[Federal Register Volume 90, Number 121 (Thursday, June 26, 2025)]
[Notices]
[Pages 27284-27287]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2025-11798]


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DEPARTMENT OF COMMERCE

Patent and Trademark Office


Agency Information Collection Activities; Submission to the 
Office of Management and Budget for Review and Approval; Comment 
Request; Requirements for Patent Applications Containing Nucleotide 
Sequence and/or Amino Acid Sequence Disclosures

AGENCY: United States Patent and Trademark Office, Department of 
Commerce.

ACTION: Notice of information collection; request for comments.

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SUMMARY: The United States Patent and Trademark Office (USPTO), as 
required by the Paperwork Reduction Act of 1995, invites comments on 
the extension and revision of an existing information collection: 0651-
0024 (Requirements for Patent Applications Containing Nucleotide 
Sequence and/or Amino Acid Sequence Disclosures). The purpose of this 
notice is to allow 60 days for public comments preceding submission of 
the information collection to the Office of Management and Budget 
(OMB).

DATES: To ensure consideration, you must submit comments regarding this 
information collection on or before August 25, 2025.

ADDRESSES: Interested persons are invited to submit written comments by 
any of the following methods. Do not submit Confidential Business 
Information or otherwise sensitive or protected information.
     Email: [email protected]. Include ``0651-
0024 comment'' in the subject line of the message.
     Federal eRulemaking Portal: http://www.regulations.gov.
     Mail: Justin Isaac, Office of the Chief Administrative 
Officer, United States Patent and Trademark Office, P.O. Box 1450, 
Alexandria, VA 22313-1450.

FOR FURTHER INFORMATION CONTACT: Request for additional information 
should be directed to Raul Tamayo, Senior Legal Advisor, at: United 
States Patent and Trademark Office, P.O. Box 1450, Alexandria, VA 
22313-1450; 571-272-7728; or [email protected] with ``0651-0024 
comment'' in the subject line. Additional information about this 
information collection is also available at http://www.reginfo.gov 
under ``Information Collection Review.''

SUPPLEMENTARY INFORMATION:

I. Abstract

    Patent applications that contain nucleotide and/or amino acid 
sequence disclosures falling within the definitions of 37 CFR 1.831 
(for applications filed on or after July 1, 2022) or 37 CFR 1.821(a) 
(for applications filed on or before June 30, 2022) must include, as a 
separate part of the application disclosure, a copy of the sequence 
listing in accordance with the requirements in 37 CFR 1.831-1.835 or 37 
CFR 1.821-1.825, respectively. Applicants may submit sequence listings 
for both U.S. and international patent applications. For more 
information concerning the submissions of sequence listings in 
international applications, see the Patent Cooperation Treaty (PCT) 
Rules 5.2 and 13ter, Annex C of the PCT Administrative Instructions, 
and section 1848 of the Manual of Patent Examining Procedure

[[Page 27285]]

(MPEP) (9th ed., Rev. 01.2024, November 2024).
    The USPTO uses the sequence listings during the examination process 
to determine the patentability of the invention claimed in the 
application. The USPTO also uses the sequence listings for pre-grant 
publication of applications and issued patents. Applicants use sequence 
listings when preparing both national and international patent 
applications that disclose nucleotide and/or amino acid sequences to 
provide a written description of the invention and to distinguish the 
claimed subject matter from the prior art.
    This information collection only covers the submission of sequence 
listing information. Information pertaining to the initial filing of a 
U.S. patent application is collected under OMB Control Number 0651-0032 
(Initial Patent Applications), and information pertaining to the 
initial filing of international applications is collected under OMB 
Control Number 0651-0021 (Patent Cooperation Treaty).
    For sequence listings filed as 37 CFR 1.825 amendments in 
applications having a filing date of on or before June 30, 2022, this 
information collection also accounts for the submission of a new or 
substitute computer readable form (CRF) copy of the sequence listing 
under 37 CFR 1.821(e) and 1.824, with the amendment incorporated 
therein, if necessary, under 37 CFR 1.825(a)(5)(ii) or (b)(6)(ii).

II. Method of Collection

    Sequence listings for applications having a filing date of on or 
after July 1, 2022, must be submitted as XML files, either by 
electronically transmitting the XML file through the USPTO patent 
electronic filing system (Patent Center), where the file does not 
exceed 100MB without compression, or on read-only optical discs. 
Sequence listings filed as 37 CFR 1.825 amendments in applications 
having a filing date of on or before June 30, 2022, are preferably 
submitted as an ASCII plain text file via Patent Center or on a read-
only optical disc. They may also be submitted electronically through 
Patent Center as a PDF or on paper with a submission that is mailed or 
hand delivered.

