[Federal Register Volume 90, Number 242 (Friday, December 19, 2025)]
[Proposed Rules]
[Pages 59441-59463]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2025-23464]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

Centers for Medicare & Medicaid Services

42 CFR Parts 441 and 457

[CMS-2451-P]
RIN 0938-AV73


Medicaid Program; Prohibition on Federal Medicaid and Children's 
Health Insurance Program Funding for Sex-Rejecting Procedures Furnished 
to Children

AGENCY: Centers for Medicare & Medicaid Services (CMS), Department of 
Health and Human Services (HHS).

ACTION: Proposed rule.

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SUMMARY: This proposed rule would require that a State Medicaid plan 
must provide that the Medicaid agency will not make payment under the 
plan for sex-rejecting procedures for children under 18 and prohibit 
the use of Federal Medicaid dollars to fund sex-rejecting procedures 
for individuals under the age of 18. In addition, it would require that 
a separate State Children's Health Insurance Program (CHIP) plan must 
provide that the CHIP agency will not make payment under the plan for 
sex-rejecting procedures for children under 19 and prohibit the use of 
Federal CHIP dollars to fund sex-rejecting procedures for individuals 
under the age of 19.

DATES: To be assured consideration, comments must be received at one of 
the addresses provided below, no later than 5 p.m. on February 17, 
2026.

ADDRESSES: In commenting, please refer to file code CMS-2451-P.
    Comments, including mass comment submissions, must be submitted in 
one of the following three ways (please choose only one of the ways 
listed):
    1. Electronically. You may submit electronic comments on this 
regulation to http://www.regulations.gov. Follow the ``Submit a 
comment'' instructions.
    2. By regular mail. You may mail written comments to the following 
address ONLY: Centers for Medicare & Medicaid Services, Department of 
Health and Human Services, Attention: CMS-2451-P, P.O. Box 8016, 
Baltimore, MD 21244-8016.
    Please allow sufficient time for mailed comments to be received 
before the close of the comment period.
    3. By express or overnight mail. You may send written comments to 
the following address ONLY: Centers for Medicare & Medicaid Services, 
Department of Health and Human Services, Attention: CMS-2451-P, Mail 
Stop C4-26-05, 7500 Security Boulevard, Baltimore, MD 21244-1850.
    For information on viewing public comments, see the beginning of 
the SUPPLEMENTARY INFORMATION section.

FOR FURTHER INFORMATION CONTACT: [email protected].

SUPPLEMENTARY INFORMATION: Inspection of Public Comments: All comments 
received before the close of the comment period are available for 
viewing by the public, including any personally identifiable or 
confidential business information that is included in a comment. We 
post all comments received before the close of the comment period on 
the following website as soon as possible after they have been 
received: https://www.regulations.gov Follow the search instructions on 
that website to view public comments. CMS will not post on 
Regulations.gov public comments that make threats to individuals or 
institutions or suggest that the commenter will take actions to harm an 
individual. CMS continues to encourage individuals not to submit 
duplicative comments. We will post acceptable comments from multiple 
unique commenters even if the content is identical or nearly identical 
to other comments. We encourage commenters to include supporting facts, 
research, and evidence in their comments. When doing so, commenters are 
encouraged to provide citations to the published materials referenced, 
including active hyperlinks. Likewise, commenters who reference 
materials which have not been published are encouraged to upload 
relevant data collection instruments, data sets, and detailed findings 
as a part of their comment.
    Plain Language Summary: In accordance with 5 U.S.C. 553(b)(4), a 
plain language summary of this proposed rule may be found at https://www.regulations.gov/.

I. Background 1
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    \1\ This document contains links to non-U.S. Government 
websites. We are providing these links because they contain 
additional information relevant to the topics discussed in this 
document or that otherwise may be useful to the reader. We cannot 
attest to the accuracy of information provided on the cited third-
party websites or any other linked third-party site. We are 
providing these links for reference only; linking to a non-U.S. 
Government website does not constitute an endorsement by CMS, HHS, 
or any of their employees of the sponsors or the information and/or 
any products presented on the website. Also, please be aware that 
the privacy protections generally provided by U.S. Government 
websites do not apply to third-party sites.
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    Title XIX of the Social Security Act (the Act) authorizes Federal 
grants to the States for Medicaid programs to

[[Page 59442]]

provide medical assistance to persons with limited income and resources 
and title XXI of the Act authorizes Federal grants to States to provide 
child health assistance to targeted low-income children under age 19 
through a separate CHIP, a Medicaid-expansion program, or a combination 
of the two. Separate CHIPs are programs under which a State receives 
Federal funding from its title XXI allotment to provide child health 
assistance through coverage that meets the requirements of section 2103 
of the Act and 42 CFR 457.402. For the purposes of this proposed rule, 
the term CHIP is used to refer to separate CHIPs. Medicaid and CHIP 
programs are administered primarily by the States, subject to Federal 
oversight and approval. Each State establishes its own Medicaid and 
CHIP eligibility standards, benefits packages, and payment rates in 
accordance with (and subject to) Federal statutory and regulatory 
requirements. If States comply with requirements in the Federal 
Medicaid and CHIP statutes and regulations (such as reflected in the 
provisions of their Federally-approved State plans), the Federal 
Government will match their expenditures with Federal funds. Each State 
Medicaid program and CHIP must be described and administered in 
accordance with a Federally approved State plan. This comprehensive 
document describes the nature and scope of the States' Medicaid program 
and CHIP and provides assurances that they will be administered in 
conformity with applicable Federal requirements.
    Under title XIX, the Federal Government makes matching payments to 
States for medical assistance expenditures according to the formula 
described in sections 1903 and 1905(b) of the Act. Under title XXI, the 
Federal Government makes matching payments to States for child health 
assistance at the enhanced Federal medical assistance percentage (FMAP) 
established under section 2105 of the Act. Section 1903 of the Act 
requires that the Secretary of Health and Human Services (the 
Secretary) (except as otherwise provided) pay to each State which has a 
plan approved under title XIX of the Act, for each quarter, an amount 
equal to the FMAP of the total amount expended by the State during such 
quarter as medical assistance under the State plan. Section 1905(b) of 
the Act defines the FMAP. For CHIP, section 2105 requires the Secretary 
to pay each State with an approved plan under title XXI of the Act, for 
each quarter, an amount equal to the enhanced FMAP of expenditures in 
the quarter, paid from the State allotment. The enhanced FMAP, as 
defined at section 2105(b), for a State for a fiscal year, is equal to 
the FMAP (as defined in the first sentence of section 1905(b)) for the 
State increased by a number of percentage points equal to 30 percent of 
the number of percentage points by which (1) such FMAP for the State is 
less than (2) 100 percent; but in no case shall the enhanced FMAP for a 
State exceed 85 percent.
    As relevant to this proposed rule, among the statutory requirements 
for Medicaid State plans, section 1902(a)(19) of the Act \2\ requires 
that a State plan for medical assistance provide such safeguards as may 
be necessary to assure that care and services under the plan will be 
provided in a manner consistent with the best interests of the 
recipients. Furthermore, under section 1902(a)(30)(A) of the Act,\3\ 
the State plan must provide such methods and procedures relating to 
payment for care and services as may be necessary to assure that 
payments are consistent with quality of care. Among the statutory 
requirements for CHIP State plans, under section 2101(a) of the Act, 
funds are provided to States to provide health care services to 
uninsured, low-income children in an effective and efficient manner 
that is coordinated with other sources of health benefits coverage for 
children.
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    \2\ Section 1902(a)(19) of the Act states that a State plan for 
medical assistance must ``provide such safeguards as may be 
necessary to assure that eligibility for care and services under the 
plan will be determined, and such care and services will be 
provided, in a manner consistent with simplicity of administration 
and the best interests of the recipients.''
    \3\ Section 1902(a)(30)(A) of the Act states that a State plan 
for medical assistance must ``provide such methods and procedures 
relating to the utilization of, and the payment for, care and 
services available under the plan (including but not limited to 
utilization review plans as provided for in section 1903(i)(4) of 
the Act) as may be necessary to safeguard against unnecessary 
utilization of such care and services and to assure that payments 
are consistent with efficiency, economy, and quality of care and are 
sufficient to enlist enough providers so that care and services are 
available under the plan at least to the extent that such care and 
services are available to the general population in the geographic 
area.''
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    Section 1102 of the Act requires the Secretary to make and publish 
such rules and regulations, not inconsistent with the Act, as may be 
necessary for the efficient administration of the functions with which 
the Secretary is charged under the Act. In Medicaid, these Secretarial 
functions would include oversight of Medicaid State programs for 
consistency with the requirements of sections 1902(a)(19) and 
1902(a)(30)(A) of the Act. In CHIP, these Secretarial functions would 
include oversight of CHIP under section 2101(a), which calls for 
effective and efficient administration of CHIP and coordination with 
other health care programs, including Medicaid, and under section 
2107(e) of the Act, carrying out the functions required by the Medicaid 
provisions that apply to title XXI in the same manner as they apply 
under title XIX.
    On January 28, 2025, President Trump issued Executive Order (E.O.) 
14187, Protecting Children from Chemical and Surgical Mutilation (E.O. 
14187). Section 5(a) of that order directs the Secretary to take all 
appropriate actions consistent with applicable law to end what the 
order refers to as the chemical and surgical mutilation of children, 
including regulatory and sub-regulatory actions for specific programs, 
including Medicaid. The Centers for Medicare & Medicaid Services (CMS) 
is aware that the U.S. District Court for the Western District of 
Washington has issued a preliminary injunction that enjoins defendant 
agencies from enforcing or implementing section 4 of E.O. 14187 within 
the plaintiff States, as well as sections 3(e) or 3(g) of E.O. 14168, 
Defending Women From Gender Ideology Extremism and Restoring Biological 
Truth to the Federal Government (E.O. 14168), to condition or withhold 
Federal funding based on the fact that a health care entity or health 
professional provides ``gender-affirming care'' within the plaintiff 
States. Washington v. Trump, 768 F. Supp. 3d 1239, 1282 (W.D. Wash. 
2025). In addition, the U.S. District Court for the District of 
Maryland has issued a preliminary injunction that enjoins the Federal 
defendants in that case from conditioning, withholding, or terminating 
Federal funding under section 3(g) of E.O. 14168 and section 4 of E.O. 
14187, based on the fact that a healthcare entity or health 
professional provides ``gender-affirming care'' to a patient under the 
age of 19 and required that written notice of this order be given to 
the aforementioned groups that Defendants may not take any steps to 
implement, give effect to, or reinstate under a different name the 
directives in section 3(g) of E.O. 14168 or section 4 of E.O. 14187 
that condition or withhold Federal funding based on the fact that a 
healthcare entity or health professional provides ``gender-affirming 
medical care'' to a patient under the age of 19. PFLAG, Inc. v. Trump, 
769 F. Supp. 3d 405, 455 (D. Md. 2025). We note that if this proposed 
rule were to be finalized, it would not conflict with those preliminary 
injunctions because, among other things, it would be based

[[Page 59443]]

on independent legal authority and section 5(a) of E.O. 14187 and not 
the enjoined sections of the executive orders. In any event, any 
regulatory provisions on this issue would not be effective until the 
specified effective date of any final rule, and would not be 
implemented, made effective, or enforced in contravention of any court 
orders.
    As further discussed later in this proposed rule, we propose to 
implement sections 1902(a)(19) and 1902(a)(30)(A) of the Act by adding 
a new subpart N to 42 CFR part 441 to prohibit the use of Federal 
Medicaid dollars to fund sex-rejecting procedures, as defined in this 
proposed rule, for individuals under the age of 18. In addition, we 
propose to implement section 2103 of the Act by revising subpart D of 
part 457 of the Act to prohibit the use of Federal CHIP dollars to fund 
sex-rejecting procedures, as defined in this proposed rule, for 
individuals under the age of 19. These proposed changes would not 
prevent States from providing coverage for sex-rejecting procedures 
with State-only funds outside of the Federally-matched Medicaid program 
or CHIP.

A. The Rise of Sex-Rejecting Procedures for Treatment of Gender 
Dysphoria in Minors

    Over the past decade, increasing numbers of children and 
adolescents have been diagnosed with gender dysphoria. The recorded 
prevalence of gender dysphoria/incongruence increased substantially in 
children and young people between 2011 and 2021, particularly in 
recorded females. Levels of anxiety, depression and self-harm were 
high, indicating an urgent need for better prevention and treatment of 
mental health difficulties in these patients [with gender 
dysphoria].\4\
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    \4\ Stuart William Jarviset al., ``Epidemiology of gender 
dysphoria and gender incongruence in children and young people 
attending primary care practices in England: retrospective cohort 
study,'' Archives of Disease in Childhood 110 (2025): 612, 
doi:10.1136/archdischild-2024-327992.
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    Similar research in Germany showed increasing rates in the 
diagnosis of gender incongruence.\5\ Additionally, research in England 
explained that ``[r]ecent increases in incidence of gender dysphoria/
incongruence have a range of potential explanations, including social 
factors (for example, . . . increasing use of social media and 
networking); increasing rates of emotional distress and poor mental 
health in this age group, particularly for females; and changes in 
supply and delivery of healthcare.'' \6\ The number of children 
receiving medical interventions for gender dysphoria rose significantly 
following the publication of the ``Dutch Protocol'' in an article in 
the European Journal of Endocrinology in 2006.\7\ Over the past decade, 
increasing numbers of children have received diagnoses of gender 
dysphoria and received sex-rejecting procedures as recommended by the 
World Professional Association for Transgender Health (WPATH) and the 
Endocrine Society (ES).8 9 The WPATH Standards of Care for 
the Health of Transgender and Gender Diverse People, Version 8 (SOC-8) 
noted that the creation of a chapter on adolescents was due in part to 
the ``exponential growth in adolescent referral rates.'' \10\ Surveys 
measuring ``transgender'' identity find prevalence of 1.2 percent among 
adolescents and ``gender diverse'' identities as high as 9 percent.\11\ 
WPATH also noted that female adolescents were seeking such procedures 
at twice to seven times the rate of males.\12\
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    \5\ Christian J. Bachmann et al., ``Gender identity disorders 
among young people in Germany: Prevalence and trends, 2013-2022. An 
analysis of nationwide routine insurance data,'' Deutsches 
[Auml]rzteblatt International 121 (2024): 370-371, doi:10.3238/
arztebl.m2024.0098. ``Gender incongruence'' as defined by ICD-11 is 
``characterized by a marked and persistent incongruence between an 
individual's experienced gender and the assigned sex.'' See 
``International Classification of Diseases 11th Revision (ICD-11),'' 
World Health Organization, accessed September 9, 2025, https://icd.who.int/en/.
    \6\ Jarvis et al., ``Epidemiology of gender dysphoria,'' 619.
    \7\ Henriette A. Delemarre-van de Waal and Peggy T. Cohen-
Kettenis, ``Clinical management of gender identity disorder in 
adolescents: A protocol on psychological and pediatric endocrinology 
aspects,'' European Journal of Endocrinology 155, Supp 1 (2006): 
S131-S137, https://doi.org/10.1530/eje.1.02231.
    \8\ E. Coleman et al., ``Standards of Care for the Health of 
Transgender and Gender Diverse People, Version 8,'' International 
Journal of Transgender Health 23, Supp 1 (2022): S1-S258, https://doi.org/10.1080/26895269.2022.2100644.
    \9\ Wylie C. Hembree et al., ``Endocrine Treatment of Gender-
Dysphoric/Gender-Incongruent Persons: An Endocrine Society Clinical 
Practice Guideline,'' The Journal of Clinical Endocrinology & 
Metabolism 102, no. 11 (2017): 3869-3903, https://doi.org/10.1210/jc.2017-01658.
    \10\ E. Coleman et al., ``Standards of Care,'' S43.
    \11\ E. Coleman et al., ``Standards of Care,'' S43.
    \12\ E. Coleman et al., ``Standards of Care,'' S43.
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    Included in SOC-8 is the recommendation that care providers 
``undertake a comprehensive biopsychosocial assessment of adolescents'' 
who seek medical transition \13\ and ``involve relevant disciplines, 
including mental health and medical professionals,'' as well as 
parents, ``unless their involvement is determined to be harmful.'' \14\
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    \13\ Medical transition refers to the provision of hormonal or 
surgical interventions, as adapted from the Department of Health and 
Human Services, ``Treatment for Pediatric Gender Dysphoria Review of 
Evidence and Best Practices,'' (November 19, 2025): 29, https://opa.hhs.gov/sites/default/files/2025-11/gender-dysphoria-report.pdf 
[hereinafter ``HHS Review''].
    \14\ Jennifer Block, ``US transgender health guidelines leave 
age of treatment initiation open to clinical judgment,'' BMJ 378 
(2022), https://doi.org/10.1136/bmj.o2303. See also E. Coleman et 
al., ``Standards of Care,'' S50, S56, S58.
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    The number of pediatric patients seeking sex-rejecting procedures 
can only be roughly estimated. In recent years, ``the United States--
characterized by its decentralized and privatized healthcare system--
saw the emergence of many new specialty gender clinics, along with a 
proliferation of independently practicing clinicians. According to a 
recent conservative estimate, as of March 2023 there were 271 clinics 
offering [pediatric medical transition] in the U.S., though 70 were 
inactive due to legislative restrictions.'' \15\
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    \15\ HHS Review, 57-58. See Luca Borah et al., ``State 
restrictions and geographic access to gender-affirming care for 
transgender youth,'' JAMA 330, no. 4 (2023): 375-378, doi:10.1001/
jama.2023.11299.
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    An approach for gender dysphoria, referred to in this proposed rule 
as sex-rejecting procedures,\16\ can involve the use of puberty 
suppressing drugs to prevent the onset of puberty; cross-sex hormones 
to spur the secondary sex characteristics of the opposite sex; and 
surgeries including mastectomy and (in rare cases) vaginoplasty. 
``Thousands of American children and adolescents have received these 
interventions.'' \17\
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    \16\ In this proposed rule, we have sought to use the term 
``sex-rejecting procedures'' to refer to the set of procedures 
encompassed in the proposed definition.
    \17\ HHS Review, 9.
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    A study published in 2023 estimated that between 2016 and 2020, 
nearly 3,700 children between the ages of 12 and 18 diagnosed with 
gender dysphoria underwent surgical procedures, including over 3,200 
children who had breast or chest surgery, and over 400 children who had 
genital surgery.\18\ Another analysis found that between 2017 and 2021, 
more than 120,000 children ages 6 to 17 were diagnosed with gender 
dysphoria and, of that group, more than 4,700 started taking puberty 
blockers and more than 14,000 started hormonal therapy.\19\ However, as 
discussed later in this proposed rule, current medical evidence does 
not support a favorable

