[Federal Register Volume 86, Number 6 (Monday, January 11, 2021)]
[Notices]
[Pages 1981-1982]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2021-00227]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Interagency Coordinating Committee on the Validation of 
Alternative Methods Communities of Practice Webinar on Non-Animal 
Approaches for Mixtures Assessment; Notice of Public Webinar; 
Registration Information

AGENCY: National Institutes of Health, HHS.

ACTION: Notice.

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SUMMARY: The Interagency Coordinating Committee on the Validation of 
Alternative Methods (ICCVAM) announces a public webinar ``Non-animal 
Approaches for Mixtures Assessment.'' The webinar is organized on 
behalf of ICCVAM by the National Toxicology Program Interagency Center 
for the Evaluation of Alternative Toxicological Methods (NICEATM). 
Interested persons may participate via WebEx. Time will be allotted for 
questions from the audience. Information about the webinar and 
registration are available at https://ntp.niehs.nih.gov/go/commprac-2021.

DATES: 
    Webinar: January 26, 2021, 9:00 a.m. to approximately 11:00 a.m. 
EST.
    Registration for Webinar: January 4, 2021, until 11:00 a.m. EST 
January 26, 2021.
    Registration to view the webinar is required.

ADDRESSES: Webinar web page https://ntp.niehs.nih.gov/go/commprac-2021.

FOR FURTHER INFORMATION CONTACT: Dr. Nicole Kleinstreuer, Acting 
Director, NICEATM, Division of NTP, NIEHS, P.O. Box 12233, K2-16 
Research Triangle Park, NC 27709. Phone: 984-287-3150, Email: 
[email protected]. Hand Deliver/Courier address: 530 Davis 
Drive, Room K2032, Morrisville, NC 27560.

SUPPLEMENTARY INFORMATION: 
    Background: ICCVAM promotes the development and validation of 
toxicity testing methods that protect human health and the environment 
while replacing, reducing, or refining animal use. ICCVAM also provides 
guidance to test method developers and facilitates collaborations that 
promote the development of new test methods. To address these goals, 
ICCVAM will hold a Communities of Practice webinar on ``Non-animal 
Approaches for Mixtures Assessment.''
    While most available toxicity data are for single chemicals, humans 
are often

[[Page 1982]]

exposed to chemicals as mixtures. Assessing the safety of a mixture is 
a complex process that requires consideration of both the toxicity of 
each chemical component of the mixture and the potential for 
interaction among the components to affect toxicity of the overall 
mixture. Additionally, most alternative methods and approaches used for 
assessing chemical safety are developed and evaluated using single 
chemicals. This can result in lack of clarity about whether a method is 
appropriate to use for assessing toxicity of a particular mixture.
    This webinar will discuss new approach methodologies for assessing 
exposure to, and potential hazards associated with, chemical mixtures. 
Key insights and ongoing activities will be described in three 
presentations featuring speakers from U.S. federal research and 
regulatory agencies. The preliminary agenda and additional information 
about presentations will be posted at https://ntp.niehs.nih.gov/go/commprac-2021 as available.
    Webinar and Registration: This webinar is open to the public with 
time scheduled for questions by participants following each 
presentation. Registration for the webinar is required and will be open 
from January 4, 2021, through 11:00 a.m. EST on January 26, 2021. 
Registration is available at https://ntp.niehs.nih.gov/go/commprac-2021. Interested individuals are encouraged to visit this web page to 
stay abreast of the most current webinar information. Registrants will 
receive instructions on how to access and participate in the webinar in 
the email confirming their registration.
    Background Information on ICCVAM and NICEATM: ICCVAM is an 
interagency committee composed of representatives from 17 federal 
regulatory and research agencies that require, use, generate, or 
disseminate toxicological and safety testing information. ICCVAM 
conducts technical evaluations of new, revised, and alternative safety 
testing methods and integrated testing strategies with regulatory 
applicability. ICCVAM also promotes the scientific validation and 
regulatory acceptance of testing methods that more accurately assess 
the safety and hazards of chemicals and products and replace, reduce, 
or refine (enhance animal well-being and lessen or avoid pain and 
distress) animal use.
    The ICCVAM Authorization Act of 2000 (42 U.S.C. 285l-3) establishes 
ICCVAM as a permanent interagency committee of NIEHS and provides the 
authority for ICCVAM involvement in activities relevant to the 
development of alternative test methods. Additional information about 
ICCVAM can be found at https://ntp.niehs.nih.gov/go/iccvam.
    NICEATM administers ICCVAM, provides scientific and operational 
support for ICCVAM-related activities, and conducts and publishes 
analyses and evaluations of data from new, revised, and alternative 
testing approaches. NICEATM and ICCVAM work collaboratively to evaluate 
new and improved testing approaches applicable to the needs of U.S. 
federal agencies. NICEATM and ICCVAM welcome the public nomination of 
new, revised, and alternative test methods and strategies for 
validation studies and technical evaluations. Additional information 
about NICEATM can be found at https://ntp.niehs.nih.gov/go/niceatm.

    Dated: January 6, 2021.
Brian R. Berridge,
Associate Director, National Toxicology Program.
[FR Doc. 2021-00227 Filed 1-8-21; 8:45 am]
BILLING CODE 4140-01-P