[Federal Register Volume 90, Number 125 (Wednesday, July 2, 2025)]
[Notices]
[Pages 29025-29027]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2025-12308]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

Food and Drug Administration

[Docket No. FDA-2025-N-0339]


Agency Information Collection Activities; Proposed Collection; 
Comment Request; Mitigation Strategies To Protect Food Against 
Intentional Adulteration

AGENCY: Food and Drug Administration, HHS.

ACTION: Notice.

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SUMMARY: The Food and Drug Administration (FDA, Agency, or we) is 
announcing an opportunity for public comment on the proposed collection 
of certain information by the Agency. Under the Paperwork Reduction Act 
of 1995 (PRA), Federal Agencies are required to publish notice in the 
Federal Register concerning each proposed collection of information, 
including each proposed extension of an existing collection of 
information, and to allow 60 days for public comment in response to the 
notice. This notice solicits comments on collections of information 
applicable to mitigation strategies to protect food against intentional 
adulteration.

DATES: Either electronic or written comments on the collection of 
information must be submitted by September 2, 2025.

ADDRESSES: You may submit comments as follows. Please note that late,

[[Page 29026]]

untimely filed comments will not be considered. The https://www.regulations.gov electronic filing system will accept comments until 
11:59 p.m. Eastern Time at the end of September 2, 2025. Comments 
received by mail/hand delivery/courier (for written/paper submissions) 
will be considered timely if they are received on or before that date.

Electronic Submissions

    Submit electronic comments in the following way:
     Federal eRulemaking Portal: https://www.regulations.gov. 
Follow the instructions for submitting comments. Comments submitted 
electronically, including attachments, to https://www.regulations.gov 
will be posted to the docket unchanged. Because your comment will be 
made public, you are solely responsible for ensuring that your comment 
does not include any confidential information that you or a third party 
may not wish to be posted, such as medical information, your or anyone 
else's Social Security number, or confidential business information, 
such as a manufacturing process. Please note that if you include your 
name, contact information, or other information that identifies you in 
the body of your comments, that information will be posted on https://www.regulations.gov.
     If you want to submit a comment with confidential 
information that you do not wish to be made available to the public, 
submit the comment as a written/paper submission and in the manner 
detailed (see ``Written/Paper Submissions'' and ``Instructions'').

Written/Paper Submissions

    Submit written/paper submissions as follows:
     Mail/Hand Delivery/Courier (for written/paper 
submissions): Dockets Management Staff (HFA-305), Food and Drug 
Administration, 5630 Fishers Lane, Rm. 1061, Rockville, MD 20852.
     For written/paper comments submitted to the Dockets 
Management Staff, FDA will post your comment, as well as any 
attachments, except for information submitted, marked and identified, 
as confidential, if submitted as detailed in ``Instructions.''
    Instructions: All submissions received must include the Docket No. 
FDA-2025-N-0339 for ``Agency Information Collection Activities; 
Proposed Collection; Comment Request; Mitigation Strategies To Protect 
Food Against Intentional Adulteration.'' Received comments, those filed 
in a timely manner (see ADDRESSES), will be placed in the docket and, 
except for those submitted as ``Confidential Submissions,'' publicly 
viewable at https://www.regulations.gov or at the Dockets Management 
Staff between 9 a.m. and 4 p.m., Monday through Friday, 240-402-7500.
     Confidential Submissions--To submit a comment with 
confidential information that you do not wish to be made publicly 
available, submit your comments only as a written/paper submission. You 
should submit two copies total. One copy will include the information 
you claim to be confidential with a heading or cover note that states 
``THIS DOCUMENT CONTAINS CONFIDENTIAL INFORMATION.'' The Agency will 
review this copy, including the claimed confidential information, in 
its consideration of comments. The second copy, which will have the 
claimed confidential information redacted/blacked out, will be 
available for public viewing and posted on https://www.regulations.gov. 
Submit both copies to the Dockets Management Staff. If you do not wish 
your name and contact information to be made publicly available, you 
can provide this information on the cover sheet and not in the body of 
your comments and you must identify this information as 
``confidential.'' Any information marked as ``confidential'' will not 
be disclosed except in accordance with 21 CFR 10.20 and other 
applicable disclosure law. For more information about FDA's posting of 
comments to public dockets, see 80 FR 56469, September 18, 2015, or 
access the information at: https://www.govinfo.gov/content/pkg/FR-2015-09-18/pdf/2015-23389.pdf.
    Docket: For access to the docket to read background documents or 
the electronic and written/paper comments received, go to https://www.regulations.gov and insert the docket number, found in brackets in 
the heading of this document, into the ``Search'' box and follow the 
prompts and/or go to the Dockets Management Staff, 5630 Fishers Lane, 
Rm. 1061, Rockville, MD 20852, 240-402-7500.

FOR FURTHER INFORMATION CONTACT: Domini Bean, Office of Operations, 
Food and Drug Administration, Three White Flint North, 10A-12M, 11601 
Landsdown St., North Bethesda, MD 20852, 301-796-5733, 
[email protected].