[[Page 59444]]

risk/benefit profile for the use of chemical or surgical procedures in 
children to treat gender dysphoria.
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    \18\ Jason D. Wright et al., ``National Estimates of Gender-
Affirming Surgery in the US,'' Jama Network Open 6, no. 8 (2023), 
doi:10.1001/jamanetworkopen.2023.30348.
    \19\ Robin Respaut and Chad Terhune, ``Putting numbers on the 
rise in children seeking gender care,'' Reuters, October 6, 2022, 
https://www.reuters.com/investigates/special-report/usa-transyouth-data/.
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B. Medical Evidence Regarding Sex-Rejecting Procedures for Minors

    The existing guidelines to support the care of children and 
adolescents experiencing gender dysphoria around the world vary in 
their methodological rigor and quality.
    On May 1, 2025, the United States Department of Health and Human 
Services (HHS) released a comprehensive review of the evidence and best 
practices for promoting the health of children and adolescents 
diagnosed with gender dysphoria.\20\ On November 19, 2025, HHS 
published a final version of the review following conclusion of the 
peer review process (HHS Review).\21\ The HHS Review, informed by an 
evidence-based medicine approach, indicated serious concerns about 
outcomes associated with certain medical interventions, such as puberty 
blockers, cross-sex hormones, and surgeries, that attempt to transition 
children and adolescents away from their sex.\22\ The HHS Review 
highlights evidence pointing to significant risks associated with the 
use of these procedures, including irreversible harms such as 
infertility, and finds extremely weak evidence of benefit. 
Significantly, the HHS Review finds that the evidence base does not 
support conclusions about the effectiveness of medical and surgical 
interventions in improving mental health or reducing gender dysphoria 
symptoms, stating that ``[a]nalysis of the biological plausibility of 
harms is necessary, and suggests that some short- and long-term harms 
are likely (in some cases expected) sequalae of treatment.'' \23\ 
Likewise, the data considered in the HHS Review indicate that the risk/
benefit profile of medical and surgical interventions for children and 
adolescents diagnosed with gender dysphoria is unfavorable. While the 
HHS Review itself does not make clinical, policy, or legislative 
recommendations, it provides critical insights that should inform 
policymakers as they make decisions to promote health and safety, 
especially for vulnerable populations such as minors.
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    \20\ HHS Review, 1. ``HHS Releases Comprehensive Review of 
Medical Interventions for Children and Adolescents with Gender 
Dysphoria,'' U.S. Department of Health and Human Services, released 
May 1, 2025, https://www.hhs.gov/press-room/gender-dysphoria-report-release.html.
    \21\ ``HHS Releases Peer-Reviewed Report Discrediting Pediatric 
Sex-Rejecting Procedures,'' U.S. Department of Health and Human 
Services, released November 19, 2025, https://www.hhs.gov/press-room/hhs-releases-peer-reviewed-report-discrediting-pediatric-sex-rejecting-procedures.html.
    \22\ See ``Information Quality Guidelines,'' Office of the 
Assistant Secretary for Planning and Evaluation (ASPE), accessed 
August 11, 2025, https://aspe.hhs.gov/topics/data/information-quality-guidelines; ``HHS Information Quality Peer Review,'' ASPE, 
accessed August 11, 2025, https://aspe.hhs.gov/hhs-information-quality-peer-review.
    \23\ HHS Review, 134.
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    Specifically, the HHS Review conducted an overview of systematic 
reviews--also known as an ``umbrella review''--to evaluate the evidence 
regarding the benefits and harms of hormonal and surgical interventions 
for children and adolescents diagnosed with gender dysphoria. Existing 
systematic reviews of evidence, including several that have informed 
health authorities in Europe, were assessed for methodological quality. 
The umbrella review found that the overall quality of evidence 
concerning the effects of sex-rejecting procedures on psychological 
outcomes, quality of life, regret, or long-term health, is very low.
    Although the HHS Review acknowledges that systematic reviews offer 
limited evidence regarding the harms of sex-rejecting procedures in 
minors, it also provides plausible explanations for why evidence of 
harms may not have been sought, detected or reported. This may be due 
to several factors: the relatively recent adoption of hormonal and 
surgical treatment approaches, shortcomings in existing studies in 
consistently monitoring and reporting adverse effects, and publication 
bias. Even in the absence of strong evidence from large-scale 
population studies, the HHS Review notes, based on what is known about 
human physiology and the effects and mechanisms of the pharmacological 
agents used, there are known and plausible risks of significant harms 
from puberty blockers, cross-sex hormones, and surgeries. These include 
``infertility/sterility, sexual dysfunction, impaired bone density 
accrual, adverse cognitive impacts, cardiovascular disease and 
metabolic disorders, psychiatric disorders, surgical complications, and 
regret.'' \24\
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    \24\ HHS Review, 10.
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    The HHS Review documents the weak evidence and growing 
international retreat from the use of puberty blockers, cross-sex 
hormones, and surgeries to treat gender dysphoria in minors \25\ and 
the ``risk of significant harms.'' \26\ The HHS Review explains that 
``many treatments (e.g. surgery, hormone therapy) can lead to 
relatively common and potentially serious long-term adverse effects.'' 
\27\ The HHS Review includes a methodologically rigorous assessment of 
evidence underpinning the use of surgical or endocrine interventions, 
including puberty blockers and cross-sex hormones, while also drawing 
on international practice evaluations such as the United Kingdom's Cass 
Review, described in more detail below. The HHS Review documents 
serious concerns regarding the lack of reliable evidence of benefits, 
and risks of significant harms for this model of care that have mounted 
in recent years, and points to psychotherapy (talk therapy) as a 
noninvasive alternative. The HHS Review makes clear that ``the evidence 
for benefit of pediatric medical transition is very uncertain, while 
the evidence for harm is less uncertain.'' \28\ The HHS Review cites 
widely accepted principles of medical ethics to conclude that when 
``medical interventions pose unnecessary, disproportionate risks of 
harm, healthcare providers should refuse to offer them even when they 
are preferred, requested, or demanded by patients.'' \29\
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    \25\ HHS Review, 63-65.
    \26\ HHS Review, 10.
    \27\ HHS Review, 230.
    \28\ HHS Review, 15.
    \29\ HHS Review, 15.
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    We are aware that approximately 17 State Medicaid programs cover 
sex-rejecting procedures for children, citing guidelines from several 
major U.S. medical professional associations (American Medical 
Association, the American Academy of Pediatrics, and the American 
Psychological Association) who have issued statements deeming sex-
rejecting procedures, which they refer to as ``gender-affirming care,'' 
safe and effective.30 31 32 33 These medical society 
endorsements further supported adoption of sex-rejecting procedures by 
clinicians across the U.S. The HHS Review explains why such guidelines, 
including the WPATH Standards of Care for the Health of Transgender and

[[Page 59445]]

Gender Diverse People, Version 8 (SOC-8), are not trustworthy according 
to accepted standards for evaluating guideline quality. As the HHS 
Review documents in detail, the creation of SOC-8 marked a ``clear 
departure from the principles of unbiased, evidence-driven clinical 
guideline development.'' \34\ In the context of developing its 
recommendations, WPATH suppressed systematic reviews of evidence, 
failed to manage conflicts of interest, and relied on legal and 
political considerations rather than clinical ones.\35\ A recent 
systematic review of international guideline quality concluded that 
``[h]ealthcare professionals should consider the lack of quality and 
independence of available guidance when utilizing this [WPATH and 
Endocrine Society international guidelines] for practice.'' \36\
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    \30\ Stacy Weiner, ``States are banning gender-affirming care 
for minors. What does that mean for patients and providers?,'' 
AAMCNews, February 20, 2024, https://www.aamc.org/news/states-are-banning-gender-affirming-care-minors-what-does-mean-patients-and-providers.
    \31\ ``APA adopts groundbreaking policy supporting transgender, 
gender diverse, nonbinary individuals,'' American Psychological 
Association, released February 28, 2024, https://www.apa.org/news/press/releases/2024/02/policy-supporting-transgender-nonbinary.
    \32\ Alyson Sulaski Wyckoff, ``AAP continues to support care of 
transgender youths as more states push restrictions,'' AAP News, 
January 6, 2022, https://publications.aap.org/aapnews/news/19021/AAP-continues-to-support-care-of-transgender.
    \33\ ``Criminalizing Gender Affirmative Care with Minors,'' 
American Psychological Association, accessed September 2, 2025, 
https://www.apa.org/topics/lgbtq/gender-affirmative-care.
    \34\ HHS Review, 181.
    \35\ HHS Review, 182.
    \36\ Jo Taylor et al., ``Clinical guidelines for children and 
adolescents experiencing gender dysphoria or incongruence: a 
systematic review of guideline quality (part 1),'' Archives of 
Disease in Childhood 109, Supp. 2 (2024): s65-s72, doi:10.1136/
archdischild-2023-326499.
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1. European Approaches for the Treatment of Pediatric Gender Dysphoria

    The HHS Review's current findings are aligned with conclusions 
reached by multiple European countries. Sweden, Finland, and the United 
Kingdom conducted independent systematic reviews of evidence 
commissioned by their public health authorities. ``All three concluded 
that the risks of medicalization \37\ may outweigh the benefits for 
children and adolescents with gender dysphoria at the population level, 
and subsequently sharply restricted access to medical gender transition 
interventions for minors.'' \38\ These three countries now recommend 
exploratory psychotherapy as the first line of treatment. Sweden and 
Finland reserve hormonal interventions only for exceptional cases, 
recognizing their experimental status.39 40 41
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    \37\ ``Medicalization'' means ``the act of considering something 
to be a medical problem, or representing it as a medical problem.'' 
Cambridge Dictionary, accessed August 8, 2025, https://dictionary.cambridge.org/us/dictionary/english/medicalization. This 
definition is based on a plain meaning approach and note that the 
authors of the study did not otherwise supply a specific definition 
for the term.
    \38\ HHS Review, 255. See Jonas F. Ludvigsson et al., ``A 
systematic review of hormone treatment for children with gender 
dysphoria and recommendations for research,'' Acta Paediatrica 112, 
no. 11 (2023): 2279-2292, https://doi.org/10.1111/apa.16791; 
National Institute for Health and Care Excellence (NICE), ``Evidence 
Review: Gender Affirming Hormones for Children and Adolescents with 
Gender Dysphoria,'' (2020), https://cass.independent-review.uk/wp-content/uploads/2022/09/20220726_Evidence-review_Gender-affirming-hormones_For-upload_Final.pdf; National Institute for Health and 
Care Excellence (NICE), ``Evidence Review: Gonadotrophin Releasing 
Hormone Analogues for Children and Adolescents with Gender 
Dysphoria,'' (2020), https://cass.independent-review.uk/wp-content/uploads/2022/09/20220726_Evidence-review_GnRH-analogues_For-upload_Final.pdf; I. Pasternack et al., 
``L[auml][auml]ketieteelliset menetelm[auml]t sukupuolivariaatioihin 
liittyv[auml]n dysforian hoidossa: Systemaattinen katsaus [Medical 
approaches to treating gender dysphoria: A systematic review],'' 
Summaryx Oy (2019); Jo Taylor et al., ``Interventions to suppress 
puberty in adolescents experiencing gender dysphoria or 
incongruence: A systematic review,'' Archives of Disease in 
Childhood 109, Supp 2 (2024): s33-s47, doi:10.1136/archdischild-
2023-326669; Jo Taylor et al., ``Masculinising and feminising 
hormone interventions for adolescents experiencing gender dysphoria 
or incongruence: A systematic review,'' Archives of Disease in 
Childhood 109, Supp 2 (2024): s48-s56, doi:10.1136/archdischild-
2023-326670.
    \39\ ``Children and young people's gender services: implementing 
the Cass Review recommendations,'' NHS England, last updated August 
29, 2024, https://www.england.nhs.uk/long-read/children-and-young-peoples-gender-services-implementing-the-cass-review-recommendations/.
    \40\ ``Care of children and adolescents with gender dysphoria-
summary of national guidelines,'' The Swedish National Board of 
Health and Welfare (Socialstyrelsen), December 2022, https://www.socialstyrelsen.se/globalassets/sharepoint-dokument/artikelkatalog/kunskapsstod/2023-1-8330.pdf.
    \41\ ``One Year Since Finland Broke with WPATH `Standards of 
Care','' Society for Evidence Based Gender Medicine, July 2, 2021, 
https://segm.org/Finland_deviates_from_WPATH_prioritizing_psychotherapy_no_surgery_for_minors.
---------------------------------------------------------------------------

    In particular, the most influential effort to date has been the 
United Kingdom's Cass Review--a 4-year independent evaluation of 
pediatric gender medicine that was published in April 2024.\42\ The 
findings of the Cass Review led to the closure of the United Kingdom's 
Gender Identity Development Service (GIDS), which had been given a 
rating of ``inadequate'' by the Care Quality Commission in 2021. The 
Cass Review recommended a restructuring of the care delivery model--
away from the centralized ``gender clinic'' model of care toward a more 
holistic framework centering on psychosocial support, to be delivered 
through regional hubs. The Cass Review's findings also led the United 
Kingdom to ban the use of puberty blockers outside of clinical trials, 
and to significantly restrict cross-sex hormones. While cross-sex 
hormones are still officially an available treatment, the National 
Health Service (NHS) recently revealed that since the Cass Review was 
published, no minor has been found eligible to receive cross-sex 
hormones according to the updated policy. In the United Kingdom, minors 
have never received gender dysphoria-related surgery through the NHS.
---------------------------------------------------------------------------

    \42\ Hilary Cass, ``Independent review of gender identity 
services for children and young people: Final report,'' (2024), 
https://cass.independent-review.uk/home/publications/final-report/.
---------------------------------------------------------------------------

    In 2022, Sweden's National Board of Health and Welfare (NBHW) 
reviewed and updated its guidelines for minors under the age of 18. 
Sweden's NBHW determined that the risks of puberty suppressing 
treatment with GnRH-analogues (injectable drugs that prevent the 
ovaries and testicles from producing sex hormones) and gender-affirming 
hormonal treatment likely outweigh the possible benefits.\43\ 
Specifically, Sweden's NBHW outlined that the first line of treatment 
should be mental health support and exploratory psychological care. 
Hormonal interventions can be a last resort measure for some youth. 
Sweden has made the decision to no longer offer gender transition [sex-
rejecting procedures] to minors outside of research settings, and 
restricted eligibility to the early childhood-onset of gender 
dysphoria.
---------------------------------------------------------------------------

    \43\ ``Care of children and adolescents with gender dysphoria-
summary of national guidelines,'' The Swedish National Board of 
Health and Welfare (Socialstyrelsen), December 2022, https://www.socialstyrelsen.se/globalassets/sharepoint-dokument/artikelkatalog/kunskapsstod/2023-1-8330.pdf. See also the Swedish 
National Board of Health and Welfare (Socialstyrelsen), ``Care of 
children and young people with gender Dysphoria--national knowledge 
support with recommendations for the profession and decision 
makers,'' (2022), https://www.socialstyrelsen.se/globalassets/sharepoint-dokument/artikelkatalog/kunskapsstod/2022-12-8302.pdf.
---------------------------------------------------------------------------

    In 2020, Finland's Council for Choices in Health Care, a monitoring 
agency for the country's public health services, issued guidelines that 
called for psychosocial support as the first line treatment, hormone 
therapy on a case-by-case basis after careful consideration, and no 
surgical treatment for minors. Finland has restricted eligibility for 
hormone therapy to minors with early childhood-onset of gender 
dysphoria and no mental health comorbidities.\44\
---------------------------------------------------------------------------

    \44\ Council for Choices in Healthcare in Finland, ``Summary of 
a recommendation by COHERE Finland,'' June 16, 2020, https://palveluvalikoima.fi/documents/1237350/22895008/Summary_minors_en+(1).pdf/fa2054c5-8c35-8492-59d6-b3de1c00de49/
Summary_minors_en+(1).pdf?t=1631773838474.
---------------------------------------------------------------------------

    In Denmark, more than 1300 minors with gender incongruence were 
``referred to the national service between 2016 and 2022 with 
increasing referral numbers over time,'' of which females constituted 
70 percent.\45\ The

[[Page 59446]]

increase in the number of referrals for these procedures and reports of 
regret or reversal of hormone-induced changes to the body led Denmark 
to take an approach that focuses on assessment and psychosocial support 
for minors, and postpones decisions on hormone therapy, including 
puberty blockers and cross-sex hormones, in circumstances ``when gender 
incongruence has been brief,'' such as ``when there are concerns about 
the stability of the experienced gender identity.'' \46\
---------------------------------------------------------------------------

    \45\ Nanna Ravnborg et al., ``Gender Incongruence in Danish 
Youth (GenDa): A Protocol for a Retrospective Cohort Study of Danish 
Children and Adolescents Referred to a National Gender Identity 
Service,'' Journal of Clinical Medicine 13 (2024), https://doi.org/10.3390/jcm13226658.
    \46\ Ravnborg et al., ``Gender Incongruence in Danish Youth 
(GenDa).''
---------------------------------------------------------------------------

    In Norway, the Norwegian Commission for the Investigation of Health 
Care Services (UKOM), an independent State-owned agency, made 
recommendations in 2023 on the treatment offered to children and young 
people with gender incongruence.\47\ The recommendations consisted of: 
defining puberty blockers and surgical treatment for children as 
experimental, revising national guidelines based on a systematic 
knowledge summary, and consideration for a national registry to improve 
quality and reduce variation in patient treatment. Norway's public 
health authority has signaled an intention to respond to UKOM's 
concerns by considering whether the current treatment guidelines need 
to be adjusted.\48\
---------------------------------------------------------------------------

    \47\ Norwegian Healthcare Investigation Board (Ukom), 
``Pasientsikkerhet for barn og unge med kj[oslash]nnsinkongruens 
[Patient safety for children and adolescents with gender 
incongruence],'' March 2023, https://ukom.no/rapporter/pasientsikkerhet-for-barn-og-unge-med-kjonnsinkongruens/sammendrag.
    \48\ Jennifer Block, ``Norway's guidance on paediatric gender 
treatment is unsafe, says review,'' BMJ 380 (2023), doi:10.1136/
bmj.p697.
---------------------------------------------------------------------------

