[Federal Register Volume 79, Number 190 (Wednesday, October 1, 2014)]
[Notices]
[Pages 59277-59278]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2014-23345]



[[Page 59277]]

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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Government-Owned Inventions; Availability for Licensing

AGENCY: National Institutes of Health, HHS.

ACTION: Notice.

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SUMMARY: The inventions listed below are owned by an agency of the U.S. 
Government and are available for licensing in the U.S. in accordance 
with 35 U.S.C. 209 and 37 CFR Part 404 to achieve expeditious 
commercialization of results of federally-funded research and 
development. Foreign patent applications are filed on selected 
inventions to extend market coverage for companies and may also be 
available for licensing.

FOR FURTHER INFORMATION CONTACT: Licensing information and copies of 
the U.S. patent applications listed below may be obtained by writing to 
the indicated licensing contact at the Office of Technology Transfer, 
National Institutes of Health, 6011 Executive Boulevard, Suite 325, 
Rockville, Maryland 20852-3804; telephone: 301-496-7057; fax: 301-402-
0220. A signed Confidential Disclosure Agreement will be required to 
receive copies of the patent applications.

SUPPLEMENTARY INFORMATION: Technology descriptions follow.

Device and System for Enhancing Cardiopulmonary Resuscitation

    Description of Technology: The invention pertains to devices and 
systems for externally compressing or collapsing peripheral vasculature 
during Cardiopulmonary Resuscitation (CPR) to redirect blood to the 
torso and head regions, thereby enhancing the likelihood of CPR 
success. The system includes a plurality of sleeves adapted for 
placement on a patient's limbs during CPR, each sleeve including at 
least one inflatable fluid chamber and at least one inflation source 
fluidly coupled to each of the inflatable fluid chambers of the 
sleeves. The sleeve chambers can be inflated to a desired compression 
pressure and maintained at the desired compression pressure 
continuously throughout CPR to prevent or restrict blood flow in the 
limbs. The desired compression pressure can be sufficient to redirect 
substantial blood volume from the patient's limbs to the patient's 
torso and head regions during CPR.
    Potential Commercial Applications:
     Cardiopulmonary resuscitation.
     Peripheral blood occlusion.
    Competitive Advantages: Improves CPR outcomes--
     Can be used with or independent of automated CPR devices 
and pharamacotherapies.
     Can be utilized in a public setting by a lay person.
     Extent and duration of vascular occlusion can be 
specifically prescribed.
     May be used to alter preload.
     May increase pulse wave velocity and/or wave reflection 
magnitude resulting in increased pulse and/or perfusion pressures.
    Development Stage:
     Early-stage
     Prototype
    Inventor: Matthew T. Oberdier (NIA).
    Intellectual Property: HHS Reference No. E-224-2014/0--US 
Provisional Application No. 62/042,588 filed 27 Aug 2014.
    Licensing Contact: Michael Shmilovich, Esq., CLP; 301-435-5019; 
[email protected].
    Collaborative Research Opportunity: The National Institute on Aging 
is seeking statements of capability or interest from parties interested 
in collaborative research to further develop, evaluate or commercialize 
this technology. For collaboration opportunities, please contact Vio 
Conley, M.S. at [email protected] or 240-276-5531.

A Current Amplifier for Local Coil Pre-amplification of NMR/MRI Signals

    Description of Technology: The magnetic resonance imaging (MRI) 
systems are used for a variety of imaging application. The present 
invention discloses an improving MRI device and method by amplifying 
signals received by resonant NMR coils of MRI systems. It utilizes 
positive feedback from low-noise Field-Effect Transistor to amplify the 
signal current that can be coupled out to receiving loops positioned 
externally without loss in sensitivity. Therefore, the NMR coil can be 
flexibly positioned near internal tissues and used to develop high-
resolution images in highly invasive situations. The disclosed device 
can be developed in kit form as integrated modules that are designed to 
be added to tuned NMR receiver coils and tailored to deliver specific 
gains at NMR frequencies.
    Potential Commercial Applications:
     Medical and scientific research.
     Device for diagnostic.
    Competitive Advantages:
     Sensitivity.
     Easy to be integrated into the existed device.
    Development Stage:
     In vitro data available.
     In vivo data available (animal).
    Inventors: Joseph A. Murphy-Boesch, Stephen J. Dodd, Alan P. 
Koretsky, Chunqi Qian (all of NINDS).
    Publications:
    1. Qian C, et al. Wireless amplified nuclear MR detector (WAND) for 
high-spatial-resolution MR imaging of internal organs: preclinical 
demonstration in a rodent model. Radiology. 2013 Jul;268(1):228-36. 
[PMID 23392428]
    2. Qian C, et al. Sensitivity enhancement of remotely coupled NMR 
detectors using wirelessly powered parametric amplification. Magn Reson 
Med. 2012 Sep;68(3):989-96. [PMID 22246567]
    3. Mueller OM, et al. Preamplifier circuit for magnetic resonance 
system. US Patent 5,545,999 (1996).
    4. Ratzel D. Low-noise preamplifier, in particular, for nuclear 
magnetic resonance (NMR). US Patent 7,123,090 (2006).
    Intellectual Property: HHS Reference No. E-122-2014/0--US Patent 
Application No. 61/989,795 filed 07 May 2014.
    Licensing Contact: John Stansberry, Ph.D.; 301-435-5236; 
[email protected].
    Collaborative Research Opportunity: The National Institute of 
Neurological Disorders and Stroke, Laboratory for Functional and 
Molecular Imaging, is seeking statements of capability or interest from 
parties interested in collaborative research to further develop, 
evaluate or commercialize a surgically implantable NMR detector, 
battery powered, for imaging of the pituitary. For collaboration 
opportunities, please contact Joseph Murphy-Boesch at 
[email protected].

