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2018-02-22
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Use of High Throughput Assays and Computational Tools; Endocrine Disruptor Screening Program; Notice of Availability and Opportunity for Comment
Notices
D09002ee1bdc2f988
D09002ee1bdc2fa1f
United States
Environmental Protection Agency
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org
United States Government Agency or Subagency
This document describes how EPA is planning to incorporate an alternative scientific approach to screen chemicals for their ability to interact with the endocrine system. This will improve the Agency's ability to fulfill its statutory mandate to screen pesticide chemicals and other substances for their ability to cause adverse effects by their interaction with the endocrine system. The approach incorporates validated high throughput assays and a computational model and, based on current research, can serve as an alternative for some of the current assays in the Endocrine Disruptor Screening Program (EDSP) Tier 1 battery. EPA has partial screening results for over 1800 chemicals that have been evaluated using high throughput assays and a computational model for the estrogen receptor pathway. In the future, EPA anticipates that additional alternative methods will be available for EDSP chemical screening based on further advancements of high throughput assays and computational models for other endocrine pathways. Use of these alternative methods will accelerate the pace of screening, decrease costs, and reduce animal testing. In addition, this approach advances the goal of providing sensitive, specific, quantitative, and efficient screening using alternative test methods to some assays in the Tier 1 battery to protect human health and the environment.
80 FR 35350
https://www.govinfo.gov/app/details/FR-2015-06-19/2015-15182
2015-15182
fr19jn15-72
6560-50-P
EPA-HQ-OPPT-2015-0305
FRL-9928-69
https://www.govinfo.gov/app/details/FR-2015-06-19/2015-15182
https://www.govinfo.gov/content/pkg/FR-2015-06-19/html/2015-15182.htm
https://www.govinfo.gov/content/pkg/FR-2015-06-19/pdf/2015-15182.pdf
6 p.
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80 FR 35350
Use of High Throughput Assays and Computational Tools; Endocrine Disruptor Screening Program; Notice of Availability and Opportunity for Comment; Federal Register Vol. 80, Issue
NOTICE
2015-15182
ENVIRONMENTAL PROTECTION AGENCY
2015-08-18
EPA-HQ-OPPT-2015-0305
FRL-9928-69
6560-50-P
2015-15182
Notice.
This document describes how EPA is planning to incorporate an alternative scientific approach to screen chemicals for their ability to interact with the endocrine system. This will improve the Agency's ability to fulfill its statutory mandate to screen pesticide chemicals and other substances for their ability to cause adverse effects by their interaction with the endocrine system. The approach incorporates validated high throughput assays and a computational model and, based on current research, can serve as an alternative for some of the current assays in the Endocrine Disruptor Screening Program (EDSP) Tier 1 battery. EPA has partial screening results for over 1800 chemicals that have been evaluated using high throughput assays and a computational model for the estrogen receptor pathway. In the future, EPA anticipates that additional alternative methods will be available for EDSP chemical screening based on further advancements of high throughput assays and computational models for other endocrine pathways. Use of these alternative methods will accelerate the pace of screening, decrease costs, and reduce animal testing. In addition, this approach advances the goal of providing sensitive, specific, quantitative, and efficient screening using alternative test methods to some assays in the Tier 1 battery to protect human health and the environment.
Comments must be received on or before August 18, 2015.
For technical information contact: Jane Robbins, Office of Science Coordination and Policy (OSCP), Office of Chemical Safety and Pollution Prevention, Environmental Protection Agency, 1200 Pennsylvania Ave. NW., Washington, DC 20460-0001;
Endocrine Disruptor Screening Program:
Use of High Throughput Assays and Computational Tools
,
robbins.jane@epa.gov
TSCA-Hotline@epa.gov
http://actor.epa.gov/dashboard
http://actor.epa.gov/edsp21
http://dx.doi.org/10.1787/9789264067417-en
http://epa.gov/ncct
http://pubs.acs.org/journal/esthag
http://www.epa.gov/dockets
http://www.epa.gov/dockets/comments.html
http://www.epa.gov/dockets/contacts.html
http://www.epa.gov/endo
http://www.epa.gov/endo/pubs/assayvalidation/listserv.htm
http://www.epa.gov/endo/pubs/edsp21_work_plan_summary%20_overview_final.pdf
http://www.epa.gov/endo/pubs/edsp_chemical_universe_and_general_validations_white_paper_11_12.pdf
http://www.epa.gov/endo/pubs/edspoverview/finalrpt.htm
http://www.epa.gov/endo/pubs/toresources/index.htm
http://www.epa.gov/ocspp/pubs/frs/publications/Test_Guidelines/series890.htm
http://www.epa.gov/scipoly/sap/meetings/2014/december/120214minutes.pdf
http://www.gpo.gov/fdsys/pkg/FR-2013-06-14/pdf/2013-14232.pdf
http://www.regulations.gov
http://www.regulations.gov/#!documentDetail
http://www.who.int/ipcs/publications/new_issues/endocrine_disruptors/en
regulations.gov
Federal Register
Vol. 80, no. 118
Office of the Federal Register, National Archives and Records Administration
2015-06-19
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399 p.
Table of Contents:
AE 2.7:
GS 4.107:
AE 2.106:
KF70.A2
https://www.govinfo.gov/app/details/FR-2015-06-19
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0042-1219
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https://www.govinfo.gov/app/details/FR-2015-06-19
https://www.govinfo.gov/content/pkg/FR-2015-06-19/pdf/FR-2015-06-19.pdf
https://www.govinfo.gov/content/pkg/FR-2015-06-19/xml/FR-2015-06-19.xml
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2018-02-22
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FR-2015-06-19
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