    Other countries which have restricted various approaches to 
treatment for minors (or have contemplated restrictions) include: New 
Zealand,\49\ Italy,\50\ Brazil,\51\ and Australia.\52\
---------------------------------------------------------------------------

    \49\ Eva Corlett, ``New Zealand bans puberty blockers for young 
transgender people,'' The Guardian, November 19, 2025, https://www.theguardian.com/world/2025/nov/19/new-zealand-bans-new-prescriptions-of-puberty-blockers-for-young-transgender-people.
    \50\ Alvise Armellini, ``Italy moves to tighten controls on 
gender-affirming medical care for minors,'' Reuters, August 5, 2025, 
https://www.reuters.com/business/healthcare-pharmaceuticals/italy-moves-tighten-controls-gender-affirming-medical-care-minors-2025-08-05/.
    \51\ AFP, ``Brazil prohibits hormone therapy for transgender 
minors,'' MSN News, April 20, 2025, https://www.msn.com/en-in/news/other/brazil-prohibits-hormone-therapyfor-transgender-minors/ar-AA1D66l7.
    \52\ Australian Associated Press, ``Queensland halts 
prescription of puberty blockers and hormones for children with 
gender dysphoria,'' The Guardian, January 28, 2025, https://www.theguardian.com/australia-news/2025/jan/28/queensland-halts-prescription-of-puberty-blockers-and-hormones-for-children-with-gender-dysphoria.
---------------------------------------------------------------------------

    In sum, there is growing international concern about the use of 
hormonal and surgical interventions for pediatric gender dysphoria. We 
are aware that some medical associations have endorsed sex-rejecting 
procedures, but as the HHS Review makes clear, their endorsement is not 
based on sound principles of evidence-based medicine. In addition to 
other issues, we solicit comment of any published findings that measure 
the effects of similar restrictions as proposed on insurers, providers, 
and patients in these countries.
2. Medical Professional Societies Supporting Sex-Rejecting Procedures
    We are aware that numerous organizations \53\ (including the 
American Medical Association (AMA),\54\ the American Academy of 
Pediatrics (AAP),\55\ and the American Psychological Association 
56 57) have issued statements supporting access to sex-
rejecting procedures, including for minors. The most influential 
sources of clinical guidance for treating pediatric gender dysphoria in 
the U.S. are the WPATH and the ES clinical practice guidelines and the 
AAP guidance document. We reviewed each of these documents and agree 
with the conclusions of a recent systematic review of international 
guideline quality by researchers at the University of York (the York 
appraisal) that found all three documents as very low quality and 
should not be implemented.\58\
---------------------------------------------------------------------------

    \53\ ``Medical Organization Statements,'' Advocates For Trans 
Equality's Trans Health Project, accessed November 20, 2025, https://transhealthproject.org/resources/medical-organization-statements/.
    \54\ ``Clarification of Evidence-Based Gender-Affirming Care H-
185.927,'' American Medical Association, last modified 2024, https://policysearch.ama-assn.org/policyfinder/detail/%22Clarification%20of%20Evidence-Based%20Gender-Affirming%20Care%22?uri=%2FAMADoc%2FHOD-185.927.xml.
    \55\ Alyson Sulaski Wyckoff, ``AAP continues to support care of 
transgender youths as more states push restrictions,'' AAP News, 
January 6, 2022, https://publications.aap.org/aapnews/news/19021/AAP-continues-to-support-care-of-transgender.
    \56\ ``APA adopts groundbreaking policy supporting transgender, 
gender diverse, nonbinary individuals,'' American Psychological 
Association, released February 28, 2024, https://www.apa.org/news/press/releases/2024/02/policy-supporting-transgender-nonbinary.
    \57\ ``Criminalizing Gender Affirmative Care with Minors,'' 
American Psychological Association, accessed September 2, 2025, 
https://www.apa.org/topics/lgbtq/gender-affirmative-care.
    \58\ HHS Review, 141.
---------------------------------------------------------------------------

    As the HHS Review notes regarding the role of medical organizations 
in the treatment of pediatric gender medicine:
    U.S. medical associations played a key role in creating a 
perception that there is professional consensus in support of pediatric 
medical transition (PMT). This apparent consensus, however, is driven 
primarily by a small number of specialized committees, influenced by 
WPATH. It is not clear that the official views of these associations 
are shared by the wider medical community, or even by most of their 
members. There is evidence that some medical and mental health 
associations have suppressed dissent and stifled debate about this 
issue among their members.\59\
---------------------------------------------------------------------------

    \59\ HHS Review, 15.
---------------------------------------------------------------------------

    The Endocrine Society (ES) issued clinical practice guidelines in 
2017 entitled ``Endocrine Treatment of Gender-Dysphoric/Gender-
Incongruent Persons.'' \60\ As the HHS Review notes:
---------------------------------------------------------------------------

    \60\ Wylie C. Hembree et al., ``Endocrine Treatment of Gender-
Dysphoric/Gender-Incongruent Persons: An Endocrine Society Clinical 
Practice Guideline,'' The Journal of Clinical Endocrinology & 
Metabolism 102, no. 11 (2017): 3869-3903, https://doi.org/10.1210/jc.2017-01658.
---------------------------------------------------------------------------

    In WPATH and ES guidelines, the principal goal of CSH 
administration [cross sex hormone] is to induce physical 
characteristics typical of the opposite sex. When hormone levels rise 
beyond the typical reference range for a person's sex, they are 
considered supraphysiologic. ES guidelines suggest that the sex an 
individual identifies as--as opposed to their biological sex--should 
determine the target reference range for hormonal concentrations. 
Critics have argued that perceived identity does not alter 
physiological processes and that such a belief can result in 
inappropriate and potentially dangerous hormone dosing.\61\
---------------------------------------------------------------------------

    \61\ HHS Review, 124.
---------------------------------------------------------------------------

    The HHS Review states:
    The ES 2017 guideline, which used the GRADE [Grading of 
Recommendations Assessment, Development and Evaluation] framework, has 
been criticized for making strong recommendations for hormonal 
interventions in the setting of a weak evidence base. Notably, none of 
the systematic reviews that supported the ES guidelines were based on 
outcomes for children or adolescents. The ES recommendation to initiate 
puberty blockade using gonadotropin-releasing hormone agonists was 
derived by putting a higher value on achieving a ``satisfactory 
physical appearance'' while putting the lowest value on avoiding 
physical harms. The ES recommendation for the initiation of cross-sex 
hormones no earlier than age 16 was justified by placing a higher value 
on adolescent's purported ability to meaningfully consent to cross-sex 
hormones (CSH) and placing a lower

[[Page 59447]]

value on avoiding harm from potentially prolonged pubertal 
suppression.\62\
---------------------------------------------------------------------------

    \62\ HHS Review, 147.
---------------------------------------------------------------------------

    As explained in Chapter 9 of HHS Review, the guidelines issued by 
the World Professional Association for Transgender Health (WPATH) 
``have been rated among the lowest in quality and have not been 
recommended for implementation by systematic reviews (SRs) of 
guidelines.'' \63\ As the HHS Review points out: ``Despite their lack 
of trustworthiness, for more than a decade WPATH guidelines have served 
as the foundation of the healthcare infrastructure for gender dysphoric 
(GD) youth in the United States. The WPATH Standards of Care guidelines 
are embedded in nearly all aspects of healthcare including clinical 
education, delivery of care, and reimbursement decisions by private and 
public insurers.'' \64\ In 2022, WPATH issued guidelines entitled 
``Standards of Care for the Health of Transgender and Gender Diverse 
People, Version 8'' (SOC-8).\65\ These guidelines relaxed eligibility 
criteria for children to access sex-rejecting procedures, and 
ultimately recommend that adolescents wishing to undergo sex-rejecting 
procedures receive them. Besides the problems identified in systematic 
reviews of international guidelines, as the HHS Review states, ``in the 
process of developing SOC-8, WPATH suppressed systematic reviews its 
leaders believed would undermine its favored treatment approach. SOC-8 
developers also violated conflict of interest management requirements 
and eliminated nearly all recommended age minimums for medical and 
surgical interventions in response to political pressures.'' \66\
---------------------------------------------------------------------------

    \63\ HHS Review, 157.
    \64\ HHS Review, 157.
    \65\ E. Coleman et al., ``Standards of Care.''
    \66\ HHS Review, 14.
---------------------------------------------------------------------------

    The HHS Review goes on to explain: ``The recommendations are 
couched in cautious-sounding language, stating that GD should be 
`sustained over time,' particularly before administering CSH. However, 
no clear standard is set; the only guidance offered is the vague and 
clinically meaningless phrase `several years, leaving critical 
decisions open to broad and subjective interpretation.' '' \67\
---------------------------------------------------------------------------

    \67\ HHS Review, 165.
---------------------------------------------------------------------------

    Regarding the WPATH guidelines, the HHS review states:
    On the surface, WPATH SOC-8 might appear to recommend a cautious 
approach toward assessment. Mental health providers are to conduct a 
``comprehensive biopsychosocial assessment'' prior to initiating 
medical interventions in order ``to understand the adolescent's 
strengths, vulnerabilities, diagnostic profile, and unique needs to 
individualize their care.'' At the same time, however, WPATH recommends 
that clinicians use the International Classification of Diseases (ICD-
11) diagnosis of ``Gender Incongruence of Adolescence and Adulthood,'' 
which, unlike the DSM-5 diagnosis of ``Gender Dysphoria,'' requires 
only ``marked and persistent incongruence between an individual's 
experienced gender and the assigned sex.'' Because SOC-8 defines 
transgender in a similar way (``people whose gender identities and/or 
gender expressions are not what is typically expected for the sex to 
which they were assigned at birth'') and provides no meaningful 
distinction between this meaning of transgender and gender non-
conformity, SOC-8 effectively recognizes transgender identification as 
a medical condition justifying medical interventions.\68\
---------------------------------------------------------------------------

    \68\ HHS Review, 194-195.
---------------------------------------------------------------------------

    The HHS Review also argues: ``Although WPATH's guidelines do not 
necessarily discourage mental healthcare, they likewise do not require 
it as a precondition for PMT [pediatric medical transition]. Some 
guideline authors opposed even minimal requirements for mental health 
support, arguing that such provisions were analogous to ``conversion 
therapy.'' SOC-8's only formal recommendation is for a ``comprehensive 
biopsychosocial assessment,'' although WPATH emphasizes that its 
guideline is ``flexible,'' thereby leaving room for considerable 
variation in clinical practice.'' \69\
---------------------------------------------------------------------------

    \69\ HHS Review, 196.
---------------------------------------------------------------------------

    While AMA and the AAP have not issued their own treatment 
guidelines, they support the ES and WPATH guidelines, as discussed 
previously in this proposed rule. AAP issued a policy statement in 2018 
supporting the use of puberty blockers, cross-sex hormones, and 
surgeries for minors.\70\ In support of sex-rejecting surgeries, AAP 
stated that while ``current protocols [(ES, WPATH)] typically reserve 
surgical interventions for adults, they are occasionally pursued during 
adolescence on a case-by-case basis, considering the necessity and 
benefit to the adolescent's overall health and often including 
multidisciplinary input from medical, mental health, and surgical 
providers as well as from the adolescent and family.'' The AAP 
reaffirmed its policy statement in 2023, but also stated that it was 
conducting its own review of the evidence and guideline development--
which still have not been released.\71\ Regarding the AAP policy 
statement, the HHS Review states:
---------------------------------------------------------------------------

    \70\ Jason Rafferty, AAP Committee on Psychosocial Aspects of 
Child and Family Health, AAP Committee on Adolescence, AAP Section 
on Lesbian, Gay, Bisexual, and Transgender Health and Wellness, 
``Ensuring Comprehensive Care and Support for Transgender and Gender 
Diverse Children and Adolescents,'' Pediatrics 142, no. 4 (2018), 
doi.org/10.1542/peds.2018-2162.
    \71\ Alyson Sulaski Wyckoff, ``AAP reaffirms gender-affirming 
care policy, authorizes systematic review of evidence to guide 
update,'' AAP News, August 4, 2023, https://publications.aap.org/aapnews/news/25340/AAP-reaffirms-gender-affirming-care-policy.
---------------------------------------------------------------------------

    The AAP 2018 policy statement is not technically a CPG [clinical 
practice guideline] but has been widely cited in the U.S. as 
influential in establishing how pediatricians respond to children and 
adolescents with GD. Because the document offers extensive clinical 
recommendations regarding every step of PMT--from social transition to 
PBs [puberty blockers], CSH, and surgery--the York team assessed the 
trustworthiness of the AAP guidance using the same criteria they 
applied to CPGs. Using the AGREE II criteria, the AAP policy statement 
received the second-lowest average score among all international 
guidelines: 2 out of 7. As noted in Chapter 2, the AAP's policy 
statement's use of ``gender diverse'' casts a very wide net regarding 
which patients the organization considers eligible for medical 
intervention. The statement has been heavily criticized in peer-
reviewed articles, which have pointed out that it is rife with 
referencing errors and inaccurate citations. Despite persistent 
advocacy among its members, who have petitioned the organization to 
release updated, evidence-based guidance for treating pediatric GD, the 
organization chose to reaffirm their policy statement in 2023.\72\
---------------------------------------------------------------------------

    \72\ HHS Review, 148-149.
---------------------------------------------------------------------------

    In addition to other issues, we solicit comment of any published 
peer-reviewed findings that measure the effects of restrictions similar 
to those in this proposed rule on insurers, providers, and patients in 
international settings as well as the U.S.

C. United States' State Bans of and Coverage of Sex-Rejecting 
Procedures

    State lawmakers have adopted policy positions reflecting the 
emerging evidence of sex-rejecting procedures administered to youth. 
There are 27 States and one Territory that have enacted laws 
restricting sex-rejecting procedures.\73\ These include Alabama,

[[Page 59448]]

Arkansas, Arizona, Florida, Georgia, Iowa, Idaho, Indiana, Kansas, 
Kentucky, Louisiana, Missouri, Mississippi, Montana, North Carolina, 
New Hampshire,\74\ North Dakota, Nebraska, Ohio, Oklahoma, Puerto Rico, 
South Carolina, South Dakota, Tennessee, Texas, Utah, West Virginia, 
and Wyoming. As of August 8, 2025, some of these States have ongoing 
litigation proceedings impacting whether the State laws are partially 
or fully enjoined by a court.
---------------------------------------------------------------------------

    \73\ See ``Policy Tracker: Youth Access to Gender Affirming Care 
and State Policy Restrictions,'' KFF, last updated June 18, 2025, 
https://www.kff.org/other/dashboard/gender-affirming-care-policy-tracker; ``Equality Maps: Bans on Best Practice Medical Care for 
Transgender Youth,'' Movement Advancement Project, accessed August 
11, 2025, https://www.lgbtmap.org/equality-maps/healthcare/youth_medical_care_bans.
    \74\ New Hampshire's laws go into effect January 1, 2026 under 
NH HB712 and NH HB377.
---------------------------------------------------------------------------

    There are a mix of age ranges for these bans. Of the 28 States and 
Territories with enacted laws/policies (in effect or not), 25 States 
prohibit some sex-rejecting procedures to young people under the age of 
18, two States prohibit them for those under the age of 19, and Puerto 
Rico prohibits them for those under the age of 21.
    Of the 24 States and one Territory with restriction statutes in 
effect as of August 8, 2025, 21 States and one Territory prohibit both 
the prescribing of at least one type of sex-rejecting medication and 
surgeries.\75\ No State bans only medications without also banning 
surgeries. However, all the States and the Territory with restrictions 
provide exceptions to the law/policies. The most common exceptions 
include procedures to treat:
---------------------------------------------------------------------------

    \75\ Arizona and New Hampshire currently do not prohibit sex-
rejecting procedures using medications; however, New Hampshire has a 
new policy (NH HB377) taking effect January 1, 2026, that would 
restrict sex-rejecting procedures using medications for minors. 
Nebraska currently restricts, but does not fully ban, access to sex-
rejecting procedures using medications, so it was not included in 
this count.
---------------------------------------------------------------------------

     A medically verifiable disorder of sexual development. 
This allows treatment for children who are born with medical conditions 
that affect their sexual development. These are rare conditions where a 
child's reproductive or sexual anatomy does not develop in typical ways 
due to genetic, hormonal, or other medical factors that can be 
medically verified.
     Any infection, injury, disease, or disorder that has been 
caused or exacerbated by the performance of gender transition 
procedures.
     A physical disorder, physical injury, or physical illness 
that would otherwise place the minor in danger of death or impairment 
of bodily function.
    We note that 12 States provide tapering off periods for patients 
who started puberty blockers or hormones before enactment of the State 
restriction, with some specifying specific dates (for example, in South 
Carolina services cannot go beyond January 31, 2025) and others 
specifying a period of time from the time of enactment (ranging between 
6 months and 1 year). Ten States have grandfather clauses primarily 
allowing minors who were already receiving treatment to continue 
receiving it indefinitely. However, we note that many of these States 
do not provide such exceptions or grandfather clauses for purposes of 
prohibitions on State funding, including for State funding under the 
Medicaid program and CHIP, for sex-rejecting procedures.
    Conversely, 14 States and the District of Columbia have shield laws 
protecting some or all sex-rejecting procedures, and three States have 
executive orders (State EOs) protecting these procedures. These States 
are Arizona,\76\ California, Colorado, Connecticut, Delaware, Illinois, 
Maine, Maryland, Massachusetts, Minnesota, New Jersey, New Mexico, New 
York, Oregon, Rhode Island, Vermont, and Washington. Shield laws and 
State E.O.s often describe various types of sex-rejecting procedures 
broadly, including medications and surgeries, and include these under 
broader definitions of protected health care activities. These laws and 
State E.O.s generally attempt to shield providers and recipients (of 
all ages) against laws in other States that restrict these services. 
They also often protect providers from adverse action by medical 
malpractice insurers and licensure boards and allow for their address 
to remain confidential. One State, Maine, has a shield law specific to 
minors that allows minors 16 and over to receive hormone therapy when 
the guardian has refused sex-rejecting procedures. Four States 
explicitly provide child abuse and child custody protections for 
parents who supported their children in receiving sex-rejecting 
procedures. Four States have requirements for sex-rejecting procedures 
to be covered under health plans. Arizona requires coverage for State 
employee health plans. Illinois, Oregon, and Vermont require some level 
of coverage of sex-rejecting procedures by all health insurance 
providers. Vermont includes an exception for services that do not 
comply with Federal law.
---------------------------------------------------------------------------

