[Federal Register Volume 90, Number 227 (Friday, November 28, 2025)]
[Presidential Documents]
[Pages 55035-55039]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2025-21665]
Presidential Documents
Federal Register / Vol. 90 , No. 227 / Friday, November 28, 2025 /
Presidential Documents
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Executive Order 14363 of November 24, 2025
Launching the Genesis Mission
By the authority vested in me as President by the
Constitution and the laws of the United States of
America, it is hereby ordered:
Section 1. Purpose. From the founding of our Republic,
scientific discovery and technological innovation have
driven American progress and prosperity. Today, America
is in a race for global technology dominance in the
development of artificial intelligence (AI), an
important frontier of scientific discovery and economic
growth. To that end, my Administration has taken a
number of actions to win that race, including issuing
multiple Executive Orders and implementing America's AI
Action Plan, which recognizes the need to invest in AI-
enabled science to accelerate scientific advancement.
In this pivotal moment, the challenges we face require
a historic national effort, comparable in urgency and
ambition to the Manhattan Project that was instrumental
to our victory in World War II and was a critical basis
for the foundation of the Department of Energy (DOE)
and its national laboratories.
This order launches the ``Genesis Mission'' as a
dedicated, coordinated national effort to unleash a new
age of AI-accelerated innovation and discovery that can
solve the most challenging problems of this century.
The Genesis Mission will build an integrated AI
platform to harness Federal scientific datasets--the
world's largest collection of such datasets, developed
over decades of Federal investments--to train
scientific foundation models and create AI agents to
test new hypotheses, automate research workflows, and
accelerate scientific breakthroughs. The Genesis
Mission will bring together our Nation's research and
development resources--combining the efforts of
brilliant American scientists, including those at our
national laboratories, with pioneering American
businesses; world-renowned universities; and existing
research infrastructure, data repositories, production
plants, and national security sites--to achieve
dramatic acceleration in AI development and
utilization. We will harness for the benefit of our
Nation the revolution underway in computing, and build
on decades of innovation in semiconductors and high-
performance computing. The Genesis Mission will
dramatically accelerate scientific discovery,
strengthen national security, secure energy dominance,
enhance workforce productivity, and multiply the return
on taxpayer investment into research and development,
thereby furthering America's technological dominance
and global strategic leadership.
Sec. 2. Establishment of the Genesis Mission. (a) There
is hereby established the Genesis Mission (Mission), a
national effort to accelerate the application of AI for
transformative scientific discovery focused on pressing
national challenges.
(b) The Secretary of Energy (Secretary) shall be
responsible for implementing the Mission within DOE,
consistent with the provisions of this order,
including, as appropriate and authorized by law,
setting priorities and ensuring that all DOE resources
used for elements of the Mission are integrated into a
secure, unified platform. The Secretary may designate a
senior political appointee to oversee day-to-day
operations of the Mission.
(c) The Assistant to the President for Science and
Technology (APST) shall provide general leadership of
the Mission, including coordination of
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participating executive departments and agencies
(agencies) through the National Science and Technology
Council (NSTC) and the issuance of guidance to ensure
that the Mission is aligned with national objectives.
Sec. 3. Operation of the American Science and Security
Platform. (a) The Secretary shall establish and operate
the American Science and Security Platform (Platform)
to serve as the infrastructure for the Mission with the
purpose of providing, in an integrated manner and to
the maximum extent practicable and consistent with law:
(i) high-performance computing resources, including DOE national laboratory
supercomputers and secure cloud-based AI computing environments, capable of
supporting large-scale model training, simulation, and inference;
(ii) AI modeling and analysis frameworks, including AI agents to explore
design spaces, evaluate experimental outcomes, and automate workflows;
(iii) computational tools, including AI-enabled predictive models,
simulation models, and design optimization tools;
(iv) domain-specific foundation models across the range of scientific
domains covered;
(v) secure access to appropriate datasets, including proprietary, federally
curated, and open scientific datasets, in addition to synthetic data
generated through DOE computing resources, consistent with applicable law;
applicable classification, privacy, and intellectual property protections;
and Federal data-access and data-management standards; and
(vi) experimental and production tools to enable autonomous and AI-
augmented experimentation and manufacturing in high-impact domains.
