[Federal Register Volume 83, Number 228 (Tuesday, November 27, 2018)]
[Notices]
[Pages 60900-60903]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2018-25865]


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DEPARTMENT OF JUSTICE

Drug Enforcement Administration

[Docket No. DEA-392]


Bulk Manufacturer of Controlled Substances Application: Cayman 
Chemical Company

ACTION: Notice of application.

-----------------------------------------------------------------------

DATES: Registered bulk manufacturers of the affected basic classes, and 
applicants therefore, may file written comments on or objections to the 
issuance of the proposed registration on or before January 28, 2019.

ADDRESSES: Written comments should be sent to: Drug Enforcement 
Administration, Attention: DEA Federal Register Representative/DPW, 
8701 Morrissette Drive, Springfield, Virginia 22152.

SUPPLEMENTARY INFORMATION: The Attorney General has delegated his 
authority under the Controlled Substances Act to the Administrator of 
the Drug Enforcement Administration (DEA), 28 CFR 0.100(b). Authority 
to exercise all necessary functions with respect to the promulgation 
and implementation of 21 CFR part 1301, incident to the registration of 
manufacturers, distributors, dispensers, importers, and exporters of 
controlled substances (other than final orders in connection with 
suspension, denial, or revocation of registration) has been redelegated 
to the Assistant Administrator of the DEA Diversion Control Division 
(``Assistant Administrator'') pursuant to section 7 of 28 CFR part 0, 
appendix to subpart R.
    In accordance with 21 CFR 1301.33(a), this is notice that on July 
25, 2018, Cayman Chemical Company, 1180 East Ellsworth Road, Ann Arbor, 
Michigan 48108 applied to be registered as a bulk manufacturer for the 
basic classes of controlled substances:

------------------------------------------------------------------------
       Controlled substance           Drug code           Schedule
------------------------------------------------------------------------
3-Fluoro-N-methylcathinone (3-               1233  I
 FMC).
Cathinone........................            1235  I
Methcathinone....................            1237  I
4-Fluoro-N-methylcathinone (4-               1238  I
 FMC).

[[Page 60901]]