    \76\ Arizona banned pediatric sex-rejecting surgeries in 2022. 
However, in 2023 the governor issued an executive order which 
removes the exclusion of coverage for sex-rejecting surgery under 
the state's healthcare plan for state employees and prohibits 
investigative assistance to impose criminal or civil liability or 
professional sanctions on persons or entities for providing, 
assisting, seeking, or obtaining gender affirming care.
---------------------------------------------------------------------------

    Some States may experience negative financial impacts as a result 
of having built their Medicaid programs and CHIPs, including policies 
and operations, on the understanding that we would make Federal 
Medicaid and CHIP payments to States for services that this proposed 
rule would define as sex-rejecting procedures. We believe protecting 
children enrolled in Medicaid and CHIP from the harms of sex-rejecting 
procedures, including possible long-term and irreversible harms, 
outweighs the possible financial costs some States may experience if 
they begin to pay with State funds the full cost of sex-rejecting 
procedures for children enrolled in Medicaid and CHIP.
    Providers in these States may be concerned that this proposed 
regulation would interfere with the physician-patient relationship. 
This proposed regulation would only prohibit Federal Medicaid and CHIP 
payment for certain services and does not require providers to 
communicate certain advice or information to patients. Federal Medicaid 
and CHIP payments will still be available for mental health counseling 
and psychotherapy for gender dysphoria. We believe a prohibition on 
Federal Medicaid and CHIP payments for sex-rejecting procedures is 
needed to avoid the possibility of minors receiving irreversible or 
risky pharmaceutical or surgical interventions, particularly in 
circumstances where the minor may be of an age to not have the capacity 
to understand the irreversible or long-term risks of these procedures 
or have the capacity to continue to communicate with providers their 
preferences regarding treatment after treatment has already begun.
    Certain medical providers may also be relying on continued Federal 
funding for sex-rejecting procedures. These providers may face 
financial harm by the loss of the revenue from the proposed limitations 
on Federal payment for these procedures; however, these providers have 
other avenues to continue to receive compensation for providing medical 
care. Providers may continue to receive payment for pharmaceutical or 
surgical interventions for purposes of aligning a child's physical 
appearance or body with an asserted identity that differs from the 
child's sex from sources other than Medicaid or CHIP. Providers may 
also receive payment for these services when

[[Page 59449]]

providing these procedures for the exempted purposes as outlined in the 
proposed rule. Lastly, providers may be paid through Medicaid and CHIP 
for providing other types of care for individuals diagnosed with gender 
dysphoria, such as psychotherapy.
    We also recognize that Medicaid and CHIP beneficiaries and their 
families would be impacted by this proposed rule. Families of these 
beneficiaries may look to obtain other health insurance or privately 
pay for these services. Medicaid and CHIP beneficiaries who are unable 
to find alternative means to pay for these services may either have to 
rely on other methods of intervention such as psychotherapy or mental 
health counseling, or never begin receiving these services because of 
this proposed rule, if finalized. We are concerned about the 
difficulties that these minors may experience and encourage other, less 
invasive, ways to support these individuals, such as encouraging 
psychotherapy as a first line of treatment.
    This proposed rule would help to protect these children from the 
risks of adverse effects of sex-rejecting procedures. CMS carefully 
considered the scope of its limitation on Federal Medicaid and CHIP 
payments and permits coverage of other procedures, such as 
psychotherapy, which does not carry the same concerns of pharmaceutical 
or surgical interventions included in the definition of sex-rejecting 
procedures. Moreover, CMS does not believe Federal Medicaid and CHIP 
payment for these sex-rejecting procedures is consistent with quality 
of care given the state of the research into the effectiveness of these 
procedures for the purposes included in our proposed definition of this 
term, namely as treatments for gender dysphoria. In light of the HHS 
Review, CMS believes State reliance on certain medical organizations 
and the SOC-8 to justify covering sex-rejecting procedures is 
misplaced.
    In addition to other issues, we solicit comment on any published 
studies or findings that measure the effects of similar restrictions as 
proposed (or laws protecting these procedures) on insurers, providers, 
and patients in these States.
    Recently, the U.S. Supreme Court in United States v. Skrmetti, 605 
U.S. 495 (2025), upheld Tennessee's law restricting certain surgical 
and chemical interventions for minors diagnosed with gender dysphoria 
(and similar conditions), referred to as Senate Bill 1 or ``SB1'' in 
litigation challenging that law under the Equal Protection Clause of 
the U.S. Constitution. SB1 prohibits a healthcare provider from 
performing medical procedures, including surgery, and prescribing 
puberty blockers, for a minor for the purpose of enabling the minor to 
identify with a purported identity inconsistent with the minor's sex. 
At the same time, SB1 allows healthcare providers to perform medical 
procedures for minors if the procedure is to treat a minor's congenital 
defect, precocious puberty, disease, or physical injury. On June 18, 
2025, the Court found that SB1's prohibition of certain medical 
procedures for minors diagnosed with gender dysphoria incorporates 
classifications based on age and medical use--not the minor's sex. 
Because the classifications turned on age and medical use rather than 
sex, the Court held that SB1 was not subject to heightened scrutiny 
under the Equal Protection Clause of the Fourteenth Amendment and went 
on to find the law satisfied rational basis review. As discussed in 
more detail later in this proposed rule, like the law at issue in 
Skrmetti, this proposed rule would not discriminate on the basis of sex 
and it is not based on an invidious discriminatory purpose. The 
proposed rule is animated by significant child safety concerns when 
sex-rejecting procedures are used for certain medical uses-that is to 
align a child's physical appearance or body with an asserted identity 
that differs from the child's sex.

D. Psychotherapy as the First Line Treatment for Children Diagnosed 
With Gender Dysphoria

    Since 2010, there has been a significant increase in mental health 
conditions among teens and young adults.\77\ Current research has not 
revealed a simple explanation for this rise in the need for youth 
mental health services. The etiology of gender dysphoria remains 
understudied.\78\ However, patients presenting to pediatric gender 
medicine clinics have a high rate of comorbid mental health 
conditions.\79\
---------------------------------------------------------------------------

    \77\ Patrick McGorry et al., ``The Lancet Psychiatry Commission 
on youth mental health,'' Lancet Psychiatry 11, no. 9 (September 
2024): 731-774, doi:10.1016/S2215-0366(24)00163-9.
    \78\ HHS Review, 257.
    \79\ HHS Review, 68.
---------------------------------------------------------------------------

    We believe interested parties supporting the use of sex-rejecting 
procedures to treat gender dysphoria in children may state that 
limiting access to these treatments (which prohibiting Federal Medicaid 
and CHIP funding for them could do) will exacerbate these comorbidities 
and lead to adverse mental health outcomes and increase suicide risks. 
As noted previously, the Cass Review emphasized the lack of robust 
evidence regarding the effectiveness of interventions such as puberty 
blockers and cross-sex hormones to treat gender dysphoria and 
incongruence in children and adolescents.\80\ Taylor et al. recently 
conducted a review of 23 international, national, and regional clinical 
guidelines that contained recommendations about the management of 
children/adolescents experiencing gender dysphoria. They found that the 
majority of these guidelines were developed without an independent or 
evidence-based approach and raised questions about the credibility of 
available guidance.\81\ As Sweden's national health authority has 
recommended, ``[p]sychosocial support that helps adolescents deal with 
natal puberty without medication needs to be the first option when 
choosing care measures.'' \82\
---------------------------------------------------------------------------

    \80\ Cass, ``Cass Review.''
    \81\ Jo Taylor et al., ``Clinical guidelines for children and 
adolescents experiencing gender dysphoria or incongruence: a 
systematic review of guideline quality (part 1),'' Archives of 
Disease in Childhood 109, Supp. 2 (2024): s65-s72, doi:10.1136/
archdischild-2023-326499.
    \82\ HHS Review, 256.
---------------------------------------------------------------------------

    While evidence on the benefits of medical and surgical 
interventions to improve mental health or reduce symptoms of gender 
dysphoria is lacking, psychotherapy has been proven to be an effective 
intervention for many of the neurodevelopmental disorders and mental 
health conditions that are highly prevalent in children and 
adolescents, including those frequently co-occurring in patients 
diagnosed with gender dysphoria.\83\ Psychotherapy and mental health 
counseling are non-invasive interventions that would remain available 
to youth under Medicaid's mandatory Early and Periodic Screening, 
Diagnostic and Treatment (EPSDT) provisions in section 1905(r) of the 
Act. EPSDT requires the provision of screening, vision, dental, and 
hearing services, and such other necessary health care, diagnostic 
services, treatment, and other measures described in section 1905(a) of 
the Act to correct or ameliorate defects and physical and mental 
illness and conditions discovered by the screening services, whether or 
not such services are covered under the State plan. Most children 
enrolled in Medicaid are entitled to coverage of robust and 
comprehensive psychotherapy services under EPSDT . We note that under a 
State's EPSDT program, States may only include tentative limits on 
services and must take into account the individual needs of the child. 
Thus, EPSDT is key

[[Page 59450]]

to ensuring that children receive appropriate mental health screenings 
and treatments. Furthermore, we have developed numerous resources to 
provide information regarding services and good practices for children 
and youth with mental health conditions.\84\ While EPSDT is not a 
required CHIP benefit for States that have separate CHIPs, many States 
with such programs have opted to provide EPSDT services that mirror the 
Medicaid standards set out at section 1905(r) of the Act to children 
enrolled in CHIP. In addition, section 2103(c)(7) of the Act requires 
States to provide mental health services in CHIP that are applied in 
the same manner as required under section 2726(a) of the Public Health 
Service Act [([42 U.S.C. 300gg-26(a)])] for group health plans under 
such section.
---------------------------------------------------------------------------

    \83\ HHS Review, 257-260.
    \84\ ``Children and Youth,'' Medicaid, accessed June 12, 2025, 
https://www.medicaid.gov/medicaid/benefits/behavioral-health-services/children-and-youth.
---------------------------------------------------------------------------

E. States' Duty To Ensure Medicaid and CHIP Services for Children Are 
Consistent With Quality of Care and the Best Interests of Beneficiaries

    Under section 1902(a)(19) of the Act, State Medicaid agencies are 
required to ensure that Medicaid-covered services are in the best 
interests of beneficiaries; as relevant to this proposed rule, children 
under age 18. Additionally, States are required, under section 
1902(a)(30)(A) of the Act, to ensure that Medicaid payments for 
Medicaid covered services are consistent, in relevant part, with 
quality of care. Under section 2101(a) of the Act, CHIP programs are 
required to provide health care services to uninsured, low-income 
children in an effective and efficient manner that is coordinated with 
other sources of health benefits coverage for children, including State 
Medicaid programs. The research described previously in this proposed 
rule indicates that sex-rejecting procedures lack the necessary 
outcomes data to reasonably rely on for evidence of long-term 
effectiveness.
    On April 11, 2025, we issued a letter to State Medicaid Directors 
to ensure Medicaid agencies were aware of growing utilization of 
certain interventions offered to children to treat gender dysphoria, 
and to remind States of their statutory responsibilities to ensure that 
Medicaid payments are consistent with quality of care and that covered 
services are provided in a manner consistent with the best interests of 
recipients.\85\ In the letter, we also stated that due to the 
underdeveloped body of evidence, the use of sex-rejecting procedures to 
treat gender dysphoria lacks reliable evidence of long-term benefits 
for minors and are now known to cause long-term and irreparable harm 
for some children.\86\ A second letter, issued on May 28, 2025, was 
sent to a number of hospitals to address significant issues concerning 
quality standards and specific procedures affecting children diagnosed 
with gender dysphoria. The letter requested hospitals to provide 
information on their policies and procedures related to the adequacy of 
informed consent protocols for children diagnosed with gender 
dysphoria, including how children are deemed capable of making these 
potentially life changing decisions and when parental consent is 
required; changes to clinical practice guidelines and protocols that 
the institution plans to enact in light of the recent comprehensive 
review and guidance released by the Department; medical evidence and 
any adverse events related to these procedures, particularly children 
who later look to detransition; and complete financial data for all 
pediatric sex-rejecting procedures performed at the institution and 
paid, in whole or in part, by the Federal Government.\87\
---------------------------------------------------------------------------

    \85\ CMS, ``Puberty Blockers, Cross-sex Hormones, and Surgery 
Related to Gender Dysphoria,'' April 11, 2025, https://www.cms.gov/files/document/letter-stm.pdf.
    \86\ CMS, ``Puberty Blockers.''
    \87\ Department of Health & Human Services, Centers for Medicare 
and Medicaid Services, Urgent Review of Quality Standards and Gender 
Transition Procedures, May 28, 2025, www.cms.gov/files/document/hospital-oversight-letter-generic.pdf.
---------------------------------------------------------------------------

    As outlined previously in this proposed rule, we take very 
seriously the absence of rigorous scientific data demonstrating the 
effectiveness of sex-rejecting procedures and the considerable evidence 
regarding the risks. Given the potential risks and lack of clear 
benefits associated with sex-rejecting procedures, we believe that 
covering them with Federal Medicaid or CHIP funding would be, for 
Medicaid beneficiaries, inconsistent with their best interests and with 
quality of care; and, for CHIP beneficiaries, inconsistent with the 
provision of health care services to uninsured, low-income children in 
an effective and efficient manner that is coordinated with other 
sources of health benefits coverage. In this section, we describe how 
this proposed rule would intersect with existing statutory and 
regulatory provisions.
1. Intersection With Nondiscrimination (Section 1557 of the Patient 
Protection and Affordable Care Act)
    This proposed rule is not a form of sex discrimination in violation 
of section 1557 of the Patient Protection and Affordable Care Act 
(Affordable Care Act).\88\ Section 1557 of the Affordable Care Act 
prohibits discrimination on the basis of race, color, national origin, 
sex, age, or disability in health programs or activities, any part of 
which is receiving Federal financial assistance.
---------------------------------------------------------------------------

    \88\ The Patient Protection and Affordable Care Act (Pub. L. 
111-148, 124 Stat. 119) was enacted on March 23, 2010. The 
Healthcare and Education Reconciliation Act of 2010 (Pub. L. 111-
152, 124 Stat. 1049), which amended and revised several provisions 
of the Patient Protection and Affordable Care Act, was enacted on 
March 30, 2010. In this rulemaking, the two statutes are referred to 
collectively as the ``Patient Protection and Affordable Care Act,'' 
``Affordable Care Act,'' or ``ACA''.
---------------------------------------------------------------------------

    A Federal court recently considered the question of whether the 
prohibition on sex discrimination found in section 1557 of the 
Affordable Care Act includes discrimination on the basis of gender 
identity. On October 22, 2025, in State of Tennessee et al v. Kennedy 
et al,\89\ the district court declared that ``HHS exceeded its 
statutory authority when (1) it interpreted Title IX, as incorporated 
into Section 1557, to prohibit discrimination on the basis of gender 
identity, and (2) when it implemented Section 1557 regulations 
concerning gender identity and `gender affirming care.' '' Accordingly, 
the Court vacated the following regulations to the extent that they 
expand Title IX's definition of sex discrimination to include gender-
identity discrimination: 42 CFR 438.3(d)(4), 438.206(c)(2), 440.262, 
460.98(b)(3), and 460.112(a), and 45 CFR 92.101(a)(2)(iv), 
92.206(b)(1)-(4), Sec.  92.207(b)(3) through(5), 92.8(b)(1), 
92.10(a)(1)(i), and 92.208.\90\
---------------------------------------------------------------------------

    \89\ Tennessee v. Kennedy, ---F. Supp. 3d---,1:24CV161-LG-BWR, 
2025 WL 2982069 (S.D. Miss. Oct. 22, 2025).
    \90\ As part of a 2024 rulemaking implementing section 1557 of 
the Affordable Care Act, HHS amended 42 CFR 440.262, 438.3(d) and 
438.206(c)(2) to specifically include discrimination based on 
``gender identity'' as a form of ``sex discrimination,'' and amended 
42 CFR 457.495 to cross-reference amended 440.262. The amendments to 
sections 438.3(d) and 438.206(c)(2) also apply to CHIP managed care 
through cross references in Sec. Sec.  457.1201(d) and 457.1230(a) 
that predated the section 1557 rulemaking. These amendments to the 
Medicaid and CHIP rules were based on sections 1902(a)(4), 
1902(a)(19), and 2101(a) of the Act. See Nondiscrimination in Health 
Programs and Activities, 89 FR 37522 (May 6, 2024). In Tennessee v. 
Kennedy, ---F. Supp. 3d---, 1:24CV161-LG-BWR, 2025 WL 2982069 (S.D. 
Miss. Oct. 22, 2025), the court vacated 42 CFR 440.262, 438.3(d)(4), 
and 438.206(c)(2) (among others) ``to the extent that they expand 
Title IX's definition of sex discrimination to include gender 
identity discrimination'' and declared HHS had ``exceeded its 
statutory authority when (1) it interpreted Title IX, as 
incorporated into Section 1557, to prohibit discrimination on the 
basis of gender identity, and (2) when it implemented Section 1557 
regulations concerning gender identity and `gender affirming 
care.''' See also Texas v. Becerra, No. 6:24-CV-211-JDK (E.D. Tex. 
Aug. 30, 2024), in which the court entered a nationwide stay of 
certain regulations of the final rule, including 42 CFR 440.262, 
438.3(d)(4), and 438.206(c)(2). Given Skrmetti's holding, we believe 
that the outcome of this litigation will not affect the proposed 
rule. As a result, CMS does not further discuss 42 CFR 440.262, 
438.3, and 438.206 in this proposed rule.

