United States Government Publishing Office publisher pbl distributor dst United States National Archives and Records Administration Office of the Federal Register author aut Government Organization text government publication eng FR Regulatory Information 2013_register executive 2013-07-27 article Notices D09002ee1c7fb30de D09002ee1c7fb3160 United States Department of Health and Human Services originator org United States Government Agency or Subagency United States National Institutes of Health originator org United States Government Agency or Subagency The National Institute of Environmental Health Sciences (NIEHS)/National Toxicology Program (NTP) is interested in the identification and prioritization of a comprehensive list of environmentally responsive genes that might be targets for screening cells or tissues obtained from humans, rats, mice, zebrafish, and Caenorhabditis elegans against large numbers of substances. The goal is to generate a minimum list of 1000 genes for each species that would provide the maximal toxicogenomic information on (1) effects that reflect general cellular responses, independent of cell type or species, and (2) gene expression changes that are specific by organ and/or cell type. The NIEHS/NTP also seeks recommendations on criteria to use for prioritizing the genes in order to identify those potentially most useful in a screening paradigm. Such a list of environmentally responsive genes may be useful also in biomarker development and basic research efforts. 78 FR 45542 https://www.govinfo.gov/app/details/FR-2013-07-29/2013-18058 2013-18058 fr29jy13-65 4140-01-P https://www.govinfo.gov/app/details/FR-2013-07-29/2013-18058 https://www.govinfo.gov/content/pkg/FR-2013-07-29/html/2013-18058.htm https://www.govinfo.gov/content/pkg/FR-2013-07-29/pdf/2013-18058.pdf 2 p. 45542 45543 78 FR 45542 Request for Information: The National Institute of Environmental Health Sciences/National Toxicology Program Requests the Nomination and Prioritization of Environmentally Responsive Genes for Use in Screening Large Numbers of Substances Using Toxicogenomic Technologies; Federal Register Vol. 78, Issue NOTICE 2013-18058 DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health 4140-01-P 2013-18058

The National Institute of Environmental Health Sciences (NIEHS)/National Toxicology Program (NTP) is interested in the identification and prioritization of a comprehensive list of environmentally responsive genes that might be targets for screening cells or tissues obtained from humans, rats, mice, zebrafish, and Caenorhabditis elegans against large numbers of substances. The goal is to generate a minimum list of 1000 genes for each species that would provide the maximal toxicogenomic information on (1) effects that reflect general cellular responses, independent of cell type or species, and (2) gene expression changes that are specific by organ and/or cell type. The NIEHS/NTP also seeks recommendations on criteria to use for prioritizing the genes in order to identify those potentially most useful in a screening paradigm. Such a list of environmentally responsive genes may be useful also in biomarker development and basic research efforts.

The deadline for receipt of information is August 23, 2013. Dr. Elizabeth Maull, NIEHS, P. O. Box 12233 (MD K2-17), Research Triangle Park, NC 27709; email: maull@niehs.nih.gov. Requests for Information: National Institute of Environmental Health Sciences/National Toxicology Program , Genelist@niehs.nih.gov maull@niehs.nih.gov http://ntp.niehs.nih.gov http://www.niehs.nih.gov Vol. 78, no. 145 Office of the Federal Register, National Archives and Records Administration 2013-07-29 continuing daily deposited born digital 409 p. Table of Contents: AE 2.7: GS 4.107: AE 2.106: KF70.A2 https://www.govinfo.gov/app/details/FR-2013-07-29 P0b002ee185b0d119 0097-6326 0042-1219 0364-1406 769-004-00000-9 000582072 f:fr29jy13 https://www.govinfo.gov/app/details/FR-2013-07-29 https://www.govinfo.gov/content/pkg/FR-2013-07-29/pdf/FR-2013-07-29.pdf https://www.govinfo.gov/content/pkg/FR-2013-07-29/xml/FR-2013-07-29.xml fdlp 45441 45839 DGPO 2013-07-27 2024-06-03 FR-2013-07-29 machine generated eng FR FR-2013-07-29 78 145