[Federal Register Volume 89, Number 11 (Wednesday, January 17, 2024)]
[Notices]
[Pages 2963-2964]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2024-00758]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Interagency Coordinating Committee on the Validation of 
Alternative Methods Communities of Practice Webinar on Implementing 
Computational Approaches for Regulatory Safety Assessments; Notice of 
Public Webinar; Registration Information

AGENCY: National Institutes of Health, HHS.

ACTION: Notice.

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SUMMARY: The Interagency Coordinating Committee on the Validation of 
Alternative Methods (ICCVAM) announces the public webinar 
``Implementing Computational Approaches for Regulatory Safety 
Assessments.'' The webinar is organized on behalf of ICCVAM by the 
National Toxicology Program Interagency Center for the Evaluation of 
Alternative Toxicological Methods (NICEATM). Interested persons may 
participate via the web meeting platform. Time will be allotted for 
questions from the audience. Information about the webinar and 
registration are available at https://ntp.niehs.nih.gov/go/commprac-2024.

DATES: 
    Webinar: January 29, 2024, 10 a.m. to approximately 12 noon EST.
    Registration for Webinar: January 10, 2024, until 12:00 noon EST 
January 29, 2024. Registration to view the webinar is required.

ADDRESSES: Webinar web page: https://ntp.niehs.nih.gov/go/commprac-2024.

FOR FURTHER INFORMATION CONTACT: Dr. Helena Hogberg, Staff Scientist, 
NICEATM, email: [email protected], telephone: (984) 287-
3150.

SUPPLEMENTARY INFORMATION: 
    Background: ICCVAM promotes the development and validation of 
toxicity testing methods that protect human health and the environment 
while replacing, reducing, or refining animal use. ICCVAM also provides 
guidance to test method developers and facilitates collaborations that 
promote the development of new test methods. To address these goals, 
ICCVAM will hold a Communities of Practice webinar on ``Implementing 
Computational Approaches for Regulatory Safety Assessments.''
    Computational toxicology methods can be useful for generating 
bioactivity predictions for chemicals for which limited toxicity data 
are available. They can also help users understand and interpret large, 
diverse bioactivity data sets, or predict how a chemical might behave 
in the body. However, users with limited experience with such methods 
may find it difficult to use them or interpret their outputs, or even 
understand how the methods could be applied in a specific context.
    This webinar will discuss how to establish confidence in 
computational approaches for regulatory applications. Ongoing 
activities and key insights will be described in three presentations by 
speakers from the U.S. government and the private sector focusing on 
applications of tools such as structure-based models to predict 
chemical bioactivity and pharmacokinetic models to support 
understanding of chemical metabolism and disposition. The preliminary 
agenda and additional information about presentations will be posted at 
https://ntp.niehs.nih.gov/go/commprac-2024 as they become available.
    Webinar and Registration: This webinar is open to the public with 
time scheduled for questions by participants following each 
presentation. Registration for the webinar is required. Registration 
will open on or before January 10, 2024, and remain open through 12 
noon EST on January 29, 2024. Registration is available at https://ntp.niehs.nih.gov/go/commprac-2024. Interested individuals are 
encouraged to visit this web page to stay abreast of the most current 
webinar information. Registrants will receive instructions on how to 
access and participate in the webinar in the email confirming their 
registration. TTY users should contact the Federal TTY Relay Service at 
800-877-8339. Requests should be made at least five business days in 
advance of the event.
    Background Information on ICCVAM and NICEATM: ICCVAM is an 
interagency committee composed of representatives from 17 Federal 
regulatory and research agencies that require, use, generate, or 
disseminate toxicological and safety testing information. ICCVAM 
conducts technical evaluations of new, revised, and alternative safety 
testing methods and integrated testing strategies with regulatory 
applicability. ICCVAM also promotes the scientific validation and 
regulatory acceptance of testing methods that more accurately assess 
the safety and hazards of chemicals and products and replace, reduce, 
or refine animal use.
    The ICCVAM Authorization Act of 2000 (42 U.S.C. 285l-3) establishes 
ICCVAM as a permanent interagency committee of the National Institute 
of Environmental Health Sciences and provides the authority for ICCVAM 
involvement in activities relevant to the development of alternative 
test methods. Additional information about ICCVAM can be found at 
https://ntp.niehs.nih.gov/go/iccvam.
    NICEATM administers ICCVAM, provides support for ICCVAM-related 
activities, and conducts and publishes analyses and evaluations of data 
from new, revised, and alternative testing approaches. NICEATM and 
ICCVAM work collaboratively to evaluate new and improved testing 
approaches applicable to the needs of U.S. Federal agencies. NICEATM 
and ICCVAM welcome the public nomination of new,

[[Page 2964]]

revised, and alternative test methods and strategies for validation 
studies and technical evaluations. Additional information about NICEATM 
can be found at https://ntp.niehs.nih.gov/go/niceatm.

    Dated: January 10, 2024.
Richard P. Woychik,
Director, National Institute of Environmental Health Sciences and 
National Toxicology Program, National Institutes of Health.
[FR Doc. 2024-00758 Filed 1-16-24; 8:45 am]
BILLING CODE 4140-01-P