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[[Page 59451]]

    Notwithstanding the outcome of this litigation, the Court's holding 
in Skrmetti, as explained previously in this proposed rule and 
expounded upon below, supports our position that this proposed rule 
would not discriminate on the basis of sex. In 2023, Tennessee enacted 
a State law,\91\ SB1, which, in relevant part, prohibits a healthcare 
provider from performing certain medical procedures, including surgery, 
and from prescribing puberty blockers, for a minor for the purpose of 
enabling the minor to identify with a purported identity inconsistent 
with the minor's sex.\92\ SB1 does not prohibit healthcare providers 
from providing those procedures if done to treat a minor's congenital 
defect, precocious puberty, disease, or physical injury. The U.S. 
Supreme Court analyzed SB1 under the Equal Protection Clause of the 
Fourteenth Amendment and held that SB1 does not turn on sex-based 
classifications, noting ``the law does not prohibit conduct for one sex 
that it permits for the other.'' \93\
---------------------------------------------------------------------------

    \91\ Tenn. Code Ann. Sec.  68-33-101 et seq.
    \92\ As defined by SB1, ``minor'' means an individual under 
eighteen (18) years of age. Tenn. Code Ann. Sec.  68-33-102.
    \93\ United States v. Skrmetti, 145 S. Ct. 1816 (2025).
---------------------------------------------------------------------------

    Like SB1, this proposed rule would apply uniformly to all children 
regardless of the child's sex. This proposed rule would treat all 
children the same when it would prohibit a State Medicaid or CHIP 
agency from covering, as part of its Federally funded Medicaid program 
and CHIP, the procedures that the proposed rule would define as sex-
rejecting procedures. At the same time, this proposed rule would permit 
State Medicaid and CHIP agencies to continue to so cover procedures 
when the child has a medically verifiable disorder of sexual 
development, needs the procedure for a purpose other than attempting to 
align the child's physical appearance or body with an asserted identity 
that differs from the child's sex, or has complications, including any 
infection, injury, disease, or disorder that has been caused by or 
exacerbated by the performance of sex-rejecting procedure(s).
    Further, this proposed rule would be neither arbitrary nor based on 
an invidious discriminatory purpose. Rather, based on the review of 
current research and the reasoning for similar conclusions reached and 
actions taken by multiple European countries discussed previously in 
this proposed rule, we believe that Medicaid and CHIP coverage and 
payment of sex-rejecting procedures are not in the best interests of 
minors and not consistent with quality of care or the effective and 
efficient standard required under section 2101(a) of the Act. 
Therefore, we are proposing to prohibit Federal funding for these 
procedures in Medicaid and CHIP. This proposal is based on careful 
consideration of the facts as described in detail in section I.B. of 
this proposed rule and on our determination that the risks of sex-
rejecting procedures for children outweigh the benefits. We continue to 
support Medicaid and CHIP coverage of services for children that 
research shows may be helpful for treating gender dysphoria in children 
without the risks of harm. Further, while State laws may differ, State 
Medicaid agencies are not currently specifically prohibited under 
Federal law from covering sex-rejecting procedures for Medicaid 
beneficiaries who are 18 years of age and older.
2. Intersection With Sufficiency of Amount, Duration, and Scope (Sec.  
440.230(c))
    This proposed rule would also be consistent with 42 CFR 440.230, 
which provides that a Medicaid State plan must specify the amount, 
duration, and scope of covered services. CMS has long afforded State 
Medicaid agencies considerable flexibility under Sec.  440.230 to 
establish the amount, duration, and scope of covered Medicaid services, 
and to develop State-specific medical necessity criteria and 
utilization control procedures for covered services. State-specific 
limits on amount, duration, and scope are frequently applied based on 
an assessment of a beneficiary's specific circumstances, rather than 
being blanket limitations. In addition to specifying the amount, 
duration, and scope of covered services, historically, States have 
determined whether, and how, to cover services and we make Federal 
Medicaid payments to States if the services otherwise complied with 
Federal law and regulation. Within CHIP, under Sec.  457.402(x), States 
have the ability to add coverage of additional services if recognized 
by State law.
    Some States may be using the authorities under sections 1905 and 
2110 of the Act, such as sections 1905(a)(6) and 2110(a)(24) of the 
Act,\94\ to cover sex-rejecting procedures as services that are 
recognized under State law.
---------------------------------------------------------------------------

    \94\ Section 1905(a)(6) of the Act states ``medical care, or any 
other type of remedial care recognized under State law, furnished by 
licensed practitioners within the scope of their practice as defined 
by State law'' and section 2110(a)(24) of the Act defines ``child 
health assistance'' as ``payment for part or all of the cost of 
health benefits coverage for targeted low-income children that 
includes any of the following . . . (24) Any other medical, 
diagnostic, screening, preventive, restorative, remedial, 
therapeutic, or rehabilitative services . . . if recognized by State 
law . . .''
---------------------------------------------------------------------------

    However, this flexibility under Sec.  440.230 is not absolute. 
Section 440.230 requires State Medicaid agencies to comply with certain 
guidelines when determining the amount, duration, and scope of covered 
services. States must detail their proposed coverage of services in a 
State plan amendment and submit the State plan amendment to CMS for 
approval. We review the State plan amendment to ensure that States meet 
these guidelines. For example, under Sec.  440.230(b), State Medicaid 
agencies must ensure that any covered service is sufficient in amount, 
duration, and scope to reasonably achieve its purpose. If a state 
limits the amount, duration or scope of a service without exception for 
medical necessity, the State must explain to us the reasoning and 
evidence to support the limitation prior to CMS approving the State's 
submission. Similarly in CHIP, the flexibility under Sec.  457.402(x) 
is not absolute. Section 457.60 requires States to submit a State plan 
amendment when a State is making a change in policy or operation of the 
program that affects the benefits provided. Like in Medicaid, States 
must detail their proposed coverage of services in a State plan 
amendment and submit the State plan amendment to CMS for approval. We 
review the State plan amendment to ensure that States meet these 
guidelines.
    For this proposed rule, we have considered the risk/benefit profile 
of sex-rejecting procedures for the purposes included in our proposed 
definition and the alternative treatments available, before determining 
that a national response prohibiting Federal Medicaid funding for sex-
rejecting procedures for children under age 18 enrolled in Medicaid and 
under age 19 enrolled in CHIP is warranted. This prohibition includes 
circumstances in which a provider may determine that a sex-rejecting 
procedure is medically necessary for a child diagnosed with gender 
dysphoria.

[[Page 59452]]

    Lastly, this proposed rule is consistent with Sec.  440.230(c), 
which prohibits State Medicaid agencies from arbitrarily denying or 
reducing the amount, duration, or scope of a covered service to an 
otherwise eligible beneficiary solely because of the diagnosis, type of 
illness, or condition. This proposed rule reflects the agency's efforts 
to address significant concerns about the risk/benefit profile of sex-
rejecting procedures for the uses included in our proposed definition 
of that term, due to the safety concerns, risks of irreversible harm, 
long-term health outcomes, and unestablished effectiveness associated 
with those uses, as explained previously. This proposed rule takes into 
account the different risk/benefit profiles of different uses of these 
procedures, which is why it focuses on purposes that might be 
associated with a particular diagnosis, type of illness or condition. 
Our proposed definition of sex-rejecting procedures would exclude from 
the definition certain uses of these procedures for which the risk/
benefit profile creates less significant concerns. Additionally, other 
treatments, such as mental health treatment, would remain Federally 
funded for children diagnosed with gender dysphoria.
    As discussed previously in this proposed rule, we have considered 
the concerns of States, providers, and beneficiaries who have relied on 
CMS making Federal Medicaid and CHIP payment for these services. 
Notwithstanding the potential financial burden to States, providers, 
and individuals, and the psychological and physical impact on 
beneficiaries who wish to receive these services, a nationwide 
prohibition on Federal Medicaid and CHIP payments for these services is 
warranted. We believe that the concerns of States, providers and 
beneficiaries described previously in this proposed rule are outweighed 
by the potential harm of sex-rejecting procedures for minors, including 
potential long-term harm, especially when the possible benefits of 
these services are unproven and the procedures are irreversible. More 
data is needed on how the procedures that the proposed rule would 
define as sex-rejecting procedures in children under age 18 in Medicaid 
and under age 19 in CHIP affect the long-term health of such 
individuals, including any impact on fertility, and whether these 
procedures result in, or increase the risk of, sexual dysfunction, 
impaired boned density, adverse cognitive impacts and other health 
deviations, as mentioned previously.
3. Intersection With Early and Periodic Screening, Diagnostic and 
Treatment (EPSDT)
    This proposed rule also would be consistent with States' 
obligations under the EPSDT requirement, even though it would limit 
States' longstanding flexibility to develop State-specific processes 
for determining when a service is medically necessary for an EPSDT-
eligible beneficiary under section 1905(r)(5) of the Act. Under EPSDT, 
States must cover medically necessary services described in section 
1905(a) of the Act for most Medicaid eligible children under the age of 
21. Children eligible for EPSDT generally include beneficiaries under 
the age of 21 enrolled: in Medicaid through a categorically needy 
group; in Medicaid through a medically needy group in a State that has 
elected to include EPSDT in the medically needy benefit package; in a 
Medicaid-expansion CHIP program; or in a separate CHIP program that has 
elected to cover EPSDT. This includes beneficiaries with an 
institutional level of care who are eligible for Medicaid by virtue of 
their enrollment in a home and community-based services (HCBS) waiver 
under section 1915(c) of the Act. EPSDT is not available to 
beneficiaries without satisfactory immigration status who are eligible 
only for treatment of an emergency medical condition and other groups 
of individuals under age 21 who are eligible only for limited services 
as part of their Medicaid eligibility, such as, for example, family 
planning services.
    Under this proposed rule, sex-rejecting procedures for the uses 
included in our proposed definition would no longer be Federally funded 
as Medicaid-covered services for individuals under the age of 18 or as 
CHIP-covered services for individuals under the age of 19, because such 
services may pose a risk of harm to children, including long-term 
irreversible harm, and result in adverse outcomes on their health 
including infertility/sterility, sexual dysfunction, impaired bone 
density accrual, adverse cognitive impacts, cardiovascular disease and 
metabolic disorders, and psychiatric disorders. We are not endorsing or 
requiring any particular treatment modality for gender dysphoria.
    In our prior EPSDT coverage guidance,95 96we discuss how 
States should approach their determination of whether a service is 
medically necessary. In this prior guidance, we emphasize that States 
(or their delegated entity) must take into account the particular needs 
of the child. We explain that States should consider the child's long-
term needs, not just what is required to address the immediate 
situation. The State should consider all aspects of a child's needs, 
including nutrition, social development, and mental health and 
substance use disorders. Accordingly, while sex-rejecting procedures 
have been covered by some State Medicaid programs to address gender 
dysphoria to alleviate its symptoms, these procedures can involve use 
of puberty suppressing drugs to prevent the onset of puberty and cross-
sex hormones to spur the secondary sex characteristics of the opposite 
sex. For children under 18 (or under 19 in CHIP) who have undergone the 
suppression of puberty, these procedures may pose a significant risk of 
harm, including possible long-term harm to a child's health, including 
the risk of infertility and bone density loss, as discussed previously.
---------------------------------------------------------------------------

    \95\ CMS, ``EPSDT-A Guide for States: Coverage in the Medicaid 
Benefit for Children and Adolescents,'' June 2014, https://www.medicaid.gov/medicaid/benefits/downloads/epsdt-coverage-guide.pdf.
    \96\ CMS, State Health Official Letter #24-005, ``Best Practices 
for Adhering to Early and Periodic Screening, Diagnostic, and 
Treatment (EPSDT) Requirements,'' September 26, 2024, https://www.medicaid.gov/federal-policy-guidance/downloads/sho24005.pdf.
---------------------------------------------------------------------------

    As discussed previously in this proposed rule, some State Medicaid 
programs and CHIPs have relied upon clinical guidelines that have 
failed to meet the principles of unbiased, evidence-driven clinical 
guideline development. As a result of this reliance, State Medicaid 
programs and CHIPs have developed coverage criteria which may not have 
considered the full effects of all aspects of a child's needs 
(including long-term needs) as required under EPSDT.

F. Prohibition on Federal Funding and Coverage in a Separate CHIP

    Title XXI of the Act allows States to implement CHIP as a separate 
CHIP, a Medicaid-expansion program, or a combination of the two. Title 
XXI-funded Medicaid expansion programs generally follow Medicaid rules. 
This section relates to separate CHIPs.
    States with separate CHIPs receive Federal funding from the title 
XXI allotment to provide child health assistance through obtaining 
coverage that meets the requirements of section 2103 of the Act and 
regulations at Sec.  457.402. Section 2101(a) of the Act calls for the 
provision of CHIP in a manner that is effective and efficient and 
coordinated with other sources of

[[Page 59453]]

health benefits coverage for children, notwithstanding section 
2110(a)(24) of the Act that allows States to cover additional services 
that are recognized by State law. While CMS recognizes the considerable 
State flexibility provided to States under section 2110(a)(24) of the 
Act, CMS has concluded that it is in the best interest of children 
under age 19 enrolled in CHIP to no longer permit Federal funding for 
coverage of procedures when utilized for purposes of sex-rejecting 
procedures because such services may result in adverse outcomes on 
their health including infertility/sterility, sexual dysfunction, 
impaired bone density accrual, diverse cognitive, cardiovascular 
disease and metabolic disorders, and psychiatric disorders. Therefore, 
CMS has concluded it is most efficient and effective, and in the best 
interests of children, for CHIP to align and coordinate with the 
Medicaid program.
    Section 2103 of the Act and Sec.  457.410 allow States to choose 
any of the following four types of health benefits coverage for 
separate CHIPs: (1) Benchmark coverage in accordance with Sec.  
457.420; (2) Benchmark-equivalent coverage in accordance with Sec.  
457.430; (3) Existing comprehensive State-based coverage in accordance 
with Sec.  457.440; and (4) Secretary-approved coverage in accordance 
with Sec.  457.450. Regardless of the type of health coverage selected 
by a State, States are required to provide all services identified at 
Sec.  457.410(b) to children enrolled in CHIP. In addition to these 
services, States have the flexibility to cover additional services at 
Sec.  457.402, which lists the services included in ``child health 
assistance.'' In addition to the specified services, Sec.  457.402(x) 
permits states to select additional services and treatments that it 
will cover. The majority of separate CHIP States have elected 
Secretary-approved coverage. Under Secretary-approved coverage at Sec.  
457.450, the Secretary currently has the discretion to determine 
whether the coverage provided by a State is appropriate coverage for 
the population of targeted low-income children covered under the 
program. Recently, there have also been changes to allowable procedures 
under the benchmark coverage options for CHIP under Sec.  457.420 as 
described later in this proposed rule.
    On June 20, 2025, we issued the ``Patient Protection and Affordable 
Care Act; Marketplace Integrity and Affordability,'' final rule (90 FR 
27074) (referred to hereafter as the ``2025 Marketplace final rule''), 
which prohibits issuers of non-grandfathered individual and small group 
market health insurance coverage--that is, issuers of coverage subject 
to the essential health benefit (EHB) requirements--from providing 
coverage for ``specified sex-trait modification procedures'' as an EHB 
beginning with Plan Year 2026. This prohibition was proposed and 
finalized because section 1302(b)(2)(A) of the ACA requires that the 
scope of the EHB be equal to the scope of benefits provided under a 
typical employer plan, and coverage of such procedures is not typically 
included in employer-sponsored plans.\97\ In addition, on January 31, 
2025, the U.S. Office of Personnel Management issued letter 2025-01A, 
which prohibited coverage of certain surgeries and hormone treatments 
for covered individuals in Federal Employees Health Benefits (FEHB) and 
Postal Service Health Benefits (PSHB) Programs under age 19. That 
letter was amended by letter 2015-01B, issued on August 15, 2025, which 
eliminated the age limit and advised that for Plan Year 2026, chemical 
and surgical modification of an individual's sex traits through medical 
interventions (to include ``gender transition'' services) will no 
longer be covered under the FEHB or PSHB Programs. Specifically, it 
excludes hormone treatments that pertain to chemical and surgical 
modification of an individual's sex traits (including as part of 
``gender transition'' services) and clarifies that carriers should not 
exclude coverage for entire classes of pharmaceuticals. For example, 
GnRH agonists may be prescribed during in vitro fertilization (IVF), 
for reduction of endometriosis or fibroids, and for cancer treatment or 
prostate cancer/tumor growth prevention.\98\
---------------------------------------------------------------------------

    \97\ Patient Protection and Affordable Care Act; Marketplace 
Integrity and Affordability, 90 FR 27152 (June 25, 2025). While 
portions of the ``Patient Protection and Affordable Care Act; 
Marketplace Integrity and Affordability,'' final rule (90 FR 27074), 
have been challenged, the requirement that issuers of non-
grandfathered individual and small group market health insurance 
coverage--that is, issuers of coverage subject to the essential 
health benefit (EHB) requirements--cannot provide coverage for 
``specified sex-trait modifications'' as an EHB will begin with Plan 
Year 2026.
    \98\ U.S. Office of Personnel Management (OPM) FEHB Program 
Carrier Letter, Letter Number 2025-01A, ``Addendum to Call Letter 
for Plan Year 2026,'' January 31, 2025, https://www.opm.gov/healthcare-insurance/carriers/fehb/2025/2025-1a.pdf. Amended by OPM 
FEHB Programs Carrier Letter, Letter Number 2025-01B, ``Subject: 
Chemical and Surgical Sex-Trait Modification Services for Plan Year 
2026 Proposals,'' August 15, 2025, https://www.opm.gov/healthcare-insurance/carriers/fehb/2025/2025-01b.pdf.
---------------------------------------------------------------------------

    As previously noted, section 2101(a) of the Act provides funds to 
States to enable them to initiate and expand the provision of child 
health assistance to uninsured, low-income children in an effective and 
efficient manner that is coordinated with other sources of health 
benefits coverage for children. As outlined previously in this proposed 
rule, while the prohibitions on coverage are not identical, they will 
effectively result in prohibition of coverage of sex-rejecting 
procedures in both the FEHB Program and as an EHB beginning with Plan 
Year 2026. Therefore, we are proposing to add a new section Sec.  
457.476 to prohibit Federal financial participation for sex-rejecting 
procedures under CHIP, to align CHIP with Medicaid, the FEHB Program, 
and EHBs. Although title XXI of the Act does not apply EHB rules under 
a separate CHIP, the services which must be covered under title XXI 
also are EHBs. We note that similar to Medicaid, this proposed change 
in CHIP would not prohibit Federal payment for procedures undertaken to 
treat a child with a medically verifiable disorder of sexual 
development; for purposes other than attempting to align a child's 
physical appearance or body with an asserted identity that differs from 
the child's sex; or to treat complications, including any infection, 
injury, disease, or disorder that has been caused by or exacerbated by 
the performance of sex-rejecting procedure(s).
    We also note that section 2107(e) of the Act applies numerous 
provisions in Medicaid in the same manner to title XXI as would be the 
case under this proposed rule.
    We take very seriously the weak evidence base supporting the safety 
or effectiveness of sex-rejecting procedures in minors, and the 
plausible evidence of harm, for the purposes included in our proposed 
definition. Based on these factors, we propose to prohibit Federal CHIP 
funds for sex-rejecting procedures for the purposes included in our 
proposed definition. It is also important to reiterate that these 
regulatory changes would not prohibit the use of Federal CHIP dollars 
for mental health treatments for conditions such as gender dysphoria.

