[Federal Register Volume 87, Number 250 (Friday, December 30, 2022)]
[Notices]
[Pages 80556-80565]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2022-28404]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Prospective Grant of an Exclusive Patent License: Development and 
Commercialization of Natural Killer Cell Therapies for Cancer

AGENCY: National Institutes of Health, HHS.

ACTION: Notice.

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SUMMARY: The National Cancer Institute, an institute of the National 
Institutes of Health, Department of Health and Human Services, is 
contemplating the grant of an Exclusive Patent License to practice the 
inventions embodied in the Patents and Patent Applications listed in 
the Supplementary Information section of this notice to Replay Holdings 
LLC (``Replay'') located in San Diego, California.

DATES: Only written comments and/or applications for a license which 
are received by the National Cancer Institute's Technology Transfer 
Center on or before January 17, 2023 will be considered.

ADDRESSES: Requests for copies of the patent application, inquiries, 
and comments relating to the contemplated an Exclusive Patent License 
should be directed to: Suna Gulay French, Technology Transfer Manager, 
Telephone: (240) 276-7424; Email: [email protected].

SUPPLEMENTARY INFORMATION: 

Intellectual Property

Group A

    1. United States Provisional Patent Application No. 62/084,654 
filed November 26, 2014, entitled ``Anti-Mutated KRAS T Cell 
Receptors'' [HHS Reference No. E-028-2015-0-US-01];
    2. PCT Patent Application No. PCT/US2015/062269 filed November 24, 
2015, entitled ``Anti-Mutated KRAS T Cell Receptors'' [HHS Reference 
No. E-028-2015-1-PCT-01];
    3. Australian Patent No. 2015353720 issued June 11, 2020, entitled 
``Anti-Mutated KRAS T Cell Receptors'' [HHS Reference No. E-028-2015-1-
AU-02];
    4. Canadian Patent Application No. 2,968,399 effective filing date 
of November 24, 2015, entitled ``Anti-Mutated KRAS T Cell Receptors'' 
[HHS Reference No. E-028-2015-1-CA-03];
    5. Chinese Patent No. ZL201580070673.7 issued November 16, 2021, 
entitled ``Anti-Mutated KRAS T Cell Receptors'' [HHS Reference No. E-
028-2015-1-CN-04];
    6. European Patent No. 3223850 issued January 8, 2020, entitled 
``Anti-Mutated KRAS T Cell Receptors'' [HHS Reference No. E-028-2015-1-
EP-05];
    a. Validated in the following jurisdictions: AT, BE, CH, CZ, DE, 
ES, FR, GB, GR, IE, IT, NL, NO, PL, PT, SE, SI, SK, TR;
    7. Israeli Patent No. 252258 issued March 2, 2022, entitled ``Anti-
Mutated KRAS T Cell Receptors'' [HHS Reference No. E-028-2015-1-IL-06];
    8. Japanese Patent No. 6863893 issued April 5, 2021, entitled 
``Anti-Mutated KRAS T Cell Receptors'' [HHS Reference No. E-028-2015-1-
JP-07];
    9. Korean Patent Application No. 2017-7017289 effective filing date 
of November 24, 2015, entitled ``Anti-Mutated KRAS T Cell Receptors'' 
[HHS Reference No. E-028-2015-1-KR-08];
    10. Mexican Patent No. 384919 issued July 29, 2021, entitled 
``Anti-Mutated KRAS T Cell Receptors'' [HHS Reference No. E-028-2015-1-
MX-09];
    11. New Zealand Patent Application No. 732045 effective filing date 
of November 24, 2015, entitled ``Anti-Mutated KRAS T Cell Receptors'' 
[HHS Reference No. E-028-2015-1-NZ-10];
    12. Saudi Arabian Patent No. 7697 issued March 11, 2021, entitled 
``Anti-Mutated KRAS T Cell Receptors'' [HHS Reference No. E-028-2015-1-
SA-11];
    13. Singapore Patent Application No. 11201704155U effective filing 
date of November 24, 2015, entitled ``Anti-Mutated KRAS T Cell 
Receptors'' [HHS Reference No. E-028-2015-1-SG-12];
    14. United States Patent No. 11,207,394 issued December 28, 2021, 
entitled ``Anti-Mutated KRAS T Cell Receptors'' [HHS Reference No. E-
028-2015-1-US-13];
    15. Hong Kong Patent No. 1243642 issued January 22, 2021, entitled 
``Anti-Mutated KRAS T Cell Receptors'' [HHS Reference No. E-028-2015-1-
HK-14];
    16. European Patent Application No. 20150279.6 filed January 3, 
2020, entitled ``Anti-Mutated KRAS T Cell Receptors'' [HHS Reference 
No. E-028-2015-1-EP-15];
    17. Singapore Patent Application No. 10201913978R filed December 
31, 2019, entitled ``Anti-Mutated KRAS T Cell Receptors'' [HHS 
Reference No. E-028-2015-1-SG-16];
    18. Australian Patent Application No. 2020203465 filed May 26, 
2020, entitled ``Anti-Mutated KRAS T Cell Receptors'' [HHS Reference 
No. E-028-2015-1-AU-36];
    19. Saudi Arabian Patent Application No. 520420365 filed October 
15, 2020, entitled ``Anti-Mutated KRAS T Cell Receptors'' [HHS 
Reference No. E-028-2015-1-SA-37];
    20. Hong Kong Patent Application No. 42020021375.9 effective filing 
date of November 24, 2015, entitled ``Anti-Mutated KRAS T Cell 
Receptors'' [HHS Reference No. E-028-2015-1-HK-38];
    21. Japanese Patent Application No. 2021-063092 filed April 1, 
2021, entitled ``Anti-Mutated KRAS T Cell Receptors'' [HHS Reference 
No. E-028-2015-1-JP-40];
    22. Chinese Patent Application No. 202111263859.8 filed October 27, 
2021, entitled ``Anti-Mutated KRAS T Cell

[[Page 80557]]

