[Federal Register Volume 81, Number 37 (Thursday, February 25, 2016)]
[Notices]
[Page 9491]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2016-03990]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Government-Owned Inventions; Availability for Licensing

AGENCY: National Institutes of Health, HHS.

ACTION: Notice.

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SUMMARY: The inventions listed below are owned by an agency of the U.S. 
Government and are available for licensing in the U.S. in accordance 
with 35 U.S.C. 209 and 37 CFR part 404 to achieve expeditious 
commercialization of results of federally-funded research and 
development.

FOR FURTHER INFORMATION CONTACT: Licensing information may be obtained 
by emailing the indicated licensing contact at the National Heart, 
Lung, and Blood, Office of Technology Transfer and Development Office 
of Technology Transfer, 31 Center Drive Room 4A29, MSC2479, Bethesda, 
MD 20892-2479; telephone: 301-402-5579. A signed Confidential 
Disclosure Agreement may be required to receive any unpublished 
information.

SUPPLEMENTARY INFORMATION: Technology description follows.

Software for Fully Automating Myocardial Perfusion Quantification 
Description of Technology

    Software is has been developed and available for licensing that 
fully automates image processing for the quantification of myocardial 
blood flow (MBF) pixel maps from first-pass contrast-enhanced cardiac 
magnetic resonance (CMR) perfusion images. The system removes the need 
for laborious manual quantitative CMR perfusion pixel map processing 
and can process prospective and retrospective studies acquired from 
various imaging protocols. In full automation, arterial input function 
(AIF) images are processed for motion correction and myocardial 
perfusion images are corrected for intensity bias. The corrected AIF 
images are processed for left ventricle signal detection and the 
corrected myocardial perfusion images and processed for myocardial 
signal detection. Both data sets are then corrected for nonlinear 
signaling, synchronized, and pixel-wise deconvolution processed. The 
resulting pixel map shows accurate myocardial blood flow.
    Potential Commercial Applications:

 MRI Imaging of the myocardium
 Blood Perfusion Imaging
    Development Stage:
 In vivo data
 Software system
 Source code.

    Inventors: Li-Yueh Hsu, Matthew Jacobs, Mitchel Benovoy, Andrew 
Arai (NHLBI)
    Intellectual Property: HHS Reference No. E-097-2016/0--Software 
Materials.
    Licensing Contact: Michael Shmilovich, Esq, CLP; 301-435-5019; 
[email protected].

    Dated: January 15, 2016.
Michael Shmilovich,
Senior Licensing and Patenting Manager, National Heart, Lung, and Blood 
Institute, Office of Technology Transfer and Development.
[FR Doc. 2016-03990 Filed 2-24-16; 8:45 am]
 BILLING CODE 4140-01-P