II. Provisions of the Proposed Regulations

A. General Discussion

    We propose to exercise our separate authorities under sections 
1902(a)(19) and 1902(a)(30)(A) of the Act to add a new subpart N to 
part 441 to prohibit Federal Financial Participation (FFP) in Medicaid 
for sex-rejecting procedures for the purposes included in our proposed 
definition for individuals under the age of 18, as this is the age of 
majority in most States. For CHIP, we

[[Page 59454]]

propose to exercise our authority under section 2103(c) of the Act to 
revise subpart D of 42 CFR part 457 to prohibit the use of Federal CHIP 
dollars to fund sex-rejecting procedures for the purposes included in 
our proposed definition for individuals under the age of 19, as this 
age aligns with the statutory definition of ``child'' at 2110(c)(1) of 
the Act. While this proposal aligns with section 5(a) of E.O. 14187, we 
are also proposing this change based on current evidence, which does 
not conclusively support the use of sex-rejecting procedures to treat 
gender dysphoria in children. It is important to emphasize that these 
proposed regulatory changes would not prohibit the use of Federal 
Medicaid or CHIP dollars for mental health treatments for conditions 
such as gender dysphoria. Nor would these proposed changes prevent 
States from providing coverage for sex-rejecting procedures with State-
only funds outside of the Federally-matched Medicaid program or CHIP. 
We note that this proposed rule also does not prohibit Federal 
reimbursement of procedures undertaken (i) to treat a child with a 
medically verifiable disorder of sexual development; (ii) for purposes 
other than attempting to align a child's physical appearance or body 
with an asserted identity that differs from the child's sex; or (iii) 
to treat complications, including any infection, injury, disease, or 
disorder that has been caused by or exacerbated by the performance of 
sex-rejecting procedure(s).

B. Prohibition on Medicaid Payment for Sex-Rejecting Procedures (Sec.  
441.800)

    We propose to add a new subpart N to 42 CFR part 441 to protect 
Medicaid beneficiaries and ensure Medicaid payments are consistent with 
quality of care by prohibiting Federal Medicaid payments to States for 
sex-rejecting procedures provided to children under the age of 18. The 
basis and purpose of proposed subpart N (as described previously in 
this proposed rule) is reflected in proposed Sec.  441.800.
    Within new subpart N, we propose at Sec.  441.802(a) that State 
Medicaid plans must provide that the Medicaid agency will not make 
payment under the plan for sex-rejecting procedures for children under 
the age of 18. Per 42 CFR 430.10, the State plan is the vehicle through 
which States assure that their Medicaid programs will be administered 
in conformity with title XIX of the Act (including sections 1902(a)(19) 
and 1902(a)(30)(A) of the Act) and CMS' implementing regulations, and 
the State plan must also contain all information necessary for CMS to 
determine whether the plan can serve as a basis for FFP. Proposed Sec.  
441.802(a) would not preclude States from covering sex-rejecting 
procedures with State-only funding outside of their Federally-matched 
Medicaid programs. We propose at Sec.  441.802(b) that FFP would not be 
available in State expenditures for sex-rejecting procedures for 
children under the age of 18.
    Proposed Sec.  441.801 would define sex-rejecting procedures as any 
pharmaceutical or surgical intervention that attempts to align a 
child's physical appearance or body with an asserted identity that 
differs from the child's sex either by: (1) intentionally disrupting or 
suppressing the normal development of natural biological functions, 
including primary or secondary sex-based traits; or (2) intentionally 
altering a child's physical appearance or body, including amputating, 
minimizing, or destroying primary or secondary sex-based traits such as 
the sexual and reproductive organs. However, our proposed definition 
also provides that the term sex-rejecting procedures would not include 
procedures undertaken: (i) to treat a child with a medically verifiable 
disorder of sexual development; (ii) for purposes other than attempting 
to align a child's physical appearance or body with an asserted 
identity that differs from the child's sex; or (iii) to treat 
complications, including any infection, injury, disease, or disorder 
that has been caused by or exacerbated by the performance of sex-
rejecting procedure(s).
    Given States' obligations under sections 1902(a)(19) and 
1902(a)(30)(A) of the Act to assure care and services are provided 
consistent with the best interests of Medicaid recipients and that 
payments are consistent with quality of care, respectively, we believe 
that our proposed prohibition of FFP in State expenditures for sex-
rejecting procedures for children under age 18 is necessary given the 
lack of an adequate evidence base for the effectiveness of these 
treatments for the purposes that would be included in our proposed 
definition and the significant potential for negative and irreversible 
side effects.
    We note that CMS has imposed age limitations on the availability of 
Federal funding for certain procedures in the Medicaid program before. 
CMS has long prohibited, at Sec.  441.253, Federal funding for 
permanent sterilizations furnished to individuals under age 21, 
motivated by concerns about potential coercion, informed consent, and 
patient regret that were based on data specifically related to 
permanent sterilizations (see preamble discussion at 43 FR 52146, 52151 
through 52153). In this context, our concerns about the effectiveness 
of sex-rejecting procedures and the plausible evidence of harm motivate 
our proposal to prohibit Federal funding for sex-rejecting procedures 
for children under the age of 18. Specifically, this proposed rule 
recognizes that the more cautious approach of psychosocial support to 
treat individuals diagnosed with gender dysphoria prior to age 18--the 
legal age of majority in nearly all U.S. States and Territories 
99 100--better protects children and youth from adverse 
effects of any such procedures.
---------------------------------------------------------------------------

    \99\ CMS is aware that 3 States--Alabama, Nebraska, and 
Mississippi--recognize higher ages as the age of majority. See ``Age 
of Majority by State 2025,'' World Population Review, accessed 
August 11, 2025, https://worldpopulationreview.com/state-rankings/age-of-majority-by-state. CMS is proposing to prohibit FFP in State 
expenditures within the Medicaid program for sex-rejecting 
procedures for children under the age of 18 to correspond to the 
legal age of majority used by the overwhelming majority of States 
and Territories. Because section 2110(c)(1) of the Act defines 
``child'' for purposes of CHIP as an individual under age 19, CMS is 
proposing to prohibit FFP in State expenditures within CHIP for sex-
rejecting procedures for children under age 19.
    \100\ ``Age of Majority by State 2025,'' World Population 
Review, accessed September 9, 2025, https://worldpopulationreview.com/state-rankings/age-of-majority-by-state.
---------------------------------------------------------------------------

    Three states have a different, higher age of majority. Alabama and 
Nebraska's age of majority is 19 and Mississippi has the highest age of 
majority at 21.\101\ This rule would not conflict with the age of 
majority in Alabama, Nebraska and Mississippi because these States 
recognize higher ages of majority than this proposed rule. Under this 
proposed rule, sex-rejecting procedures would be available for Medicaid 
coverage at age 18, which is a lower age than the age of majority in 
these States. Additionally, nothing in this proposed rule preempts 
State authority to regulate the age of majority in their State, nor 
does it interfere with a State's ability to fund these services with 
State-only funds. Further, it is clear that in making policy choices 
for the administration of a Federal program, State law is not 
controlling. This proposed rule would make age 18 the floor of Federal 
coverage for sex-rejecting procedures under the Medicaid program, 
should a State include such procedures in their program.
---------------------------------------------------------------------------

    \101\ ``Age of Majority by State 2025,'' World Population 
Review, accessed September 9, 2025, https://worldpopulationreview.com/state-rankings/age-of-majority-by-state.
---------------------------------------------------------------------------

    We originally considered establishing the prohibition on Federal 
reimbursement of sex-rejecting procedures to individuals under age 19 
as we are now proposing for CHIP.

[[Page 59455]]

However, age 19 has no specific meaning for the Medicaid program and, 
as stated, is a year older than the legal age of majority in nearly all 
U.S. States and Territories. By comparison, this is not true under 
CHIP, as the statutory definition of a child in CHIP under section 
2110(c)(1) of the Act is an individual under 19 years of age. In 
addition to other issues, we solicit comment on the operational 
feasibility of States in implementing the under age 18 prohibition in 
Medicaid and the under age 19 prohibition in CHIP.
    As discussed previously, States have obligations under sections 
1902(a)(19) and 1902(a)(30)(A) of the Act to ensure that Medicaid-
covered care and services are provided in a manner consistent with the 
best interests of beneficiaries and to assure that payments for 
Medicaid-covered care and services are consistent with quality of care. 
For the reasons discussed in this proposed rule, CMS believes 
prohibiting Federal Medicaid funding for sex-rejecting procedures for 
children under the age of 18 is warranted to help ensure that States 
meet these statutory obligations.
    We believe that the proposed definition of sex-rejecting procedures 
provides an appropriate degree of clarity and certainty regarding which 
sex-rejecting procedures would and would not be subject to the 
prohibitions at proposed Sec.  441.802. We believe the proposed 
definition is narrowly tailored and appropriate to exclude only 
treatments CMS has determined to lack sufficient evidence of safety for 
their intended purposes. Examples such as procedures to treat 
precocious puberty, therapy subsequent to a traumatic injury, or the 
use of hormone replacement therapy to treat a growth hormone deficiency 
would not fall under the proposed definition of sex-rejecting 
procedures, and Federal Medicaid payment for such procedures would 
therefore not be prohibited for individuals under the age of 18, when 
medically necessary. As the HHS Review explains, central precocious 
puberty and gender dysphoria are distinct clinical entities. In 
addition, because the proposed definition is narrowly tailored in this 
way, we believe that States will be able to administer Medicaid 
coverage for drugs in a manner that is consistent with both the 
proposed rule and the requirements in section 1927 of the Act. Section 
1927 of the Act governs the Medicaid Drug Rebate Program and payment 
for covered outpatient drugs (CODs), which are defined in section 
1927(k)(2) of the Act. In general, if manufacturers enter into a 
National Drug Rebate Agreement (NDRA) as set forth in section 1927(a) 
of the Act, payment is available for the CODs covered under that NDRA 
for medically accepted indications.\102\ As defined in section 
1927(k)(6) of the Act, ``medically accepted indications'' mean use for 
a COD approved under the Federal Food, Drug, and Cosmetic Act or 
approved for inclusion in any of the compendia described in subsection 
1927(g)(1)(B)(i) of the Act. There is no pharmaceutical that is solely 
indicated for these sex-rejecting procedures; the pharmaceuticals that 
are used for these procedures are approved for other indications. Thus, 
these pharmaceuticals will continue to be coverable by Medicaid 
programs for other indications in accordance with section 1927 of the 
Act. In addition, we note that this proposed rule only applies to 
pharmaceuticals that are used in the proposed definition and would not 
apply to other pharmaceuticals that are prescribed to a child.
---------------------------------------------------------------------------

    \102\ The NDRA does not have a specific OMB number, however the 
OMB package that contains all of the information a manufacturer has 
to report once entering into an NDRA is included in CMS 367a-367e.
---------------------------------------------------------------------------

    As noted previously, the proposed definition of sex-rejecting 
procedures categorically would exclude procedures undertaken (1) to 
treat a child with a medically verifiable disorder of sexual 
development; (2) for purposes other than attempting to align a child's 
physical appearance or body with an asserted identity that differs from 
the child's sex; or (3) to treat complications, including any 
infection, injury, disease, or disorder that has been caused by or 
exacerbated by the performance of sex-rejecting procedure(s). We 
reiterate that these proposed regulatory changes would not prohibit the 
use of Federal Medicaid dollars for mental health treatments for 
conditions such as gender dysphoria.
    In addition, to further explain the meaning of terms used in the 
proposed sex-rejecting procedures definition, we also propose 
definitions at new Sec.  441.801 that would apply to subpart N of part 
441. We propose to define FFP for purposes of subpart N of part 441 as 
Federal financial participation, recognizing the longstanding term used 
in the Medicaid program to describe the Federal Government's matching 
arrangement with States and Territories. We also propose to define 
``female'' as a person of the sex characterized by a reproductive 
system with the biological function of (at maturity, absent disruption 
or congenital anomaly) producing eggs (ova). We propose to define 
``male'' as a person of the sex characterized by a reproductive system 
with the biological function of (at maturity, absent disruption or 
congenital anomaly) producing sperm. We propose to define ``sex'' as a 
person's immutable biological classification as either male or female.
    A landmark study of and model for anisogamy established that 
differences in gamete size, and the associated differences in gamete 
production time, lead to stable sexual dimorphism and the establishment 
of two biological sexes: ovum producers (females) and sperm producers 
(males).\103\ Additionally, more recent literature acknowledges 
differences in sex roles but maintains that such differences can still 
be traced to the concept of anisogamy and the resultant sexual 
dimorphism that remain the root cause of sex specific selection, the 
sex roles, and the determination of biological sex.\104\ We believe our 
proposed definitions of female, male, and sex are appropriately rooted 
in this concept and biological reality. In addition to other issues, we 
solicit comments on whether these proposed definitions of ``sex'', 
``male'', and ``female'' could pose challenges to States in 
operationalizing this proposed prohibition on Federal reimbursement of 
sex-rejecting procedures or other aspects of the Medicaid program or 
CHIP.
---------------------------------------------------------------------------

    \103\ G.A. Parker et al., ``The origin and evolution of gamete 
dimorphism and the male-female phenomenon,'' Journal of Theoretical 
Biology 36, no. 3 (1972): 529-553, https://doi.org/10.1016/0022-5193(72)90007-0.
    \104\ Lukas Sch[auml]rer et al., ``Anisogamy, chance and the 
evolution of sex roles,'' Trends in Ecology & Evolution 27, no. 5 
(2012): 260-264, https://doi.org/10.1016/j.tree.2011.12.006.
---------------------------------------------------------------------------

    Given the weak evidence base underlying sex-rejecting procedures 
for children and the potential risk of harm, including long-term harm, 
we believe this proposed rule appropriately implements the directives 
to States under sections 1902(a)(19) and 1902(a)(30)(A) of the Act that 
care and treatment provided under Medicaid must be in the best 
interests of recipients, and that payment for services must be 
consistent with quality of care.

C. Prohibition on CHIP Payment for Sex-Rejecting Procedures

    We propose to revise subpart D in 42 CFR part 457 to prohibit 
Federal CHIP payments to States for sex-rejecting procedures provided 
to children. The purpose of this section is to ensure that CHIP is 
operated in an effective and efficient manner that is coordinated with 
other sources of health benefits coverage, including Medicaid, for 
children consistent with section 2101(a) of the Act by prohibiting 
Federal financial participation in payments by

[[Page 59456]]

States for sex-rejecting procedures for a child under the age of 19. 
This would create consistency between CHIP coverage and Medicaid.
    The prohibition on Federal financial participation for payments by 
States for sex-rejecting procedures for children applies in the same 
manner described in Medicaid at Sec.  441.802 to a State administering 
a separate CHIP except that it applies to children under the age of 19 
in accordance with the definition of a targeted low-income child at 
Sec.  457.310. This prohibition applies to CHIP regardless of the type 
of health benefit coverage option described at Sec.  457.410. The 
definitions applied under Medicaid at Sec.  441.801 apply equally to a 
separate CHIP.
    We believe that our proposed prohibition of Federal CHIP payment 
for sex-rejecting procedures is necessary given the need to align CHIP 
coverage with coverage of these services in Medicaid, the lack of 
scientific evidence regarding the effectiveness of these treatments, 
and the significant potential for negative and often irreversible side 
effects when used for the purposes included in our proposed definition 
in children.
    For each of these provisions outlined previously in this proposed 
rule, we anticipate stopping the Federal reimbursement of sex-rejecting 
procedures immediately upon the effective date of the rule finalizing 
these provisions, for both Medicaid and CHIP.

III. Collection of Information Requirements

    Under the Paperwork Reduction Act of 1995 (PRA), 44 U.S.C. 3501-
3520, we are required to provide notice in the Federal Register and 
solicit public comment before a ``collection of information'' 
requirement is submitted to the Office of Management and Budget (OMB) 
for review and approval. Collection of information is defined under 5 
CFR 1320.3(c) of the PRA's implementing regulations.
    To fairly evaluate whether an information collection should be 
approved by OMB, 44 U.S.C. 3506(c)(2)(A) requires that we solicit 
comment on the following issues:
     The need for the information collection and its usefulness 
in carrying out the proper functions of our agency.
     The accuracy of our estimate of the information collection 
burden.
     The quality, utility, and clarity of the information to be 
collected.
     Recommendations to minimize the information collection 
burden on the affected public, including automated collection 
techniques.
    We are soliciting public comment on each of these issues for the 
following sections of this document that contain information collection 
requirements. Comments, if received, will be responded to within the 
subsequent final rule (CMS-2451-F, RIN 0938-AV73), if this proposed 
rule is finalized.

A. Wage Estimates

    To derive average costs, we used data from the U.S. Bureau of Labor 
Statistics' May 2024 National Occupational Employment and Wage 
Statistics for all salary estimates (https://www.bls.gov/oes/tables.htm). In this regard, Table 1 presents BLS' mean hourly wage, 
our estimated cost of fringe benefits and other indirect costs 
(calculated at 100 percent of salary), and our adjusted hourly wage.

                          Table 1--National Occupational Employment and Wage Estimates
----------------------------------------------------------------------------------------------------------------
                                                                                 Fringe benefits
                                                  Occupation      Mean hourly       and other        Adjusted
               Occupation title                      code         wage ($/hr)    indirect costs   hourly wage ($/
                                                                                     ($/hr)             hr)
----------------------------------------------------------------------------------------------------------------
Business Operations Specialist................         13-1000           43.76             43.76           87.52
General and Operations Manager................         11-1021           64.00             64.00          128.00
----------------------------------------------------------------------------------------------------------------

    As indicated, we are adjusting our employee hourly wage estimates 
by a factor of 100 percent. This is necessarily a rough adjustment, 
both because fringe benefits and other indirect costs vary 
significantly from employer to employer, and because methods of 
estimating these costs vary widely from study to study. Nonetheless, we 
believe that doubling the hourly wage to estimate the total cost is a 
reasonably accurate estimation method.

