Methyl AP-237 in Schedule I; Correction, Vol. 90, no. 105 Office of the Federal Register, National Archives and Records Administration 2025-06-03 continuing daily deposited born digital 197 p. Table of Contents: AE 2.7: GS 4.107: AE 2.106: KF70.A2 https://www.govinfo.gov/app/details/FR-2025-06-03 P0b002ee1d3a4dce1 0097-6326 0042-1219 0364-1406 769-004-00000-9 000582072 f:fr03jn25 https://www.govinfo.gov/app/details/FR-2025-06-03 https://www.govinfo.gov/content/pkg/FR-2025-06-03/pdf/FR-2025-06-03.pdf https://www.govinfo.gov/content/pkg/FR-2025-06-03/xml/FR-2025-06-03.xml fdlp 23421 23608 DGPO 2025-06-03 2025-06-03 FR-2025-06-03 machine generated eng FR FR-2025-06-03 90 105