III. Data

    OMB Control Number: 0651-0024.
    Forms: None.
    Type of Review: Extension and revision of a currently approved 
information collection.
    Affected Public: Private sector.
    Respondent's Obligation: Required to obtain or retain benefits.
    Frequency: On occasion.
    Estimated Number of Annual Respondents: 30,000 respondents.
    Estimated Number of Annual Responses: 30,000 responses.
    Estimated Time per Response: The USPTO estimates that the responses 
in this information collection will take the public approximately 6 
hours to complete. This includes the time to gather the necessary 
information, create the document, and submit the completed items to the 
USPTO.
    Estimated Total Annual Respondent Burden Hours: 180,000 hours.
    Estimated Total Annual Respondent Hourly Cost Burden: $80,460,000.

                                       Table 1--Total Burden Hours and Hourly Costs to Private Sector Respondents
--------------------------------------------------------------------------------------------------------------------------------------------------------
                                    Estimated                                       Estimated time                                      Estimated annual
  Item No.          Item             annual       Responses per   Estimated annual   for response    Estimated burden   Rate \1\ ($/    respondent cost
                                   respondents     respondent        responses          (hours)        (hour/year)          hour)            burden
                                            (a)             (b)    (a) x (b) = (c)             (d)    (c) x (d) = (e)             (f)    (e) x (f) = (g)
--------------------------------------------------------------------------------------------------------------------------------------------------------
1..........  Sequence Listing            30,000               1             30,000               6            180,000            $447        $80,460,000
              in Application.
                                ------------------------------------------------------------------------------------------------------------------------
                Totals.........          30,000  ..............             30,000  ..............            180,000  ..............         80,460,000
--------------------------------------------------------------------------------------------------------------------------------------------------------
\1\ 2023 Report of the Economic Survey, published by the Committee on Economics of Legal Practice of the American Intellectual Property Law Association;
  pg. F-41. The USPTO uses the average billing rate for intellectual property work in all firms which is $447 per hour (https://www.aipla.org/home/news-publications/economic-survey).

    Estimated Total Annual Respondent Non-hourly Cost Burden: $336,973. 
There are no capital start-up costs, maintenance costs, or 
recordkeeping costs associated with this information collection. 
However, the USPTO estimates that the total annual non-hour cost burden 
for this information collection, in the form of filing fees and paid 
postage, is $336,973.

Filing Fees

Sequence Listings for Applications Filed on or After July 1, 2022
    Applicants must submit sequence listings as XML files, either by 
electronically transmitting the XML file through Patent Center, where 
the file does not exceed 100MB without compression, or on read-only 
optical discs. Accordingly, the size fees for excess pages under 35 
U.S.C. 41(a)(1)(G) and 37 CFR 1.16(s), 1.52(f), and 1.492(j), from 
which XML file submissions via Patent Center or read-only optical discs 
are excluded, do not apply to sequence listings filed in applications 
having a filing date of on or after July 1, 2022.
Sequence Listings for Applications Filed on or Before June 30, 2022
    Sequence listings may still be filed in applications having a 
filing date of on or before June 30, 2022, as amendments that meet the 
requirements of 37 CFR 1.825. The USPTO prefers that such an amendment 
be submitted as an ASCII plain text file via Patent Center or a read-
only optical disc. If so, the size fees for excess pages under 35 
U.S.C. 41(a)(1)(G) and 37 CFR 1.16(s) and 1.52(f), from which ASCII 
plain text file submissions via Patent Center or read-only optical 
discs are excluded, do not apply.
    However, the USPTO permits the amendment to be submitted 
electronically through Patent Center as a PDF or on paper. When doing 
so, the submission may incur a size fee for excess pages under 35 
U.S.C. 41(a)(1)(G) and 37 CFR 1.16(s) and 1.52(f).
    Specifically, under 37 CFR 1.16(s), if a patent application 
inclusive of a sequence listing amendment filed as a PDF or on paper 
exceeds 100 pages, the application size fee is $450 ($180 for small 
entities, $90 for micro entities) for each additional 50 pages or 
fraction thereof. For the purposes of this calculation, the USPTO 
assumes that the average length of a sequence listing filed as a PDF or 
on paper is 150 pages, which would result in a total size fee of three 
times the $450 application size fee under 37 CFR 1.16(s), i.e., $1,350 
($540 for small entities, $270 for micro entities) for applications 
that are at least 100 pages long prior to the sequence listing 
amendment. The USPTO estimates that 67 respondents annually will file 
sequence listing amendments as a PDF or on paper that will require the 
payment, on average, of $1,350 for the

[[Page 27286]]

undiscounted utility application size fee under 37 CFR 1.16(s). The 
USPTO presents this estimate in Table 2 below as 201 responses annually 
for the undiscounted utility application size fee under 37 CFR 1.16(s) 
of $450 (67 respondents paying the fee three times). Table 2 also 
reflects similar adjustments for the small and micro entity discounted 
utility application size fee under 37 CFR 1.16(s).
Mega-Sequence Listings
    Regardless of application filing date, the USPTO's receipt in 
electronic form of a very lengthy sequence listing (mega-sequence 
listing) in an application under 35 U.S.C. 111 or 371 is subject to the 
fee under 37 CFR 1.21(o). In particular, the first receipt by the USPTO 
of a sequence listing in electronic form ranging in size from 300MB to 
800MB (without file compression) incurs the fee under 37 CFR 
1.21(o)(1). The first receipt by the USPTO of a sequence listing in 
electronic form exceeding 800MB (without file compression) incurs the 
fee under 37 CFR 1.21(o)(2).
Late Furnishing Fee in PCT Applications
    Where a PCT applicant has not provided a sequence listing, and the 
USPTO acts as the International Searching Authority (ISA) or 
International Preliminary Examining Authority (IPEA), the USPTO may 
invite the applicant to furnish a sequence listing, with a late 
furnishing fee under 37 CFR 1.445(a)(5) and 1.482(c), under PCT Rule 
13ter. See section 1848(I) of the MPEP for more information.