B. Proposed Information Collection Requirements (ICRs)

1. ICRs Regarding Definitions (Sec.  441.801)
    We anticipate that the proposed definitions (adding and defining 
``female'', ``male'', ``sex'', and ``sex-rejecting procedure'') may 
result in the need for some States to amend existing policy/manual 
documents where those items are inconsistent with the parameters of 
this proposed rule. However, we do not anticipate that this would 
impact any active claims/billing forms or their instructions.
    We estimate a potential of 56 Medicaid respondents and 56 CHIP 
respondents consisting of 50 States, the District of Colombia, American 
Samoa, Commonwealth of the Mariana Islands, Guam, Puerto Rico, and the 
US Virgin Islands. Based on research discussed in section I.1.C. 
(United States' State Bans of and Coverage of Sex-Rejecting Procedures) 
of this proposed rule, approximately 27 States and one Territory have 
laws enacted restricting some or all of the sex-rejecting procedures 
that would be covered by this proposed rule. For these States and 
Territories, we do not anticipate State staff will need to conduct a 
review of policy documents for Medicaid or CHIP as these procedures are 
currently banned (or will be banned).
    For the remainder of States and Territories, we assume that State 
staff will conduct a review for both Medicaid policy documents and CHIP 
policy documents. As a result, we estimate 28 States and Territories 
that would need to amend their existing policy documents consistent 
with these definitions. We estimate it will take 3 hours at $87.52/hr 
for a Business Operations Specialist to review existing State policy 
documents to ensure consistency with the proposed definitions and 1 
hour at $128.00/hr for a General and Operations Manager to review and 
approve the necessary State policy document changes.
    In aggregate we estimate a one-time State burden of 112 hours (28 
States x 4 hr/response) at a cost of $10,936 [(3 hr x $87.52/hr x 28 
States) + (1 hr x $128.00/hr x 28 States)]. When taking into account 
the Federal administrative match of 50 percent, we estimate a one-time 
State cost of $5,468 ($10,936 * 0.5). We assumed all services meeting 
the proposed definition would no longer be covered by Medicaid nor 
CHIP, and thus not eligible for Federal matching funds.

[[Page 59457]]

2. ICRs Regarding the Prohibition on Payment for Sex-Rejecting 
Procedures (Sec.  441.802)
    If this proposed rule is finalized, the following changes and 
associated SPA template will be made available for public review/
comment under control number CMS-10398 #97, OMB 0938-1148) via the 
standard PRA process which includes the publication of 60- and 30-day 
Federal Register notices. In the meantime, the following scores the 
potential impact for preparing and submitting the SPA. We will revisit 
these preliminary estimates during the standard PRA process and revise 
if needed.
    Under the proposed provision, States and Territories would be 
required to submit SPAs specifically indicating adherence to the 
prohibition on claiming Federal funding of sex-rejecting procedures for 
individuals under the age of 18 for Medicaid and for individuals under 
the age of 19 for CHIP. The content of the SPA would be a simple 
recitation of the prohibition. As indicated above, the template will be 
made available for public review and comment if this proposed rule is 
finalized. We intend to require all States and Territories to submit 
this template for approval as part of their State plan.
    We estimate a potential of 56 Medicaid and CHIP respondents 
consisting of 50 States, the District of Colombia, American Samoa, 
Commonwealth of the Mariana Islands, Guam, Puerto Rico, and the US 
Virgin Islands. We estimate it will take 2 hours at $87.52/hr for a 
Business Operations Specialist to prepare an initial SPA and 1 hour at 
$128.00/hr for a General and Operations Manager to review and approve 
the SPA for submission to CMS.
    In aggregate, we estimate a one-time State burden of 168 hours (56 
States x 3 hr/response) at a cost of $16,970 [(2 hr x $87.52/hr x 56 
States) + (1 hr x $128.00/hr x 56 States)]. When taking into account 
the Federal administrative match of 50 percent, we estimate a one-time 
State cost of $8,485 ($16,970 * 0.5). We assumed all services meeting 
the proposed definition would no longer be covered by Medicaid nor 
CHIP, and thus not eligible for Federal matching funds.

C. Summary of Proposed Requirements and Burden Estimates

                                                     Table 2--Proposed Requirements/Burden Estimates
--------------------------------------------------------------------------------------------------------------------------------------------------------
                                                                                                        Time per    Total     Labor
 Regulation section(s) under   OMB control No. (CMS         Respondents        Responses      Total     response    time    costs ($/   Total     State
     Title 42 of the CFR              ID No.)                                 (per State)   responses     (hr)      (hr)       hr)    cost ($)  cost ($)
--------------------------------------------------------------------------------------------------------------------------------------------------------
Sec.   441.801..............  N/A...................  28 States and                     1          28          4       112    Varies    10,936     5,468
                                                       Territories.
Sec.   441.802..............  CMS-10398 #97, OMB      56 States and                     1          56          3       168    Varies    16,970     8,485
                               0938-1148.              Territories.
                                                     ---------------------------------------------------------------------------------------------------
    Total...................  ......................  56....................            2          84     Varies       280    Varies    27,906    13,953
--------------------------------------------------------------------------------------------------------------------------------------------------------

D. Submission of PRA-Related Comments

    We have submitted a copy of this proposed rule to OMB for its 
review of the proposed rule's information collection requirements. The 
requirements are not effective until they have been approved by OMB.
    To obtain copies of the supporting statement and any related forms 
for the proposed collections discussed previously, please visit the CMS 
website at https://www.cms.gov/regulations-and-guidance/legislation/paperworkreductionactof1995/pra-listing, or call the Reports Clearance 
Office at 410-786-1326.
    We invite public comments on these potential information collection 
requirements. If you wish to comment, please submit your comments 
electronically as specified in the DATES and ADDRESSES sections of this 
proposed rule and identify the proposed rule (CMS-2451-P, RIN 0938-
AV73), the ICR's CFR citation, and the OMB control number.

IV. Response to Comments

    Because of the large number of public comments we normally receive 
on Federal Register documents, we are not able to acknowledge or 
respond to them individually. We will consider all comments we receive 
by the date and time specified in the DATES section of this preamble, 
and, when we proceed with a subsequent document, we will respond to the 
comments in the preamble to that document.

V. Regulatory Impact Statement

A. Statement of Need

    Throughout the U.S., thousands of children are receiving sex-
rejecting procedures for the purpose of attempting to align their 
bodies with an asserted identity that differs from their sex. As 
outlined in this proposed rule, however, the current medical evidence 
does not support conclusively these interventions and indicates that 
they might lack clear benefits while posing a health and safety risk to 
children. To help ensure that Medicaid services are provided in a 
manner consistent with the best interests of the recipients and that 
Medicaid payments are consistent with quality of care, we are proposing 
a prohibition on State Medicaid Agencies from providing payment under 
the plan for sex-rejecting procedures for children under the age of 18 
and proposing a prohibition on State CHIPs from providing payment under 
the plan for sex-rejecting procedures for children under the age of 19.

B. Overall Impact

    We have examined the impacts of this proposed rule as required by 
Executive Order 12866, ``Regulatory Planning and Review''; Executive 
Order 13132, ``Federalism''; Executive Order 13563, ``Improving 
Regulation and Regulatory Review''; Executive Order 14192, ``Unleashing 
Prosperity Through Deregulation''; the Regulatory Flexibility Act (RFA) 
(Pub. L. 96-354); section 1102(b) of the Social Security Act; and 
section 202 of the Unfunded Mandates Reform Act of 1995 (Pub. L. 104-
4).
    Executive Orders 12866 and 13563 direct agencies to assess all 
costs and benefits of available regulatory alternatives and, if 
regulation is necessary, to select those regulatory approaches that 
maximize net benefits (including potential economic, environmental, 
public health and safety, and other advantages; distributive impacts). 
Section 3(f) of Executive Order 12866 defines a ``significant 
regulatory action'' as any regulatory action that is likely to result 
in a rule that may: (1) have an annual effect on the economy of $100 
million or more or adversely affect in a material way the economy, a 
sector of the economy, productivity, competition, jobs, the 
environment, public health or safety, or State, local, or Tribal 
governments or communities; (2) create a serious inconsistency or 
otherwise interfere with an action taken or planned by another agency; 
(3) materially alter the budgetary impact of entitlements, grants, user 
fees, or loan

[[Page 59458]]

programs or the rights and obligations of recipients thereof; or (4) 
raise novel legal or policy issues arising out of legal mandates, or 
the President's priorities.
    A regulatory impact analysis (RIA) must be prepared for a 
regulatory action that is significant under section 3(f)(1) of E.O. 
12866. Based on our estimates, the Office of Management and Budget's 
(OMB) Office of Information and Regulatory Affairs (OIRA) has 
determined this rulemaking is significant per section 3(f). 
Accordingly, we have prepared a Regulatory Impact Analysis that to the 
best of our ability presents the costs and benefits of the rulemaking.

C. Detailed Economic Analysis

1. Impacts on Federal Expenditures and Other Transfers
    We estimate that this proposal would reduce Federal Medicaid 
spending by about $188 million from fiscal year 2027 through fiscal 
year 2036 (in real 2027 dollars). To estimate the impact of this 
proposal, we analyzed data from T-MSIS TAF v8.0 for 2023. We selected 
all claims with a gender dysphoria diagnosis and in the following 
claims categories: inpatient hospital with surgical procedure; 
outpatient hospital with surgical procedure; and professional services 
and prescription drugs with hormone therapy. We included fee-for-
service and managed care encounter data. We also analyzed this data by 
beneficiary age group and counted only spending for individuals ages 17 
and younger. We note that the proposed policy would not prohibit 
payment by a State Medicaid agency for these services for those age 18, 
and those individuals and costs are not included as part of the 
estimates. This data also includes CHIP expenditures for these 
services.
    For 2023, we identified about $31 million in total computable 
Medicaid and CHIP spending for these services and individuals. States 
that had not banned gender dysphoria treatments for children as of 2023 
accounted for 76 percent of spending, including 92 percent of inpatient 
treatment with surgery and 87 percent of outpatient treatment with 
surgery.

     Table 3--Medicaid Expenditures on Gender Dysphoria Treatment by Category of Service and Age Group, 2023
----------------------------------------------------------------------------------------------------------------
                                                     Age 6-12        Age 13-14       Age 15-18         Total
----------------------------------------------------------------------------------------------------------------
Inpatient hospital with surgery.................              $0              $0        $180,553        $180,553
Outpatient hospital with surgery................          15,526          23,534       2,145,082       2,184,142
Professional services hormone therapy...........         482,924       1,180,610       3,089,948       4,753,482
Prescription drug hormone therapy...............       2,566,749       6,130,955      14,779,884      23,477,588
                                                 ---------------------------------------------------------------
    Total.......................................       3,065,198       7,335,099      20,195,468      30,595,765
----------------------------------------------------------------------------------------------------------------
Source: Analysis of T-MSIS TAF v8.0.
Note: The T-MSIS data includes enrollment and spending by age groups, which includes ages 15-18 as one group.
  The policy in this proposed rule would only affect Medicaid enrollees under age 18 (ages 15-17), but the table
  above includes spending for individuals age 18. We note that we have adjusted for this when developing the
  estimates in the RIA.

    We projected this spending forward from 2023 through 2035 using 
projected growth in Medicaid and CHIP spending on children from the 
Mid-Session Review of the President's fiscal year 2026 Budget. We 
assumed all services would no longer be covered by Medicaid or CHIP, 
and thus not eligible for Federal matching funds. We solicit comment on 
whether states that currently cover services would continue to cover 
these services absent FFP as described in this proposed rulemaking.
    States that currently cover these services under Medicaid would see 
the largest reductions in Medicaid spending. We also assumed about 3 
percent of spending would be delayed until individuals reach age 18, 
reflecting 50 percent of the surgical procedures being paid by Medicaid 
and CHIP in the future. Absent data or analysis on the impact of 
prohibitions on these procedures, we assumed some individuals would 
ultimately receive these services once eligible and believe 50 percent 
is reasonable (considering that some individuals would no longer be 
eligible for Medicaid in the future and some individuals may find other 
sources of coverage).
    Table 4 shows the annual impact of the proposal on total and 
Federal Medicaid and CHIP spending in millions of dollars. These 
estimates assume the policies in the proposed rule would be effective 
as of October 1, 2026. Total Medicaid and CHIP spending would be 
reduced by $318 million over 10 years, Federal spending would be 
reduced by $188 million, and State spending would be reduced by $130 
million (in real 2027 dollars). Actual impacts may vary from these 
estimates. We have relied on the most recently available program data 
for this analysis and projections of future enrollment and spending. 
Actual future costs may vary if enrollment and spending are higher or 
lower than projected.

              Table 4--Projected Impacts of Prohibiting Coverage of Sex-Rejecting Procedures for Individuals Under 18 on Medicaid Spending
                                                           [In millions of real 2027 dollars]
--------------------------------------------------------------------------------------------------------------------------------------------------------
                                                              2027    2028    2029    2030    2031    2032    2033    2034    2035    2036    2027-2036
--------------------------------------------------------------------------------------------------------------------------------------------------------
Total......................................................     -30     -30     -30     -31     -32     -32     -32     -33     -34     -34         -318
Federal....................................................     -18     -18     -18     -18     -19     -19     -19     -19     -20     -20         -188
State......................................................     -12     -12     -12     -13     -13     -13     -13     -14     -14     -14         -130
--------------------------------------------------------------------------------------------------------------------------------------------------------

    We have made reasonable assumptions about how individuals may use 
these services in the future. A greater or lesser number of individuals 
may still receive coverage for these services upon reaching age 18 than 
we have assumed. In addition, it is possible some individuals may find 
alternative coverage for these services (for example,

[[Page 59459]]

States covering services without Federal funding, or private 
insurance). We have also not estimated if there would be any other 
impacts on Federal expenditures (for example, increases in other 
healthcare services related to gender dysphoria).
2. Costs
    In addition, the proposed rule may result in several costs. States 
would need to update State plans or waivers to comply with the proposed 
changes to covered benefits. Those impacts are described in section 
III. of this proposed rule. In addition, the changes in this proposed 
rule may prevent or delay individuals from receiving these healthcare 
services.
3. Alternatives
    As an alternative to this proposed rule, we considered taking no 
action to require that a State Medicaid or CHIP plan must provide that 
the Medicaid or CHIP agency will not make payment under the plan for 
sex-rejecting procedures for children in Medicaid under the age of 18 
and children in CHIP under the age of 19 and to prohibit the use of 
Federal Medicaid or CHIP dollars to fund sex-rejecting procedures for 
these individuals. On January 28, 2025, President Trump issued E.O. 
14187, Protecting Children from Chemical and Surgical Mutilation. 
Section 5(a) of that order directs the Secretary to take all 
appropriate actions consistent with applicable law to end what the 
order refers to as the chemical and surgical mutilation of children 
including regulatory and sub-regulatory actions for specific programs, 
including Medicaid. In alignment with the Executive Order and the 
evidence outlined in section I.B. of this proposed rule, CMS decided to 
pursue this proposed policy. These proposed changes would not prevent 
States from providing coverage for sex-rejecting procedures with State-
only funds outside of the Federally-matched Medicaid program or CHIP.

D. Regulatory Flexibility Act (RFA)

    The RFA requires agencies to analyze options for regulatory relief 
of small entities, if a rule has a significant economic impact on a 
substantial number of small entities. For purposes of the RFA, we 
estimate that almost all hospitals and other healthcare providers are 
small entities as that term is used in the RFA (including small 
businesses, small nonprofit organizations, and small governmental 
jurisdictions). The great majority of hospitals and most other 
healthcare providers are small entities, either by being nonprofit 
organizations or by meeting the Small Business Administration (SBA) 
definition of a small business (having revenues of less than $9.0 
million to $47.0 million in any 1 year). Individuals and States are not 
included in the definition of a small entity.
    For purposes of the RFA, approximately 96 percent of the health 
care industries impacted are considered small businesses according to 
the Small Business Administration's size standards. According to the 
SBA's website at http://www.sba.gov/content/small-business-size-standards, the health care industries impacted fall in the North 
American Industrial Classification System (NAICS) 446110 Pharmacies and 
Drug Stores; 622111 Offices of Physicians (except Mental Health 
Specialists); 621112 Offices of Physicians, Mental Health Specialists; 
621493 Freestanding Ambulatory Surgical and Emergency Centers; 621498 
All Other Outpatient Care Centers; and 622110 General Medical and 
Surgical Hospitals. Table 5 shows the industry size standards for each 
of these health care industries.

                                  Table 5--Health Care Industry Size Standards
----------------------------------------------------------------------------------------------------------------
                                                                             SBA size standard/
            NAICS (6-digit)                Industry subsector description       small entity        Total small
                                                                             threshold (million)    businesses
----------------------------------------------------------------------------------------------------------------
446110.................................  Pharmacies and Drug Stores.......                 $37.5          18,461
621111.................................  Offices of Physicians (except                      16.0         129,117
                                          Mental Health Specialists).
621112.................................  Offices of Physicians, Mental                      13.5          12,325
                                          Health Specialists.
621493.................................  Freestanding Ambulatory Surgical                   19.0           5,569
                                          and Emergency Centers.
621498.................................  All Other Outpatient Care Centers                  25.5           9,801
622110.................................  General Medical and Surgical                       47.0           1,169
                                          Hospitals.
----------------------------------------------------------------------------------------------------------------
Source: 2022 Statistics of U.S. Businesses, available at https://www.census.gov/programs-surveys/susb.html.

    Tables 6 through 11 aid in showing the distribution of firms and 
revenues at their 6 digits NAICS code level. These tables aim to 
provide an understanding of the disproportionate impacts among firms, 
between small and large firms.

                                Table 6--NAICS 446110 Pharmacies and Drug Stores
                                          [$37.5 Million size standard]
----------------------------------------------------------------------------------------------------------------
                Firm size (by receipts)                     Firm count      % of small firms     Avg. revenue
----------------------------------------------------------------------------------------------------------------
SMALL FIRMS...........................................             18,461                100       $3,930,615.08
    <$100K............................................                560                  3           50,953.57
    $100K-$499K.......................................              1,733                  9          292,525.68
    $500-$999K........................................              1,764                 10          753,448.41
    $1M-$2.499M.......................................              4,810                 26        1,760,637.01
    $2.5M-$4.999M.....................................              5,159                 28        3,606,681.53
    $5M-$7.499M.......................................              2,137                 12        6,079,067.38
    $7.5M-$9.999M.....................................                869                  5        8,624,350.98
    $10M-$14.999M.....................................                762                  4       11,934,971.13
    $15M-$19.999M.....................................                318                  2       16,805,396.23
    $20M-$24.999M.....................................                146                  1       21,375,342.47
    $25M-$29.999M.....................................                 98                  1       26,077,561.22
    $30M-$34.999M.....................................                 64                  0       27,529,546.88
    $35M-$39.999M.....................................                 41                  0       30,746,414.63

[[Page 59460]]

 
LARGE FIRMS...........................................  .................  .................  ..................
    Receipts>$40M.....................................                396                N/A      672,827,431.82
----------------------------------------------------------------------------------------------------------------
Source: 2022 Statistics of U.S. Businesses, available at https://www.census.gov/programs-surveys/susb.html.


