[Federal Register Volume 79, Number 122 (Wednesday, June 25, 2014)]
[Notices]
[Pages 36078-36079]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2014-14740]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Office of Health Assessment and Translation Webinar on Lessons 
Learned in Application of the OHAT Framework for Systematic Review and 
Evidence Integration to Case Studies; Notice of Public Webinar and 
Registration Information

SUMMARY: The National Toxicology Program (NTP) announces a public 
webinar, ``Lessons Learned in Application of the Office of Health 
Assessment and Translation (OHAT) Framework for Systematic Review and

[[Page 36079]]

Evidence Integration to Case Studies.'' The OHAT, Division of the 
National Toxicology Program (DNTP), National Institute of Environmental 
Health Sciences (NIEHS) will host the web-based meeting and the public 
can register to participate at http://ntp.niehs.nih.gov/go/41629.

DATES: 
    Webinar: July 31, 2014, 12:30 p.m. to approximately 3:30 p.m. 
Eastern Daylight Time (EDT).
    Registration for Webinar: June 17, 2014 through July 28, 2014.

ADDRESSES: Webinar Web page: http://ntp.niehs.nih.gov/go/41629.

FOR FURTHER INFORMATION CONTACT: Dr. Andrew Rooney, Deputy Director, 
OHAT, Division of NTP, NIEHS, P.O. Box 12233, K2-04, Research Triangle 
Park, NC 27709. Phone: 919-541-2999, Fax: 301-480-3299, Email: 
[email protected]. Hand Delivery/Courier: 530 Davis Drive, Room 
K2154, Morrisville, NC 27560.

SUPPLEMENTARY INFORMATION: 
    Background: The OHAT has developed a systematic review framework, 
the OHAT Approach, to address environmental health questions by 
extending approaches developed for clinical medicine to address the 
greater range of data relevant to environmental health sciences (e.g., 
human, animal, and mechanistic studies) (available at http://ntp.niehs.nih.gov/go/38673). The OHAT adapted guidance from authorities 
on systematic review and sought advice during development of the OHAT 
Approach through consultation with technical experts in systematic 
review and human health assessment as well as scientific advisory 
groups and the public.
    The approach includes seven steps that provide a framework for 
incorporating systematic review and evidence integration into NTP 
literature-based, non-cancer health assessments. The framework, 
released as the Draft OHAT Approach in February 2013 and published in 
April 2014 (http://ehp.niehs.nih.gov/1307972/), was assessed and 
refined through application of the procedures to case-study 
evaluations. The OHAT applied the approach to two case studies: (1) An 
evaluation of the association of bisphenol A (BPA) exposure with 
obesity and (2) an evaluation of the association of perflurooctanoic 
acid (PFOA) or perfluorooctane sulfonate (PFOS) exposure with 
immunotoxicity.
    The purpose of this webinar is to present lessons learned during 
the case-study process. The meeting will be conducted in a presentation 
and discussion format. The first part of the webinar will consist of a 
series of topic or ``lesson'' focused presentations, followed by a 
short question-and-answer period. The second part of the webinar will 
be a general discussion period when the public can make brief comments 
on or ask questions about the application of the OHAT Approach to the 
case studies and lessons learned.
    Webinar and Registration: The webinar is scheduled for July 31, 
2014, 12:30 p.m. to 3:30 p.m. EDT and may end early if discussions are 
finished. Registration for the webinar is required and is open from 
June 17, 2014, through July 28, 2014, at http://ntp.niehs.nih.gov/go/41629. Registrants will receive instructions by email on accessing the 
webinar on or before July 28, 2014. Registrants are encouraged to 
access the Web site to stay abreast of current information about this 
event.
    Public Participation: As noted above, the meeting format includes 
time after each lesson-presentation and during the general discussion 
session for the public to ask questions or make brief remarks. 
Individuals with disabilities who need accommodations to participate in 
this event should contact Dr. Andrew Rooney (See FOR FURTHER 
INFORMATION CONTACT). TTY users should contact the Federal TTY Relay 
Service at (800) 877-8330. Requests should be made at least 5 business 
days in advance of the web-based meeting.
    Background Information on OHAT: The OHAT was established to serve 
as an environmental health resource to the public and regulatory and 
health agencies (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094430). 
This office conducts evaluations to assess the evidence that 
environmental chemicals, physical substances, or mixtures (collectively 
referred to as ``substances'') cause adverse health effects and 
provides opinions on whether these substances may be of concern given 
what is known about current human exposure levels. The OHAT also 
organizes workshops or state-of-the-science evaluations to address 
issues of importance in environmental health sciences. The OHAT 
assessments are published as NTP Monographs. Information about the OHAT 
is found at http://ntp.niehs.nih.gov/go/ohat.

    Dated: June 17, 2014.
John R. Bucher,
Associate Director, National Toxicology Program.
[FR Doc. 2014-14740 Filed 6-24-14; 8:45 am]
BILLING CODE 4140-01-P