[Federal Register Volume 79, Number 122 (Wednesday, June 25, 2014)]
[Notices]
[Pages 36079-36080]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2014-14738]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Adverse Outcome Pathways: From Research to Regulation Workshop; 
Notice of Public Meeting and Registration Information

SUMMARY: The National Toxicology Program (NTP) Interagency Center for 
the Evaluation of Alternative Toxicological Methods (NICEATM) announces 
a workshop on ``Adverse Outcome Pathways: From Research to 
Regulation.'' The workshop proposes to initiate stakeholder interaction 
and collaboration to enhance scientific development of the Adverse 
Outcome Pathway (AOP) concept with the goal of improving regulatory 
assessment of chemical toxicity. Registration is requested for 
attendance and required to access the webcast. Information about the 
meeting and registration is available at http://ntp.niehs.nih.gov/go/41374.

DATES: 
    Meeting: September 3-5, 2014, from 8:30 a.m. to approximately 5:30 
p.m. Eastern Daylight Time (EDT) on September 3 and 4 and from 9:00 
a.m. to approximately 4:00 p.m. EDT on September 5. A poster session 
will be held on September 4 from 6:30 p.m. to 8:30 p.m.
    Meeting Registration: Registration is open through August 15, 2014. 
Registration to view the plenary sessions of the workshop via webcast 
is required.

ADDRESSES: 
    Meeting Location: William H. Natcher Conference Center, National 
Institutes of Health, Bethesda, Maryland 20892.
    Meeting Web page: The preliminary agenda, registration, and other 
meeting materials are at http://ntp.niehs.nih.gov/go/41374.

FOR FURTHER INFORMATION CONTACT: Dr. Warren S. Casey, Director, 
NICEATM; email: [email protected]; telephone: (919) 316-4729.

SUPPLEMENTARY INFORMATION: 
    Background: Traditional toxicology test methods expose multiple 
animals to test substances and observe adverse outcomes; these methods 
may not efficiently serve future scientific and regulatory needs. To 
improve the regulatory assessment of chemical toxicity, NICEATM is 
evaluating the use of AOPs, a conceptual framework relating toxic 
exposures to illness or injury in an individual or a population through 
specific molecular and cellular changes.
    Through plenary presentations, case studies, and breakout sessions, 
the

[[Page 36080]]

workshop will engage stakeholders in how the scientific development of 
AOPs could enhance regulatory assessment of chemical toxicity. The 
workshop steering committee is comprised of members from government and 
nongovernment stakeholders including the NTP, Physicians Committee for 
Responsible Medicine, European Union Reference Laboratory for 
Alternatives to Animal Testing, Consumer Product Safety Commission, Dow 
Chemical Company, U.S. Environmental Protection Agency, U.S. Food and 
Drug Administration, Health and Environmental Sciences Institute, and 
Proctor & Gamble.
    Meeting and Registration: This meeting is open to the public, free 
of charge, with attendance limited only by the space available. A 
preliminary agenda and additional information are available at http://ntp.niehs.nih.gov/go/41374. The plenary sessions of the workshop will 
be webcast. Registration is required to view the webcast; the URL for 
the webcast will be provided in an email prior to the meeting. 
Individuals who plan to attend in person should register at http://ntp.niehs.nih.gov/go/41374 by August 15, 2014, to facilitate planning 
for the workshop. Individuals interested in this workshop are 
encouraged to visit the Web page to stay abreast of the most current 
information.
    Information for visitors to the William H. Natcher Conference 
Center is available at http://www.orf.od.nih.gov/AboutORF/BFM/Pages/45Beth.aspx. Individuals with disabilities who need accommodation to 
participate in this event should contact Dr. Elizabeth Maull at phone: 
(919) 316-4668 or email: [email protected]. TTY users should contact 
the Federal TTY Relay Service at (800) 877-8339. Requests should be 
made at least five business days in advance of the event.
    Background Information on NICEATM: NICEATM conducts data analyses, 
workshops, independent validation studies, and other activities to 
assess new, revised, and alternative test methods and strategies. 
NICEATM also provides support for the Interagency Coordinating 
Committee on the Validation of Alternative Methods (ICCVAM). The ICCVAM 
Authorization Act of 2000 (42 U.S.C. 285l-3) provides authority for 
ICCVAM and NICEATM in the development and implementation of alternative 
test methods in regulatory safety testing. Information about NICEATM 
and ICCVAM is found at http://ntp.niehs.nih.gov/go/niceatm and http://ntp.niehs.nih.gov/go/iccvam.

    Dated: June 17, 2014.
John R. Bucher,
Associate Director, National Toxicology Program.
[FR Doc. 2014-14738 Filed 6-24-14; 8:45 am]
BILLING CODE 4140-01-P