 
Pentedrone ([alpha]-                         1246  I
 methylaminovalerophenone).
Mephedrone (4-Methyl-N-                      1248  I
 methylcathinone).
4-Methyl-N-ethylcathinone (4-MEC)            1249  I
Naphyrone........................            1258  I
N-Ethylamphetamine...............            1475  I
N,N-Dimethylamphetamine..........            1480  I
Fenethylline.....................            1503  I
Aminorex.........................            1585  I
4-Methylaminorex (cis isomer)....            1590  I
Gamma Hydroxybutyric Acid........            2010  I
Methaqualone.....................            2565  I
Mecloqualone.....................            2572  I
JWH-250 (1-Pentyl-3-(2-                      6250  I
 methoxyphenylacetyl) indole).
SR-18 (Also known as RCS-8) (1-              7008  I
 Cyclohexylethyl-3-(2-
 methoxyphenylacetyl) indole).
ADB-FUBINACA (N-(1-amino-3,3-                7010  I
 dimethyl-1-oxobutan-2-yl)-1-(4-
 fluorobenzyl)-1H-indazole-3-
 carboxamide).
5-Fluoro-UR-144 and XLR11 [1-(5-             7011  I
 Fluoro-pentyl)1H-indol-3-
 yl](2,2,3,3-
 tetramethylcyclopropyl)methanone.
AB-FUBINACA (N-(1-amino-3-methyl-            7012  I
 1-oxobutan-2-yl)-1-(4-
 fluorobenzyl)-1H-indazole-3-
 carboxamide).
JWH-019 (1-Hexyl-3-(1-                       7019  I
 naphthoyl)indole).
MDMB-FUBINACA (Methyl 2-(1-(4-               7020  I
 fluorobenzyl)-1H-indazole-3-
 carboxamido)-3,3-
 dimethylbutanoate).
2-(1-(4-fluorobenzyl)-1Hinsazole-            7021  I
 3-carboxamido)-3-methylbutanoate.
AB-PINACA (N-(1-amino-3-methyl-1-            7023  I
 oxobutan-2-yl)-1-pentyl-1H-
 indazole-3-carboxamide).
THJ-2201 [1-(5-fluoropentyl)-1H-             7024  I
 indazol-3-yl](naphthalen-1-
 yl)methanone.
5F-AB-PINACA (N-(1-amino-3-methyl-           7025  I
 1-oxobutan-2yl)-1-(5-
 fluoropentyl)-1 H-indazole-3-
 carboxamide).
AB-CHMINACA (N-(1-amino-3-methyl-            7031  I
 1-oxobutan-2-yl)-1-
 (cyclohexylmethyl)-1H-indazole-3-
 carboxamide.
MAB-CHMINACA (N-(1-amino-                    7032  I
 3,3dimethyl-1-oxobutan-2-yl)-1-
 (cyclohexylmethyl)-1H-indazole-3-
 carboxamide).
5F-AMB (Methyl 2-(1-(5-                      7033  I
 fluoropentyl)-1H-indazole-3-
 carboxamido)-3-methylbutanoate).
5F-ADB; 5F-MDMB-PINACA (Methyl 2-            7034  I
 (1-(5-fluoropentyl)-1H-indazole-
 3-carboxamido)-3,3-
 dimethylbutanoate).
ADB-PINACA (N-(1-amino-3,3-                  7035  I
 dimethyl-1-oxobutan-2-yl)-1-
 pentyl-1H-indazole-3-
 carboxamide).
MDMB-CHMICA, MMB-CHMINACA (Methyl            7042  I
 2-(1-(cyclohexylmethyl)-1H-
 indole-3-carboxamido)-3,3-
 dimethylbutanoate).
MMB-CHMICA, AMB-CHMICA (methyl 2-            7044  I
 (1(cyclohexylmethyl)-1 H-indole-
 3-carboxamido)-3methylbutanoate).
APINACA and AKB48 N-(1-Adamantyl)-           7048  I
 1-pentyl-1H-indazole-3-
 carboxamide.
5F-APINACA, 5F-AKB48 (N-                     7049  I
 (adamantan-1-yl)-1-(5-
 fluoropentyl)-1H-indazole-3-
 carboxamide).
JWH-081 (1-Pentyl-3-(1-(4-                   7081  I
 methoxynaphthoyl) indole).
5F-CUMYL-P7AICA (1-(5-                       7085  I
 fluoropentyl)-N-(2phenylpropan-2-
 yl)-1 H-pyrrolo[2,3-b]pyridine-
 3carboxamide).
4-CN-CUMYL-BUTINACA (1-(4-                   7089  I
 cyanobutyl)-N-(2phenylpropan-2-
 yl)-1 H-indazole-3-carboxamide).
SR-19 (Also known as RCS-4) (1-              7104  I
 Pentyl-3-[(4-methoxy)-benzoyl]
 indole.
JWH-018 (also known as AM678) (1-            7118  I
 Pentyl-3-(1-naphthoyl)indole).
JWH-122 (1-Pentyl-3-(4-methyl-1-             7122  I
 naphthoyl) indole).
UR-144 (1-Pentyl-1H-indol-3-                 7144  I
 yl)(2,2,3,3-
 tetramethylcyclopropyl)methanone.
JWH-073 (1-Butyl-3-(1-                       7173  I
 naphthoyl)indole).
JWH-200 (1-[2-(4-                            7200  I
 Morpholinyl)ethyl]-3-(1-
 naphthoyl)indole).
AM2201 (1-(5-Fluoropentyl)-3-(1-             7201  I
 naphthoyl) indole).
JWH-203 (1-Pentyl-3-(2-                      7203  I
 chlorophenylacetyl) indole).
NM2201; CBL2201 (Naphthalen-1-yl             7221  I
 1-(5-fluoropentyl)1 H-indole-3-
 carboxylate).
PB-22 (Quinolin-8-yl 1-pentyl-1H-            7222  I
 indole-3-carboxylate).
5F-PB-22 (Quinolin-8-yl 1-(5-                7225  I
 fluoropentyl)-1H-indole-3-
 carboxylate).
Alpha-ethyltryptamine............            7249  I
Ibogaine.........................            7260  I
CP-47,497 (5-(1,1-Dimethylheptyl)-           7297  I
 2-[(1R,3S)-3-hydroxycyclohexyl-
 phenol).
CP-47,497 C8 Homologue (5-(1,1-              7298  I
 Dimethyloctyl)-2-[(1R,3S)3-
 hydroxycyclohexyl-phenol).
Lysergic acid diethylamide.......            7315  I
2,5-Dimethoxy-4-(n)-                         7348  I
 propylthiophenethylamine (2C-T-
 7).
Marihuana........................            7360  I
Tetrahydrocannabinols............            7370  I
Mescaline........................            7381  I
2-(4-Ethylthio-2,5-                          7385  I
 dimethoxyphenyl) ethanamine (2C-
 T-2 ).
3,4,5-Trimethoxyamphetamine......            7390  I
4-Bromo-2,5-dimethoxyamphetamine.            7391  I
4-Bromo-2,5-                                 7392  I
 dimethoxyphenethylamine.
4-Methyl-2,5-dimethoxyamphetamine            7395  I
2,5-Dimethoxyamphetamine.........            7396  I
JWH-398 (1-Pentyl-3-(4-chloro-1-             7398  I
 naphthoyl) indole).
2,5-Dimethoxy-4-ethylamphetamine.            7399  I
3,4-Methylenedioxyamphetamine....            7400  I
5-Methoxy-3,4-                               7401  I
 methylenedioxyamphetamine.
N-Hydroxy-3,4-                               7402  I
 methylenedioxyamphetamine.
3,4-Methylenedioxy-N-                        7404  I
 ethylamphetamine.
3,4-Methylenedioxymethamphetamine            7405  I
4-Methoxyamphetamine.............            7411  I
5-Methoxy-N-N-dimethyltryptamine.            7431  I
Alpha-methyltryptamine...........            7432  I
Diethyltryptamine................            7434  I
Dimethyltryptamine...............            7435  I