(b) The Secretary shall take necessary steps to
ensure that the Platform is operated in a manner that
meets security requirements consistent with its
national security and competitiveness mission,
including applicable classification, supply chain
security, and Federal cybersecurity standards and best
practices.
(c) Within 90 days of the date of this order, the
Secretary shall identify Federal computing, storage,
and networking resources available to support the
Mission, including both DOE on-premises and cloud-based
high-performance computing systems, and resources
available through industry partners. The Secretary
shall also identify any additional partnerships or
infrastructure enhancements that could support the
computational foundation for the Platform.
(d) Within 120 days of the date of this order, the
Secretary shall:
(i) identify a set of initial data and model assets for use in the Mission,
including digitization, standardization, metadata, and provenance tracking;
and
(ii) develop a plan, with appropriate risk-based cybersecurity measures,
for incorporating datasets from federally funded research, other agencies,
academic institutions, and approved private-sector partners, as
appropriate.
(e) Within 240 days of the date of this order, the
Secretary shall review capabilities across the DOE
national laboratories and other participating Federal
research facilities for robotic laboratories and
production facilities with the ability to engage in AI-
directed experimentation and manufacturing, including
automated and AI-augmented workflows and the related
technical and operational standards needed.
(f) Within 270 days of the date of this order, the
Secretary shall, consistent with applicable law and
subject to available appropriations, seek to
demonstrate an initial operating capability of the
Platform for at least one of the national science and
technology challenges identified pursuant to section 4
of this order.
Sec. 4. Identification of National Science and
Technology Challenges. (a) Within 60 days of the date
of this order, the Secretary shall identify and submit
to the APST a detailed list of at least 20 science and
technology
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challenges of national importance that the Secretary
assesses to have potential to be addressed through the
Mission and that span priority domains consistent with
National Science and Technology Memorandum 2 of
September 23, 2025, including:
(i) advanced manufacturing;
(ii) biotechnology;
(iii) critical materials;
(iv) nuclear fission and fusion energy;
(v) quantum information science; and
(vi) semiconductors and microelectronics.
(b) Within 30 days of submission of the list
described in subsection (a) of this section, the APST
shall review the proposed list and, working with
participating agency members of the NSTC, coordinate
the development of an expanded list that can serve as
the initial set of national science and technology
challenges to be addressed by the Mission, including
additional challenges proposed by participating
agencies through the NSTC, subject to available
appropriations.
(c) Following development of the expanded list
described in subsection (b) of this section, agencies
participating in the Mission shall use the Platform to
advance research and development aligned with the
national science and technology challenges identified
in the expanded list, consistent with applicable law
and their respective missions, and subject to available
appropriations.
(d) On an annual basis thereafter, the Secretary
shall review and update the list of challenges in
consultation with the APST and the NSTC to reflect
progress achieved, emerging national needs, and
alignment with my Administration's research and
development priorities.
Sec. 5. Interagency Coordination and External
Engagement. (a) The APST, through the NSTC, and with
support from the Federal Chief Data Officer Council and
the Chief AI Officer Council, shall convene relevant
and interested agencies to:
(i) assist participating agencies in aligning, to the extent permitted by
law, their AI-related programs, datasets, and research and development
activities with the objectives of the Mission in their respective areas of
expertise, while avoiding duplication of effort across the Federal
Government and promoting interoperability;
(ii) identify data sources that may support the Mission's aim;
(iii) develop a process and resourcing plan in coordination with
participating agencies for integrating appropriate and available agency
data and infrastructure into the Mission, to the extent permitted by law
and subject to available appropriations, including methods under which all
agencies contributing to the Mission are encouraged to implement
appropriate risk-based security measures that reflect cybersecurity best
practices;
(iv) launch coordinated funding opportunities or prize competitions across
participating agencies, to the extent permitted by law and subject to
available appropriations, to incentivize private-sector participation in
AI-driven scientific research aligned with Mission objectives; and
(v) establish mechanisms to coordinate research and development funding
opportunities and experimental resources across participating agencies,
ensuring agencies can participate effectively in the Mission.
