[List of CFR Sections Affected (LSA), December 2025] [From the U.S. Government Publishing Office, www.gpo.gov] TITLE 21_FOOD AND DRUGS Chapter I_Food and Drug Administration, Department of Health and Human Services (Parts 1_1299) 1.280 (a)(2) revised...............................................46055 1.281 (a)(5)(iv), (b)(4)(iv), (10), (11), and (c)(5)(iv) revised.............................................46055 1.283 (a)(6), (c)(1), and (2) revised..............................46055 1.285 (g) and (i)(1) revised.......................................46055 14.100 (c)(3) removed; (c)(4) through (18) redesignated as new (c)(3) through (17)........................42135 16.1 CFR correction: (b)(1) reinstated.............................35407 73 Correction: Order...............................................37793 73.69 (c) revised..................................................20104 73.69 Regulation at 90 FR 20104 eff. 6-26-25.......................40704 73.80 Added........................................................20100 73.80 Regulation at 90 FR 20100 eff. 6-26-25.......................40704 73.167 Added.......................................................20108 73.167 Regulation at 90 FR 20108 eff. 6-26-25......................40703 73.168 Added.......................................................31590 73.168 Regulation at 90 FR 31590 confirmed.........................47229 73.297 Regulation at 90 FR 5594 confirmed..........................22627 145.116 Removed....................................................33272 145.116 Regulation at 90 FR 33272 eff. date confirmed......................................................46348 145.126 Removed....................................................33272 145.126 Regulation at 90 FR 33272 eff. date confirmed......................................................46348 145.131 Removed....................................................33272 145.131 Regulation at 90 FR 33272 eff. date confirmed......................................................46348 145.134 Removed....................................................33272 145.134 Regulation at 90 FR 33272 eff. date confirmed......................................................46348 145.136 Removed....................................................33272 145.136 Regulation at 90 FR 33272 eff. date confirmed......................................................46348 145.140 Removed....................................................33272 145.140 Regulation at 90 FR 33272 eff. date confirmed......................................................46348 145.171 Removed....................................................33272 145.171 Regulation at 90 FR 33272 eff. date confirmed......................................................46348 145.176 Removed....................................................33272 145.176 Regulation at 90 FR 33272 eff. date confirmed......................................................46348 145.181 Removed....................................................33272 145.181 Regulation at 90 FR 33272 eff. date confirmed......................................................46348 155.131 Removed....................................................33272 155.131 Regulation at 90 FR 33272 eff. date confirmed......................................................46348 155.172 Removed....................................................33272 155.172 Regulation at 90 FR 33272 eff. date confirmed......................................................46348 172.380 (b) revised; (c)(11) added.................................42704 173.356 Revised....................................................42537 291 Notification...................................................20393 510.600 (c)(1) table and (2) table amended..................19624, 40968 516.2106 Added.....................................................19624 520.35 (c)(2) amended..............................................40969 520.304 (b)(1) amended.............................................19625 520.304 (b)(1) amended.............................................40969 [[Page 55]] 520.446 (b)(2) amended.............................................40969 520.812 (b)(2) amended.............................................40969 520.1287 (c)(2) amended............................................40969 520.1375 (b) and (c)(1) revised....................................40970 520.2090 (c)(2) revised............................................40970 520.2455 (b)(2) revised; (b)(4) removed............................40970 522.311 (b) amended................................................40970 522.480 (b) revised; (c)(3) removed................................40970 522.772 (d)(1)(ii) amended.........................................19625 522.970 (b)(1) and (3) amended.....................................40970 522.1260 (e)(2)(iii) revised.......................................40970 522.2005 (b) introductory text revised.............................19625 522.2662 (b)(2) amended............................................19625 524.814 (b) amended................................................19625 524.1144j Added....................................................40970 524.1146 (b)(2) and (3) amended....................................40970 524.1312 Added.....................................................40970 528.2000 Added.....................................................40970 558.68 (e)(1)(ii) and (vii) revised................................40971 558.68 Correction: (e)(1)(ii) revised..............................45134 558.355 (b)(2), (e)(1)(vii), (xiv), and (2)(ii) through (v) revised............................................40971 558.635 (e)(3)(ii) through (viii) added............................40972 573.920 (a)(6) and (b) revised; (i) added..........................21220 801.30 (a)(2) revised..............................................55979 801.45 (e) revised.................................................55979 803.18 (e) revised.................................................55979 809.3 (a) amended..................................................45136 812.1 (a) revised..................................................55979 812.35 (a)(3)(iii)(A) and (iv)(A) revised..........................55980 860.15 (a) revised.................................................55980 860.84 (d)(4) revised..............................................55980 860.240 (c)(2) revised.............................................55980 862 Authority citation revised.....................................55980 