[[Page 60902]]

 
Psilocybin.......................            7437  I
Psilocyn.........................            7438  I
5-Methoxy-N,N-                               7439  I
 diisopropyltryptamine.
N-Ethyl-1-phenylcyclohexylamine..            7455  I
1-(1-Phenylcyclohexyl)pyrrolidine            7458  I
1-[1-(2-                                     7470  I
 Thienyl)cyclohexyl]piperidine.
1-[1-(2-                                     7473  I
 Thienyl)cyclohexyl]pyrrolidine.
N-Benzylpiperazine...............            7493  I
2-(2,5-Dimethoxy-4-methylphenyl)             7508  I
 ethanamine (2C-D).
2-(2,5-Dimethoxy-4-ethylphenyl)              7509  I
 ethanamine (2C-E ).
2-(2,5-Dimethoxyphenyl)                      7517  I
 ethanamine (2C-H).
2-(4-iodo-2,5-dimethoxyphenyl)               7518  I
 ethanamine (2C-I).
2-(4-Chloro-2,5-dimethoxyphenyl)             7519  I
 ethanamine (2C-C).
2-(2,5-Dimethoxy-4-nitro-phenyl)             7521  I
 ethanamine (2C-N).
2-(2,5-Dimethoxy-4-(n)-                      7524  I
 propylphenyl) ethanamine (2C-P).
2-(4-Isopropylthio)-2,5-                     7532  I
 dimethoxyphenyl) ethanamine (2C-
 T-4 ).
MDPV (3,4-                                   7535  I
 Methylenedioxypyrovalerone).
2-(4-bromo-2,5-dimethoxyphenyl)-N-           7536  I
 (2-methoxybenzyl) ethanamine
 (25B-NBOMe).
2-(4-chloro-2,5-dimethoxyphenyl)-            7537  I
 N-(2-methoxybenzyl) ethanamine
 (25C-NBOMe).
2-(4-iodo-2,5-dimethoxyphenyl)-N-            7538  I
 (2-methoxybenzyl) ethanamine
 (25I-NBOMe).
Methylone (3,4-Methylenedioxy-N-             7540  I
 methylcathinone).
Butylone.........................            7541  I
Pentylone........................            7542  I
alpha-pyrrolidinopentiophenone               7545  I
 ([alpha]-PVP).
alpha-pyrrolidinobutiophenone                7546  I
 ([alpha]-PBP).
AM-694 (1-(5-Fluoropentyl)-3-(2-             7694  I
 iodobenzoyl) indole).
Acetyldihydrocodeine.............            9051  I
Benzylmorphine...................            9052  I
Codeine-N-oxide..................            9053  I
Desomorphine.....................            9055  I
Etorphine (except HCl)...........            9056  I
Codeine methylbromide............            9070  I
Dihydromorphine..................            9145  I
Heroin...........................            9200  I
Morphine-N-oxide.................            9307  I
Normorphine......................            9313  I
U-47700 (3,4-dichloro-N-[2-                  9547  I
 (dimethylamino)cyclohexyl]-N-
 methylbenzamide).
MT-45 (1-cyclohexyl-4-(1,2-                  9560  I
 diphenylethyl)piperazine)).
Tilidine.........................            9750  I
Acryl fentanyl (N-(1-                        9811  I
 phenethylpiperidin-4-yl)-N-
 phenylacrylamide).
Para-Fluorofentanyl..............            9812  I
3-Methylfentanyl.................            9813  I
Alpha-methylfentanyl.............            9814  I
Acetyl-alpha-methylfentanyl......            9815  I
N-(2-fluorophenyl)-N-(1-                     9816  I
 phenethylpiperidin-4-
 yl)propionamide.
Acetyl Fentanyl (N-(1-                       9821  I
 phenethylpiperidin-4-yl)-N-
 phenylacetamide).
Butyryl Fentanyl.................            9822  I
Para-fluorobutyryl fentanyl......            9823  I
4-Fluoroisobutyryl fentanyl (N-(4-           9824  I
 fluorophenyl)-N-(1-
 phenethylpiperidin-4-
 yl)isobutyramide).
2-methoxy-N-(1-phenethylpiperidin-           9825  I
 4-yl)-N-phenylacetamide.
Para-chloroisobutyryl fentanyl...            9826  I
Isobutyryl fentanyl..............            9827  I
Beta-hydroxyfentanyl.............            9830  I
Beta-hydroxy-3-methylfentanyl....            9831  I
Alpha-methylthiofentanyl.........            9832  I
3-Methylthiofentanyl.............            9833  I
Furanyl fentanyl (N-(1-                      9834  I
 phenethylpiperidin-4-yl)-N-
 phenylfuran-2-carboxamide).
Thiofentanyl.....................            9835  I
Beta-hydroxythiofentanyl.........            9836  I
Para-methoxybutyryl fentanyl.....            9837  I
Ocfentanil.......................            9838  I
Valeryl fentanyl.................            9840  I
N-(1-phenethylpiperidin-4-yl)-N-             9843  I
 phenyltetrahydrofuran-2-
 carboxamide.
Cyclopropyl Fentanyl.............            9845  I
Cyclopentyl fentanyl.............            9847  I
Fentanyl related-compounds as                9850  I
 defined in 21 CFR 1308.11&h).
Amphetamine......................            1100  II
Methamphetamine..................            1105  II
Lisdexamfetamine.................            1205  II
Phenmetrazine....................            1631  II
Methylphenidate..................            1724  II
Amobarbital......................            2125  II
Pentobarbital....................            2270  II
Secobarbital.....................            2315  II

