[Federal Register Volume 90, Number 93 (Thursday, May 15, 2025)]
[Presidential Documents]
[Pages 20749-20751]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2025-08876]



[[Page 20747]]

Vol. 90

Thursday,

No. 93

May 15, 2025

Part II





The President





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Executive Order 14297--Delivering Most-Favored-Nation Prescription Drug 
Pricing to American Patients


                        Presidential Documents 



Federal Register / Vol. 90 , No. 93 / Thursday, May 15, 2025 / 
Presidential Documents

___________________________________________________________________

Title 3--
The President

[[Page 20749]]

                Executive Order 14297 of May 12, 2025

                
Delivering Most-Favored-Nation Prescription Drug 
                Pricing to American Patients

                By the authority vested in me as President by the 
                Constitution and the laws of the United States of 
                America, it is hereby ordered:

                Section 1. Purpose. The United States has less than 
                five percent of the world's population and yet funds 
                around three quarters of global pharmaceutical profits. 
                This egregious imbalance is orchestrated through a 
                purposeful scheme in which drug manufacturers deeply 
                discount their products to access foreign markets, and 
                subsidize that decrease through enormously high prices 
                in the United States.

                The United States has for too long turned its back on 
                Americans, who unwittingly sponsor both drug 
                manufacturers and other countries. These entities today 
                rely on price markups on American consumers, generous 
                public subsidies for research and development primarily 
                through the National Institutes of Health, and robust 
                public financing of prescription drug consumption 
                through Federal and State healthcare programs. Drug 
                manufacturers, rather than seeking to equalize evident 
                price discrimination, agree to other countries' demands 
                for low prices, and simultaneously fight against the 
                ability for public and private payers in the United 
                States to negotiate the best prices for patients. The 
                inflated prices in the United States fuel global 
                innovation while foreign health systems get a free 
                ride.

                This abuse of Americans' generosity, who deserve low-
                cost pharmaceuticals on the same terms as other 
                developed nations, must end. Americans will no longer 
                be forced to pay almost three times more for the exact 
                same medicines, often made in the exact same factories. 
                As the largest purchaser of pharmaceuticals, Americans 
                should get the best deal.

                Sec. 2. Policy. Americans should not be forced to 
                subsidize low-cost prescription drugs and biologics in 
                other developed countries, and face overcharges for the 
                same products in the United States. Americans must 
                therefore have access to the most-favored-nation price 
                for these products.

                My Administration will take immediate steps to end 
                global freeloading and, should drug manufacturers fail 
                to offer American consumers the most-favored-nation 
                lowest price, my Administration will take additional 
                aggressive action.

                Sec. 3. Addressing Foreign Nations Freeloading on 
                American-Financed Innovation. The Secretary of Commerce 
                and the United States Trade Representative shall take 
                all necessary and appropriate action to ensure foreign 
                countries are not engaged in any act, policy, or 
                practice that may be unreasonable or discriminatory or 
                that may impair United States national security and 
                that has the effect of forcing American patients to pay 
                for a disproportionate amount of global pharmaceutical 
                research and development, including by suppressing the 
                price of pharmaceutical products below fair market 
                value in foreign countries.

                Sec. 4. Enabling Direct-to-Consumer Sales to American 
                Patients at the Most-Favored-Nation Price. To the 
                extent consistent with law, the Secretary of Health and 
                Human Services (Secretary) shall facilitate direct-to-
                consumer purchasing programs for pharmaceutical 
                manufacturers that sell their products to American 
                patients at the most-favored-nation price.

[[Page 20750]]

                Sec. 5. Establishing Most-Favored-Nation Pricing. (a) 
                Within 30 days of the date of this order, the Secretary 
                shall, in coordination with the Assistant to the 
                President for Domestic Policy, the Administrator for 
                the Centers for Medicare and Medicaid Services, and 
                other relevant executive department and agency (agency) 
                officials, communicate most-favored-nation price 
                targets to pharmaceutical manufacturers to bring prices 
                for American patients in line with comparably developed 
                nations.

                    (b) If, following the action described in 
                subsection (a) of this section, significant progress 
                towards most-favored-nation pricing for American 
                patients is not delivered, to the extent consistent 
                with law:

(i) the Secretary shall propose a rulemaking plan to impose most-favored-
nation pricing;

(ii) the Secretary shall consider certification to the Congress that 
importation under section 804(j) of the Federal Food, Drug, and Cosmetic 
Act (FDCA) will pose no additional risk to the public's health and safety 
and result in a significant reduction in the cost of prescription drugs to 
the American consumer; and if the Secretary so certifies, then the 
Commissioner of Food and Drugs shall take action under section 804(j)(2)(B) 
of the FDCA to describe circumstances under which waivers will be 
consistently granted to import prescription drugs on a case-by-case basis 
from developed nations with low-cost prescription drugs;

(iii) following the report issued under section 13 of Executive Order 14273 
of April 15, 2025 (Lowering Drug Prices by Once Again Putting Americans 
First), the Attorney General and the Chairman of the Federal Trade 
Commission shall, to the extent consistent with law, undertake enforcement 
action against any anti-competitive practices identified within such 
report, including through use of sections 1 and 2 of the Sherman Antitrust 
Act and section 5 of the Federal Trade Commission Act, as appropriate;

(iv) the Secretary of Commerce, and the heads of other relevant agencies as 
necessary, shall review and consider all necessary action regarding the 
export of pharmaceutical drugs or precursor material that may be fueling 
the global price discrimination;

(v) the Commissioner of Food and Drugs shall review and potentially modify 
or revoke approvals granted for drugs, for those drugs that maybe be 
unsafe, ineffective, or improperly marketed; and

(vi) the heads of agencies shall take all action available, in coordination 
with the Assistant to the President for Domestic Policy, to address global 
freeloading and price discrimination against American patients.

                Sec. 6. General Provisions. (a) Nothing in this order 
                shall be construed to impair or otherwise affect:

(i) the authority granted by law to an executive department or agency, or 
the head thereof; or

(ii) the functions of the Director of the Office of Management and Budget 
relating to budgetary, administrative, or legislative proposals.

                    (b) This order shall be implemented consistent with 
                applicable law and subject to the availability of 
                appropriations.
                    (c) This order is not intended to, and does not, 
                create any right or benefit, substantive or procedural, 
                enforceable at law or in equity by any party against 
                the United States, its departments, agencies, or 
                entities, its officers, employees, or agents, or any 
                other person.

[[Page 20751]]

                    (d) The Department of Health and Human Services 
                shall provide funding for publication of this order in 
                the Federal Register.
                
                
                    (Presidential Sig.)

                THE WHITE HOUSE,

                    May 12, 2025.

[FR Doc. 2025-08876
Filed 5-14-25; 2:00 pm]
Billing code 4150-28-P