862.1092 Added.....................................................22850 862.1093 Added.....................................................40708 862.1220 (b)(2) revised............................................55980 862.1488 Added.....................................................27230 862.1493 Added.....................................................19628 862.1506 Added.....................................................27228 862.2050 (b) revised...............................................55980 862.2270 (b) revised...............................................55980 862.3364 Added.....................................................40706 862.3460 Added.....................................................22629 862.3970 Added.....................................................19626 864.1850 (b) revised...............................................55981 864.1880 Added.....................................................27233 864.2240 (b) revised...............................................55981 864.3010 (b) revised...............................................55981 864.3250 (b) revised...............................................55981 864.3260 (b) revised...............................................55981 864.3600 (b) revised...............................................55981 864.4010 (b) revised...............................................55981 864.5430 Added.....................................................19630 864.7010 (b)(3) revised............................................55981 866 Order..........................................................22633 866.1650 Added.....................................................24963 866.2120 (b) revised...............................................55981 866.2180 (b) revised...............................................55981 866.2190 (b)(7) revised............................................55982 866.2440 (b) revised...............................................55982 866.2540 (b) revised...............................................55982 866.2600 (b) revised...............................................55982 866.2950 Added.....................................................19645 866.3172 Added.....................................................44975 866.3173 Added.....................................................44976 866.3174 Added.....................................................44977 866.3181 Added.....................................................19636 866.3215 (b)(6) revised............................................55982 866.3230 Added.....................................................19643 866.3231 Added.....................................................23282 866.3307 Added.....................................................27235 866.3309 (b)(7) revised............................................55982 866.3361 (b)(4) revised............................................55982 866.3367 Added.....................................................19638 866.3376 Added.....................................................24968 866.3378 Added.....................................................24965 866.3393 Added.....................................................19633 866.3935 Added.....................................................22633 866.3960 (b)(8) revised............................................55982 866.3970 (b)(10) revised...........................................55982 866.3975 Added.....................................................40728 866.4001 Added.....................................................40711 866.5780 Added.....................................................40725 866.5920 Added.....................................................40715 866.5970 Added.....................................................22631 866.6070 Added.....................................................40723 866.6090 Added.....................................................40718 866.6100 Added.....................................................19640 868.1030 (b) revised...............................................55982 868.1965 (b) revised...............................................55982 868.5220 (b) revised...............................................55983 868.5420 (b) revised...............................................55983 868.5760 (b) revised...............................................55983 868.5795 (b) revised...............................................55983 868.6175 (b) revised...............................................55983 868.6225 (b) revised...............................................55983 872.1905 (b) revised...............................................55983 872.3140 (b) revised...............................................55983 872.3150 (b) revised...............................................55983 872.3220 (b) revised...............................................55983 872.3670 (b) revised...............................................55983 872.3730 (b) revised...............................................55984 [[Page 56]] 872.6010 (b) revised...............................................55984 872.6050 (b) revised...............................................55984 872.6140 (b) revised...............................................55984 872.6200 (b) revised...............................................55984 872.6290 (b) revised...............................................55984 872.6300 (b) revised...............................................55984 872.6570 (b) revised...............................................55984 872.6650 (b) revised...............................................55984 872.6670 (b) revised...............................................55984 872.6855 (b) revised...............................................55984 872.6870 (b) revised...............................................55985 872.6880 (b) revised...............................................55985 872.6890 (b) revised...............................................55985 874.1500 (b) revised...............................................55985 874.3540 (b) revised...............................................55985 874.5220 (b) revised...............................................55985 876 Authority citation revised.....................................55985 876.1510 Added.....................................................54232 876.5210 (b) revised...............................................55985 876.5250 (b)(2) revised............................................55985 876.5360 Added.....................................................40730 