[Federal Register Volume 84, Number 41 (Friday, March 1, 2019)]
[Notices]
[Pages 7082-7084]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2019-03675]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
Food and Drug Administration
[Docket No. FDA-2019-N-0077]
Patient Perspectives on the Impact of Rare Diseases: Bridging the
Commonalities; Public Meeting; Request for Comments
AGENCY: Food and Drug Administration, HHS.
ACTION: Notice of public meeting; request for comments.
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SUMMARY: The Food and Drug Administration (FDA or the Agency) is
announcing a public meeting and an opportunity for public comment on
``Patient Perspectives on the Impact of Rare Diseases: Bridging the
Commonalities.'' This public meeting is intended to obtain patients'
and caregivers' perspectives on impacts of rare diseases on daily life
and to assess commonalities that may help the Agency and medical
product developers further understand and advance the development of
treatments for rare diseases. Developing a treatment for a rare disease
can present unique challenges, such as the small number of individuals
affected and heterogenous etiologies and manifestations. While the
differences between rare diseases are critically important, it is also
important to assess commonalities to synergize product development in
rare diseases. The goal of this meeting is to identify common issues
and symptoms in rare diseases to help advance medical product
development, potentially through the creation of novel endpoints or
trial designs that focus on commonalities across a variety of rare
diseases.
DATES: The public meeting will be held on April 29, 2019, from 1 p.m.
to 5 p.m. The online registration to attend must be received by April
15, 2019. Onsite registration on the day of the meeting will be based
on space availability. Submit either electronic or written comments on
the public meeting by May 30, 2019. See the SUPPLEMENTARY INFORMATION
section for registration date and information.
ADDRESSES: The public meeting will be held at the FDA White Oak Campus,
10903 New Hampshire Ave., Building 31 Conference Center, the Great Room
(Rm. 1503), Silver Spring, MD 20993-0002. Entrance for the public
meeting participants (non-FDA employees) is through Building 1, where
routine security check procedures will be performed. For parking and
security information, please refer to https://www.fda.gov/AboutFDA/WorkingatFDA/BuildingsandFacilities/WhiteOakCampusInformation/ucm241740.htm.
You may submit comments as follows. Please note that late, untimely
filed comments will not be considered. Electronic comments must be
submitted on or before May 30, 2019. The https://www.regulations.gov
electronic filing system will accept comments until midnight Eastern
Time at the end of May 30, 2019. Comments received by mail/hand
delivery/courier (for written/paper submissions) will be considered
timely if they are postmarked or the delivery service acceptance
receipt is on or before that date.
Electronic Submissions
Submit electronic comments in the following way:
Federal eRulemaking Portal: https://www.regulations.gov.
Follow the instructions for submitting comments. Comments submitted
electronically, including attachments, to https://www.regulations.gov
will be posted to the docket unchanged. Because your comment will be
made public, you are solely responsible for ensuring that your comment
does not include any confidential information that you or a third party
may not wish to be posted, such as medical information, your or anyone
else's Social Security number, or confidential business information,
such as a manufacturing process. Please note that if you include your
name, contact information, or other information that identifies you in
the body of your comments, that information will be posted on https://www.regulations.gov.
If you want to submit a comment with confidential
information that you do not wish to be made available to the public,
submit the comment as a written/paper submission and in the manner
detailed (see ``Written/Paper Submissions'' and ``Instructions'').
[[Page 7083]]
Written/Paper Submissions
Submit written/paper submissions as follows:
Mail/Hand delivery/Courier (for written/paper
submissions): Dockets Management Staff (HFA-305), Food and Drug
Administration, 5630 Fishers Lane, Rm. 1061, Rockville, MD 20852.
For written/paper comments submitted to the Dockets
Management Staff, FDA will post your comment, as well as any
attachments, except for information submitted, marked and identified,
as confidential, if submitted as detailed in ``Instructions.''
Instructions: All submissions received must include the Docket No.