Inhibition of HIV Infection Through Chemoprophylaxis Using 
Emtricitabine and Tenofovir

    Description of Technology: The invention is directed to 
prophylactic administration of emtricitabine (FTC) in combination with 
tenofovir or its prodrug, tenofovir disoproxil fumarate (TDF), to 
protect against transmission of human immunodeficiency virus (HIV) 
infection. Also disclosed are other nucleoside reverse transcriptase 
inhibitors (NRTIs) and nucleotide reverse transcriptase inhibitors 
(NtRTIs) that, when administered in combination, protect against HIV 
infection. CDC researchers demonstrated that daily pre-exposure 
prophylaxis (PrEP) with a combination of antiretroviral NRTI and NtTRI 
drugs, including FTC and TDF, significantly

[[Page 59278]]

increases the level of protection against HIV transmission.
    Potential Commercial Applications: Oral, prophylactic delivery of 
combination drugs to inhibit HIV infection.
    Development Stage:
     In vivo data available (animal).
     In vivo data available (human).
    Inventors: Walid Heneine, Thomas Folks, Robert Janssen, Ronald 
Otten, J. Gerardo Garcia-Lerma (all of CDC).
    Publications:
    1. Garcia-Lerma J, et al. Prevention of rectal SHIV transmission in 
macaques by daily or intermittent prophylaxis with emtricitabine and 
tenofovir. PLoS Med. 2008 Feb;5(2):e28. [PMID 18254653]
    2. Garcia-Lerma J, et al. Intermittent prophylaxis with oral 
truvada protects macaques from rectal SHIV infection. Sci Transl Med. 
2010 Jan 13;2(14):14ra4. [PMID 20371467]
    Intellectual Property: HHS Reference No. E-195-2013/0--
     US Provisional Application No. 60/764,811 filed 3 Feb 
2006.
     US Patent Application No. 11/669,547 filed 31 Jan 2007.
     PCT Application No. PCT/US2007/002926 filed 01 Feb 2007.
     European Patent No. 2015753 issued 01 May 2013.
     German Patent No. 2015753 issued 01 May 2013.
     French Patent No. 2015753 issued 01 May 2013.
     U.K. Patent No. 2015753 issued 01 May 2013.
     Australian Patent No. 2007212583 issued 25 Mar 2013.
     Canadian Patent Application No. 2641388 filed 01 Aug 2008.
     Indian Patent Application No. 7408/DELNP/2008 filed 01 Jul 
2008.
    Licensing Contact: Tara L. Kirby, Ph.D.; 301-435-4426; 
[email protected].

Synthetic Peptides With Antimicrobial Activity

    Description of Technology: This technology relates to a class of 
synthetic peptides with antimicrobial activity. The lead candidate 
identified among this class is EC5. The EC5 peptide has shown efficient 
binding and selective bactericidal activity against E. coli and P. 
aeruginosa, while having little activity against S. aureus, S. 
epidermidis, B. cereus, and K. pneumonia. EC5 shows inhibitory activity 
at low concentrations (MIC 8 [micro]g/ml for E. coli and 8-32 [micro]g/
ml for P. aeruginosa) and appears to bind to, disrupt, and permeabilize 
the bacterial cell membranes in a manner similar to Polymyxin B. EC5 
also appears to retain its bactericidal activity in the presence of 
platelets and plasma, while exhibiting little cytotoxic activity or 
hemolytic activity against red blood cells, in vitro. EC5's profile of 
activity and low toxicity suggest it may be a favorable candidate for 
drug development, as an independent or combination therapy and for 
specific bacterial detection/diagnostics. With the increasing 
prevalence of drug resistant bacterial infections, there is a need to 
develop novel antimicrobial agents that are specific, safe, and 
effective.
    Potential Commercial Applications: Antimicrobial therapy.
    Competitive Advantages:
     Significant and specific bactericidal activity.
     Promising in vitro safety profile.
    Development Stage:
     Early-state.
     In vitro data available.
    Inventors: Chintamani Atreya (FDA), Ketha Mohan (FDA), Shilpakala 
Sainath Rao (ORISE Contract Fellow).
    Publication: Sainath Rao S, et al. A peptide derived from phage 
display library exhibits antibacterial activity against E. coli and 
Pseudomonas aeruginosa. PLoS ONE 8(2): e56081. [PMID 23409125]
    Intellectual Property: HHS Reference No. E-226-2012/0--PCT 
Application PCT/US2012/050969 filed 15 Aug 2012.
    Licensing Contact: Edward (Tedd) Fenn; 424-297-0336; 
[email protected].
    Collaborative Research Opportunity: The Food and Drug 
Administration, Center for Biologics Evaluation and Research, is 
seeking statements of capability or interest from parties interested in 
collaborative research to further develop, evaluate or commercialize 
drug development, as an independent or combination therapy and for 
bacterial diagnostics. For collaboration opportunities, please contact 
Nisha Narayan at 240-402-9770.

    Dated: September 27, 2014.
Richard U. Rodriguez,
Director, Division of Technology Development and Transfer, Office of 
Technology Transfer, National Institutes of Health.
[FR Doc. 2014-23345 Filed 9-30-14; 8:45 am]
BILLING CODE 4140-01-P