United States Government Publishing Office publisher pbl distributor dst United States National Archives and Records Administration Office of the Federal Register author aut Government Organization text government publication eng FR Regulatory Information 2012_register executive 2012-12-22 article Notices D09002ee1c7fc09ea D09002ee1c7fc0abe United States Department of Health and Human Services originator org United States Government Agency or Subagency United States Office of the Secretary originator org United States Government Agency or Subagency Notice is hereby given that the Office of Research Integrity (ORI) has taken final action in the following case: Terry S. Elton, Ph.D., The Ohio State University: Based on the reports of two investigations conducted by The Ohio State University (OSU) and additional analysis conducted by ORI in its oversight review, ORI found that Dr. Terry S. Elton, Professor, College of Pharmacy and Davis Heart and Lung Research Institute, OSU, engaged in research misconduct in research supported by National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), grants R01 HL048848, R01 HL084498, and P01 HL70294, National Institute of Child Health and Human Development (NICHD), NIH, grant R21 HD058997, National Institute on Aging (NIA), NIH, grant R01 AG021912, National Institute of Allergy and Infectious Diseases (NIAID), NIH, grant R01 AI39963, and National Eye Institute (NEI), NIH, grant R01 ES012241. ORI found that the Respondent engaged in research misconduct by falsifying and/or fabricating data that were included in 1 R21 HD058997-01, 1 R21 HD058997-01A1, 1 R21 HD058997-01A2, 1 RC1 HL100298- 01, and in: 1. Kuhn, D.E., Nuovo, G.J., Terry, A.V. Jr., Martin, M.M., Malana, G.E., Sansom, SE., Pleister, A.P., Beck, W.D., Head, E., Feldman, D.S., & Elton, T.S. "Chromosome 21-derived microRNAs provide an etiological basis for aberrant protein expression in human Down syndrome brains." J Biol Chem 285(2):1529-43, 2010 Jan 8. 2. Kuhn, D.E., Nuovo, G.J., Martin, M.M., Malana, G.E., Pleister, A.P., Jiang, J., Schmittgen, T.D., Terry, A.V. Jr., Gardiner, K., Head, E., Feldman, D.S., & Elton, T.S. "Human chromosome 21-derived miRNAs are overexpressed in Down syndrome brains and hearts." Biochem Biophys Res Commun 370(3):473-7, 2008 Jun 6. 3. Martin, M.M., Buckenberger, J.A., Jiang, J., Malana, G.E., Knoell, D.L., Feldman, D.S., & Elton, T.S. "TGF[szlig]1 stimulates human AT1 receptor expression in lung fibroblasts by cross talk between the Smad, p38 MAPK, JNK, and PI3K signaling pathways." Am. J. Physiol. Lung Cell. Mol. Physiol. 293(3):L790-9, 2007 Sept. (Retracted: Am. J. Physiol. Lung Cell. Mol. Physiol. 302(7):L719, 2012 Apr.) 4. Martin, M.M., Buckenberger, J.A., Jiang, J., Malana, G.E., Nuovo, G.J., Chotani, M., Feldman, D.S., Schmittgen, T.D., & Elton, T.S. "The human angiotensin II type 1 receptor +1166 A/C polymorphism attenuates microRNA-155 binding." J Biol Chem 282(33):24262-9, 2007, Aug 17. 5. Martin, M.M., Buckenberger, J.A., Knoell, D.L., Strauch, A.R., & Elton, T.S. "TGF-beta(1) regulation of human AT1 receptor mRNA splice variants harboring exon 2." Mol Cell Endocrinol 249(1-2):21-31, 2006 Apr 25. 6. Duffy, A.A., Martin, M.M., & Elton, T.S. "Transcriptional regulation of the AT1 receptor gene in immortalized human trophoblast cells." Biochim. Biophys. Acta. 1680(3):158-70, 2004 Nov 5. As a result of its investigation, OSU has recommended that all of the above publications be retracted. Specifically, ORI finds that Respondent: <bullet> Falsified and/or fabricated Western blots in an NIH grant application in three submissions of the same grant application: 77 FR 76041 https://www.govinfo.gov/app/details/FR-2012-12-26/2012-30866 2012-30866 fr26de12-102 4150-31-P https://www.govinfo.gov/app/details/FR-2012-12-26/2012-30866 https://www.govinfo.gov/content/pkg/FR-2012-12-26/html/2012-30866.htm https://www.govinfo.gov/content/pkg/FR-2012-12-26/pdf/2012-30866.pdf 2 p. 76041 76042 77 FR 76041 Findings of Research Misconduct; Federal Register Vol. 77, Issue NOTICE 2012-30866 DEPARTMENT OF HEALTH AND HUMAN SERVICES Office of the Secretary 4150-31-P 2012-30866 Notice.