Receptors'' [HHS Reference No. E-028-2015-1-CN-41];
    23. United States Patent Application No. 17/535,318 filed November 
24, 2021, entitled ``Anti-Mutated KRAS T Cell Receptors'' [HHS 
Reference No. E-028-2015-1-US-42];
    24. Hong Kong Patent Application No. 42022054674.1 filed June 27, 
2022, entitled ``Anti-Mutated KRAS T Cell Receptors'' [HHS Reference 
No. E-028-2015-1-HK-43];
    25. United States Provisional Patent Application No. 62/171,321 
filed June 5, 2015, entitled ``Anti-Mutated KRAS T Cell Receptors'' 
[HHS Reference No. E-180-2015-0-US-01];
    26. United States Provisional Patent Application No. 62/218,688 
filed September 15, 2015, entitled ``T Cell Receptors Recognizing HLA-
CW8 Restricted Mutated KRAS'' [HHS Reference No. E-265-2015-0-US-01];
    27. PCT Patent Application No. PCT/US2016/050875 filed September 9, 
2016, entitled ``T Cell Receptors Recognizing HLA-CW8 Restricted 
Mutated KRAS'' [HHS Reference No. E-265-2015-0-PCT-02];
    28. Australian Patent No. 2016323017 issued February 25, 2021, 
entitled ``T Cell Receptors Recognizing HLA-CW8 Restricted Mutated 
KRAS'' [HHS Reference No. E-265-2015-0-AU-03];
    29. Canadian Patent Application No. 2,998,869 effective filing date 
of September 9, 2016, entitled ``T Cell Receptors Recognizing HLA-CW8 
Restricted Mutated KRAS'' [HHS Reference No. E-265-2015-0-CA-04];
    30. Chinese Patent No. ZL201680058891.3 issued October 8, 2021, 
entitled ``T Cell Receptors Recognizing HLA-CW8 Restricted Mutated 
KRAS'' [HHS Reference No. E-265-2015-0-CN-05];
    31. European Patent No. 3350213 issued March 31, 2021, entitled ``T 
Cell Receptors Recognizing HLA-CW8 Restricted Mutated KRAS'' [HHS 
Reference No. E-265-2015-0-EP-06];
    a. Validated in the following jurisdictions: BE, CH, DE, DK, ES, 
FR, GB, IE, IT, NL, NO and SE.
    32. Israeli Patent Application No. 257840 effective filing date of 
September 9, 2016, entitled ``T Cell Receptors Recognizing HLA-CW8 
Restricted Mutated KRAS'' [HHS Reference No. E-265-2015-0-IL-07];
    33. Japanese Patent Application No. 2018-513423 effective filing 
date of September 9, 2016, entitled ``T Cell Receptors Recognizing HLA-
CW8 Restricted Mutated KRAS'' [HHS Reference No. E-265-2015-0-JP-08];
    34. Korean Patent Application No. 2018-7010326, effective filing 
date of September 9, 2016, entitled ``T Cell Receptors Recognizing HLA-
CW8 Restricted Mutated KRAS'' [HHS Reference No. E-265-2015-0-KR-09];
    35. Mexican Patent Application No. MX/a/2018/003062 effective 
filing date of September 9, 2016, entitled ``T Cell Receptors 
Recognizing HLA-CW8 Restricted Mutated KRAS'' [HHS Reference No. E-265-
2015-0-MX-10];
    36. New Zealand Patent Application No. 740714 effective filing date 
of September 9, 2016, entitled ``T Cell Receptors Recognizing HLA-CW8 
Restricted Mutated KRAS'' [HHS Reference No. E-265-2015-0-NZ-11];
    37. Saudi Arabian Patent Application No. 518391109 effective filing 
date of September 9, 2016, entitled ``T Cell Receptors Recognizing HLA-
CW8 Restricted Mutated KRAS'' [HHS Reference No. E-265-2015-0-SA-12];
    38. Singapore Patent No. 11201802069U issued March 31, 2022, 
entitled ``T Cell Receptors Recognizing HLA-CW8 Restricted Mutated 
KRAS'' [HHS Reference No. E-265-2015-0-SG-13];
    39. United States Patent No. 10,556,940 issued February 11, 2020, 
entitled ``T Cell Receptors Recognizing HLA-CW8 Restricted Mutated 
KRAS'' [HHS Reference No. E-265-2015-0-US-14];
    40. Hong Kong Patent No. HK1257902 issued December 24, 2021, 
entitled ``T Cell Receptors Recognizing HLA-CW8 Restricted Mutated 
KRAS'' [HHS Reference No. E-265-2015-0-HK-15];
    41. United States Patent Application No. 16/739,310 filed January 
10, 2020, entitled ``T Cell Receptors Recognizing HLA-CW8 Restricted 
Mutated KRAS'' [HHS Reference No. E-265-2015-0-US-16];
    42. Singapore Patent Application No. 10201913868X filed December 
30, 2019, entitled ``T Cell Receptors Recognizing HLA-CW8 Restricted 
Mutated KRAS'' [HHS Reference No. E-265-2015-0-SG-17];
    43. Australian Patent No. 2021200833 issued August 18, 2022, 
entitled ``T Cell Receptors Recognizing HLA-CW8 Restricted Mutated 
KRAS'' [HHS Reference No. E-265-2015-0-AU-18];
    44. European Patent Application No. 21162567.8 filed March 15, 
2021, entitled ``T Cell Receptors Recognizing HLA-CW8 Restricted 
Mutated KRAS'' [HHS Reference No. E-265-2015-0-EP-19];
    45. Saudi Arabian Patent Application No. 521421309 filed February 
23, 2021, entitled ``T Cell Receptors Recognizing HLA-CW8 Restricted 
Mutated KRAS'' [HHS Reference No. E-265-2015-0-SA-20];
    46. Chinese Patent Application No. 202111083392.9 filed September 
15, 2021, entitled ``T Cell Receptors Recognizing HLA-CW8 Restricted 
Mutated KRAS'' [HHS Reference No. E-265-2015-0-CN-33];
    47. New Zealand Patent Application No. 779633 filed September 2, 
2021, entitled ``T Cell Receptors Recognizing HLA-CW8 Restricted 
Mutated KRAS'' [HHS Reference No. E-265-2015-0-NZ-34];
    48. Australian Patent Application No. 2022209229 filed July 26, 
2022, entitled ``T Cell Receptors Recognizing HLA-CW8 Restricted 
Mutated KRAS'' [HHS Reference No. E-265-2015-0-AU-35];
    49. United States Provisional Patent Application No. 62/369,883 
filed August 2, 2016, entitled ``Anti-KRAS G12D T Cell Receptors'' [HHS 
Reference No. E-175-2016-0-US-01];
    50. PCT Patent Application No. PCT/US2017/044615 filed July 31, 
2017, entitled ``Anti-KRAS G12D T Cell Receptors'' [HHS Reference No. 
E-175-2016-0-PCT-02];
    51. Australian Patent Application No. 2017306038 effective filing 
date of July 31, 2017, entitled ``Anti-KRAS G12D T Cell Receptors'' 
[HHS Reference No. E-175-2016-0-AU-03];
    52. Canadian Patent Application No. 3,032,870 effective filing date 
of July 31, 2017, entitled ``Anti-KRAS G12D T Cell Receptors'' [HHS 
Reference No. E-175-2016-0-CA-04];
    53. Chinese Patent Application No. 201780059356.4 effective filing 
date of July 31, 2017, entitled ``Anti-KRAS G12D T Cell Receptors'' 
[HHS Reference No. E-175-2016-0-CN-05];
    54. European Patent No. 3494133 issued July 6, 2022, entitled 
``Anti-KRAS G12D T Cell Receptors'' [HHS Reference No. E-175-2016-0-EP-
06];
    a. Validated in the following jurisdictions: AL, AT, BE, BG, CH, 
CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, HR, IE, IS, IT, LT, LU, LV, 
MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM and TR.
    55. Japanese Patent Application No. 2019-505220 effective filing 
date of July 31, 2017, entitled ``Anti-KRAS G12D T Cell Receptors'' 
[HHS Reference No. E-175-2016-0-JP-07];
    56. United States Patent No. 10,611,816 issued April 7, 2020, 
entitled ``Anti-KRAS G12D T Cell Receptors'' [HHS Reference No. E-175-
2016-0-US-08];
    57. Israeli Patent Application No. 264425 effective filing date of 
July 31, 2017, entitled ``Anti-KRAS G12D T Cell Receptors'' [HHS 
Reference No. E-175-2016-0-IL-09];
    58. Korean Patent Application No. 2019-7005837 effective filing 
date of July 31, 2017, entitled ``Anti-KRAS

[[Page 80558]]

G12D T Cell Receptors'' [HHS Reference No. E-175-2016-0-KR-10];
    59. Singapore Patent Application No. 11201900654Q effective filing 
date of July 31, 2017, entitled ``Anti-KRAS G12D T Cell Receptors'' 
[HHS Reference No. E-175-2016-0-SG-11];
    60. Hong Kong Patent Application No. 19133082.8 effective filing 
date of July 31, 2017, entitled ``Anti-KRAS G12D T Cell Receptors'' 
[HHS Reference No. E-175-2016-0-HK-12];
    61. Hong Kong Patent Application No. 19132196.7 effective filing 
date of July 31, 2017, entitled ``Anti-KRAS G12D T Cell Receptors'' 
[HHS Reference No. E-175-2016-0-HK-13];
    62. Singapore Patent Application No. 10201913959W filed December 
31, 2019, entitled ``Anti-KRAS G12D T Cell Receptors'' [HHS Reference 
No. E-175-2016-0-SG-14];
    63. United States Patent No. 11,208,456 issued December 28, 2021, 
entitled ``Anti-KRAS G12D T Cell Receptors'' [HHS Reference No. E-175-
2016-0-US-15];
    64. United States Patent Application No. 17/345,390 filed June 11, 
2021, entitled ``Anti-KRAS G12D T Cell Receptors'' [HHS Reference No. 
E-175-2016-0-US-16];
    65. United States Patent Application No. 17/541,619 filed December 
3, 2021, entitled ``Anti-KRAS G12D T Cell Receptors'' [HHS Reference 
No. E-175-2016-0-US-17];
    66. Japanese Patent Application No. 2021-199878 filed December 9, 
2021, entitled ``Anti-KRAS G12D T Cell Receptors'' [HHS Reference No. 
E-175-2016-0-JP-18];
    67. European Patent Application No. 22182473.3 filed July 1, 2022, 
entitled ``Anti-KRAS G12D T Cell Receptors'' [HHS Reference No. E-175-
2016-0-EP-19];
    68. United States Provisional Patent Application No. 62/560,930 
filed September 20, 2017, entitled ``HLA Class II-Restricted T Cell 
Receptors Against Mutated RAS'' [HHS Reference No. E-181-2017-0-US-01];
    69. PCT Patent Application No. PCT/US2018/051641 filed September 
19, 2018, entitled ``HLA Class II-Restricted T Cell Receptors Against 
Mutated RAS'' [HHS Reference No. E-181-2017-0-PCT-02];
    70. Argentina Patent Application No. P180102695 effective filing 
date of September 19, 2018, entitled ``HLA Class II-Restricted T Cell 
Receptors Against Mutated RAS'' [HHS Reference No. E-181-2017-0-AR-03];
    71. Taiwanese Patent Application No. 107133221 filed September 20, 
2018, entitled ``HLA Class II-Restricted T Cell Receptors Against 
Mutated RAS'' [HHS Reference No. E-181-2017-0-TW-05];
    72. United States Patent No. 11,306,132 issued April 19, 2022, 
entitled ``HLA Class II-Restricted T Cell Receptors Against Mutated 
RAS'' [HHS Reference No. E-181-2017-0-US-06];
    73. Australian Patent Application No. 2018335274 effective filing 
date of September 19, 2018, entitled ``HLA Class II-Restricted T Cell 
Receptors Against Mutated RAS'' [HHS Reference No. E-181-2017-0-AU-07];
    74. Brazilian Patent Application No. BR112020005469-0 effective 
filing date of September 19, 2018, entitled ``HLA Class II-Restricted T 
Cell Receptors Against Mutated RAS'' [HHS Reference No. E-181-2017-0-
BR-08];
    75. Canadian Patent Application No. 3,076,339 effective filing date 
of September 19, 2018, entitled ``HLA Class II-Restricted T Cell 
Receptors Against Mutated RAS'' [HHS Reference No. E-181-2017-0-CA-09];
    76. Chinese Patent Application No. 201880060535.4 effective filing 
date of September 19, 2018, entitled ``HLA Class II-Restricted T Cell 
Receptors Against Mutated RAS'' [HHS Reference No. E-181-2017-0-CN-10];
    77. Costa Rican Patent Application No. 2020-0150 effective filing 
date of September 19, 2018, entitled ``HLA Class II-Restricted T Cell 
Receptors Against Mutated RAS'' [HHS Reference No. E-181-2017-0-CR-11];
    78. Eurasian Patent Application No. 202090652 effective filing date 
of September 19, 2018, entitled ``HLA Class II-Restricted T Cell 
Receptors Against Mutated RAS'' [HHS Reference No. E-181-2017-0-EA-12];
    79. European Patent Application No. 18792591.2 effective filing 
date of September 19, 2018, entitled ``HLA Class II-Restricted T Cell 
Receptors Against Mutated RAS'' [HHS Reference No. E-181-2017-0-EP-13];
    80. Israeli Patent Application No. 273254 effective filing date of 
September 19, 2018, entitled ``HLA Class II-Restricted T Cell Receptors 
Against Mutated RAS'' [HHS Reference No. E-181-2017-0-IL-14];
    81. Indian Patent Application No. 202047011647 effective filing 
date of September 19, 2018, entitled ``HLA Class II-Restricted T Cell 
Receptors Against Mutated RAS'' [HHS Reference No. E-181-2017-0-IN-15];
    82. Japanese Patent Application No. 2020-516422 effective filing 
date of September 19, 2018, entitled ``HLA Class II-Restricted T Cell 
Receptors Against Mutated RAS'' [HHS Reference No. E-181-2017-0-JP-16];
    83. Korean Patent Application No. 2020-7011112 effective filing 
date of September 19, 2018, entitled ``HLA Class II-Restricted T Cell 
Receptors Against Mutated RAS'' [HHS Reference No. E-181-2017-0-KR-17];
    84. Mexican Patent Application No. MX/a/2020/003117 effective 
filing date of September 19, 2018, entitled ``HLA Class II-Restricted T 
Cell Receptors Against Mutated RAS'' [HHS Reference No. E-181-2017-0-
MX-18];
    85. New Zealand Patent Application No. 762831 effective filing date 
of September 19, 2018, entitled ``HLA Class II-Restricted T Cell 
Receptors Against Mutated RAS'' [HHS Reference No. E-181-2017-0-NZ-19];
    86. Singapore Patent Application No. 11202002425P effective filing 
date of September 19, 2018, entitled ``HLA Class II-Restricted T Cell 
Receptors Against Mutated RAS'' [HHS Reference No. E-181-2017-0-SG-20];
    87. Hong Kong Patent Application No. 62020019700.7 effective filing 
date of September 19, 2018, entitled ``HLA Class II-Restricted T Cell 
Receptors Against Mutated RAS'' [HHS Reference No. E-181-2017-0-HK-21];
    88. Brazilian Patent Application No. BR122021018418-6 filed 
September 16, 2021, entitled ``HLA Class II-Restricted T Cell Receptors 
Against Mutated RAS'' [HHS Reference No. E-181-2017-0-BR-22];
    89. United States Patent Application No. 17/692,787 filed March 11, 
2022, entitled ``HLA Class II-Restricted T Cell Receptors Against 
Mutated RAS'' [HHS Reference No. E-181-2017-0-US-23];
    90. United States Provisional Patent Application No. 62/594,244 
filed December 4, 2017, entitled ``HLA Class I-Restricted T Cell 
Receptors Against Mutated RAS'' [HHS Reference No. E-239-2017-0-US-01];
    91. PCT Patent Application No. PCT/US2018/063581 filed December 3, 
2018, entitled ``HLA Class I-Restricted T Cell Receptors Against 
Mutated RAS'' [HHS Reference No. E-239-2017-0-PCT-02];
    92. Australian Patent Application No. 2018378200 effective filing 
date of December 3, 2018, entitled ``HLA Class I-Restricted T Cell 
Receptors Against Mutated RAS'' [HHS Reference No. E-239-2017-0-AU-03];
    93. Brazilian Patent Application No. BR112020011111-2 effective 
filing date of December 3, 2018, entitled ``HLA Class I-Restricted T 
Cell Receptors Against Mutated RAS'' [HHS Reference No. E-239-2017-0-
BR-04];
    94. Canadian Application No. 3,084,246 effective filing date of 
December 3, 2018, entitled ``HLA Class I-Restricted T Cell Receptors 
Against Mutated RAS'' [HHS Reference No. E-239-2017-0-CA-05];

