[Federal Register Volume 86, Number 60 (Wednesday, March 31, 2021)]
[Rules and Regulations]
[Pages 16667-16669]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2021-06596]



 ========================================================================
 Rules and Regulations
                                                 Federal Register
 ________________________________________________________________________
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 This section of the FEDERAL REGISTER contains regulatory documents 
 having general applicability and legal effect, most of which are keyed 
 to and codified in the Code of Federal Regulations, which is published 
 under 50 titles pursuant to 44 U.S.C. 1510.
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 The Code of Federal Regulations is sold by the Superintendent of Documents. 
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  Federal Register / Vol. 86, No. 60 / Wednesday, March 31, 2021 / 
Rules and Regulations  

[[Page 16667]]



DEPARTMENT OF JUSTICE

Drug Enforcement Administration

21 CFR Part 1308

[Docket No. DEA-565]


Schedules of Controlled Substances: Placement of cyclopentyl 
fentanyl, isobutyryl fentanyl, para-chloroisobutyryl fentanyl, para-
methoxybutyryl fentanyl, and valeryl fentanyl in Schedule I; Correction

AGENCY: Drug Enforcement Administration, Department of Justice.

ACTION: Final rule; correcting amendment.

-----------------------------------------------------------------------

SUMMARY: The Drug Enforcement Administration is correcting a final rule 
that appeared in the Federal Register on November 25, 2020. The 
document issued an action placing five fentanyl-related substances 
(cyclopentyl fentanyl (N-(1-phenethylpiperidin-4-yl)-N-
phenylcyclopentanecarboxamide), isobutyryl fentanyl (N-(1-
phenethylpiperidin-4-yl)-N-phenylisobutyramide), para-chloroisobutyryl 
fentanyl (N-(4-chlorophenyl)-N-(1-phenethylpiperidin-4-
yl)isobutyramide), para-methoxybutyryl fentanyl (N-(4-methoxyphenyl)-N-
(1-phenethylpiperidin-4-yl)butyramide), and valeryl fentanyl (N-(1-
phenethylpiperidin-4-yl)-N-phenylpentanamide), including their isomers, 
esters, ethers, salts, and salts of isomers, esters, and ethers, 
permanently in schedule I of the Controlled Substances Act, 
specifically to the opiates list under DEA regulations. The published 
document assigned incorrect paragraph numbers to all five substances, 
and inadvertently removed four other substances from the listed 
opiates.

DATES: Effective date: March 31, 2021.

FOR FURTHER INFORMATION CONTACT: Terrence L. Boos, Drug and Chemical 
Evaluation Section, Diversion Control Division, Drug Enforcement 
Administration; Telephone: (571) 362-3249.

SUPPLEMENTARY INFORMATION: On November 25, 2020, the Drug Enforcement 
Administration (DEA) permanently placed five fentanyl-related 
substances (cyclopentyl fentanyl (N-(1-phenethylpiperidin-4-yl)-N-
phenylcyclopentanecarboxamide), isobutyryl fentanyl (N-(1-
phenethylpiperidin-4-yl)-N-phenylisobutyramide), para-chloroisobutyryl 
fentanyl (N-(4-chlorophenyl)-N-(1-phenethylpiperidin-4-
yl)isobutyramide), para-methoxybutyryl fentanyl (N-(4-methoxyphenyl)-N-
(1-phenethylpiperidin-4-yl)butyramide), and valeryl fentanyl (N-(1-
phenethylpiperidin-4-yl)-N-phenylpentanamide) in schedule I of the 
Controlled Substances Act (CSA), specifically to the opiates list under 
21 CFR 1308.11(b). 85 FR 75231. The final rule incorrectly assigned 
paragraph numbers 22, 40, 56, and 59 under paragraph (b) to cyclopentyl 
fentanyl, isobutyryl fentanyl, para-chloroisobutyryl fentanyl, and 
para-methoxybutyryl fentanyl, respectively, overriding previously 
assigned paragraph numbers for four listed opiates crotonyl fentanyl, 
ketobemidone, para-fluorofentanyl, and phenampromide (i.e., (b)(22), 
(40), (56), and (59)). In addition, the final rule incorrectly added 
valeryl fentanyl as a new paragraph (b)(75) instead of (b)(76). This 
document updates the numbering of all listed opiates in paragraph (b), 
and specifically corrects the paragraph numbers for cyclopentyl 
fentanyl, isobutyryl fentanyl, para-chloroisobutyryl fentanyl, para-
methoxybutyryl fentanyl, and valeryl fentanyl, and reassigns paragraph 
numbers for crotonyl fentanyl, ketobemidone, para-fluorofentanyl, and 
phenampromide. It bears emphasis that DEA still considers the four 
substances (crotonyl fentanyl, ketobemidone, para-fluorofentanyl, and 
phenampromide) to have been schedule I substances during the time 
period from the issuance of the November 25, 2020, final rule to this 
correction, despite these inadvertent numbering errors.\1\
---------------------------------------------------------------------------

