[Federal Register Volume 79, Number 131 (Wednesday, July 9, 2014)]
[Notices]
[Pages 38922-38923]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2014-16029]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Government-Owned Inventions; Availability for Licensing

AGENCY: National Institutes of Health, HHS.

ACTION: Notice.

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SUMMARY: The inventions listed below are owned by an agency of the U.S. 
Government and are available for licensing in the U.S. in accordance 
with 35 U.S.C. 209 and 37 CFR Part 404 to achieve expeditious 
commercialization of results of federally-funded research and 
development. Foreign patent applications are filed on selected 
inventions to extend market coverage for companies and may also be 
available for licensing.

FOR FURTHER INFORMATION CONTACT: Licensing information and copies of 
the U.S. patent applications listed below may be obtained by writing to 
the indicated licensing contact at the Office of Technology Transfer, 
National Institutes of Health, 6011 Executive Boulevard, Suite 325, 
Rockville, Maryland 20852-3804; telephone: 301-496-7057; fax: 301-402-
0220. A signed Confidential Disclosure Agreement will

[[Page 38923]]

be required to receive copies of the patent applications.

SUPPLEMENTARY INFORMATION: Technology descriptions follow.

Interactive Clinical Protocol Services Software

    Description of Technology: The invention pertains to a C/C++ and C 
sharp application toolkit named (Interactive Protocol Services) iPS 
that loads into the Allscripts HealthCare System as a Dynamic Link 
Library (DLL). The application provides users with a GUI that opens 
into a window of one of the SCM's tabs. The toolkit could be rendered 
compatible with any off-the-shelf healthcare system that allows loading 
library files. The toolkit provides healthcare professionals with a 
custom structure language to be used in designing customized layouts 
and accessing data sources within the patient care. This custom 
structure language is provided to iPS during the COTS (e.g., SCM) 
application startup process or during an interface communication 
transaction. Usually, the custom structured language or design layout 
is stored in the COTS application database system and is retrieved 
during the startup process of iPS. The custom structure language 
instructs iPS in how to build and manipulate defined User Control 
Widgets through properties. These defined User Control Widgets are 
created in object pairs. These object pairs can be accessible through 
the iPS application/DLL. iPS also contains a nested list of layout 
controls that place the User Control Widgets at certain coordinates on 
the display screen. Each User Control Widget contains code events that 
allow it to respond to user-defined events, actions, web commands and 
SQL procedure calls.
    Potential Commercial Applications:
     COTS healthcare system.
     Medical/hospital information systems.
    Competitive Advantages:
     Customized views.
     Integrates into exiting management tool libraries.
    Development Stage:
     Early-stage.
     Prototype.
    Inventor: Steven D. Moore (NIH-CC).
    Intellectual Property: HHS Reference No. E-172-2014/0--Software. 
Patent protection is not being pursued for this technology.
    Licensing Contact: Michael Shmilovich, Esq., CLP; 301-435-5019; 
[email protected].
    Collaborative Research Opportunity: The NIH Clinical Center is 
seeking statements of capability or interest from parties interested in 
collaborative research to further develop, evaluate or commercialize 
Interactive Clinical Protocol Services Software. For collaboration 
opportunities, please contact Eric Cole at [email protected] or 301-451-
4430.

Non-Contact Total Emission Detection Methods for Multiphoton 
Microscopy: Improved Image Fidelity and Biological Sample Analysis

    Description of Technology: The technology offered for licensing and 
for further development is in the field of multiphoton microscopy 
(MPM). More specifically, the invention pertains to optical designs 
that can enhance and extend the capabilities of MPM in spectral imaging 
of biological samples. The unique design of the light collection and 
the detection optics maximizes the collection of emitted light, thus 
increasing the signal and hence the signal-to-noise ratio (SNR). 
Improvement in image fidelity will result in improved analysis of 
biological samples and thus will favorably impact medical research and 
possibly clinical diagnosis. The present technology is a further 
improvement on the TED (Total Emission Detection) technology, first 
disclosed by Dr. Robert Balaban et al. at the NIH in 2006 and claimed 
in US Patent 7,667,210 (issued February 23, 2010). The earlier NIH TED 
technology proposed an optical design based on enveloping the entirety 
of a small sample in a parabolic mirror/condenser combination so light 
emanated by a sample in all directions is redirected to the detector. 
The present technology further expands the capabilities of TED as its 
unique design employing parabolic, toric and conic mirrors ensures 
maximum light collection from large samples in cases where there is 
only access to one side of the tissues (e.g., in vivo or ex vivo). This 
is accomplished by the redirection of all attainable light (i.e., light 
escaping the tissue or a whole animal in the epi and sideway 
directions) to the detector.
    Potential Commercial Applications:
     Tissue and cell analysis in biomedical research.
     Potential applications in clinical diagnostics.
    Competitive Advantages:
     Increased signal-to-noise ratio.
     Enhanced image resolution due to SNR.
     Improved analytical capabilities.
     Non-contact.
     May readily be adaptable to commercial microscopes.
    Development Stage:
     In vitro data available.
     Prototype.
    Inventors: Jay R. Knutson, Christian A. Combs, Robert S. Balaban 
(all of NHLBI).
    Publications:

1. Combs CA, et al. Optimization of multiphoton excitation 
microscopy by total emission detection using a parabolic light 
reflector. J Microsc. 2007 Dec;228(Pt3):330-7. [PMID 18045327]
2. Combs CA, et al. Compact non-contact total emission detection for 
in vivo multiphoton excitation microscopy. J Microsc. 2014 
Feb;253(2):83-92. [PMID 24251437]
3. Combs CA, et al. Optimizing multiphoton fluorescence microscopy 
light collection from living tissue by noncontact total emission 
detection (epiTED). J Microsc. 2011 Feb;241(2):153-61. [PMID 
21118209]

    Intellectual Property: HHS Reference No. E-236-2009/0--
     US Provisional Patent Application 61/224,772 filed July 
10, 2009.
     US Patent 8,759,792 issued June 24, 2014.
     European Patent Application 10797972.6 filed July 12, 
2010.
    Related Technology: HHS Reference No. E-257-2005/0--US Patent 
7,667,210 issued February 23, 2010.
    Licensing Contact: Michael Shmilovich, Esq., CLP; 301-435-5019; 
[email protected].
    Collaborative Research Opportunity: The NHLBI Laboratory of 
Molecular Biophysics is seeking statements of capability or interest 
from parties interested in collaborative research to further develop, 
evaluate, or commercialize an enhanced method of multiphoton microscopy 
that is suitable for the spectral imaging of biological samples. Please 
contact Brian W. Bailey, Ph.D. at [email protected] for more 
information.

    Dated: July 7, 2014.
Richard U. Rodriguez,
Director, Division of Technology Development and Transfer, Office of 
Technology Transfer, National Institutes of Health.
[FR Doc. 2014-16029 Filed 7-8-14; 8:45 am]
BILLING CODE 4140-01-P