[[Page 80559]]

    95. Chinese Application No. 201880087270.7 effective filing date of 
December 3, 2018, entitled ``HLA Class I-Restricted T Cell Receptors 
Against Mutated RAS'' [HHS Reference No. E-239-2017-0-CN-06];
    96. Costa Rican Application No. 2020-0287 effective filing date of 
December 3, 2018, entitled ``HLA Class I-Restricted T Cell Receptors 
Against Mutated RAS'' [HHS Reference No. E-239-2017-0-CR-07];
    97. Eurasian Application No. 202091335 effective filing date of 
December 3, 2018, entitled ``HLA Class I-Restricted T Cell Receptors 
Against Mutated RAS'' [HHS Reference No. E-239-2017-0-EA-08];
    98. European Application No. 18830062.8 effective filing date of 
December 3, 2018, entitled ``HLA Class I-Restricted T Cell Receptors 
Against Mutated RAS'' [HHS Reference No. E-239-2017-0-EP-09];
    99. Israeli Application No. 275031 effective filing date of 
December 3, 2018, entitled ``HLA Class I-Restricted T Cell Receptors 
Against Mutated RAS'' [HHS Reference No. E-239-2017-0-IL-10];
    100. Indian Application No. 202047026991 effective filing date of 
December 3, 2018, entitled ``HLA Class I-Restricted T Cell Receptors 
Against Mutated RAS'' [HHS Reference No. E-239-2017-0-IN-11];
    101. Japanese Application No. 2020-530325 effective filing date of 
December 3, 2018, entitled ``HLA Class I-Restricted T Cell Receptors 
Against Mutated RAS'' [HHS Reference No. E-239-2017-0-JP-12];
    102. Korean Application No. 2020-7019185 effective filing date of 
December 3, 2018, entitled ``HLA Class I-Restricted T Cell Receptors 
Against Mutated RAS'' [HHS Reference No. E-239-2017-0-KR-13];
    103. Mexican Application No. MX/a/2020/005765 effective filing date 
of December 3, 2018, entitled ``HLA Class I-Restricted T Cell Receptors 
Against Mutated RAS'' [HHS Reference No. E-239-2017-0-MX-14];
    104. New Zealand Application No. 765440 effective filing date of 
December 3, 2018, entitled ``HLA Class I-Restricted T Cell Receptors 
Against Mutated RAS'' [HHS Reference No. E-239-2017-0-NZ-15];
    105. Singapore Application No. 11202005236Q effective filing date 
of December 3, 2018, entitled ``HLA Class I-Restricted T Cell Receptors 
Against Mutated RAS'' [HHS Reference No. E-239-2017-0-SG-16];
    106. United States Patent Application No. 16/769,144 effective 
filing date of December 3, 2018, entitled ``HLA Class I-Restricted T 
Cell Receptors Against Mutated RAS'' [HHS Reference No. E-239-2017-0-
US-17];
    107. Hong Kong Patent Application No. 62021026617.2 effective 
filing date of December 3, 2018, entitled ``HLA Class I-Restricted T 
Cell Receptors Against Mutated RAS'' [HHS Reference No. E-239-2017-0-
HK-18];
    108. Brazilian Patent Application No. BR122021024382-4 filed 
December 2, 2021, entitled ``HLA Class I-Restricted T Cell Receptors 
Against Mutated RAS'' [HHS Reference No. E-239-2017-0-BR-19];
    109. United States Patent Application No. 17/931,391 filed 
September 12, 2022, entitled ``HLA Class I-Restricted T Cell Receptors 
Against Mutated RAS'' [HHS Reference No. E-239-2017-0-US-20];
    110. United States Provisional Patent Application No. 62/795,203 
filed January 22, 2019, entitled ``HLA Class II-Restricted T Cell 
Receptors Against RAS with G12R Mutation'' [HHS Reference No. E-029-
2019-0-US-01];
    111. Taiwanese Patent Application No. 109102511 filed January 22, 
2020, entitled ``HLA Class II-Restricted T Cell Receptors Against RAS 
with G12R Mutation'' [HHS Reference No. E-029-2019-0-TW-02];
    112. PCT Patent Application No. PCT/US2020/014382 filed January 21, 
2020, entitled ``HLA Class II-Restricted T Cell Receptors Against RAS 
with G12R Mutation'' [HHS Reference No. E-029-2019-0-PCT-03];
    113. Australian Patent Application No. 2020211922 effective filing 
date of January 21, 2020, entitled ``HLA Class II-Restricted T Cell 
Receptors Against RAS with G12R Mutation'' [HHS Reference No. E-029-
2019-0-AU-04];
    114. Canadian Patent Application No. 3,127,096 effective filing 
date of January 21, 2020, entitled ``HLA Class II-Restricted T Cell 
Receptors Against RAS with G12R Mutation'' [HHS Reference No. E-029-
2019-0-CA-05];
    115. Chinese Patent Application No. 202080010373.0 effective filing 
date of January 21, 2020, entitled ``HLA Class II-Restricted T Cell 
Receptors Against RAS with G12R Mutation'' [HHS Reference No. E-029-
2019-0-CN-06];
    116. European Patent Application No. 20705599.7 effective filing 
date of January 21, 2020, entitled ``HLA Class II-Restricted T Cell 
Receptors Against RAS with G12R Mutation'' [HHS Reference No. E-029-
2019-0-EP-07];
    117. Japanese Patent Application No. 2021-542206 effective filing 
date of January 21, 2020, entitled ``HLA Class II-Restricted T Cell 
Receptors Against RAS with G12R Mutation'' [HHS Reference No. E-029-
2019-0-JP-08];
    118. Korean Patent Application No. 2021-7026169 effective filing 
date of January 21, 2020, entitled ``HLA Class II-Restricted T Cell 
Receptors Against RAS with G12R Mutation'' [HHS Reference No. E-029-
2019-0-KR-09];
    119. United States Patent Application No. 17/424,591 effective 
filing date of January 21, 2020, entitled ``HLA Class II-Restricted T 
Cell Receptors Against RAS with G12R Mutation'' [HHS Reference No. E-
029-2019-0-US-10];
    120. Hong Kong Patent Application No. 62022048432.8 effective 
filing date of January 21, 2020, entitled ``HLA Class II-Restricted T 
Cell Receptors Against RAS with G12R Mutation'' [HHS Reference No. E-
029-2019-0-HK-11];
    121. Hong Kong Patent Application No. 62022047561.5 effective 
filing date of January 21, 2020, entitled ``HLA Class II-Restricted T 
Cell Receptors Against RAS with G12R Mutation'' [HHS Reference No. E-
029-2019-0-HK-12];
    122. United States Provisional Patent Application No. 62/975,544 
filed February 12, 2020, entitled ``HLA Class I-Restricted T Cell 
Receptors Against RAS with G12D Mutation'' [HHS Ref. No. E-031-2020-0-
US-01];
    123. PCT Patent Application No. PCT/US2021/017794 filed February 
12, 2021, entitled ``HLA Class I-Restricted T Cell Receptors Against 
RAS with G12D Mutation'' [HHS Ref. No. E-031-2020-0-PCT-02];
    124. Taiwanese Patent Application No. 110105194 filed February 12, 
2021, entitled ``HLA Class I-Restricted T Cell Receptors Against RAS 
with G12D Mutation'' [HHS Ref. No. E-031-2020-0-TW-03];
    125. Australian Patent Application No. 2021221138 effective filing 
date of February 12, 2021, entitled ``HLA Class I-Restricted T Cell 
Receptors Against RAS with G12D Mutation'' [HHS Ref. No. E-031-2020-0-
AU-04];
    126. Canadian Patent Application No. 3,168,015 effective filing 
date of February 12, 2021, entitled ``HLA Class I-Restricted T Cell 
Receptors Against RAS with G12D Mutation'' [HHS Ref. No. E-031-2020-0-
CA-05];
    127. Chinese Patent Application No. 202180014038.2 effective filing 
date of February 12, 2021, entitled ``HLA Class I-Restricted T Cell 
Receptors Against RAS with G12D Mutation'' [HHS Ref. No. E-031-2020-0-
CN-06];
    128. European Patent Application No. 21710730.9 effective filing 
date of February 12, 2021, entitled ``HLA Class I-Restricted T Cell 
Receptors Against RAS with G12D Mutation'' [HHS Ref. No. E-031-2020-0-
EP-07];
    129. Indian Patent Application No. 202247050250 effective filing 
date of February 12, 2021, entitled ``HLA Class