                                                                  Table 2--Filing Fees
--------------------------------------------------------------------------------------------------------------------------------------------------------
                                                                          Estimated                       Estimated
                              Fee                                          annual         Number of     annual number                   Non-hourly cost
         Item No.             code                 Item                  respondents    responses per   of fees being  Filing fee ($)        burden
                                                                        paying a fee     respondent         paid
                                                                                  (a)             (b)             (c)             (d)    (c) x (d) = (e)
--------------------------------------------------------------------------------------------------------------------------------------------------------
1.........................     1081  Utility application size fee                  67               3             201            $450            $90,450
                                      under 37 CFR 1.16(s)
                                      (undiscounted entity).
1.........................     2081  Utility application size fee                  82               3             246             180             44,280
                                      under 37 CFR 1.16(s) (small
                                      entity).
1.........................     3081  Utility application size fee                   1               3               3              90                270
                                      under 37 CFR 1.16(s) (micro
                                      entity).
1.........................     1091  Submission of sequence listings               10               1              10           1,140             11,400
                                      of 300MB to 800MB (undiscounted
                                      entity).
1.........................     2091  Submission of sequence listings                1               1               1             456                456
                                      of 300MB to 800MB (small
                                      entity).
1.........................     3091  Submission of sequence listings                1               1               1             228                228
                                      of 300MB to 800MB (micro
                                      entity).
1.........................     1092  Submission of sequence listings                1               1               1          11,290             11,290
                                      of more than 800MB
                                      (undiscounted entity).
1.........................     2092  Submission of sequence listings                1               1               1           4,516              4,516
                                      of more than 800MB (small
                                      entity).
1.........................     3092  Submission of sequence listings                1               1               1           2,258              2,258
                                      of more than 800MB (micro
                                      entity).
1.........................     1627  Late Furnishing Fee for                      230               1             230             345             79,350
                                      Providing a Sequence Listing in
                                      Response to an Invitation Under
                                      PCT Rule 13ter (undiscounted
                                      entity).
1.........................     2627  Late Furnishing Fee for                      645               1             645             138             89,010
                                      Providing a Sequence Listing in
                                      Response to an Invitation Under
                                      PCT Rule 13ter (small entity).
1.........................     3627  Late Furnishing Fee for                        5               1               5              69                345
                                      Providing a Sequence Listing in
                                      Response to an Invitation Under
                                      PCT Rule 13ter (micro entity).
                                                                      ----------------------------------------------------------------------------------
                                        Totals.......................           1,045  ..............           1,345  ..............            333,853
--------------------------------------------------------------------------------------------------------------------------------------------------------

Postage Costs

    Sequence listings filed as 37 CFR 1.825 amendments in applications 
having a filing date of on or before June 30, 2022, may be submitted by 
mail through the United States Postal Service. The USPTO estimates that 
at most 1% of the 30,000 items will be submitted in the mail resulting 
in 300 mailed items. The USPTO estimates that the average postage cost 
for a mailed submission, using a Priority Mail legal flat rate 
envelope, will be $10.40. Therefore, the USPTO estimates the total 
mailing costs for this information collection at $3,120.

IV. Request for Comments

    The USPTO is soliciting public comments to:
    (a) Evaluate whether the collection of information is necessary for 
the proper performance of the functions of the agency, including 
whether the information will have practical utility;
    (b) Evaluate the accuracy of the agency's estimate of the burden of 
the collection of information, including the validity of the 
methodology and assumptions used;
    (c) Enhance the quality, utility, and clarity of the information to 
be collected; and
    (d) Minimize the burden of the collection of information on those 
who are to respond, including through the use of appropriate automated, 
electronic, mechanical, or other technological collection techniques or 
other forms of information technology, e.g., permitting electronic 
submission of responses.
    All comments submitted in response to this notice are a matter of 
public record. The USPTO will include or summarize each comment in the 
request to OMB to approve this information collection. Before including 
an address, phone number, email address, or other personally 
identifiable information (PII) in a comment, be aware that the entire 
comment--including PII--may be made publicly available at any time. 
While one may ask in a comment to withhold

[[Page 27287]]

PII from public view, the USPTO cannot guarantee that it will be able 
to do so.

Justin Isaac,
Information Collections Officer, Office of the Chief Administrative 
Officer, United States Patent and Trademark Office.
[FR Doc. 2025-11798 Filed 6-25-25; 8:45 am]
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