[Federal Register Volume 88, Number 5 (Monday, January 9, 2023)]
[Notices]
[Pages 1240-1241]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2023-00147]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Interagency Coordinating Committee on the Validation of 
Alternative Methods Communities of Practice Webinar on Emerging 
Approaches for Anchoring Biological Relevance of New Approach 
Methodologies; Notice of Public Webinar; Registration Information

AGENCY: National Institutes of Health, HHS.

ACTION: Notice.

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SUMMARY: The Interagency Coordinating Committee on the Validation of 
Alternative Methods (ICCVAM) announces a public webinar ``Emerging 
Approaches for Anchoring Biological Relevance of New Approach 
Methodologies.'' The webinar is organized on behalf of ICCVAM by the 
National Toxicology Program Interagency Center for the Evaluation of 
Alternative Toxicological Methods (NICEATM). Interested persons may 
participate via the web meeting platform. Time will be allotted for 
questions from the audience. Information about the webinar and 
registration are available at https://ntp.niehs.nih.gov/go/commprac-2023.

DATES: 
    Webinar: January 30, 2023, 10:00 a.m. to approximately 12:00 noon 
EST.
    Registration for Webinar: January 10, 2023, until 12:00 noon EST 
January 30, 2023. Registration to view the webinar is required.

ADDRESSES: Webinar web page: https://ntp.niehs.nih.gov/go/commprac-2023.

FOR FURTHER INFORMATION CONTACT: Dr. Nicole Kleinstreuer, Director, 
NICEATM, email: [email protected], telephone: (984) 287-3150.

SUPPLEMENTARY INFORMATION: 
    Background: ICCVAM promotes the development and validation of 
toxicity testing methods that protect human health and the environment 
while replacing, reducing, or refining animal use. ICCVAM also provides 
guidance to test method developers and facilitates collaborations that 
promote the development of new test methods. To address these goals, 
ICCVAM will hold a Communities of Practice webinar on ``Emerging 
Approaches for Anchoring Biological Relevance of New Approach 
Methodologies.''
    ``New approach methodologies'' (NAMs) refers to approaches that can 
be used alone or in combination to provide information on chemical 
hazard and risk assessment without traditional animal tests. 
Traditional approaches to evaluating NAMs consider how well the results 
of chemical tests using NAMs correspond with the results of animal 
tests of the same chemicals. However, the usefulness of this approach 
is limited, especially when the animal results are variable, or the 
animal model does not adequately represent the species or effect of 
regulatory interest.
    This webinar will discuss approaches to build confidence in NAMs 
that are based on evaluating the biological relevance of the NAM to the 
species of regulatory interest. Ongoing activities and key insights 
will be described in three presentations by speakers from the academic 
and private sector focusing on applications of small model organisms, 
organs-on-chips, and models of absorption, distribution, metabolism, 
and excretion. The preliminary agenda and additional information about 
presentations will be posted at https://ntp.niehs.nih.gov/go/commprac-2023 as available.
    Webinar and Registration: This webinar is open to the public with 
time scheduled for questions by participants following each 
presentation. Registration for the webinar is required. Registration 
will open on or before January 10, 2023 and remain open through 12:00 
noon EST on January 30, 2023. Registration is available at https://ntp.niehs.nih.gov/go/commprac-2023. Interested individuals are 
encouraged to visit this web page to stay abreast of the most current 
webinar information. Registrants will receive instructions on how to 
access and participate in the webinar in the email confirming their 
registration.
    Background Information on ICCVAM and NICEATM: ICCVAM is an 
interagency committee composed of representatives from 17 federal 
regulatory and research agencies that require, use, generate, or 
disseminate toxicological and safety testing information. ICCVAM 
conducts technical evaluations of new, revised, and alternative safety 
testing methods and integrated testing strategies with regulatory 
applicability. ICCVAM also promotes the scientific validation and 
regulatory acceptance of testing methods that more accurately assess 
the safety and hazards of chemicals and products and replace, reduce, 
or refine animal use.

[[Page 1241]]

    The ICCVAM Authorization Act of 2000 (42 U.S.C. 285l-3) establishes 
ICCVAM as a permanent interagency committee of the National Institute 
of Environmental Health Sciences and provides the authority for ICCVAM 
involvement in activities relevant to the development of alternative 
test methods. Additional information about ICCVAM can be found at 
https://ntp.niehs.nih.gov/go/iccvam.
    NICEATM administers ICCVAM, provides support for ICCVAM-related 
activities, and conducts and publishes analyses and evaluations of data 
from new, revised, and alternative testing approaches. NICEATM and 
ICCVAM work collaboratively to evaluate new and improved testing 
approaches applicable to the needs of U.S. federal agencies. NICEATM 
and ICCVAM welcome the public nomination of new, revised, and 
alternative test methods and strategies for validation studies and 
technical evaluations. Additional information about NICEATM can be 
found at https://ntp.niehs.nih.gov/go/niceatm.

    Dated: January 3, 2023.
Brian R. Berridge,
Associate Director, National Toxicology Program, National Institutes of 
Health.
[FR Doc. 2023-00147 Filed 1-6-23; 8:45 am]
BILLING CODE 4140-01-P