[[Page 80560]]

I-Restricted T Cell Receptors Against RAS with G12D Mutation'' [HHS 
Ref. No. E-031-2020-0-IN-08];
    130. Japanese Patent Application No. 2022-548811 effective filing 
date of February 12, 2021, entitled ``HLA Class I-Restricted T Cell 
Receptors Against RAS with G12D Mutation'' [HHS Ref. No. E-031-2020-0-
JP-09];
    131. Korean Patent Application No. 2022-7031175 effective filing 
date of February 12, 2021, entitled ``HLA Class I-Restricted T Cell 
Receptors Against RAS with G12D Mutation'' [HHS Ref. No. E-031-2020-0-
KR-10];
    132. Singapore Patent Application No. 11202251837Y effective filing 
date of February 12, 2021, entitled ``HLA Class I-Restricted T Cell 
Receptors Against RAS with G12D Mutation'' [HHS Ref. No. E-031-2020-0-
SG-11];
    133. United Kingdom Patent Application No. 2211733.7 effective 
filing date of February 12, 2021, entitled ``HLA Class I-Restricted T 
Cell Receptors Against RAS with G12D Mutation'' [HHS Ref. No. E-031-
2020-0-GB-12];
    134. United States Patent Application No. 17/799,163 effective 
filing date of February 12, 2021, entitled ``HLA Class I-Restricted T 
Cell Receptors Against RAS with G12D Mutation'' [HHS Ref. No. E-031-
2020-0-US-13];
    135. Brazilian Patent Application No. BR112022015888-2 effective 
filing date of February 12, 2021, entitled ``HLA Class I-Restricted T 
Cell Receptors Against RAS with G12D Mutation'' [HHS Ref. No. E-031-
2020-0-BR-14];
    136. Chilean Patent Application No. 02208-2022 effective filing 
date of February 12, 2021, entitled ``HLA Class I-Restricted T Cell 
Receptors Against RAS with G12D Mutation'' [HHS Ref. No. E-031-2020-0-
CL-15];
    137. Colombian Patent Application No. NC2022/0012922 effective 
filing date of February 12, 2021, entitled ``HLA Class I-Restricted T 
Cell Receptors Against RAS with G12D Mutation'' [HHS Ref. No. E-031-
2020-0-CO-16];
    138. Israeli Patent Application No. 295252 effective filing date of 
February 12, 2021, entitled ``HLA Class I-Restricted T Cell Receptors 
Against RAS with G12D Mutation'' [HHS Ref. No. E-031-2020-0-IL-18];
    139. Mexican Patent Application No. MX/a/2022/009654 effective 
filing date of February 12, 2021, entitled ``HLA Class I-Restricted T 
Cell Receptors Against RAS with G12D Mutation'' [HHS Ref. No. E-031-
2020-0-MX-19];
    140. New Zealand Patent Application No. 790950 effective filing 
date of February 12, 2021, entitled ``HLA Class I-Restricted T Cell 
Receptors Against RAS with G12D Mutation'' [HHS Ref. No. E-031-2020-0-
NZ-20];
    141. South African Patent Application No. 2022/08853 effective 
filing date of February 12, 2021, entitled ``HLA Class I-Restricted T 
Cell Receptors Against RAS with G12D Mutation'' [HHS Ref. No. E-031-
2020-0-ZA-21];
    142. Cuban Patent Application No. 2022-0044 effective filing date 
of February 12, 2021, entitled ``HLA Class I-Restricted T Cell 
Receptors Against RAS with G12D Mutation'' [HHS Ref. No. E-031-2020-0-
CU-22];
    143. Russian Patent Application No. 2022124004 effective filing 
date of February 12, 2021, entitled ``HLA Class I-Restricted T Cell 
Receptors Against RAS with G12D Mutation'' [HHS Ref. No. E-031-2020-0-
RU-23];
    144. United States Provisional Patent Application No. 62/976,655 
filed February 14, 2020, entitled ``HLA Class I-Restricted T Cell 
Receptors Against RAS with G12V Mutation'' [HHS Ref. No. E-074-2020-0-
US-01];
    145. United States Provisional Patent Application No. 63/060,340 
filed August 3, 2020, entitled ``HLA Class I-Restricted T Cell 
Receptors Against RAS with G12V Mutation'' [HHS Ref. No. E-190-2020-0-
US-01];
    146. PCT Patent Application No. PCT/US2021/017852 filed February 
12, 2021, entitled ``HLA Class I-Restricted T Cell Receptors Against 
RAS with G12V Mutation'' [HHS Ref. No. E-074-2020-1-PCT-01];
    147. Taiwanese Patent Application No. 110105193 filed February 12, 
2021, entitled ``HLA Class I-Restricted T Cell Receptors Against RAS 
with G12V Mutation'' [HHS Ref. No. E-074-2020-1-TW-02];
    148. Australian Patent Application No. 2021220957 effective filing 
date of February 12, 2021, entitled ``HLA Class I-Restricted T Cell 
Receptors Against RAS with G12V Mutation'' [HHS Ref. No. E-074-2020-1-
AU-03];
    149. Canadian Patent Application No. 3,167,382 effective filing 
date of February 12, 2021, entitled ``HLA Class I-Restricted T Cell 
Receptors Against RAS with G12V Mutation'' [HHS Ref. No. E-074-2020-1-
CA-04];
    150. Chinese Patent Application No. 202180014281.4 effective filing 
date of February 12, 2021, entitled ``HLA Class I-Restricted T Cell 
Receptors Against RAS with G12V Mutation'' [HHS Ref. No. E-074-2020-1-
CN-05];
    151. European Patent Application No. 21710740.8 effective filing 
date of February 12, 2021, entitled ``HLA Class I-Restricted T Cell 
Receptors Against RAS with G12V Mutation'' [HHS Ref. No. E-074-2020-1-
EP-06];
    152. Indian Patent Application No. 202247050807 effective filing 
date of February 12, 2021, entitled ``HLA Class I-Restricted T Cell 
Receptors Against RAS with G12V Mutation'' [HHS Ref. No. E-074-2020-1-
IN-07];
    153. Japanese Patent Application No. 2022-549088 effective filing 
date of February 12, 2021, entitled ``HLA Class I-Restricted T Cell 
Receptors Against RAS with G12V Mutation'' [HHS Ref. No. E-074-2020-1-
JP-08];
    154. Korean Patent Application No. 2022-7031589 effective filing 
date of February 12, 2021, entitled ``HLA Class I-Restricted T Cell 
Receptors Against RAS with G12V Mutation'' [HHS Ref. No. E-074-2020-1-
KR-09];
    155. Singapore Patent Application No. 11202251947C effective filing 
date of February 12, 2021, entitled ``HLA Class I-Restricted T Cell 
Receptors Against RAS with G12V Mutation'' [HHS Ref. No. E-074-2020-1-
SG-10];
    156. United Kingdom Patent Application No. 2211757.6 effective 
filing date of February 12, 2021, entitled ``HLA Class I-Restricted T 
Cell Receptors Against RAS with G12V Mutation'' [HHS Ref. No. E-074-
2020-1-GB-11];
    157. United States Patent Application No. 17/799,193 effective 
filing date of February 12, 2021, entitled ``HLA Class I-Restricted T 
Cell Receptors Against RAS with G12V Mutation'' [HHS Ref. No. E-074-
2020-1-US-12];
    158. Brazilian Patent Application No. BR112022015897-1 effective 
filing date of February 12, 2021, entitled ``HLA Class I-Restricted T 
Cell Receptors Against RAS with G12V Mutation'' [HHS Ref. No. E-074-
2020-1-BR-13];
    159. Mexican Patent Application No. MX/a/2022/009825 effective 
filing date of February 12, 2021, entitled ``HLA Class I-Restricted T 
Cell Receptors Against RAS with G12V Mutation'' [HHS Ref. No. E-074-
2020-1-MX-14];
    160. New Zealand Patent Application No. 791024 effective filing 
date of February 12, 2021, entitled ``HLA Class I-Restricted T Cell 
Receptors Against RAS with G12V Mutation'' [HHS Ref. No. E-074-2020-1-
NZ-15];
    161. United States Provisional Patent Application No. 62/981,856 
filed February 26, 2020, entitled ``HLA Class II-Restricted T Cell 
Receptors Against RAS with G12V Mutation'' [HHS Ref. No. E-088-2020-0-
US-01];
    162. PCT Patent Application No. PCT/US2021/019775 filed February 
26, 2021, entitled ``HLA Class II-Restricted T Cell Receptors Against 
RAS with G12V Mutation'' [HHS Ref. No. E-088-2020-0-PCT-02];
    163. Taiwanese Patent Application No. 110106886 filed February 26, 
2021,

