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2014_register
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2014-10-07
article
Announcement of Requirements and Registration for the Culture-Independent Straintyping and Characterization Challenge
Notices
D09002ee1bdc3ccd3
D09002ee1bdc3cd3d
United States
Department of Health and Human Services
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org
United States Government Agency or Subagency
United States
Centers for Disease Control and Prevention
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org
United States Government Agency or Subagency
The Centers for Disease Control and Prevention (CDC) located within the Department of Health and Human Services (HHS) launches a challenge competition for the development of a method or process to accurately and efficiently identify, subtype, and characterize pathogenic microorganisms directly from clinical or environmental samples without the need for culture or culture-based enrichment. Laboratory-based infectious disease surveillance programs, such as PulseNet, the National Tuberculosis Surveillance System, and the Active Bacterial Core Surveillance program, rely on primary culture and microbiologic testing in community hospital and clinical laboratories. A new generation of non-culture-based diagnostic tests are now beginning to enter the marketplace offering physicians faster results and, in some cases, more types of information than were previously available. Unfortunately, these new tests do not typically result in isolates being available for public health purposes, and, as their use continues to grow, it will likely become increasingly difficult or impossible to detect and investigate outbreaks or other important infectious disease trends. New laboratory approaches that do not depend on isolates or culture for subtyping and characterization of microbes are needed to maintain and improve important public health activities across a range of pathogenic organisms. The Culture-Independent Straintyping and Characterization Challenge is an opportunity to develop novel approaches to identifying and characterizing pathogens similar to normal flora in a complex matrix in a process that does not require any culture, including pre-enrichment. Straintyping and characterization of the Shiga toxin-producing Escherichia coli (STEC) from clinical stool samples represents a significant challenge and has been selected as the target organism for this challenge. STEC are similar in most respects to the commensal E. coli that are carried in the intestinal tract of nearly everyone. Consistent identification, straintyping, and characterization of pathogenic STEC directly from a complex matrix, such as stool, requires the consistent identification of both a variable marker that can be used for subtyping and a second, more stable marker that can be used for definitive identification.
79 FR 51340
https://www.govinfo.gov/app/details/FR-2014-08-28/2014-20428
2014-20428
fr28au14-60
4163-18-P
https://www.govinfo.gov/app/details/FR-2014-08-28/2014-20428
https://www.govinfo.gov/content/pkg/FR-2014-08-28/html/2014-20428.htm
https://www.govinfo.gov/content/pkg/FR-2014-08-28/pdf/2014-20428.pdf
2 p.
51340
51341
79 FR 51340
Announcement of Requirements and Registration for the Culture-Independent Straintyping and Characterization Challenge; Federal Register Vol. 79, Issue
NOTICE
2014-20428
DEPARTMENT OF HEALTH AND HUMAN SERVICES
Centers for Disease Control and Prevention
2014-09-02
4163-18-P
2014-20428
Notice.
The Centers for Disease Control and Prevention (CDC) located within the Department of Health and Human Services (HHS) launches a challenge competition for the development of a method or process to accurately and efficiently identify, subtype, and characterize pathogenic microorganisms directly from clinical or environmental samples without the need for culture or culture-based enrichment. Laboratory-based infectious disease surveillance programs, such as PulseNet, the National Tuberculosis Surveillance System, and the Active Bacterial Core Surveillance program, rely on primary culture and microbiologic testing in community hospital and clinical laboratories. A new generation of non-culture-based diagnostic tests are now beginning to enter the marketplace offering physicians faster results and, in some cases, more types of information than were previously available. Unfortunately, these new tests do not typically result in isolates being available for public health purposes, and, as their use continues to grow, it will likely become increasingly difficult or impossible to detect and investigate outbreaks or other important infectious disease trends. New laboratory approaches that do not depend on isolates or culture for subtyping and characterization of microbes are needed to maintain and improve important public health activities across a range of pathogenic organisms. The Culture-Independent Straintyping and Characterization Challenge is an opportunity to develop novel approaches to identifying and characterizing pathogens similar to normal flora in a complex matrix in a process that does not require any culture, including pre-enrichment. Straintyping and characterization of the Shiga toxin-producing Escherichia coli (STEC) from clinical stool samples represents a significant challenge and has been selected as the target organism for this challenge. STEC are similar in most respects to the commensal E. coli that are carried in the intestinal tract of nearly everyone. Consistent identification, straintyping, and characterization of pathogenic STEC directly from a complex matrix, such as stool, requires the consistent identification of both a variable marker that can be used for subtyping and a second, more stable marker that can be used for definitive identification.
Contestants can submit solutions between September 2, 2014 and November 30, 2014. Judging will take place between December 1 and 10, 2014, during which time additional information, clarification or documentation may be requested. The winner will be notified and prize awarded by December 15, 2014.
Culture-Independent Straintyping and Characterization Challenge; Requirements and Registration
,
Challenge.gov
http://www.cdc.gov/amd/cidtchallenge
www.cdc.gov/amd
Federal Register
Vol. 79, no. 167
Office of the Federal Register, National Archives and Records Administration
2014-08-28
continuing
daily
deposited
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232 p.
Table of Contents:
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GS 4.107:
AE 2.106:
KF70.A2
https://www.govinfo.gov/app/details/FR-2014-08-28
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https://www.govinfo.gov/app/details/FR-2014-08-28
https://www.govinfo.gov/content/pkg/FR-2014-08-28/pdf/FR-2014-08-28.pdf
https://www.govinfo.gov/content/pkg/FR-2014-08-28/xml/FR-2014-08-28.xml
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DGPO
2014-10-07
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FR-2014-08-28
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FR
FR-2014-08-28
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