    \1\ Under the CSA, a controlled substance may only be removed 
from the schedules, or transferred to another schedule, where DEA 
expressly does so by a scheduling action issued in accordance with 
21 U.S.C. 811 and published in the Federal Register. DEA took no 
such action with respect to crotonyl fentanyl, ketobemidone, para-
fluorofentanyl, and phenampromide. Accordingly, the scheduling 
status of these four substances was never altered by the final rule 
that appeared in the Federal Register on November 25, 2020.
---------------------------------------------------------------------------

List of Subjects in 21 CFR Part 1308

    Administrative practice and procedure, Drug traffic control, 
Reporting and recordkeeping requirements.

    For the reasons set out above, 21 CFR part 1308 is amended as 
follows:

PART 1308--SCHEDULES OF CONTROLLED SUBSTANCES

0
1. The authority citation for 21 CFR part 1308 continues to read as 
follows:

    Authority: 21 U.S.C. 811, 812, 871(b), 956(b), unless otherwise 
noted.


0
2. In Sec.  1308.11(b), revise the table to read as follows:


Sec.  1308.11  Schedule I.

* * * * *
    (b) * * *

(1) Acetyl-alpha-methylfentanyl (N-[1-(1-methyl-2-phenethyl)-       9815
 4-piperidinyl]-N-phenylacetamide)...........................
(2) Acetylmethadol...........................................       9601
(3) Acetyl fentanyl (N-(1-phenethylpiperidin-4-yl)-N-               9821
 phenylacetamide)............................................
(4) Acryl fentanyl (N-(1-phenethylpiperidin-4-yl)-N-                9811
 phenylacrylamide; also known as acryloylfentanyl)...........
(5) AH-7921 (3,4-dichloro-N-[(1-                                    9551
 dimethylamino)cyclohexylmethyl]benzamide)...................
(6) Allylprodine.............................................       9602
(7) Alphacetylmethadol (except levo-alphacetylmethadol also         9603
 known as levo-alpha-acetylmethadol, levomethadyl acetate, or
 LAAM).......................................................
(8) Alphameprodine...........................................       9604
(9) Alphamethadol............................................       9605

[[Page 16668]]