[[Page 80561]]

entitled ``HLA Class II-Restricted T Cell Receptors Against RAS with 
G12V Mutation'' [HHS Ref. No. E-088-2020-0-TW-03];
    164. Australian Patent Application No. 2021225872 effective filing 
date of February 26, 2021, entitled ``HLA Class II-Restricted T Cell 
Receptors Against RAS with G12V Mutation'' [HHS Ref. No. E-088-2020-0-
AU-04];
    165. Canadian Patent Application No. 3,169,086 effective filing 
date of February 26, 2021, entitled ``HLA Class II-Restricted T Cell 
Receptors Against RAS with G12V Mutation'' [HHS Ref. No. E-088-2020-0-
CA-05];
    166. Chinese Patent Application No. 202180016761.4 effective filing 
date of February 26, 2021, entitled ``HLA Class II-Restricted T Cell 
Receptors Against RAS with G12V Mutation'' [HHS Ref. No. E-088-2020-0-
CN-06];
    167. European Patent Application No. 21712694.5 effective filing 
date of February 26, 2021, entitled ``HLA Class II-Restricted T Cell 
Receptors Against RAS with G12V Mutation'' [HHS Ref. No. E-088-2020-0-
EP-07];
    168. Indian Patent Application No. 202247052620 effective filing 
date of February 26, 2021, entitled ``HLA Class II-Restricted T Cell 
Receptors Against RAS with G12V Mutation'' [HHS Ref. No. E-088-2020-0-
IN-08];
    169. Korean Patent Application No. 2022-7033222 effective filing 
date of February 26, 2021, entitled ``HLA Class II-Restricted T Cell 
Receptors Against RAS with G12V Mutation'' [HHS Ref. No. E-088-2020-0-
KR-10];
    170. Singapore Patent Application No. 1120225235K effective filing 
date of February 26, 2021, entitled ``HLA Class II-Restricted T Cell 
Receptors Against RAS with G12V Mutation'' [HHS Ref. No. E-088-2020-0-
SG-11];
    171. United Kingdom Patent Application No. 2212195.8 effective 
filing date of February 26, 2021, entitled ``HLA Class II-Restricted T 
Cell Receptors Against RAS with G12V Mutation'' [HHS Ref. No. E-088-
2020-0-GB-12];
    172. United States Patent Application No. 17/802,464 effective 
filing date of February 26, 2021, entitled ``HLA Class II-Restricted T 
Cell Receptors Against RAS with G12V Mutation'' [HHS Ref. No. E-088-
2020-0-US-13];
    173. Brazilian Patent Application No. BR112022016661-3 effective 
filing date of February 26, 2021, entitled ``HLA Class II-Restricted T 
Cell Receptors Against RAS with G12V Mutation'' [HHS Ref. No. E-088-
2020-0-BR-14];
    174. Mexico Patent Application No. MX/a/2022/010157 effective 
filing date of February 26, 2021, entitled ``HLA Class II-Restricted T 
Cell Receptors Against RAS with G12V Mutation'' [HHS Ref. No. E-088-
2020-0-MX-15];
    175. New Zealand Patent Application No. 791348 effective filing 
date of February 26, 2021, entitled ``HLA Class II-Restricted T Cell 
Receptors Against RAS with G12V Mutation'' [HHS Ref. No. E-088-2020-0-
NZ-16];
    176. United States Provisional Patent Application No. 63/050,931 
filed July 13, 2020, entitled ``HLA Class II-Restricted DRB T Cell 
Receptors Against RAS with G12D Mutation'' [HHS Ref. No. E-165-2020-0-
US-01];
    177. PCT Patent Application No. PCT/US2021/041375 filed July 13, 
2021, entitled ``HLA Class II-Restricted DRB T Cell Receptors Against 
RAS with G12D Mutation'' [HHS Ref. No. E-165-2020-0-PCT-02];
    178. United States Provisional Patent Application No. 63/052,502 
filed July 16, 2020, entitled ``HLA Class II-Restricted DRB1*01:01 T 
Cell Receptors Against RAS with G12V Mutation'' [HHS Ref. No. E-172-
2020-0-US-01];
    179. PCT Patent Application No. PCT/US2021/041737 filed July 15, 
2021, entitled ``HLA Class II-Restricted DRB1*01:01 T Cell Receptors 
Against RAS with G12V Mutation'' [HHS Ref. No. E-172-2020-0-PCT-02];
    180. United States Provisional Patent Application No. 63/086,674 
filed October 2, 2020, entitled ``HLA Class II-Restricted DQ T Cell 
Receptors Against RAS with G13D Mutation'' [HHS Ref. No. E-189-2020-0-
US-01];
    181. PCT Patent Application No. PCT/US2021/053060 filed October 1, 
2021, entitled ``HLA Class II-Restricted DQ T Cell Receptors Against 
RAS with G13D Mutation'' [HHS Ref. No. E-189-2020-1-PCT-01];
    182. Taiwanese Patent Application No. 110136658 filed October 1, 
2021, entitled ``HLA Class II-Restricted DQ T Cell Receptors Against 
RAS with G13D Mutation'' [HHS Ref. No. E-189-2020-1-TW-02]; and
    183. United States Provisional Patent Application No. 63/284,884 
filed December 1, 2021, entitled ``HLA-A3-Restricted T Cell Receptors 
Against RAS with G12V Mutation'' [HHS Ref. No. E-219-2021-0-US-01].

Group B

    1. United States Provisional Patent Application No. 62/565,383 
filed September 29, 2017, entitled ``T Cell Receptors Recognizing 
Mutated P53'' [HHS Reference No. E-237-2017-0-US-01];
    2. PCT Patent Application No. PCT/US2018/051285 filed September 17, 
2018, entitled ``T Cell Receptors Recognizing Mutated P53'' [HHS 
Reference No. E-237-2017-2-PCT-01];
    3. Australian Patent Application No. 2018342246 effective filing 
date of September 17, 2018, entitled ``T Cell Receptors Recognizing 
Mutated P53'' [HHS Reference No. E-237-2017-2-AU-02];
    4. Brazilian Patent Application No. BR112020006012-7 effective 
filing date of September 17, 2018, entitled ``T Cell Receptors 
Recognizing Mutated P53'' [HHS Reference No. E-237-2017-2-BR-03];
    5. Canadian Patent Application No. 3,077,024 effective filing date 
of September 17, 2018, entitled ``T Cell Receptors Recognizing Mutated 
P53'' [HHS Reference No. E-237-2017-2-CA-04];
    6. Chinese Patent Application No. 201880074539.8 effective filing 
date of September 17, 2018, entitled ``T Cell Receptors Recognizing 
Mutated P53'' [HHS Reference No. E-237-2017-2-CN-05];
    7. Costa Rican Application No. 2020-0170 effective filing date of 
September 17, 2018, entitled ``T Cell Receptors Recognizing Mutated 
P53'' [HHS Reference No. E-237-2017-2-CR-06];
    8. Eurasian Application No. 202090757 effective filing date of 
September 17, 2018, entitled ``T Cell Receptors Recognizing Mutated 
P53'' [HHS Reference No. E-237-2017-2-EA-07];
    9. European Patent Application No. 18780006.5 effective filing date 
of September 17, 2018, entitled ``T Cell Receptors Recognizing Mutated 
P53'' [HHS Reference No. E-237-2017-2-EP-08];
    10. Israeli Patent Application No. 273515 effective filing date of 
September 17, 2018, entitled ``T Cell Receptors Recognizing Mutated 
P53'' [HHS Reference No. E-237-2017-2-IL-09];
    11. Indian Patent Application No. 202047013911 effective filing 
date of September 17, 2018, entitled ``T Cell Receptors Recognizing 
Mutated P53'' [HHS Reference No. E-237-2017-2-IN-10];
    12. Japanese Patent Application No. 2020-517556 effective filing 
date of September 17, 2018, entitled ``T Cell Receptors Recognizing 
Mutated P53'' [HHS Reference No. E-237-2017-2-JP-11];
    13. Korean Patent Application No. 2020-7012344 effective filing 
date of September 17, 2018, entitled ``T Cell Receptors Recognizing 
Mutated P53'' [HHS Reference No. E-237-2017-2-KR-12];
    14. Mexican Application No. MX/a/2020/003504 effective filing date 
of September 17, 2018, entitled ``T Cell Receptors Recognizing Mutated 
P53''

[[Page 80562]]