(b) The APST shall coordinate with relevant
agencies in establishing, consistent with existing
authorizing statutes and subject to available
appropriations, competitive programs for research
fellowships, internships, and apprenticeships focused
on the application of AI to scientific domains
identified as national challenges for the Mission, to
include placement of program participants at DOE
national laboratories and other participating Federal
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research facilities, with the purpose of providing
access to the Platform and training in AI-enabled
scientific discovery.
(c) The Secretary, in coordination with the APST
and the Special Advisor for AI and Crypto, shall
establish mechanisms for agency collaboration with
external partners possessing advanced AI, data, or
computing capabilities or scientific domain expertise,
including through cooperative research and development
agreements, user facility partnerships, or other
appropriate arrangements with external entities to
support and enhance the activities of the Mission, and
shall ensure that such partnerships are structured to
preserve the security of Federal research assets and
maximize public benefit. To facilitate these
collaborations, the Secretary shall:
(i) develop standardized partnership frameworks, including cooperative
research and development or other appropriate agreements, and data-use and
model-sharing agreements;
(ii) establish clear policies for ownership, licensing, trade-secret
protections, and commercialization of intellectual property developed under
the Mission, including innovations arising from AI-directed experiments;
(iii) implement uniform and stringent data access and management processes
and cybersecurity standards for non-Federal collaborators accessing
datasets, models, and computing environments, including measures requiring
compliance with classification, privacy, and export-control requirements,
as well as other applicable laws; and
(iv) establish procedures to ensure the highest standards of vetting and
authorization of users and collaborators seeking access to the resources of
the Mission and associated research activities, including the Platform and
associated Federal research resources.
(d) The APST, through the NSTC, shall, to the
extent appropriate, identify opportunities for
international scientific collaboration to support
activities under the Mission.
Sec. 6. Evaluation and Reporting. (a) Within 1 year of
the date of this order, and on an annual basis
thereafter, the Secretary shall submit a report to the
President, through the APST and the Director of the
Office of Management and Budget, describing:
(i) the Platform's operational status and capabilities;
(ii) progress toward integration across DOE national laboratories and other
participating Federal research partners, including shared access to
computing resources, data infrastructure, and research facilities;
(iii) the status of user engagement, including participation of student
researchers and any related training;
(iv) updates on research efforts and outcomes achieved, including
measurable scientific advances, publications, and prototype technologies;
(v) the scope and outcomes of public-private partnerships, including
collaborative research projects and any technology transitions or
commercialization activities; and
(vi) any identified needs or recommendations for authorities or interagency
support to achieve the Mission's objectives.
Sec. 7. General Provisions. (a) Nothing in this order
shall be construed to impair or otherwise affect:
(i) the authority granted by law to an executive department or agency, or
the head thereof; or
(ii) the functions of the Director of the Office of Management and Budget
relating to budgetary, administrative, or legislative proposals.
(b) This order shall be implemented consistent with
applicable law and subject to the availability of
appropriations.
(c) This order is not intended to, and does not,
create any right or benefit, substantive or procedural,
enforceable at law or in equity by any party
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against the United States, its departments, agencies,
or entities, its officers, employees, or agents, or any
other person.
(d) The costs for publication of this order shall
be borne by the Department of Energy.
(Presidential Sig.)
THE WHITE HOUSE,
November 24, 2025.
[FR Doc. 2025-21665
Filed 11-26-25; 11:15 am]
Billing code 6450-01-P