876.5510 Added.....................................................22636 876.5920 (b) revised...............................................55985 876.5970 (b) revised...............................................55985 878 Authority citation revised.....................................55986 878.3800 (b) revised...............................................55986 878.3910 (b) revised...............................................55986 880.2700 (b) revised...............................................55986 880.2740 (b) revised...............................................55986 880.2910 (b) revised...............................................25891 880.2930 (b) revised...............................................55986 880.5075 (b) revised...............................................55986 880.5120 (b) revised...............................................55986 880.5150 (b) revised...............................................55986 880.5160 (b) revised...............................................55986 880.5270 (b) revised...............................................55986 880.5300 (b) revised...............................................55986 880.5640 (b) revised...............................................55987 880.5680 (b) revised...............................................55987 880.5780 (b)(2) revised............................................55987 880.5820 (b) revised...............................................55987 880.6025 (b) revised...............................................55987 880.6050 (b) revised...............................................55987 880.6060 (b) revised...............................................55987 880.6070 (b) revised...............................................55987 880.6080 (b) revised...............................................55987 880.6085 (b) revised...............................................55987 880.6140 (b) revised...............................................55987 880.6185 (b) revised...............................................55988 880.6190 (b) revised...............................................55988 880.6200 (b) revised...............................................55988 880.6230 (b) revised...............................................55988 880.6265 (b) revised...............................................55988 880.6350 (b) revised...............................................55988 880.6430 (b) revised...............................................55988 880.6450 (b) revised...............................................55988 880.6730 (b) revised...............................................55988 880.6785 (b) revised...............................................55988 880.6800 (b) revised...............................................55988 880.6900 (b) revised...............................................55988 880.6960 (b) revised...............................................55989 880.6980 (b) revised...............................................55989 882.1200 (b) revised...............................................55989 882.1500 (b) revised...............................................55989 882.1525 (b) revised...............................................55989 882.1700 (b) revised...............................................55989 882.4565 Added.....................................................54234 882.5889 Added.....................................................59379 886.1140 (b) revised...............................................55989 886.1150 (b) revised...............................................55989 886.1170 (b) revised...............................................55989 886.1190 (b) revised...............................................55989 886.1200 (b) revised...............................................55989 886.1320 (b) revised...............................................55990 886.1330 (b) revised...............................................55990 886.1350 (b) revised...............................................55990 886.1375 (b) revised...............................................55990 886.1380 (b) revised...............................................55990 886.1390 (b) revised...............................................55990 886.1395 (b) revised...............................................55990 886.1400 (b) revised...............................................55990 886.1415 (b) revised...............................................55990 886.1460 (b) revised...............................................55990 886.1500 (b) revised...............................................55990 886.1605 (b) revised...............................................55990 886.1650 (b) revised...............................................55991 886.1655 (b) revised...............................................55991 886.1665 (b) revised...............................................55991 886.1700 (b) revised...............................................55991 886.1770 (b) revised...............................................55991 886.1780 (b)(2) revised............................................55991 886.1790 (b) revised...............................................55991 886.1810 (b) revised...............................................55991 886.1840 (b) revised...............................................55991 886.1860 (b) revised...............................................55991 886.1870 (b) revised...............................................55991 886.1880 (b) revised...............................................55991 886.1905 (b) revised...............................................55992 886.1910 (b) revised...............................................55992 886.4230 (b) revised...............................................55992 886.4445 (b) revised...............................................55992 886.4750 (b) revised...............................................55992 886.4770 (b) revised...............................................55992 886.4855 (b) revised...............................................55992 886.5120 (b) revised...............................................55992 886.5540 (b) revised...............................................55992 886.5600 (b) revised...............................................55992 886.5800 (b) revised...............................................55992 886.5810 (b) revised...............................................55993 886.5870 (b) revised...............................................55993 886.5910 (b) revised...............................................55993 