Notice is hereby given that the Office of Research Integrity (ORI) has taken final action in the following case: Terry S. Elton, Ph.D., The Ohio State University: Based on the reports of two investigations conducted by The Ohio State University (OSU) and additional analysis conducted by ORI in its oversight review, ORI found that Dr. Terry S. Elton, Professor, College of Pharmacy and Davis Heart and Lung Research Institute, OSU, engaged in research misconduct in research supported by National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), grants R01 HL048848, R01 HL084498, and P01 HL70294, National Institute of Child Health and Human Development (NICHD), NIH, grant R21 HD058997, National Institute on Aging (NIA), NIH, grant R01 AG021912, National Institute of Allergy and Infectious Diseases (NIAID), NIH, grant R01 AI39963, and National Eye Institute (NEI), NIH, grant R01 ES012241. ORI found that the Respondent engaged in research misconduct by falsifying and/or fabricating data that were included in 1 R21 HD058997-01, 1 R21 HD058997-01A1, 1 R21 HD058997-01A2, 1 RC1 HL100298- 01, and in: 1. Kuhn, D.E., Nuovo, G.J., Terry, A.V. Jr., Martin, M.M., Malana, G.E., Sansom, SE., Pleister, A.P., Beck, W.D., Head, E., Feldman, D.S., & Elton, T.S. "Chromosome 21-derived microRNAs provide an etiological basis for aberrant protein expression in human Down syndrome brains." J Biol Chem 285(2):1529-43, 2010 Jan 8. 2. Kuhn, D.E., Nuovo, G.J., Martin, M.M., Malana, G.E., Pleister, A.P., Jiang, J., Schmittgen, T.D., Terry, A.V. Jr., Gardiner, K., Head, E., Feldman, D.S., & Elton, T.S. "Human chromosome 21-derived miRNAs are overexpressed in Down syndrome brains and hearts." Biochem Biophys Res Commun 370(3):473-7, 2008 Jun 6. 3. Martin, M.M., Buckenberger, J.A., Jiang, J., Malana, G.E., Knoell, D.L., Feldman, D.S., & Elton, T.S. "TGF[szlig]1 stimulates human AT1 receptor expression in lung fibroblasts by cross talk between the Smad, p38 MAPK, JNK, and PI3K signaling pathways." Am. J. Physiol. Lung Cell. Mol. Physiol. 293(3):L790-9, 2007 Sept. (Retracted: Am. J. Physiol. Lung Cell. Mol. Physiol. 302(7):L719, 2012 Apr.) 4. Martin, M.M., Buckenberger, J.A., Jiang, J., Malana, G.E., Nuovo, G.J., Chotani, M., Feldman, D.S., Schmittgen, T.D., & Elton, T.S. "The human angiotensin II type 1 receptor +1166 A/C polymorphism attenuates microRNA-155 binding." J Biol Chem 282(33):24262-9, 2007, Aug 17. 5. Martin, M.M., Buckenberger, J.A., Knoell, D.L., Strauch, A.R., & Elton, T.S. "TGF-beta(1) regulation of human AT1 receptor mRNA splice variants harboring exon 2." Mol Cell Endocrinol 249(1-2):21-31, 2006 Apr 25. 6. Duffy, A.A., Martin, M.M., & Elton, T.S. "Transcriptional regulation of the AT1 receptor gene in immortalized human trophoblast cells." Biochim. Biophys. Acta. 1680(3):158-70, 2004 Nov 5. As a result of its investigation, OSU has recommended that all of the above publications be retracted. Specifically, ORI finds that Respondent: <bullet> Falsified and/or fabricated Western blots in an NIH grant application in three submissions of the same grant application:

Director, Office of Research Integrity, 1101 Wootton Parkway, Suite 750, Rockville, MD 20852, (240) 453-8200. Findings of Research Misconduct , Vol. 77, no. 247 Office of the Federal Register, National Archives and Records Administration 2012-12-26 continuing daily deposited born digital 402 p. Table of Contents: AE 2.7: GS 4.107: AE 2.106: KF70.A2 https://www.govinfo.gov/app/details/FR-2012-12-26 P0b002ee1839c2d36 0097-6326 0042-1219 0364-1406 769-004-00000-9 000582072 f:fr26de12 https://www.govinfo.gov/app/details/FR-2012-12-26 https://www.govinfo.gov/content/pkg/FR-2012-12-26/pdf/FR-2012-12-26.pdf https://www.govinfo.gov/content/pkg/FR-2012-12-26/xml/FR-2012-12-26.xml fdlp 75823 76213 DGPO 2012-12-22 2024-06-03 FR-2012-12-26 machine generated eng FR FR-2012-12-26 77 247