FDA-2019-N-0077 for ``Patient Perspectives on the Impact of Rare
Diseases: Bridging the Commonalities.'' Received comments, those filed
in a timely manner (see ADDRESSES), will be placed in the docket and,
except for those submitted as ``Confidential Submissions,'' publicly
viewable at https://www.regulations.gov or at the Dockets Management
Staff between 9 a.m. and 4 p.m., Monday through Friday.
Confidential Submissions--To submit a comment with
confidential information that you do not wish to be made publicly
available, submit your comments only as a written/paper submission. You
should submit two copies total. One copy will include the information
you claim to be confidential with a heading or cover note that states
``THIS DOCUMENT CONTAINS CONFIDENTIAL INFORMATION.'' The Agency will
review this copy, including the claimed confidential information, in
its consideration of comments. The second copy, which will have the
claimed confidential information redacted/blacked out, will be
available for public viewing and posted on https://www.regulations.gov.
Submit both copies to the Dockets Management Staff. If you do not wish
your name and contact information to be made publicly available, you
can provide this information on the cover sheet and not in the body of
your comments and you must identify this information as
``confidential.'' Any information marked as ``confidential'' will not
be disclosed except in accordance with 21 CFR 10.20 and other
applicable disclosure law. For more information about FDA's posting of
comments to public dockets, see 80 FR 56469, September 18, 2015, or
access the information at: https://www.gpo.gov/fdsys/pkg/FR-2015-09-18/pdf/2015-23389.pdf.
Docket: For access to the docket to read background documents or
the electronic and written/paper comments received, go to https://www.regulations.gov and insert the docket number, found in brackets in
the heading of this document, into the ``Search'' box and follow the
prompts and/or go to the Dockets Management Staff, 5630 Fishers Lane,
Rm. 1061, Rockville, MD 20852.
FOR FURTHER INFORMATION CONTACT: Eleanor Dixon-Terry, Office of Orphan
Products Development, Food and Drug Administration, 10903 New Hampshire
Ave., Bldg. 32, Rm. 5163, Silver Spring, MD 20933, 301-796-7634,
[email protected].
SUPPLEMENTARY INFORMATION:
I. Background
The development of drugs, biologics, and devices for rare diseases
involves unique challenges. The goal of this meeting is to identify
common issues across rare diseases to help address some of these
challenges. Rare diseases, often referred to as orphan diseases, are
defined based on rarity of occurrence. Although these diseases are
individually rare, collectively they are not. According to the National
Institutes of Health, there are approximately 7,000 rare diseases
affecting an estimated 30 million people in the United States. Many of
these rare diseases are serious or life-threatening and many affect
children.
The combination of government incentives and scientific advances
has fueled extraordinary development in orphan drugs. Since the Orphan
Drug Act was passed in 1983, drugs and biologics for over 750 rare
disease indications have been developed and approved for marketing. In
addition to drugs and biologics, there has been progress in the
development of devices for rare diseases. Since 1990, the FDA has
approved 74 medical devices for orphan indications under the Agency's
Humanitarian Device Exemption program. Despite these successes, we
recognize that thousands of rare diseases still have no approved
treatments.
Developing a treatment for a rare disease can present unique
challenges. Potential challenges include the small number of
individuals affected, lack of understanding of the natural history of
the disease, phenotypic heterogeneity, and lack of validated endpoints
for use in clinical trials. Overcoming these challenges requires
collaboration between many stakeholders, including scientists, product
developers, regulators, policy makers, and patients. FDA is committed
to working with stakeholders to advance treatment options for patients
with rare diseases.
This public meeting will focus on the perspective of those affected
by rare diseases. Patients, family members, and caregivers will provide
important input on the impact of rare diseases on daily life. While the
differences between rare diseases are critically important, this
meeting will assess commonalities. The specific goal of this meeting is
to identify common issues and symptoms in rare diseases to help advance
medical product development, potentially through the generation of
novel endpoints or trial designs that focus on commonalities across a
variety of rare disease.