886.5915 (b) revised...............................................55993 [[Page 57]] 888.4515 Added.....................................................40734 888.4520 Added.....................................................40732 888.5850 (b) revised...............................................55993 888.5890 (b) revised...............................................55993 888.5940 (b) revised...............................................55993 888.5980 (b) revised...............................................55993 890.3025 (b) revised...............................................55993 890.3075 (b) revised...............................................55993 890.3150 (b) revised...............................................55993 890.3410 (b) revised...............................................55994 890.3420 (b) revised...............................................55994 890.3475 (b) revised...............................................55994 890.3490 (b) revised...............................................55994 890.3520 (b) revised...............................................55994 890.3640 (b) revised...............................................55994 890.3665 (b) revised...............................................55994 890.3675 (b) revised...............................................55994 890.3700 (b) revised...............................................55994 890.3790 (b) revised...............................................55994 890.3825 (b) revised...............................................55994 890.3910 (b) revised...............................................55994 890.3940 (b) revised...............................................55995 890.5050 (b) revised...............................................55995 890.5125 (b) revised...............................................55995 890.5350 (b) revised...............................................55995 890.5370 (b) revised...............................................55995 890.5700 (b) revised...............................................55995 890.5730 (b) revised...............................................55995 890.5925 (b) revised...............................................55995 892.1001 Added.....................................................40735 892.1920 (b) revised...............................................55995 892.1940 (b) revised...............................................55995 892.1950 (b) revised...............................................55995 892.2090 Added.....................................................24970 892.2100 Added.....................................................23285 892.5725 (b)(2) revised............................................55996 892.6510 Added.....................................................27238 1010.4 (b)(2) revised; (b)(3) added................................44979 Chapter II_Drug Enforcement Administration, Department of Justice (Parts 1300_1399) 1301.13 (e) introductory text amended..............................47563 1307.41 Revised (temporary)........................................61306 1308 Order....................................35236, 57356, 57542, 58149 1308.11 Correction: (b)(62) through (109) redesignated as (b)(63) through (110); new (b)(62) added..................................................23438 1308.11 (d)(105) added.............................................38398 1308.11 (h)(77) and (78) added (temporary).........................39319 1308.11 (b)(21) through (58), (59) through (75), (76) through (81), (82), (83), (84) through (86), (87) through (103), and (104) through (110) redesignated as (b)(22) through (59), (61) through (77), (79) through (84), (86), (87), (89) through (91), (93) through (109), and (111) through (117); new (b)(21), new (60), new (78), new (85), new (88), new (92), and new (110) added; (h)(70) and (76) removed 44983 1308.11 (h)(79) through (85) added (temporary).....................48265 1308.11 (d)(106) added.............................................51105 1308.11 (b)(76) through (117) redesignated as (b)(78) through (119); (b)(72) through (75) redesignated as (b)(73) through new (76); new (b)(72) and (77) added; (h)(68) and (69) removed; eff. 1-22-26..........................................59972 1310.02 (a)(40) added..............................................47566 1310.04 (g)(1)(iv) through (xix) redesignated as (g)(1)(v) through (xx); new (g)(1)(iv) added 47566 1310.12 (c) table amended..........................................47566 1311.20 (b) and (c) revised........................................47580 1311.25 Revised....................................................47580 1311.40 (c) and (d) revised........................................47580 1311.60 (c) removed................................................47581 Proposed Rules: 1..................................................................38084 74.................................................................44786 101................................................................19664 106................................................................22675 117................................................................22675 131................................................................33334 133................................................................33334 135................................................................33334 136................................................................33339 139................................................................33339 145................................................................33346 146..................................................33339, 37817, 39139 155................................................................33346 161................................................................33339 169................................................................33339 172................................................................35645 184................................................................33334 573...........................................35645, 40269, 42550, 54245 730................................................................54603 864................................................................24540 866................................................................53261 [[Page 58]] 1308.......23477, 24362, 24370, 27268, 35253, 47663, 57534, 57924, 58174 1310........................................................23483, 47670 1400--1499 (Ch. II)................................................43948