[Federal Register Volume 85, Number 229 (Friday, November 27, 2020)]
[Notices]
[Pages 76087-76088]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2020-26169]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
Government-Owned Inventions; Availability for Licensing
AGENCY: National Institutes of Health, HHS.
ACTION: Notice.
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SUMMARY: The inventions listed below are owned by an agency of the U.S.
Government and are available for licensing to achieve expeditious
commercialization of results of federally-funded research and
development.
FOR FURTHER INFORMATION CONTACT: Licensing information may be obtained
by communicating with Betty B. Tong, Ph.D., National Institute of
Diabetes and Digestive and Kidney Diseases, Technology Advancement
Office, 12A South Drive Suite 3011, Bethesda, MD 20892; telephone: 301-
451-7836; email: [email protected]. A signed Confidential Disclosure
Agreement may be required to receive any unpublished information.
SUPPLEMENTARY INFORMATION: Technology description follows.
Triazole Derivatives as P2Y14 Receptor Antagonists
The technology describes the composition of small molecule
compounds that are antagonists of the P2Y14 receptor. Also provided are
methods of using the compounds, including a method of treating a
disorder, such as inflammation, diabetes, insulin resistance,
hyperglycemia, a lipid disorder, obesity, a condition associated with
metabolic syndrome, and asthma, and a method of antagonizing P2Y14
receptor activity in a cell. This technology is available for licensing
for commercial development in accordance with 35 U.S.C. 209 and 37 CFR
part 404.
Potential Commercial Applications:
Development of P2Y14 receptor antagonist for treatment of
disorders, such as:
Inflammation
diabetes
obesity
asthma
[[Page 76088]]
lipid disorder
metabolic syndrome
Development Stage
Early stage
Inventors: Kenneth A. Jacobson (NIDDK), Anna Junker, Elisa Uliassi
(NIDDK), Evgeny Kiselev (NIDDK)
Publications: Junker A, Balasubramanian R, Ciancetta A, et al.,
Structure-based design of 3-(4-aryl-1H-1,2,3-triazol-1-yl)-biphenyl
derivatives as P2Y14 receptor antagonists. J. Med. Chem.,
2016, 59:6149-6168.
Intellectual Property: HHS Reference No. E-213-2015-0, U.S. Patent
No. 10,683,277, issued June 16, 2020, EP Patent Application 16774825.0,
filed Sept. 23, 2016, Chinese Patent Application 201680064441.5, filed
Sept. 23, 2016.
Licensing Contact: Betty B. Tong, Ph.D.; 301-451-7836;
[email protected]. This notice is made in accordance with 35 U.S.C.
209 and 37 CFR part 404.
Dated: November 19, 2020.
Bei Tong,
Senior Licensing and Patenting Manager, National Institute of Diabetes
and Digestive and Kidney Diseases, Technology Advancement Office.
[FR Doc. 2020-26169 Filed 11-25-20; 8:45 am]
BILLING CODE 4140-01-P