[[Page 60903]]

 
Phencyclidine....................            7471  II
4-Anilino-N-phenethyl-4-                     8333  II
 piperidine (ANPP).
Phenylacetone....................            8501  II
1-                                           8603  II
 Piperidinocyclohexanecarbonitril
 e.
Cocaine..........................            9041  II
Codeine..........................            9050  II
Etorphine HCl....................            9059  II
Dihydrocodeine...................            9120  II
Oxycodone........................            9143  II
Hydromorphone....................            9150  II
Ecgonine.........................            9180  II
Ethylmorphine....................            9190  II
Hydrocodone......................            9193  II
Levomethorphan...................            9210  II
Levorphanol......................            9220  II
Isomethadone.....................            9226  II
Meperidine.......................            9230  II
Meperidine intermediate-B........            9233  II
Methadone........................            9250  II
Dextropropoxyphene, bulk (non-               9273  II
 dosage forms).
Morphine.........................            9300  II
Thebaine.........................            9333  II
Oxymorphone......................            9652  II
Thiafentanil.....................            9729  II
Alfentanil.......................            9737  II
Remifentanil.....................            9739  II
Sufentanil.......................            9740  II
Carfentanil......................            9743  II
Tapentadol.......................            9780  II
Fentanyl.........................            9801  II
------------------------------------------------------------------------

    The company plans to bulk manufacture the listed controlled 
substances to produce forensic and research analytical reference 
standards for distribution to its customers.

    Dated: November 16, 2018.
John J. Martin,
Assistant Administrator.
[FR Doc. 2018-25865 Filed 11-26-18; 8:45 am]
 BILLING CODE 4410-09-P