[Federal Register Volume 79, Number 86 (Monday, May 5, 2014)]
[Notices]
[Page 25595]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2014-10187]



[[Page 25595]]

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DEPARTMENT OF HEALTH AND HUMAN SERVICES

Centers for Disease Control and Prevention

[30-Day-14-0888]


Agency Forms Undergoing Paperwork Reduction Act Review

    The Centers for Disease Control and Prevention (CDC) publishes a 
list of information collection requests under review by the Office of 
Management and Budget (OMB) in compliance with the Paperwork Reduction 
Act (44 U.S.C. Chapter 35). To request a copy of these requests, call 
(404) 639-7570 or send an email to [email protected]. Send written comments 
to CDC Desk Officer, Office of Management and Budget, Washington, DC 
20503 or by fax to (202) 395-5806. Written comments should be received 
within 30 days of this notice.

Proposed Project

    Persistence of Viable Influenza Virus in Aerosols (0920-0888, 
Expiration 05/31/2014)--Revision--National Institute for Occupational 
Safety and Health (NIOSH), Centers for Disease Control and Prevention 
(CDC).

Background and Brief Description

    The National Institute for Occupational Safety and Health (NIOSH) 
is authorized to conduct research to advance the health and safety of 
workers under Section 20(a)(1) of the 1970 Occupational Safety and 
Health Act. Influenza continues to be a major public health concern 
because of the substantial health burden from seasonal influenza and 
the potential for a severe pandemic. Although influenza is known to be 
transmitted by infectious secretions, these secretions can be 
transferred from person to person in many different ways, and the 
relative importance of the different pathways is not known. The 
likelihood of the transmission of influenza virus by small infectious 
airborne particles produced during coughing and breathing is 
particularly unclear. The question of airborne transmission is 
especially important in healthcare facilities, where influenza patients 
tend to congregate during influenza season, because it directly impacts 
the infection control and personal protective measures that should be 
taken by healthcare workers.
    The purpose of this study is to measure the amount of viable 
influenza virus in airborne particles that are produced by patients 
when they cough, and the size and quantity of the particles carrying 
the virus. A better understanding of the amount of potentially 
infectious material released by patients and the size of the particles 
carrying the virus will assist in determining the possible role of 
airborne transmission in the spread of influenza and in devising 
measures to prevent it.
    Volunteer adult participants will be recruited by a test 
coordinator using a poster and flyers describing the study. Interested 
potential participants will be screened verbally to verify that they 
have influenza-like symptoms and that they do not have any medical 
conditions that would preclude their participation.
    Qualified participants who agree to participate in the study will 
be asked to read and sign an informed consent form, and then to 
complete a short health questionnaire. After completing the forms, 
medical testing will take place. This testing will include two 
nasopharyngeal swabs and one oropharyngeal swab collected from the 
participant. In the final element of medical testing, they then will be 
asked to cough repeatedly into an aerosol particle collection system, 
and the airborne particles produced by the participant during coughing 
will be collected and tested. The sounds produced during coughing will 
also be recorded for analysis and comparison to the amount of virus 
expelled. The study will require 60 volunteer test subjects each year 
for 3 years, for a total of 180 test participants. There are no costs 
to respondents other than their time. The total number of annual burden 
hours will be 168.

                                        Estimated Annualized Burden Hours
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                                                                                                     Avgerage
                                                                     Number of       Number of      burden per
       Type of respondents                   Form name              respondents    responses per   response (in
                                                                                    respondent         hrs.)
----------------------------------------------------------------------------------------------------------------
Potential participant............  Initial verbal screening.....             360               1            3/60
Qualified participant............  Informed consent form........             180               1           15/60
Qualified participant............  Health questionnaire.........             180               1            5/60
Qualified participant............  Medical testing..............             180               1           30/60
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Leroy Richardson,
Chief, Information Collection Review Office, Office of Scientific 
Integrity, Office of the Associate Director for Science, Office of the 
Director, Centers for Disease Control and Prevention.
[FR Doc. 2014-10187 Filed 5-2-14; 8:45 am]
BILLING CODE 4163-18-P