                 Table 7--NAICS 621111 Offices of Physicians (Except Mental Health Specialists)
                                          [$16.0 Million size standard]
----------------------------------------------------------------------------------------------------------------
                Firm size (by receipts)                     Firm count      % of small firms     Avg. revenue
----------------------------------------------------------------------------------------------------------------
SMALL FIRMS...........................................            129,117                100       $1,463,302.41
    <$100K............................................             11,119                  9           51,195.79
    $100K-$499K.......................................             44,138                 34          296,376.77
    $500-$999K........................................             30,224                 23          712,231.21
    $1M-$2.499M.......................................             24,522                 19        1,559,970.11
    $2.5M-$4.999M.....................................             10,388                  8        3,475,423.18
    $5M-$7.499M.......................................              3,799                  3        6,048,868.65
    $7.5M-$9.999M.....................................              1,945                  2        8,498,150.64
    $10M-$14.999M.....................................              2,003                  2       11,844,361.46
    $15M-19.999M......................................                979                  1       16,517,796.73
LARGE FIRMS...........................................  .................  .................  ..................
    Receipts >$20M....................................              3,782                N/A      116,848,659.18
----------------------------------------------------------------------------------------------------------------
Source: 2022 Statistics of U.S. Businesses, available at https://www.census.gov/programs-surveys/susb.html.


                     Table 8--NAICS 621112 Offices of Physicians, Mental Health Specialists
                                          [$13.5 Million size standard]
----------------------------------------------------------------------------------------------------------------
                Firm size (by receipts)                     Firm count      % of small firms     Avg. revenue
----------------------------------------------------------------------------------------------------------------
SMALL FIRMS...........................................             12,325                100         $634,311.40
    <$100K............................................              2,125                 17           52,448.00
    $100K-$499K.......................................              6,341                 51          261,018.29
    $500-$999K........................................              2,092                 17          686,686.90
    $1M-$2.499M.......................................              1,206                 10        1,496,716.42
    $2.5M-$4.999M.....................................                338                  3        3,331,017.75
    $5M-$7.499M.......................................                111                  1        5,735,522.52
    $7.5M-$9.999M.....................................                 52                  0        8,039,461.54
    $10M-$14.999M.....................................                 60                  0       10,485,850.00
LARGE FIRMS...........................................  .................  .................  ..................
    Receipts >$15M....................................                212                N/A       14,421,103.77
----------------------------------------------------------------------------------------------------------------
Source: 2022 Statistics of U.S. Businesses, available at https://www.census.gov/programs-surveys/susb.html.


                  Table 9--NAICS 621493 Freestanding Ambulatory Surgical and Emergency Centers
                                          [$19.0 Million size standard]
----------------------------------------------------------------------------------------------------------------
                Firm size (by receipts)                     Firm count      % of small firms     Avg. revenue
----------------------------------------------------------------------------------------------------------------
SMALL FIRMS...........................................              5,569                100       $2,713,466.15
    <$100K............................................                353                  6           48,246.46
    $100K-$499K.......................................              1,249                 22          287,140.11
    $500-$999K........................................                867                 16          724,727.80
    $1M-$2.499M.......................................              1,265                 23        1,648,132.81
    $2.5M-$4.999M.....................................                845                 15        3,602,647.34
    $5M-$7.499M.......................................                413                  7        5,999,140.44
    $7.5M-$9.999M.....................................                223                  4        8,392,170.40
    $10M-$14.999M.....................................                241                  4       11,472,634.85
    $15M-19.999M......................................                113                  2       16,496,955.75
LARGE FIRMS...........................................  .................  .................  ..................
    Receipts >$20M....................................                610                N/A       46,366,978.69
----------------------------------------------------------------------------------------------------------------
Source: 2022 Statistics of U.S. Businesses, available at https://www.census.gov/programs-surveys/susb.html.


[[Page 59461]]


                            Table 10--NAICS 621498 All Other Outpatient Care Centers
                                          [$25.5 Million size standard]
----------------------------------------------------------------------------------------------------------------
                Firm size (by receipts)                     Firm count      % of small firms     Avg. revenue
----------------------------------------------------------------------------------------------------------------
SMALL FIRMS...........................................              9,801                100       $2,124,005.00
    <$100K............................................              1,079                 11           48,916.59
    $100K-$499K.......................................              2,925                 30          283,037.26
    $500-$999K........................................              1,832                 19          719,524.02
    $1M-$2.499M.......................................              1,990                 20        1,545,938.69
    $2.5M-$4.999M.....................................                790                  8        3,409,083.54
    $5M-$7.499M.......................................                289                  3        5,739,238.75
    $7.5M-$9.999M.....................................                193                  2        7,644,943.01
    $10M-$14.999M.....................................                292                  3       10,567,616.44
    $15M-$19.999M.....................................                184                  2       13,609,652.17
    $20M-$24.999M.....................................                137                  1       16,169,890.51
    $25M-$29.999M.....................................                 90                  1       21,218,188.89
LARGE FIRMS...........................................  .................  .................  ..................
    Receipts >$30M....................................              1,008                N/A       55,938,203.37
----------------------------------------------------------------------------------------------------------------
Source: 2022 Statistics of U.S. Businesses, available at https://www.census.gov/programs-surveys/susb.html.


                          Table 11--NAICS 622110 General Medical and Surgical Hospitals
                                          [$47.0 Million size standard]
----------------------------------------------------------------------------------------------------------------
                Firm size (by receipts)                     Firm count      % of small firms     Avg. revenue
----------------------------------------------------------------------------------------------------------------
SMALL FIRMS...........................................              1,169                100      $17,598,603.93
    <$100K............................................                 59                  5           49,491.53
    $100K-$499K.......................................                150                 13          270,466.67
    $500-$999K........................................                 54                  5          696,814.81
    $1M-$2.499M.......................................                 28                  2        1,522,000.00
    $2.5M-$4.999M.....................................                 28                  2        3,739,428.57
    $5M-$7.499M.......................................                 35                  3        6,512,657.14
    $7.5M-$9.999M.....................................                 51                  4        8,550,588.24
    $10M-$14.999M.....................................                124                 11       11,777,798.39
    $15M-$19.999M.....................................                132                 11       16,993,166.67
    $20M-$24.999M.....................................                121                 10       22,389,727.27
    $25M-$29.999M.....................................                100                  9       26,686,900.00
    $30M-$34.999M.....................................                 99                  8       31,329,858.59
    $35M-$39.999M.....................................                 66                  6       35,617,636.36
    $40M-44.999M......................................                122                 10       42,184,385.25
    $45M-$49.999M.....................................              1,169                  5       17,598,603.93
LARGE FIRMS...........................................  .................  .................  ..................
    Receipts >$50M....................................              1,404                N/A      884,790,689.46
----------------------------------------------------------------------------------------------------------------
Source: 2022 Statistics of U.S. Businesses, available at https://www.census.gov/programs-surveys/susb.html.

    Individuals and States are not included in the definition of a 
small entity.
    As shown in Table 12, all the industries combined, according to the 
2022 Economic Census, earned approximately $2,364,153,884,000, while 
the small firms for all the industries combined earned approximately 
$325,819,624,000. Table 13 in section V.E. estimates a $31.6 million 
reduction in total annualized monetized transfers from the Federal 
Government and States to health care providers. This total estimated 
reduction represents less than 1 percent of the total revenues of the 
health care industries impacted and the total revenues of the small 
firms in the health care industries impacted. It also represents less 
than 1 percent of the total revenues of each health care industry 
impacted and the total revenues of the small firms in each health care 
industry impacted. As a result, this proposed rule if finalized would 
result in a change in revenue of less than 1 percent for the impacted 
health care industries.

                  Table 12--Total Revenues, All Firms and Small Firms, by NAICS Classification
----------------------------------------------------------------------------------------------------------------
                                                                       Revenue                          Revenue
                   NAICS                       Total revenues (all      test *      Total revenues       test *
                                                      firms)             (%)         (small firms)        (%)
----------------------------------------------------------------------------------------------------------------
446110 Pharmacies and Drug Stores..........      $339,002,748,000.00       0.01    $72,563,085,000.00       0.04
621111 Offices of Physicians (except Mental       630,858,846,000.00       0.00    188,937,217,000.00       0.02
 Health Specialists).......................
621112 Offices of Physicians, Mental Health        10,875,162,000.00       0.29      7,817,888,000.00       0.40
 Specialists...............................
621493 Freestanding Ambulatory Surgical and        43,395,150,000.00       0.07     15,111,293,000.00       0.21
 Emergency Centers.........................
621498 All Other Outpatient Care Centers...        77,203,082,000.00       0.04     20,817,373,000.00       0.15

[[Page 59462]]

 
622110 General Medical and Surgical             1,262,818,896,000.00       0.00     20,572,768,000.00       0.15
 Hospitals.................................
                                            --------------------------------------------------------------------
    Total..................................     2,364,153,884,000.00       0.00    325,819,624,000.00       0.01
----------------------------------------------------------------------------------------------------------------
Source: 2022 Statistics of U.S. Businesses, available at https://www.census.gov/programs-surveys/susb.html.
* Calculated using an estimated reduction in total annualized monetized transfers of $31.6 million (as shown in
  Table 13) as a percentage of total revenues.

    As its measure of significant economic impact on a substantial 
number of small entities,
    HHS uses a change in revenue of more than 3 to 5 percent. According 
to Table 12, we do not believe that the 3 to 5 percent threshold will 
be reached by the proposed requirements in this rule for NAICS 446110 
Pharmacies and Drug Stores; 622111 Offices of Physicians (except Mental 
Health Specialists); 621112 Offices of Physicians, Mental Health 
Specialists; 621493 Freestanding Ambulatory Surgical and Emergency 
Centers; 621498 All Other Outpatient Care Centers; or 622110 General 
Medical and Surgical Hospitals. Therefore, the Secretary has certified 
that this proposed rule will not have a significant economic impact on 
a substantial number of small entities in these industries.
    In addition, section 1102(b) of the Act requires us to prepare a 
regulatory impact analysis RIA if a rule may have a significant impact 
on the operations of a substantial number of small rural hospitals. 
This analysis must conform to the provisions of section 603 of the RFA. 
For purposes of section 1102(b) of the Act, we define a small rural 
hospital as a hospital that is located outside of a Metropolitan 
Statistical Area for Medicare payment regulations and has fewer than 
100 beds. We are not preparing an analysis for section 1102(b) of the 
Act because we have determined, and the Secretary certifies, that this 
proposed rule would not have a significant impact on the operations of 
a substantial number of small rural hospitals.
    Section 202 of the Unfunded Mandates Reform Act of 1995 (UMRA) also 
requires that agencies assess anticipated costs and benefits before 
issuing any rule whose mandates require spending in any 1 year of $100 
million in 1995 dollars, updated annually for inflation. In 2025, that 
threshold is approximately $187 million. The proposed rule would not 
mandate significant spending costs on State, local, or Tribal 
governments in the aggregate, or by the private sector.
    Executive Order 13132 establishes certain requirements that an 
agency must meet when it issues a rule that imposes substantial direct 
effects on the States, on the relationship between the National 
Government and the States, or on the distribution of power and 
responsibilities among the various levels of government. This proposed 
rule will have a substantial direct effect on the ability of States to 
receive Federal Medicaid funds for sex-rejecting procedures furnished 
to children under age 18 and on the ability of States to receive 
Federal CHIP funds for sex-rejecting procedures furnished to children 
under age 19.

E. Accounting Statement and Table

    Consistent with OMB Circular A-4 (available at https://www.whitehouse.gov/wp-content/uploads/2025/08/CircularA-4.pdf), we have 
prepared an accounting statement in Table 13 showing the classification 
of the impact associated with the provisions of this proposed 
rule.\105\
---------------------------------------------------------------------------

    \105\ The effects attributable to this proposed rule might be 
lower in magnitude than the aggregates presented here if other 
actions, such as the HHS/CMS proposal titled ``Medicare and Medicaid 
Programs; Hospital Condition of Participation: Prohibiting Sex-
Rejecting Procedures on Children,'' are finalized before 
finalization of this proposal.

                                         Table 13--Accounting Statement
----------------------------------------------------------------------------------------------------------------
                                                   Estimate                      Discount rate
                   Transfers                       (million)      Year dollar         (%)        Period covered
----------------------------------------------------------------------------------------------------------------
Annualized Monetized ($/year).................           $18.7            2027               7         2027-2036
                                                          18.7            2027               3         2027-2036
----------------------------------------------------------------------------------------------------------------
Quantitative:
 Estimated reduction in transfers from Federal Government to healthcare providers (including hospitals,
 physicians, and pharmacies) and to beneficiaries due to no longer covering sex-rejecting procedures for
 individuals under 18.
----------------------------------------------------------------------------------------------------------------
Annualized Monetized ($/year).................            12.9            2026               7         2027-2036
                                                          12.9            2026               3         2027-2036
----------------------------------------------------------------------------------------------------------------
Quantitative:
 Estimated reduction in transfers from States to healthcare providers (including hospitals, physicians,
 and pharmacies) and to beneficiaries due to no longer covering sex-rejecting procedures for individuals under
 18.
----------------------------------------------------------------------------------------------------------------

    Table 13 shows the annualized monetized transfer values required 
under OMB Circular A-4. At a discount rate of 7 percent, the annualized 
monetized transfers are $18.7 million to the Federal government and 
$12.9 million to the States, reflecting a reduction in payment for 
these services to healthcare providers. At a discount rate of 3 
percent, the annualized monetized transfers are also $18.7 million to 
the Federal government and $12.9 million to the States.
    Mehmet Oz, Administrator of the Centers for Medicare & Medicaid

[[Page 59463]]

Services, approved this document on December 15, 2025.

List of Subjects

42 CFR Part 441

    Grant programs--health, Health professions, Medicaid, Reporting and 
recordkeeping requirements.

42 CFR Part 457

    CHIP, Grant programs--health, Health professions, Reporting and 
recordkeeping requirements.

    For the reasons set forth in the preamble, the Centers for Medicare 
& Medicaid Services proposes to amend 42 CFR chapter IV as set forth 
below:

PART 441--SERVICES: REQUIREMENTS AND LIMITS APPLICABLE TO SPECIFIC 
SERVICES

0
1. The authority citation for part 441 continues to read as follows:

    Authority:  42 U.S.C. 1302.

0
2. Part 441 is amended by adding subpart N to read as follows:

Subpart N--Prohibition on Federal Medicaid Funding for Sex-
Rejecting Procedures Furnished to Children

Sec.
441.800 Basis and purpose.
441.801 Definitions.
441.802 General rules.


Sec.  441.800  Basis and purpose.

    Basis and purpose. The purpose of this section is to implement 
sections 1902(a)(19) and 1902(a)(30)(A) of the Act to protect Medicaid 
beneficiaries and ensure Medicaid payment is consistent with quality of 
care by prohibiting Federal financial participation in payments by 
States for sex-rejecting procedures for a child under the age of 18.
    (a) As relevant to this subpart, section 1902(a)(19) of the Act 
requires that States ensure that care and services will be provided in 
a manner consistent with the best interests of the recipients.
    (b) As relevant to this subpart, section 1902(a)(30)(A) of the Act 
requires that States' payment methods be consistent with quality of 
care.


Sec.  441.801  Definitions.

    As used in this subpart--
    FFP means Federal financial participation.
    Female means a person of the sex characterized by a reproductive 
system with the biological function of (at maturity, absent disruption 
or congenital anomaly) producing eggs (ova).
    Male means a person of the sex characterized by a reproductive 
system with the biological function of (at maturity, absent disruption 
or congenital anomaly) producing sperm.
    Sex means a person's immutable biological classification as either 
male or female.
    Sex-rejecting procedure means, except as specified in paragraph (3) 
of this definition, any pharmaceutical or surgical intervention that 
attempts to align a child's physical appearance or body with an 
asserted identity that differs from the child's sex by either of the 
following:
    (1) Intentionally disrupting or suppressing the normal development 
of natural biological functions, including primary or secondary sex-
based traits; or
    (2) Intentionally altering a child's physical appearance or body, 
including amputating, minimizing or destroying primary or secondary 
sex-based traits such as the sexual and reproductive organs.
    (3) For purposes of this definition, the term sex-rejecting 
procedure does not include procedures undertaken--
    (i) To treat a child with a medically verifiable disorder of sexual 
development; or
    (ii) For purposes other than attempting to align a child's physical 
appearance or body with an asserted identity that differs from the 
child's sex; or.
    (iii) To treat complications, including any infection, injury, 
disease, or disorder that has been caused by or exacerbated by the 
performance of sex-rejecting procedure(s).


Sec.  441.802  General rules.

    (a) A State plan must provide that the Medicaid agency will not 
make payment under the plan for sex-rejecting procedures for children 
under the age of 18.
    (b) FFP is not available in State expenditures for sex-rejecting 
procedures for children under the age of 18.

PART 457--ALLOTMENTS AND GRANTS TO STATES

0
3. The authority citation for part 457 continues to read as follows:

    Authority:  42 U.S.C. 1302.

0
4. Section 457.476 is added to subpart D to read as follows:


Sec.  457.476  Limitations on coverage: Sex-rejecting procedures.

    (a) Basis and purpose. The purpose of this section is to ensure 
that CHIP is operated in an effective and efficient manner that is 
coordinated with other sources of health benefits coverage, including 
Medicaid, for children consistent with 2101(a) by prohibiting Federal 
financial participation in payments by States for sex-rejecting 
procedures for a child under the age of 19.
    (b) The prohibition on Federal financial participation for payments 
by States for sex-rejecting procedures for children applies in the same 
manner described in Medicaid at Sec.  441.802 to a State administering 
a separate CHIP except that it applies to children under the age of 19 
in accordance with the definition of a targeted low-income child at 
Sec.  457.310. This prohibition applies to CHIP regardless of the type 
of health benefit coverage option described at Sec.  457.410. For 
purposes of this section, the definitions applied under Medicaid at 
Sec.  441.801 apply equally to a separate CHIP.

Robert F. Kennedy, Jr.,
Secretary, Department of Health and Human Services.
[FR Doc. 2025-23464 Filed 12-18-25; 8:45 am]
BILLING CODE 4120-01-P