[Federal Register Volume 79, Number 118 (Thursday, June 19, 2014)]
[Notices]
[Pages 35176-35177]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2014-14300]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Request for Information: The National Toxicology Program 
Interagency Center for the Evaluation of Alternative Toxicological 
Methods Requests Data and Information on Devices and/or Technologies 
Used for Identifying Potential Inhalation Hazards

SUMMARY: The National Toxicology Program (NTP) Interagency Center for 
the Evaluation of Alternative Toxicological Methods (NICEATM) requests 
available data and information on devices and/or technologies currently 
used for identifying potential inhalation hazards. Submitted 
information will be used to assess the state of the science and 
determine the technical needs for a dynamic nonanimal system to assess 
the potential toxicity of inhaled chemicals and nanomaterials.

DATES: The deadline for receipt of information is July 18, 2014.

ADDRESSES: Data and information should be submitted electronically to 
[email protected].

FOR FURTHER INFORMATION CONTACT: Dr. Warren S. Casey, Director, 
NICEATM; email: [email protected]; telephone: (919) 316-4729.

SUPPLEMENTARY INFORMATION: 
    Background: NICEATM fosters the evaluation and promotion of 
alternative test methods for regulatory use in acute toxicity 
assessment. Efforts to date have focused primarily on assessing test 
methods for oral and dermal hazards with limited efforts directed 
towards identifying alternatives for inhalation toxicity assessment. 
NICEATM is interested in receiving information on the state of the 
science regarding alternative test methods and testing strategies for 
acute or sub-chronic inhalation toxicity. This information will be used 
to determine the technical requirements for developing effective 
inhalation toxicity tools to assess potential chemical and nanomaterial 
hazards without the use of animals in testing.
    Request for Information: NICEATM requests available data and 
information on devices and/or technologies currently used to identify 
potential inhalation hazards. To that end, NICEATM requests that 
respondents provide information on any activities relevant to the 
development or validation of alternatives to in vivo inhalation 
toxicity test methods currently required by regulatory agencies, 
including submission of substance-specific data derived from non-animal 
tests to identify acute or sub-chronic inhalation hazard potential. If 
available, corresponding in vivo data obtained for these substances are 
also requested, including data from any ethical human or animal studies 
or accidental human exposures.
    Respondents to this request for information should include their 
name, affiliation (if applicable), mailing address, telephone, email, 
and sponsoring organization (if any) with their communications. The 
deadline for receipt of the requested information is July 18, 2014. 
Responses to this notice will be posted at http://ntp.niehs.nih.gov/go/41624 and persons submitting them will be identified by name and 
affiliation or sponsoring organization, if applicable.
    Responses to this request are voluntary. No proprietary, 
classified, confidential, or sensitive information should be included 
in responses. This request for information is for planning purposes 
only and is not a solicitation for applications or an obligation on the 
part of the U.S. Government to provide support for any ideas identified 
in response to the request. Please note that the U.S. Government will 
not pay for the preparation of any information submitted or for its use 
of that information.
    Background Information on NICEATM: NICEATM conducts data analyses, 
workshops, independent validation studies, and other activities to 
assess new, revised, and alternative

[[Page 35177]]

test methods and strategies. NICEATM also provides support for the 
Interagency Coordinating Committee on the Validation of Alternative 
Methods (ICCVAM). The ICCVAM Authorization Act of 2000 (42 U.S.C. 285l-
3) provides authority for ICCVAM and NICEATM in the development of 
alternative test methods. Information about NICEATM and ICCVAM is found 
at http://ntp.niehs.nih.gov/go/niceatm and http://ntp.niehs.nih.gov/go/iccvam.

    Dated: June 13, 2014.
John R. Bucher,
Associate Director, National Toxicology Program.
[FR Doc. 2014-14300 Filed 6-18-14; 8:45 am]
BILLING CODE 4140-01-P