SUPPLEMENTARY INFORMATION: Under the PRA (44 U.S.C. 3501-3521), Federal 
Agencies must obtain approval from the Office of Management and Budget 
(OMB) for each collection of information they conduct or sponsor. 
``Collection of information'' is defined in 44 U.S.C. 3502(3) and 5 CFR 
1320.3(c) and includes Agency requests or requirements that members of 
the public submit reports, keep records, or provide information to a 
third party. Section 3506(c)(2)(A) of the PRA (44 U.S.C. 3506(c)(2)(A)) 
requires Federal Agencies to provide a 60-day notice in the Federal 
Register concerning each proposed collection of information, including 
each proposed extension of an existing collection of information, 
before submitting the collection to OMB for approval. To comply with 
this requirement, FDA is publishing notice of the proposed collection 
of information set forth in this document.
    With respect to the following collection of information, FDA 
invites comments on these topics: (1) whether the proposed collection 
of information is necessary for the proper performance of FDA's 
functions, including whether the information will have practical 
utility; (2) the accuracy of FDA's estimate of the burden of the 
proposed collection of information, including the validity of the 
methodology and assumptions used; (3) ways to enhance the quality, 
utility, and clarity of the information to be collected; and (4) ways 
to minimize the burden of the collection of information on respondents, 
including through the use of automated collection techniques, when 
appropriate, and other forms of information technology.

Mitigation Strategies To Protect Food Against Intentional 
Adulteration--21 CFR Part 21

OMB Control Number 0910-0812--Extension

    This information collection helps support the implementation of 
statutory and regulatory requirements intended to ensure the safety of 
food. Section 418 of the Federal Food, Drug, and Cosmetic Act (FD&C 
Act) (21 U.S.C. 350g) governs the assessment and evaluation of hazard 
analyses and risk-based preventive controls intended to provide 
assurances that food is not adulterated under section 402 of the FD&C 
Act (21 U.S.C. 342). Similarly, section 419 of the FD&C Act (21 U.S.C. 
350h) establishes standards for produce safety, and section 420 of the 
FD&C Act (21 U.S.C. 350i) requires the mitigation against intentional 
adulteration of high-risk foods (exempting farms except for farms that 
produce milk).
    Agency regulations in part 121 (21 CFR part 121) establish 
requirements applicable to owners, operators, or agents in charge of 
domestic or foreign food facilities that manufacture/process, pack, or 
hold food for consumption in the United States. The regulations, 
require the preparation, retention and

[[Page 29027]]

maintenance, and implementation of written mitigation strategies and 
procedures for defense monitoring, corrective actions, and food defense 
verification procedures.
    To help facilitate the submission to FDA of required information 
and reduce burden on respondents, we have developed resources, 
including an ``FDA Food Defense Plan Builder,'' (version 2.0) available 
at https://www.fda.gov/food/food-defense/food-defense-tools-educational-materials. Other resources made available to respondents 
include two draft guidance documents entitled ``Mitigation Strategies 
To Protect Food Against Intentional Adulteration: Draft Guidance for 
Industry'' (84 FR 8103, March 6, 2019), and ``Supplemental Draft 
Guidance for Industry: Mitigation Strategies To Protect Food Against 
Intentional Adulteration'' (85 FR 8599, February 14, 2020), which are 
available at https://www.fda.gov/food/food-defense. The guidance 
documents are intended to assist respondents in developing and 
implementing requisite elements of a food defense plan. All Agency 
guidance documents are issued in accordance with our good guidance 
practice regulations in 21 CFR 10.115, which provide for public comment 
at any time. Finally, we developed the small entity compliance guide 
entitled ``Mitigation Strategies To Protect Food Against Intentional 
Adulteration'' (82 FR 40484, August 25, 2017), available at https://www.fda.gov/regulatory-information/search-fda-guidance-documents/small-entity-compliance-guide-mitigation-strategies-protect-food-against-intentional-adulteration.
    Description of Respondents: The respondents to this information 
collection are manufacturers, processors, packers, and holders of 
retail food products marketed in the United States.
    We estimate the burden of the collection of information as follows:

                                 Table 1--Estimated Annual Reporting Burden \1\
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                                                    Number of       Total
    Information collection         Number of      responses per     annual       Average burden  per      Total
   activity; 21 CFR section       respondents      respondent     responses            response           hours
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Exemption requests for very              18,080               1       18,080  0.5 (30 minutes).........    9,040
 small businesses; Sec.
 121.5.
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\1\ There are no capital costs or operating and maintenance costs associated with this collection of
  information.


                                                   Table 2--Estimated Annual Recordkeeping Burden \1\
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                                                                      Number of       Total
            Activity; 21 CFR section                 Number of       records per      annual         Average burden  per recordkeeping          Total
                                                   recordkeepers    recordkeeper     records                                                    hours
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Food Defense Plan; Sec.   121.126...............            3,247               1        3,247  23.........................................       74,681
Actionable Process Steps; Sec.   121.130........            9,759               1        9,759  20.........................................      195,180
Mitigation Strategies; Sec.   121.135(b)........            9,759               1        9,759  20.........................................      195,180
Monitoring, Corrective Actions, Verification;               9,759               1        9,759  175........................................    1,707,825
 Sec.  Sec.   121.140(a), 121.145(a)(1), and
 121.150(b).
Training; Sec.   121.4..........................          367,203               1      367,203  0.67 (40 minutes)..........................      246,026
Records; Sec.  Sec.   121.305 and 121.310.......            9,759               1        9,759  10.........................................       97,590
                                                 -------------------------------------------------------------------------------------------------------
    Total.......................................  ...............  ..............  ...........  ...........................................    2,516,482
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\1\ There are no capital costs or operating and maintenance costs associated with this collection of information.

    Based on a review of the information collection since our last 
request for OMB approval, we have made no adjustments to our burden 
estimate.

    Dated: June 24, 2025.
Grace R. Graham,
Deputy Commissioner for Policy, Legislation, and International Affairs.
[FR Doc. 2025-12308 Filed 7-1-25; 8:45 am]
BILLING CODE 4164-01-P