[Federal Register Volume 79, Number 49 (Thursday, March 13, 2014)]
[Notices]
[Pages 14257-14259]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2014-05472]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Government-Owned Inventions; Availability for Licensing

AGENCY: National Institutes of Health, HHS.

ACTION: Notice.

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SUMMARY: The inventions listed below are owned by an agency of the U.S. 
Government and are available for licensing in the U.S. in accordance 
with 35 U.S.C. 209 and 37 CFR part 404 to achieve expeditious 
commercialization of results of federally-funded research and 
development. Foreign patent applications are filed on selected 
inventions to extend market coverage for companies and may also be 
available for licensing.

FOR FURTHER INFORMATION CONTACT: Licensing information and copies of 
the U.S. patent applications listed below may be obtained by writing to 
the indicated licensing contact at the Office of Technology Transfer, 
National Institutes of Health, 6011 Executive Boulevard, Suite 325, 
Rockville, Maryland 20852-3804; telephone: 301-496-7057; fax: 301-402-
0220. A signed Confidential Disclosure Agreement will be required to 
receive copies of the patent applications.

Rabies Vaccine for the Oral Immunization of Domesticated Animals, 
Wildlife and Feral Animals

    Description of Technology: This invention, developed by the CDC and 
collaborators, entails a live, attenuated recombinant rabies virus 
vaccine that can elicit an effective anti-rabies immune response in 
animal recipients. Inoculation with a live, attenuated, rabies virus 
allows for the optimized production of immunity in the absence of 
pathogenicity. Oral administration of rabies vaccines is often a 
preferred route of vaccine delivery because it is most effective in 
wildlife. Unfortunately, availability of an oral vaccine for canines 
has been a significant hurdle to date.
    This vaccine technology could be used for immunization of stray 
dogs by an oral route. In developing nations, more than 90% of human 
exposure events and 99% of human deaths due to rabies are caused by 
rabid dogs. Using this vaccine with a broadly implemented oral 
vaccination strategy provides a promising opportunity for reducing 
transmission of rabies between stray dogs and, thereby, increasing 
protection for people.

    Potential Commercial Applications:

 Wildlife and humane shelter rabies prevention and control 
programs
 Improved rabies vaccines for pets and livestock
 Humane, targeted approach to elimination of rabies reservoirs 
in feral animal populations

    Competitive Advantages:

 Safe and effective
 Oral immunization is the most practical and efficient method 
of rabies vaccination of wildlife and feral animals
 Vaccine has demonstrated protection in vivo
 Recombinant, non-neuroinvasive virus expressing a 
neuroinvasive glycoprotein and/or pro-apoptotis gene safely induces a 
robust and desirable immunological response
    Development Stage:

 In vitro data available
 In vivo data available (animal)

    Inventors: Charles E. Rupprecht (CDC), et al.
    Intellectual Property: HHS Reference No. E-470-2013/0--U.S. Patent 
No. 7,074,413 issued 11 Jul 2006.
    Licensing Contact: Whitney Blair, J.D., M.P.H.; 301-435-4937; 
[email protected].

Cable-Line Safety System: Electro/Hydraulic Emergency Stop Device for a 
Winch, Drum or Capstan

    Description of Technology: This CDC-developed invention entails a 
system of electrical and hydraulic circuits used to stop a rotating 
winch in an emergency. Amongst other locations, one stop switch can be 
positioned on a capstan winch horn. This location makes it available to 
a victim entangled in rope being retrieved on a gypsy drum. As 
designed, the stop circuit could be used with an electrically, 
hydraulically or pneumatically operated winch. A variant of this safety 
system has been successfully tested on a purse seining fishing vessel 
in Alaskan waters.

    Potential Commercial Applications:

 Retrofitting existing winches for additional safety and 
adherence to possible future regulations
 Specifically designed and tested for the marine/fishing 
industries
 Applications in mining, construction, forestry, and/or off-
road automotive industries
 Workers' well-being concern groups
 Insurers of fishing vessels; also mining, construction and 
forestry operations
 Manufacturers of cable reel trailers and wire-drawing 
machinery

    Competitive Advantages:


[[Page 14258]]


 Complies with numerous international safety regulations 
requiring winches, drums and capstans to have a master on/off switch in 
easy reach for worker safety
 Can be packaged as a `retrofit kit' for integration with 
current commercial winch/drum usage

    Development Stage:

 In situ data available (on-site)
 Prototype

    Inventors: Chelsea Woodward, Todd Ruff, Curtis Clark, Robert 
McKibbin, John Bevan, Greg Miller, Wayne Howie, Louis Martin, Jennifer 
Lincoln (all inventors from CDC-NIOSH).
    Intellectual Property: HHS Reference No. E-355-2013/0--Research 
Tool. Patent protection is not being pursued for this technology.
    Related Technologies:

 HHS Reference No. E-504-2013/0
 HHS Reference No. E-567-2013/0
 HHS Reference No. E-568-2013/0
 HHS Reference No. E-643-2013/0

    Licensing Contact: Whitney Blair, J.D., M.P.H.; 301-435-4937; 
[email protected].