FDA will provide a summary document from this public meeting. This
meeting will include participants from FDA, the patient community,
caregivers, and other interested stakeholders.
II. Topics for Discussion at the Public Meeting
This public meeting will consist of panels of patients/caregivers
and facilitated discussions. The aim of the meeting is to hear directly
from patients with rare diseases and their caregivers and family
members. The meeting will include patients with any rare disease and
their caregivers and family members. It is not restricted to a specific
rare disease or group of rare diseases.
The meeting will focus on several related topics. Specifically, FDA
would like to hear directly from patients with rare diseases and their
caregivers and family members about disease symptoms, treatment
considerations, and factors relevant to participating in a clinical
study or registry. We invite the public to register and participate in
our panel discussions. A detailed agenda and meeting topics will be
posted on the following website in advance of the meeting: https://www.fda.gov/NewsEvents/MeetingsConferencesWorkshops/ucm628352.htm.
III. Participating in the Public Meeting
Registration: To register for the public meeting, please visit the
following website by April 15, 2019: https://patient-perspectives-rare-diseases.eventbrite.com. Please provide complete contact information
for each attendee, including name, title, affiliation, address, email,
and telephone.
Registration is free and based on space availability, with priority
given to early registrants. Persons interested in attending this public
meeting must register by April 15, 2019, 5 p.m. Eastern Time. Early
registration is recommended because seating is
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limited; therefore, FDA may limit the number of participants from each
organization. Registrants will receive confirmation when their
registration has been received. If time and space permit, onsite
registration on the day of the public meeting will be provided
beginning an hour prior to the start of the meeting.
If you need special accommodations due to a disability, please
contact Eleanor Dixon-Terry, at 301-796-7634, or
[email protected] no later than April 15, 2019.
Requests for Oral Presentations: Patients and patient
representatives who are interested in presenting comments as part of
the initial panel discussions will be asked to indicate in their
registration which topic(s) they wish to address. These patients and
patient representatives also must send to Eleanor Dixon-Terry
([email protected] or 301-796-7634) a brief summary of
responses to the meeting topics by April 1, 2019. Details regarding the
meeting agenda and topics will be available at https://www.fda.gov/NewsEvents/MeetingsConferencesWorkshops/ucm628352.htm.
FDA will hold an open public comment period to give the public an
opportunity to comment. Registration for open public comment will occur
in the meeting registration and at the registration desk on the day of
the meeting on a first-come, first-served basis.
Panelists and open public comment period speakers will be notified
of their selection approximately 7 days before the public meeting. We
will try to accommodate all patients and patient representatives who
wish to speak, either through the panel discussion, an open public
comment period, or audience participation; however, the duration of
comments may be limited by time constraints.
Streaming Webcast of the Public Meeting: For those unable to attend
in person, FDA will provide a live webcast of the meeting. To register
for the streaming webcast of the public meeting, please visit the
following website by April 28, 2019: https://www.fda.gov/NewsEvents/MeetingsConferencesWorkshops/ucm628352.htm.
If you have never attended a Connect Pro event before, test your
connection at https://collaboration.fda.gov/common/help/en/support/meeting_test.htm. To get a quick overview of the Connect Pro program,
visit https://www.adobe.com/go/connectpro_overview. FDA has verified
the website addresses in this document, as of the date this document
publishes in the Federal Register, but websites are subject to change
over time.
Transcripts: Please be advised that as soon as a transcript of the
public meeting is available, it will be accessible at https://www.regulations.gov. It may be viewed at the Dockets Management Staff
(see ADDRESSES). A link to the transcript will also be available on the
internet at https://www.fda.gov/NewsEvents/MeetingsConferencesWorkshops/ucm628352.htm.
Dated: February 26, 2019.
Lowell J. Schiller,
Acting Associate Commissioner for Policy.
[FR Doc. 2019-03675 Filed 2-28-19; 8:45 am]
BILLING CODE 4164-01-P