[Federal Register Volume 80, Number 194 (Wednesday, October 7, 2015)]
[Notices]
[Pages 60692-60693]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2015-25434]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Nominations to the Report on Carcinogens and Office of Health 
Assessment and Translation; Request for Information

SUMMARY: National Toxicology Program (NTP) Office of the Report on 
Carcinogens (ORoC) and Office of Health Assessment and Translation 
(OHAT) request information on nine substances, mixtures, and exposure 
circumstances (collectively referred to as ``substances''). Six 
substances are nominated for possible review for future editions of the 
Report on Carcinogens (RoC). Three substances are being considered by 
OHAT for evaluation of non-cancer health outcomes.

DATES: Deadline for receipt of information is November 6, 2015.

ADDRESSES: Information on substances for possible review for the RoC 
should be submitted electronically on the ORoC nominated substances 
page (http://ntp.niehs.nih.gov/go/rocnom) or to [email protected]. 
Information on OHAT nominations can be submitted electronically on the 
OHAT nominated topics page (http://ntp.niehs.nih.gov/go/763346) or to 
[email protected].

[[Page 60693]]


FOR FURTHER INFORMATION CONTACT: RoC Nominations: Dr. Ruth Lunn, 
Director, ORoC; telephone (919) 316-4637; [email protected]. OHAT 
Nominations: Dr. Kristina Thayer, Director, OHAT, telephone (919) 541-
5021; [email protected]. Address for Dr. Lunn and Dr. Thayer: DNTP, 
NIEHS, 111 T.W. Alexander Drive, P.O. Box 12233, Research Triangle 
Park, NC 27709.

SUPPLEMENTARY INFORMATION: Request for Information: The NTP requests 
information on nine substances: Six substances have been nominated for 
possible review for future editions of the RoC (see http://ntp.niehs.nih.gov/go/rocnom) and three are under consideration by OHAT 
for evaluation of non-cancer health outcomes. (see http://ntp.niehs.nih.gov/go/763346). Specifically, NTP requests information on 
each substance regarding: (1) Data on current production, use patterns, 
and human exposure; (2) published, ongoing, or planned studies related 
to evaluating adverse health outcomes (e.g., cancer, development, 
reproductive, or immunological disorders); (3) scientific issues 
important for prioritizing and assessing adverse health outcomes; and 
(4) names of scientists with expertise or knowledge about the 
substance--please include any bibliographic citations when available. 
NTP will use this information in determining which substances to 
propose for formal health hazard evaluations.

Six Substances Nominated for Possible Review for the RoC *

Flame Retardants

 Pentabromodiphenyl ether mixture (DE-71)
 Tetrabromobisphenol A, CASRN 79-94-7

Water Disinfection Byproducts

 Dibromoacetonitrile, CASRN 3252-43-5
 Di- and tri-haloacetic acids (as a class); specifically, those 
haloacetic acids with similar functional or structural properties that 
may cause similar health hazards

Other

 Fluoride, CASRN 7681-49-4
 Vinylidene chloride, CASRN 5-35-4

    * Evaluations for the RoC may seek to list a new substance in the 
report, reclassify the listing status of a substance already listed, or 
remove a listed substance.

    Three substances are being considered for OHAT evaluation of non-
cancer health outcomes.

 Mountaintop removal mining (health impacts on surrounding 
communities)
 Neonicotinoid pesticides
 Fluoride (developmental neurotoxicity and endocrine 
disruption)

    Information on RoC nominations should be submitted electronically 
on the ORoC nomination page (http://ntp.niehs.nih.gov/go/rocnom) or by 
email to [email protected]. Information on OHAT nominations should be 
submitted electronically on the OHAT nominated topics page (http://ntp.niehs.nih.gov/go/763346) or to [email protected]. Public 
comments should include the submitter's name, affiliation, sponsoring 
organization (if any) along with appropriate contact information 
(telephone and email). Written information received in response to this 
notice will be posted on the NTP Web site, and the submitter identified 
by name, affiliation, and/or sponsoring organization.
    Responses to this request for information are voluntary. This 
request for information is for planning purposes only and is not a 
solicitation for applications or an obligation on the part of the U.S. 
Government to provide support for any ideas identified in response to 
it. Please note that the U.S. Government will not pay for the 
preparation of any information submitted or for its use. No 
proprietary, classified, confidential, or sensitive information should 
be included in your response.
    Background Information on ORoC: On behalf of NTP, ORoC manages 
preparation of the RoC following an established, four-part process 
(http://ntp.niehs.nih.gov/go/rocprocess). The RoC is a congressionally 
mandated, science-based, public health report that identifies agents, 
substances, mixtures, or exposures (collectively called ``substances'') 
in our environment that pose a cancer hazard for people in the United 
States. Published biennially, each edition of the RoC is cumulative and 
consists of substances newly reviewed in addition to those listed in 
previous editions. Newly reviewed substances with their recommended 
listing are reviewed and approved by the Secretary of Health and Human 
Services. The 13th RoC, the latest edition, was published on October 2, 
2014 (available at http://ntp.niehs.nih.gov/go/roc13). The 14th RoC is 
under development.
    Background Information on OHAT: On behalf of NTP, OHAT conducts 
literature-based evaluations to assess the evidence that environmental 
chemicals, physical substances, or mixtures (collectively referred to 
as ``substances'') cause adverse non-cancer health outcomes. As part of 
these evaluations, NTP may also provide opinions on whether these 
substances might be of concern for causing adverse effects on human 
health given what is known about toxicity and current human exposure 
levels.

    Dated: October 1, 2015.
John R. Bucher,
Associate Director, National Toxicology Program.
[FR Doc. 2015-25434 Filed 10-6-15; 8:45 am]
 BILLING CODE 4140-01-P