[Federal Register Volume 84, Number 205 (Wednesday, October 23, 2019)]
[Notices]
[Page 56817]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2019-23031]



[[Page 56817]]

-----------------------------------------------------------------------

DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Government-Owned Inventions; Availability for Licensing

AGENCY: National Institutes of Health, HHS.

ACTION: Notice.

-----------------------------------------------------------------------

SUMMARY: The inventions listed below are owned by an agency of the U.S. 
Government and are available for licensing in the U.S. to achieve 
expeditious commercialization of results of federally-funded research 
and development.

FOR FURTHER INFORMATION CONTACT: Licensing information may be obtained 
by emailing Michael Shmilovich, [email protected], the licensing 
contact at the National Heart, Lung, and Blood, Office of Technology 
Transfer and Development Office of Technology Transfer, 31 Center 
Drive, Room 4A29, MSC2479, Bethesda, MD 20892-2479; telephone: 301-402-
5579. A signed Confidential Disclosure Agreement may be required to 
receive any unpublished information.

SUPPLEMENTARY INFORMATION: Technology description follows.

Resolution Enhancement for Light Sheet Microscopy Systems and Methods

    Available for licensing and commercial development is a system and 
technique for enhancing the resolution of images acquired through light 
sheet microscopy by adding additional enhanced depth-of-focus optical 
arrangements and high numerical aperture objective lenses. The 
technique employs an arrangement of three objective lenses and a 
processor for combining captured images. The first objective lens 
illuminates the sample and the second and third objective lenses 
collect the fluorescence emissions emitted by the sample. The second 
objective lens focuses a first portion of the fluorescence emissions 
for detection by a second detection component. The third objective lens 
focuses a second portion of the fluorescence emissions through a 
diffractive or refractive optic component. A processor combines the 
images resulting from first and second portions of the fluorescence 
emissions and generates a composite image with improved axial and 
lateral resolution.
    Potential Commercial Applications:

 High speed imaging
 Fast single cell and cellular dynamics imaging
 Super-resolution and single molecule imaging
 3D single particle tracking
 3D super-resolution imaging in thick samples

    Competitive Advantages:

 Resolution enhancement in light microscopy

    Development Stage:

 In vitro data available

    Inventors: Hari Shroff (NIBIB), Yicong Wu (NIBIB), and Sara 
Abrahamsson.
    Intellectual Property: HHS Reference No. E-232-2014/0.

U.S. Provisional Patent Applications 62/054,484 filed 24 September 2014
PCT Application No. PCT/US2015/052047 filed 24 September 2015
European Patent Applications No. 15843742.6 filed 24 September 2017
U.S. Patent No. US 10,401,604 issued 3 September 2019

    Related Technology: HHS Reference No. E-078-2011/0.
    Licensing Contact: Michael Shmilovich, Esq., CLP; 301-435-5019; 
[email protected]..
    Collaborative Research Opportunity: The National Institute of 
Biomedical Imaging and Bioengineering is seeking statements of 
capability or interest from parties interested in collaborative 
research to further develop, evaluate or commercialize Resolution 
Enhancement Technique for Light Sheet Microscopy Systems and Methods. 
For collaboration opportunities, please contact Michael Shmilovich 301-
435-5019 or [email protected].

    Dated: October 17, 2019.
Michael A. Shmilovich,
Senior Licensing and Patenting Manager, National Heart, Lung, and Blood 
Institute, Office of Technology Transfer and Development.
[FR Doc. 2019-23031 Filed 10-22-19; 8:45 am]
 BILLING CODE 4140-01-P