[HHS Reference No. E-237-2017-2-MX-13];
    15. New Zealand Patent Application No. 763023 effective filing date 
of September 17, 2018, entitled ``T Cell Receptors Recognizing Mutated 
P53'' [HHS Reference No. E-237-2017-2-NZ-14];
    16. Singapore Patent Application No. 11202002636P effective filing 
date of September 17, 2018, entitled ``T Cell Receptors Recognizing 
Mutated P53'' [HHS Reference No. E-237-2017-2-SG-15];
    17. United States Patent Application No. 16/651,242 effective 
filing date of September 17, 2018, entitled ``T Cell Receptors 
Recognizing Mutated P53'' [HHS Reference No. E-237-2017-2-US-16];
    18. Hong Kong Patent Application No. 62020021272.3 filed November 
30, 2020, entitled ``T Cell Receptors Recognizing Mutated P53'' [HHS 
Reference No. E-237-2017-2-HK-17];
    19. Brazilian Patent Application No. BR122021018454-2 filed 
September 16, 2021, entitled ``T Cell Receptors Recognizing Mutated 
P53'' [HHS Reference No. E-237-2017-2-BR-18];
    20. United States Provisional Patent Application No. 62/867,619 
filed June 27, 2019, entitled ``T Cell Receptors Recognizing R175H or 
Y220C Mutation in P53'' [HHS Reference No. E-135-2019-0-US-01];
    21. PCT Patent Application No. PCT/US2020/039785, filed June 26, 
2020, entitled ``T Cell Receptors Recognizing R175H or Y220C Mutation 
in P53'' [HHS Reference No. E-135-2019-0-PCT-02];
    22. Taiwanese Patent Application No. 109121744 filed June 26, 2020, 
entitled ``T Cell Receptors Recognizing R175H or Y220C Mutation in 
P53'' [HHS Reference No. E-135-2019-0-TW-03];
    23. Australian Patent Application No. 2020308004 filed January 6, 
2022, entitled ``T Cell Receptors Recognizing R175H or Y220C Mutation 
in P53'' [HHS Reference No. E-135-2019-0-AU-04];
    24. Brazilian Patent Application No. BR112021026408-6 filed 
December 24, 2021, entitled ``T Cell Receptors Recognizing R175H or 
Y220C Mutation in P53'' [HHS Reference No. E-135-2019-0-BR-05];
    25. Canadian Patent Application No. 3,144,070 filed December 16, 
2021, entitled ``T Cell Receptors Recognizing R175H or Y220C Mutation 
in P53'' [HHS Reference No. E-135-2019-0-CA-06];
    26. Chinese Patent Application No. 202080047882.0 filed December 
27, 2021, entitled ``T Cell Receptors Recognizing R175H or Y220C 
Mutation in P53'' [HHS Reference No. E-135-2019-0-CN-07];
    27. European Patent Application No. 20742583.6 filed January 27, 
2022, entitled ``T Cell Receptors Recognizing R175H or Y220C Mutation 
in P53'' [HHS Reference No. E-135-2019-0-EP-08];
    28. Indian Patent Application No. 202247003029 filed January 19, 
2022, entitled ``T Cell Receptors Recognizing R175H or Y220C Mutation 
in P53'' [HHS Reference No. E-135-2019-0-IN-09];
    29. Japanese Patent Application No. 2021-576970 filed December 24, 
2021, entitled ``T Cell Receptors Recognizing R175H or Y220C Mutation 
in P53'' [HHS Reference No. E-135-2019-0-JP-10];
    30. Mexican Patent Application No. MX/a/2021/015877 filed December 
16, 2021, entitled ``T Cell Receptors Recognizing R175H or Y220C 
Mutation in P53'' [HHS Reference No. E-135-2019-0-MX-11];
    31. Russian Patent Application No. 2022101295 filed January 20, 
2022, entitled ``T Cell Receptors Recognizing R175H or Y220C Mutation 
in P53'' [HHS Reference No. E-135-2019-0-RU-12];
    32. Singapore Patent Application No. 11202113949V filed December 
15, 2021, entitled ``T Cell Receptors Recognizing R175H or Y220C 
Mutation in P53'' [HHS Reference No. E-135-2019-0-SG-13];
    33. South African Patent Application No. 2022/00598 filed January 
12, 2022, entitled ``T Cell Receptors Recognizing R175H or Y220C 
Mutation in P53'' [HHS Reference No. E-135-2019-0-ZA-14];
    34. Korean Patent Application No. 2022-7002872 filed January 26, 
2022, entitled ``T Cell Receptors Recognizing R175H or Y220C Mutation 
in P53'' [HHS Reference No. E-135-2019-0-KR-15];
    35. United States Patent Application No. 17/620,942 filed December 
20, 2021, entitled ``T Cell Receptors Recognizing R175H or Y220C 
Mutation in P53'' [HHS Reference No. E-135-2019-0-US-16];
    36. United States Provisional Patent Application No. 63/074,747 
filed September 4, 2020, entitled ``T Cell Receptors Recognizing R273C 
or Y220C Mutation in P53'' [HHS Reference No. E-173-2020-0-US-01];
    37. PCT Patent Application No. PCT/US2021/048786 filed September 2, 
2021, entitled ``T Cell Receptors Recognizing R273C or Y220C Mutation 
in P53'' [HHS Reference No. E-173-2020-0-PCT-02];
    38. Taiwanese Patent Application No. 110132552 filed September 2, 
2021, entitled ``T Cell Receptors Recognizing R273C or Y220C Mutation 
in P53'' [HHS Reference No. E-173-2020-0-TW-03];
    39. United States Provisional Patent Application No. 63/185,805 
filed May 7, 2021, entitled ``T Cell Receptors Recognizing C135Y, R175H 
or M237I Mutation in P53'' [HHS Reference No. E-101-2021-0-US-01]; and
    40. PCT Patent Application No. PCT/US2022/028066 filed May 6, 2022, 
entitled ``T Cell Receptors Recognizing C135Y, R175H or M237I Mutation 
in P53'' [HHS Reference No. E-101-2021-0-PCT-02].

Group C

    1. United States Provisional Patent Application No. 62/004,335 
filed May 29, 2014, entitled ``Anti-Human Papillomavirus 16 E7 T Cell 
Receptors'' [HHS Reference No. E-176-2014-0-US-01];
    2. PCT Patent Application No. PCT/US2015/033129 filed May 29, 2015, 
entitled ``Anti-Human Papillomavirus 16 E7 T Cell Receptors'' [HHS 
Reference No. E-176-2014-0-PCT-02];
    3. Australian Patent No. 2015266818 issued January 16, 2020, 
entitled ``Anti-Human Papillomavirus 16 E7 T Cell Receptors'' [HHS 
Reference No. E-176-2014-0-AU-03];
    4. Brazilian Patent Application No. BR112016027805-4 effective 
filing date of May 29, 2015, entitled ``Anti-Human Papillomavirus 16 E7 
T Cell Receptors'' [HHS Reference No. E-176-2014-0-BR-04];
    5. Canadian Patent Application No. 2,950,192 effective filing date 
of May 29, 2015, entitled ``Anti-Human Papillomavirus 16 E7 T Cell 
Receptors'' [HHS Reference No. E-176-2014-0-CA-05];
    6. Chinese Patent No. ZL201580031789.X issued May 4, 2021, entitled 
``Anti-Human Papillomavirus 16 E7 T Cell Receptors'' [HHS Reference No. 
E-176-2014-0-CN-06];
    7. European Patent No. 3149031 issued December 18, 2019, entitled 
``Anti-Human Papillomavirus 16 E7 T Cell Receptors'' [HHS Reference No. 
E-176-2014-0-EP-07];
    a. Validated in the following jurisdictions: AL, AT, BE, BG, CH, 
CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, 
MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM and TR.
    8. Israeli Patent No. 248797 issued September 1, 2021, entitled 
``Anti-Human Papillomavirus 16 E7 T Cell Receptors'' [HHS Reference No. 
E-176-2014-0-IL-08];
    9. Japanese Patent No. 6742991 issued August 19, 2020, entitled 
``Anti-Human

[[Page 80563]]

Papillomavirus 16 E7 T Cell Receptors'' [HHS Reference No. E-176-2014-
0-JP-09];
    10. Korean Patent Application No. 2016-7033189 effective filing 
date of May 29, 2015, entitled ``Anti-Human Papillomavirus 16 E7 T Cell 
Receptors'' [HHS Reference No. E-176-2014-0-KR-10];
    11. Mexican Patent No. 375379 issued September 25, 2020, entitled 
``Anti-Human Papillomavirus 16 E7 T Cell Receptors'' [HHS Reference No. 
E-176-2014-0-MX-11];
    12. Saudi Arabian Patent No. 7456 issued January 5, 2021, entitled 
``Anti-Human Papillomavirus 16 E7 T Cell Receptors'' [HHS Reference No. 
E-176-2014-0-SA-12];
    13. United States Patent No. 10,174,098 issued January 8, 2019, 
entitled ``Anti-Human Papillomavirus 16 E7 T Cell Receptors'' [HHS 
Reference No. E-176-2014-0-US-13];
    14. Hong Kong Patent No. HK1236203 issued January 8, 2021, entitled 
``Anti-Human Papillomavirus 16 E7 T Cell Receptors'' [HHS Reference No. 
E-176-2014-0-HK-14];
    15. United States Patent No. 10,870,687 issued December 22, 2020, 
entitled ``Anti-Human Papillomavirus 16 E7 T Cell Receptors'' [HHS 
Reference No. E-176-2014-0-US-15];
    16. European Patent Application No. 19217074.4 filed December 17, 
2019, entitled ``Anti-Human Papillomavirus 16 E7 T Cell Receptors'' 
[HHS Reference No. E-176-2014-0-EP-16];
    17. Australian Patent No. 2019283892 issued May 13, 2021, entitled 
``Anti-Human Papillomavirus 16 E7 T Cell Receptors'' [HHS Reference No. 
E-176-2014-0-AU-17];
    18. Japanese Patent No. 6997267 issued December 20, 2021, entitled 
``Anti-Human Papillomavirus 16 E7 T Cell Receptors'' [HHS Reference No. 
E-176-2014-0-JP-53];
    19. Saudi Arabian Patent Application No. 520412601 filed August 10, 
2020, entitled ``Anti-Human Papillomavirus 16 E7 T Cell Receptors'' 
[HHS Reference No. E-176-2014-0-SA-54];
    20. Hong Kong Patent Application No. 42020020661.3 filed November 
24, 2020, entitled ``Anti-Human Papillomavirus 16 E7 T Cell Receptors'' 
[HHS Reference No. E-176-2014-0-HK-55];
    21. Mexican Patent Application No. MX/a/2020/010035 filed September 
24, 2020, entitled ``Anti-Human Papillomavirus 16 E7 T Cell Receptors'' 
[HHS Reference No. E-176-2014-0-MX-56];
    22. United States Patent No. 11,434,272 issued September 6, 2020, 
entitled ``Anti-Human Papillomavirus 16 E7 T Cell Receptors'' [HHS 
Reference No. E-176-2014-0-US-57];
    23. Australian Patent Application No. 2021202227 filed April 13, 
2021, entitled ``Anti-Human Papillomavirus 16 E7 T Cell Receptors'' 
[HHS Reference No. E-176-2014-0-AU-58];
    24. Chinese Patent Application No. 20210399056.9 filed April 14, 
2021, entitled ``Anti-Human Papillomavirus 16 E7 T Cell Receptors'' 
[HHS Reference No. E-176-2014-0-CN-59];
    25. Israeli Patent No. 282518 issued July 2, 2022, entitled ``Anti-
Human Papillomavirus 16 E7 T Cell Receptors'' [HHS Reference No. E-176-
2014-0-IL-60];
    26. Hong Kong Patent Application No. 42022046605.6 filed January 
19, 2022, entitled ``Anti-Human Papillomavirus 16 E7 T Cell Receptors'' 
[HHS Reference No. E-176-2014-0-HK-62];
    27. Japanese Patent Application No. 2021-203953 filed December 16, 
2021, entitled ``Anti-Human Papillomavirus 16 E7 T Cell Receptors'' 
[HHS Reference No. E-176-2014-0-JP-63];
    28. Israeli Patent Application No. 290655 filed February 16, 2022, 
entitled ``Anti-Human Papillomavirus 16 E7 T Cell Receptors'' [HHS 
Reference No. E-176-2014-0-IL-64];
    29. United States Patent Application No. 17/816,496 filed August 1, 
2022, entitled ``Anti-Human Papillomavirus 16 E7 T Cell Receptors'' 
[HHS Reference No. E-176-2014-0-US-65]; and
    30. Korean Patent Application No. 2022-7032043 filed September 15, 
2022, entitled ``Anti-Human Papillomavirus 16 E7 T Cell Receptors'' 
[HHS Reference No. E-176-2014-0-KR-66].