 
(10) alpha-Methylfentanyl (N-[1-(alpha-methyl-beta-                 9814
 phenyl)ethyl-4-piperidyl]propionanilide; 1-(1-methyl-2-
 phenylethyl)-4-(N-propanilido)piperidine)...................
(11) alpha-Methylthiofentanyl (N-[1-methyl-2-(2-thienyl)ethyl-      9832
 4-piperidinyl]-N-phenylpropanamide).........................
(12) Benzethidine............................................       9606
(13) Betacetylmethadol.......................................       9607
(14) beta-Hydroxyfentanyl (N-[1-(2-hydroxy-2-phenethyl)-4-          9830
 piperidinyl]-N-phenylpropanamide)...........................
(15) beta-Hydroxy-3-methylfentanyl (N-[1-(2-hydroxy-2-              9831
 phenylethyl)-3-methyl-4-piperidinyl]-N-phenylpropanamide)...
(16) beta-Hydroxythiofentanyl (N-[1-[2-hydroxy-2-(thiophen-2-       9836
 yl)ethyl]piperidin-4-yl]-N-phenylpropionamide)..............
(17) Betameprodine...........................................       9608
(18) Betamethadol............................................       9609
(19) Betaprodine.............................................       9611
(20) Butyryl fentanyl (N-(1-phenethylpiperidin-4-yl)-N-             9822
 phenylbutyramide)...........................................
(21) Clonitazene.............................................       9612
(22) Crotonyl fentanyl ((E)-N-(1-phenethylpiperidin-4-yl)-N-        9844
 phenylbut-2-enamide)........................................
(23) Cyclopentyl fentanyl (N-(1-phenethylpiperidin-4-yl)-N-         9847
 phenylcyclopentanecarboxamide)..............................
(24) Cyclopropyl fentanyl (N-(1-phenethylpiperidin-4-yl)-N-         9845
 phenylcyclopropanecarboxamide)..............................
(25) Dextromoramide..........................................       9613
(26) Diampromide.............................................       9615
(27) Diethylthiambutene......................................       9616
(28) Difenoxin...............................................       9168
(29) Dimenoxadol.............................................       9617
(30) Dimepheptanol...........................................       9618
(31) Dimethylthiambutene.....................................       9619
(32) Dioxaphetyl butyrate....................................       9621
(33) Dipipanone..............................................       9622
(34) Ethylmethylthiambutene..................................       9623
(35) Etonitazene.............................................       9624
(36) Etoxeridine.............................................       9625
(37) 4-Fluoroisobutyryl fentanyl (N-(4-fluorophenyl)-N-(1-          9824
 phenethylpiperidin-4-yl)isobutyramide; also known as para-
 fluoroisobutyryl fentanyl)..................................
(38) Furanyl fentanyl (N-(1-phenethylpiperidin-4-yl)-N-             9834
 phenylfuran-2-carboxamide)..................................
(39) Furethidine.............................................       9626
(40) Hydroxypethidine........................................       9627
(41) Isobutyryl fentanyl (N-(1-phenethylpiperidin-4-yl)-N-          9827
 phenylisobutyramide)........................................
(42) Ketobemidone............................................       9628
(43) Levomoramide............................................       9629
(44) Levophenacylmorphan.....................................       9631
(45) Methoxyacetyl fentanyl (2-methoxy-N-(1-                        9825
 phenethylpiperidin-4-yl)-N-phenylacetamide).................
(46) 3-Methylfentanyl (N-[3-methyl-1-(2-phenylethyl)-4-             9813
 piperidyl]-N-phenylpropanamide).............................
(47) 3-Methylthiofentanyl (N-[3-methyl-1-(2-thienylethyl)-4-        9833
 piperidinyl]-N-phenylpropanamide)...........................
(48) Morpheridine............................................       9632
(49) MPPP (1-methyl-4-phenyl-4-propionoxypiperidine).........       9661
(50) MT-45 (1-cyclohexyl-4-(1,2-diphenylethyl)piperazine)....       9560
(51) Noracymethadol..........................................       9633
(52) Norlevorphanol..........................................       9634
(53) Normethadone............................................       9635
(54) Norpipanone.............................................       9636
(55) Ocfentanil (N-(2-fluorophenyl)-2-methoxy-N-(1-                 9838
 phenethylpiperidin-4-yl)acetamide)..........................
(56) ortho-Fluorofentanyl (N-(2-fluorophenyl)-N-(1-                 9816
 phenethylpiperidin-4-yl)propionamide); also known as 2-
 fluorofentanyl).............................................
(57) para-Chloroisobutyryl fentanyl (N-(4-chlorophenyl)-N-(1-       9826
 phenethylpiperidin-4-yl)isobutyramide)......................
(58) para-Fluorobutyryl fentanyl (N-(4-fluorophenyl)-N-(1-          9823
 phenethylpiperidin-4-yl)butyramide).........................
(59) para-Fluorofentanyl (N-(4-fluorophenyl)-N-[1-(2-               9812
 phenylethyl)-4-piperidinyl]propanamide).....................
(60) para-Methoxybutyryl fentanyl (N-(4-methoxyphenyl)-N-(1-        9837
 phenethylpiperidin-4-yl)butyramide).........................
(61) PEPAP (1-(2-phenylethyl)-4-phenyl-4-acetoxypiperidine)..       9663
(62) Phenadoxone.............................................       9637
(63) Phenampromide...........................................       9638
(64) Phenomorphan............................................       9647
(65) Phenoperidine...........................................       9641
(66) Piritramide.............................................       9642
(67) Proheptazine............................................       9643
(68) Properidine.............................................       9644
(69) Propiram................................................       9649
(70) Racemoramide............................................       9645
(71) Tetrahydrofuranyl fentanyl (N-(1-phenethylpiperidin-4-         9843
 yl)-N-phenyltetrahydrofuran-2-carboxamide)..................
(72) Thiofentanyl (N-phenyl-N-[1-(2-thienyl)ethyl-4-                9835
 piperidinyl]propanamide)....................................
(73) Tilidine................................................       9750
(74) Trimeperidine...........................................       9646
(75) U-47700 (3,4-dichloro-N-[2-(dimethylamino)cyclohexyl]-N-       9547
 methylbenzamide)............................................
(76) Valeryl fentanyl (N-(1-phenethylpiperidin-4-yl)-N-             9840
 phenylpentanamide)..........................................
 


[[Page 16669]]

* * * * *

D. Christopher Evans,
Acting Administrator.
[FR Doc. 2021-06596 Filed 3-30-21; 8:45 am]
BILLING CODE 4410-09-P