[Federal Register Volume 84, Number 76 (Friday, April 19, 2019)]
[Rules and Regulations]
[Pages 16397-16398]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2019-07457]


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DEPARTMENT OF JUSTICE

Drug Enforcement Administration

21 CFR Part 1308

[Docket No. DEA-476]


Chemical Names of Previously Controlled Fentanyl-Related 
Substances

AGENCY: Drug Enforcement Administration, Department of Justice.

ACTION: Notification of chemical names of previously controlled 
substances.

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SUMMARY: The Drug Enforcement Administration (DEA) is providing 
additional descriptive information with respect to five specific 
substances already covered by a temporary scheduling order that 
appeared in the Federal Register on February 6, 2018. That order placed 
fentanyl-related substances temporarily in schedule I of the Controlled 
Substances Act. The order further stated that if and when DEA 
identifies a specific new substance that falls under the definition of 
a fentanyl-related substance, the agency will publish in the Federal 
Register, and on the agency website, the chemical name of such 
substance. Consistent therewith, this document provides the chemical 
names of five substances that fall within the definition of fentanyl-
related substances that were temporarily controlled under the 
scheduling order issued February 6, 2018.

DATES: This notification has the same effective period as the temporary 
scheduling order published on February 6, 2018 (83 FR 5188): February 
6, 2018 through February 6, 2020.

FOR FURTHER INFORMATION CONTACT: Lynnette M. Wingert, Diversion Control

[[Page 16398]]

Division, Drug Enforcement Administration; Mailing Address: 8701 
Morrissette Drive, Springfield, Virginia 22152; Telephone: (202) 598-
6812.

SUPPLEMENTARY INFORMATION: On February 6, 2018, DEA issued an order 
pursuant to 21 U.S.C. 811(h), which temporarily placed fentanyl-related 
substances in schedule I of the Controlled Substances Act (CSA). 83 FR 
5188. As defined in the order, fentanyl-related substances include any 
substance not otherwise controlled in any schedule (i.e., not included 
under any other Administration Controlled Substance Code Number) that 
is structurally related to fentanyl by one or more of the following 
modifications:
    1. Replacement of the phenyl portion of the phenethyl group by any 
monocycle, whether or not further substituted in or on the monocycle;
    2. substitution in or on the phenethyl group with alkyl, alkenyl, 
alkoxyl, hydroxyl, halo, haloalkyl, amino or nitro groups;
    3. substitution in or on the piperidine ring with alkyl, alkenyl, 
alkoxyl, ester, ether, hydroxyl, halo, haloalkyl, amino or nitro 
groups;
    4. replacement of the aniline ring with any aromatic monocycle 
whether or not further substituted in or on the aromatic monocycle; 
and/or
    5. replacement of the N-propionyl group by another acyl group.
    The order further stated that if and when DEA identifies a specific 
new substance that falls under the definition of a fentanyl-related 
substance, the agency will publish in the Federal Register, and on the 
agency website, the chemical name of such substance. Consistent 
therewith, DEA is hereby providing the chemical names of five 
substances, which have been identified on the illicit market in the 
United States, that fall within the existing definition of a fentanyl-
related substance:
    N-(1-(2-fluorophenethyl)piperidin-4-yl)-N-(2-
fluorophenyl)propionamide (2'-fluoro ortho-fluorofentanyl);
    N-(2-methylphenyl)-N-(1-phenethylpiperidin-4-yl)acetamide (ortho-
methyl acetylfentanyl);
    N-(1-phenethylpiperidin-4-yl)-N,3-diphenylpropanamide (beta'-phenyl 
fentanyl; hydrocinnamoyl fentanyl);
    N-(1-phenethylpiperidin-4-yl)-N-phenylthiophene-2-carboxamide 
(thiofuranyl fentanyl); and
    (E)-N-(1-phenethylpiperidin-4-yl)-N-phenylbut-2-enamide (crotonyl 
fentanyl).
    The five foregoing substances fall within the definition of 
fentanyl-related substances as they are not otherwise listed under 
another Administration Controlled Substance Code Number and are 
structurally related to fentanyl by the following modifications:
    2'-fluoro ortho-fluorofentanyl: Substitution on the phenethyl group 
with a halo group and substitution on the aniline ring (meets 
definition for modifications 2 and 4);
    ortho-methyl acetylfentanyl: Substitution on the aniline ring and 
replacement of the N-propionyl group with another acyl group (meets 
definition for modifications 4 and 5);
    beta'-phenyl fentanyl: Replacement of the N-propionyl group by 
another acyl group (meets definition for modification 5);
    thiofuranyl fentanyl: Replacement of the N-propionyl group by 
another acyl group (meets definition for modification 5);
    crotonyl fentanyl: Replacement of the N-propionyl group by another 
acyl group (meets definition for modification 5).
    It bears emphasis that, as DEA stated in the temporary scheduling 
order for fentanyl-related substances, even in the absence of this 
publication providing the chemical names of the foregoing five 
substances that fall within the definition of a fentanyl-related 
substance, these five substances (along with any others that might be 
identified in the future) were controlled as of February 6, 2018 by 
virtue of the temporary scheduling order that DEA issued on that date. 
83 FR 5188.

    Dated: April 3, 2019.
Uttam Dhillon,
Acting Administrator.
[FR Doc. 2019-07457 Filed 4-18-19; 8:45 am]
 BILLING CODE 4410-09-P