Group D

    1. United States Provisional Patent Application No. 61/535,086 
filed September 15, 2011, entitled ``T Cell Receptors Recognizing HLA-
A1- or HLA-CW7-Restricted MAGE'' [HHS Reference No. E-266-2011-0-US-
01];
    2. PCT Patent Application No. PCT/US2012/051623 filed September 11, 
2012, entitled ``T Cell Receptors Recognizing HLA-A1- or HLA-CW7-
Restricted MAGE'' [HHS Reference No. E-266-2011-0-PCT-02];
    3. Australian Patent No. 2012309830 issued July 13, 2017, entitled 
``T Cell Receptors Recognizing HLA-A1- or HLA-CW7-Restricted MAGE'' 
[HHS Reference No. E-266-2011-0-AU-03];
    4. Canadian Patent No. 2,848,209 issued June 1, 2021, entitled ``T 
Cell Receptors Recognizing HLA-A1- or HLA-CW7-Restricted MAGE'' [HHS 
Reference No. E-266-2011-0-CA-04];
    5. European Patent No. 2755997 issued July 4, 2018, entitled ``T 
Cell Receptors Recognizing HLA-A1- or HLA-CW7-Restricted MAGE'' [HHS 
Reference No. E-266-2011-0-EP-05];
    a. Validated in the following jurisdictions: AT, BE, CH, CZ, DE, 
ES, FR, GB, GR, IE, IT, NL, NO, PL, PT, SE, SI, SK and TR.
    6. Japanese Patent No. 6415322 issued October 12, 2018, entitled 
``T Cell Receptors Recognizing HLA-A1- or HLA-CW7-Restricted MAGE'' 
[HHS Reference No. E-266-2011-0-JP-06];
    7. United States Patent Application No. 14/344,354 filed March 14, 
2014, entitled ``T Cell Receptors Recognizing HLA-A1- or HLA-CW7-
Restricted MAGE'' [HHS Reference No. E-266-2011-0-US-07];
    8. Chinese Patent Application No. 201280055972.X filed May 14, 
2014, entitled ``T Cell Receptors Recognizing HLA-A1- or HLA-CW7-
Restricted MAGE'' [HHS Reference No. E-266-2011-0-CN-08];
    9. Israeli Patent No. 231323 issued November 30, 2019, entitled ``T 
Cell Receptors Recognizing HLA-A1- or HLA-CW7-Restricted MAGE'' [HHS 
Reference No. E-266-2011-0-IL-09];
    10. Australian Patent No. 2017204103 issued June 20, 2019, entitled 
``T Cell Receptors Recognizing HLA-A1- or HLA-CW7-Restricted MAGE'' 
[HHS Reference No. E-266-2011-0-AU-10];
    11. European Patent No. 3392270 issued August 26, 2020, entitled 
``T Cell Receptors Recognizing HLA-A1- or HLA-CW7-Restricted MAGE'' 
[HHS Reference No. E-266-2011-0-EP-11];
    a. Validated in: AT, BE, CH, CZ, DE, ES, FR, GB, GR, IE, IT, NL, 
NO, PL, PT, SE, SI, SK and TR.
    12. Chinese Patent Application No. 201811170958.X filed October 8, 
2018, entitled ``T Cell Receptors Recognizing HLA-A1- or HLA-CW7-
Restricted MAGE'' [HHS Reference No. E-266-2011-0-CN-14];
    13. United States Patent No. 11,306,131 issued April 19, 2022, 
entitled ``T Cell Receptors Recognizing HLA-A1- or HLA-CW7-Restricted 
MAGE'' [HHS Reference No. E-266-2011-0-US-32];
    14. Japanese Patent No. 6855426 issued March 19, 2021, entitled ``T 
Cell Receptors Recognizing HLA-A1- or HLA-CW7-Restricted MAGE'' [HHS 
Reference No. E-266-2011-0-JP-33];
    15. Hong Kong Patent No. HK1262936 issued June 4, 2021, entitled 
``T Cell Receptors Recognizing HLA-A1- or HLA-CW7-Restricted MAGE'' 
[HHS Reference No. E-266-2011-0-HK-34];
    16. Hong Kong Patent Application No. 19129278.8 filed September 6, 
2019, entitled ``T Cell Receptors Recognizing HLA-A1- or HLA-CW7-
Restricted MAGE'' [HHS Reference No. E-266-2011-0-HK-35];

[[Page 80564]]

    17. Israeli Patent No. 268157 issued July 30, 2021, entitled ``T 
Cell Receptors Recognizing HLA-A1- or HLA-CW7-Restricted MAGE'' [HHS 
Reference No. E-266-2011-0-IL-36];
    18. European Patent Application No. 20192082.4 filed July 18, 2019, 
entitled ``T Cell Receptors Recognizing HLA-A1- or HLA-CW7-Restricted 
MAGE'' [HHS Reference No. E-266-2011-0-EP-37];
    19. Israeli Patent No. 268157 issued June 2, 2022, entitled ``T 
Cell Receptors Recognizing HLA-A1- or HLA-CW7-Restricted MAGE'' [HHS 
Reference No. E-266-2011-0-IL-57];
    20. Japanese Patent Application No. 2021-043845 filed March 17, 
2021, entitled ``T Cell Receptors Recognizing HLA-A1- or HLA-CW7-
Restricted MAGE'' [HHS Reference No. E-266-2011-0-JP-58];
    21. Canadian Patent Application No. 3,114,877 filed April 13, 2021, 
entitled ``T Cell Receptors Recognizing HLA-A1- or HLA-CW7-Restricted 
MAGE'' [HHS Reference No. E-266-2011-0-CA-59];
    22. Israeli Patent Application No. 290105 filed January 25, 2022, 
entitled ``T Cell Receptors Recognizing HLA-A1- or HLA-CW7-Restricted 
MAGE'' [HHS Reference No. E-266-2011-0-IL-60];
    23. United States Patent Application No. 17/691,569 filed March 10, 
2022, entitled ``T Cell Receptors Recognizing HLA-A1- or HLA-CW7-
Restricted MAGE'' [HHS Reference No. E-266-2011-0-US-61];
    24. United States Provisional Patent Application No. 61/701,056 
filed September 14, 2012, entitled ``T Cell Receptors Recognizing MHC 
Class II-Restricted Mage-A3'' [HHS Reference No. E-230-2012-0-US-01];
    25. PCT Patent Application No. PCT/US2013/059608 filed September 
13, 2013, entitled ``T Cell Receptors Recognizing MHC Class II-
Restricted Mage-A3'' [HHS Reference No. E-230-2012-0-PCT-02];
    26. Australian Patent No. 2013315391 issued September 21, 2017, 
entitled ``T Cell Receptors Recognizing MHC Class II-Restricted Mage-
A3'' [HHS Reference No. E-230-2012-0-AU-03];
    27. Canadian Patent Application No. 2,884,743 filed September 13, 
2013, entitled ``T Cell Receptors Recognizing MHC Class II-Restricted 
Mage-A3'' [HHS Reference No. E-230-2012-0-CA-04];
    28. Chinese Patent No. ZL201380059102.4 issued September 24, 2021, 
entitled ``T Cell Receptors Recognizing MHC Class II-Restricted Mage-
A3'' [HHS Reference No. E-230-2012-0-CN-05];
    29. European Patent No. 2895509 issued December 4, 2019, entitled 
``T Cell Receptors Recognizing MHC Class II-Restricted Mage-A3'' [HHS 
Reference No. E-230-2012-0-EP-06];
    a. Validated in the following jurisdictions: AL, AT, BE, BG, CH, 
CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, 
LV, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM and TR.
    30. Israeli Patent No. 237560 issued September 1, 2020, entitled 
``T Cell Receptors Recognizing MHC Class II-Restricted Mage-A3'' [HHS 
Reference No. E-230-2012-0-IL-07];
    31. Japanese Patent No. 6461796 issued January 11, 2019, entitled 
``T Cell Receptors Recognizing MHC Class II-Restricted Mage-A3'' [HHS 
Reference No. E-230-2012-0-JP-08];
    32. Korean Patent No. 2165350 issued October 6, 2020, entitled ``T 
Cell Receptors Recognizing MHC Class II-Restricted Mage-A3'' [HHS 
Reference No. E-230-2012-0-KR-09];
    33. Mexican Patent No. 367279 issued August 13, 2019, entitled ``T 
Cell Receptors Recognizing MHC Class II-Restricted Mage-A3'' [HHS 
Reference No. E-230-2012-0-MX-10];
    34. United States Patent No. 9,879,065 issued January 30, 2018, 
entitled ``T Cell Receptors Recognizing MHC Class II-Restricted Mage-
A3'' [HHS Reference No. E-230-2012-0-US-11];
    35. Australian Patent No. 2017219019 issued August 22, 2019, 
entitled ``T Cell Receptors Recognizing MHC Class II-Restricted Mage-
A3'' [HHS Reference No. E-230-2012-0-AU-12];
    36. United States Patent No. 10,611,815 issued April 7, 2020, 
entitled ``T Cell Receptors Recognizing MHC Class II-Restricted Mage-
A3'' [HHS Reference No. E-230-2012-0-US-13];
    37. Japanese Patent No. 6728326 issued July 3, 2020, entitled ``T 
Cell Receptors Recognizing MHC Class II-Restricted Mage-A3'' [HHS 
Reference No. E-230-2012-0-JP-14];
    38. Australian Patent No. 2019213329 issued June 24, 2021, entitled 
``T Cell Receptors Recognizing MHC Class II-Restricted Mage-A3'' [HHS 
Reference No. E-230-2012-0-AU-15];
    39. Mexican Patent Application No. MX/a/2019/009641 filed August 
13, 2019, entitled ``T Cell Receptors Recognizing MHC Class II-
Restricted Mage-A3'' [HHS Reference No. E-230-2012-0-MX-16];
    40. European Patent No. 3636665 issued June 29, 2022, entitled ``T 
Cell Receptors Recognizing MHC Class II-Restricted Mage-A3'' [HHS 
Reference No. E-230-2012-0-EP-17];
    a. Validated in: BE, DK, FR, DE, IT, NL, NO, ES, SE, CH and GB.
    41. United States Patent Application No. 16/812,845 filed March 9, 
2020, entitled ``T Cell Receptors Recognizing MHC Class II-Restricted 
Mage-A3'' [HHS Reference No. E-230-2012-0-US-58];
    42. Israeli Patent No. 274003 issued February 1, 2022, entitled ``T 
Cell Receptors Recognizing MHC Class II-Restricted Mage-A3'' [HHS 
Reference No. E-230-2012-0-IL-59];
    43. Japanese Patent Application No. 2020-114090 filed July 1, 2020, 
entitled ``T Cell Receptors Recognizing MHC Class II-Restricted Mage-
A3'' [HHS Reference No. E-230-2012-0-JP-60];
    44. Hong Kong Patent Application No. 42020016865.6 filed September 
25, 2020, entitled ``T Cell Receptors Recognizing MHC Class II-
Restricted Mage-A3'' [HHS Reference No. E-230-2012-0-HK-61];
    45. Korean Patent No. 2303166 issued September 10, 2021, entitled 
``T Cell Receptors Recognizing MHC Class II-Restricted Mage-A3'' [HHS 
Reference No. E-230-2012-0-KR-62];
    46. Australian Patent Application No. 2021203746 filed June 7, 
2021, entitled ``T Cell Receptors Recognizing MHC Class II-Restricted 
Mage-A3'' [HHS Reference No. E-230-2012-0-AU-63];
    47. Japanese Patent Application No. 2021-124003 filed July 29, 
2021, entitled ``T Cell Receptors Recognizing MHC Class II-Restricted 
Mage-A3'' [HHS Reference No. E-230-2012-0-JP-64];
    48. Chinese Patent Application No. 202111028896.0 filed September 
1, 2021, entitled ``T Cell Receptors Recognizing MHC Class II-
Restricted Mage-A3'' [HHS Reference No. E-230-2012-0-CN-65];
    49. Korean Patent No. 2370307 issued February 28, 2022, entitled 
``T Cell Receptors Recognizing MHC Class II-Restricted Mage-A3'' [HHS 
Reference No. E-230-2012-0-KR-66];
    50. Israeli Patent Application No. 286786 filed September 29, 2021, 
entitled ``T Cell Receptors Recognizing MHC Class II-Restricted Mage-
A3'' [HHS Reference No. E-230-2012-0-IL-67];
    51. Hong Kong Patent Application No. 42022051280.0 filed April 7, 
2022, entitled ``T Cell Receptors Recognizing MHC Class II-Restricted 
Mage-A3'' [HHS Reference No. E-230-2012-0-HK-68];
    52. Korean Patent Application No. 10-2022-7006700 filed February 
25, 2022, entitled ``T Cell Receptors Recognizing MHC Class II-
Restricted Mage-A3'' [HHS Reference No. E-230-2012-0-KR-69];
    53. European Patent Application No. 22174521.9 filed May 20, 2022, 
entitled

[[Page 80565]]

``T Cell Receptors Recognizing MHC Class II-Restricted Mage-A3'' [HHS 
Reference No. E-230-2012-0-EP-70]; and
    54. United States Patent Application No. 17/936,006 filed September 
28, 2022, entitled ``T Cell Receptors Recognizing MHC Class II-
Restricted Mage-A3'' [HHS Reference No. E-230-2012-0-US-82].

(and U.S. and foreign patent applications claiming priority to the 
aforementioned applications)

    The patent rights in these inventions have been assigned and/or 
exclusively licensed to the government of the United States of America.
    The prospective exclusive license territory may be worldwide, and 
the field of use may be limited to the following:
    ``Development, manufacture and commercialization of allogeneic 
Natural Killer (NK) cell therapy products engineered to express a 
therapeutic T cell receptor claimed in the Licensed Patent Rights for 
the treatment or prevention of cancer in humans.
    Specifically excluded from this field of use are Natural Killer T 
(NKT) cell therapy products engineered via viral and non-viral means 
for the treatment of human cancers, wherein the NKT cell therapy 
product contains at least 50% NKT cells.''
    Intellectual Property Group A is primarily directed to isolated T 
cell receptors (TCRs) reactive to mutated Kirsten rat sarcoma viral 
oncogene homolog (KRAS), within the context of several human leukocyte 
antigens (HLAs). Mutated KRAS, which plays a well-defined driver role 
in oncogenesis, is expressed by a variety of human cancers, including 
pancreatic, lung, endometrial, ovarian and prostate. Due to its 
restricted expression in precancerous and cancerous cells, this antigen 
may be targeted on mutant KRAS-expressing tumors with minimal normal 
tissue toxicity.
    Intellectual Property Group B is primarily directed to isolated 
TCRs reactive to mutated tumor protein 53 (TP53 or P53), within the 
context of several HLAs. P53 is the archetypal tumor suppressor gene 
and the most frequently mutated gene in cancer. Contemporary estimates 
suggest that >50% of all tumors carry mutations in P53. Because of its 
prevalence in cancer and its restricted expression to precancerous and 
cancerous cells, this antigen may be targeted on mutant P53-expressing 
tumors with minimal normal tissue toxicity.
    Intellectual Property Group C is primarily directed to isolated 
TCRs reactive to the E7 oncoprotein of Human Papilloma Virus (HPV) type 
16, within the context of HLA-A*02. E7 oncoprotein drives malignant 
transformation in HPV-infected cells. Due to its specific and 
constitutive expression in cancer cells, this antigen may be targeted 
in HPV-positive malignancies, such as cervical carcinoma and 
oropharyngeal carcinoma, with minimal normal tissue toxicity.
    Intellectual Property Group D is primarily directed to isolated 
TCRs reactive to Melanoma-associated antigens 3, 6 and 12 (MAGE-A3/A6/
A12), within the context of multiple HLAs. There are twelve MAGE-A 
superfamily antigens designated A1-A12. These antigens are among the 
most commonly expressed cancer testis antigens in a variety of tumors 
and are associated with poor disease prognosis. They are not expressed 
on normal cells other than non-MHC expressing germ cells of the testis, 
which do not generate an immune response. Thus, these antigens may be 
targeted on MAGE-A-expressing tumors with minimal normal tissue 
toxicity.
    This notice is made in accordance with 35 U.S.C. 209 and 37 CFR 
part 404. The prospective exclusive license will be royalty bearing, 
and the prospective exclusive license may be granted unless within 
fifteen (15) days from the date of this published notice, the National 
Cancer Institute receives written evidence and argument that 
establishes that the grant of the license would not be consistent with 
the requirements of 35 U.S.C. 209 and 37 CFR part 404.
    In response to this Notice, the public may file comments or 
objections. Comments and objections, other than those in the form of a 
license application, will not be treated confidentially, and may be 
made publicly available.
    License applications submitted in response to this Notice will be 
presumed to contain business confidential information and any release 
of information in these license applications will be made only as 
required and upon a request under the Freedom of Information Act, 5 
U.S.C. 552.

    Dated: December 23, 2022.
Richard U. Rodriguez,
Associate Director, Technology Transfer Center, National Cancer 
Institute.
[FR Doc. 2022-28404 Filed 12-29-22; 8:45 am]
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