Lead Detection Wipes for Potentially Contaminated Surfaces

    Description of Technology: This CDC-developed invention relates to 
a method for the detection of lead on surfaces (such as, for example, 
skin, floors, walls, windows sills) using a `handwipe' system and a 
chemical test effecting a characteristic color change if contaminating 
lead is present. This invention is especially useful in detecting the 
presence of lead on skin and assessing the effectiveness of hand 
washing in removal of lead from the skin of exposed individuals. 
Further, this invention is useful in field evaluation for the presence 
of lead, exposure of individuals to lead, and the effectiveness of its 
subsequent removal in the workplace, home, school, and similar 
environments.
    Potential Commercial Applications:

 Suitable for lead-testing surfaces such as floors, walls, 
windowsills and human skin
 Evaluation of lead-removal effectiveness from surfaces in 
homes, hospitals, workplaces and schools
 Confirming hand/skin/shoe/clothing-washing effectiveness of 
lead removal for military, target range personnel

    Competitive Advantages:

 Simple color-change readout indicates the presence of lead on 
a surface
 Rapid test; lead concentration can be inferred by degree of 
color shift
 Safe for use on skin

    Development Stage:

 In vitro data available
 In situ data available (on-site)

    Inventors: Eric J. Esswein, Mark F. Boeniger, Kevin E. Ashley (all 
of CDC).
    Publications:

1. Ashley K. Field-portable methods for monitoring occupational 
exposures to metals. J Chem Health Saf. 2010;17(3):22-8. [http://dx.doi.org/10.1016/j.jchas.2009.07.002]
2. NIOSH Manual of Analytical Methods (NMAM), Fourth Edition. Method 
9105, Issue 1--Lead in Dust Wipes by Chemical Spot Test Method 
(Colorimetric Screening Method), 15 March 2003. U.S. National 
Institute for Occupational Safety and Health (NIOSH), Cincinnati, 
OH. [http://www.cdc.gov/niosh/docs/2003-154/pdfs/9105.pdf ]
    3. Esswein EJ, et al. Handwipe Method for Removing Lead from 
Skin. Journal of ASTM International. 2011 May;8(5):Paper ID 
JAI103527. [http://dx.doi.org/10.1520/JAI103527]

    Intellectual Property: HHS Reference No. E-336-2013/0--U.S. Patent 
No. 6,248,593 issued 19 Jun 2001.
    Related Technology:

 HHS Reference No. E-356-2013/0
 HHS Reference No. E-359-2013/0

    Licensing Contact: Whitney Blair, J.D., M.P.H.; 301-435-4937; 
[email protected].

Mining Safety: Personal Dust Monitor Filters for Accurate, Quantifiable 
Spectrometric Analysis and Assessment of Worker Exposure Levels

    Description of Technology: This CDC-developed invention pertains to 
a novel dust monitor filter that is specially constructed of organic 
materials for spectrometric analysis, ultimately allowing for detection 
and accurate quantification of a particular chosen analyte (e.g., 
crystalline silica/quartz dust that may lead to silicosis).
    For miners, the risk of lung disease increases with the extent of 
dust exposure, and coal worker's pneumoconiosis (aka, black lung 
disease) and silicosis are still dangers routinely faced by those in 
the industry. Expectedly, both the concentration and the composition of 
airborne particulate matter present in mining environments are points 
of regulatory concern. For some time, collecting airborne dust samples 
and subsequent determination of quartz content have been integral for 
assessing mine worker exposure and demonstrating compliance with US 
Federal regulations.
    Unfortunately, highly accurate spectrometric detection and 
quantification of particulate exposure has not always been possible. 
Generally, the filters used in existing oscillating microbalances (such 
as the TEOM[supreg] monitor) have been specially designed to for 
hydrophobicity, in order to retain as little moisture as possible on 
the filter. These specialized hydrophobic filters (and/or their 
mounting components) contain inorganic compounds that cannot be readily 
subjected to thermal or chemical destruction--a necessary first step of 
many instrumental analytical methods, such as spectroscopy.
    This CDC-developed filter consists of entirely ashable material, 
making it ideal for spectrometric analysis and rapid exposure 
assessment. As an example, this dust monitor filter can be made 
entirely of organic materials and designed for quick, easy ashing that 
will not produce interference with the spectroscopic characteristics of 
the chosen analyte(s). Further, filter ashing can be carried out by a 
variety of methods: thermal ashing, microwave ashing, low temperature 
ashing, or chemical destruction.
    Potential Commercial Applications:

 Personal dust monitors worn wherever dust exposure levels and 
the presence of potentially injurious materials is evaluated
 Occupationally-mandated pneumoconiosis, asbestosis and/or 
silicosis prevention and monitoring programs, for complying with safety 
regulations
 Miners' wellness concern groups and insurance companies

    Competitive Advantages:

 Novel dust-monitoring instrument capable of providing near 
rapid particulate exposure information to miners/users
 Improves upon older technology by allowing for accurate 
detection and quantification of chosen analyte(s) and, unlike other 
filters, does not produce overlap or interfere with spectroscopic 
analysis
 Filter can be easily ashed for analysis by thermal ashing, 
microwave ashing, low temperature ashing, or chemical destruction

    Development Stage:

 Early-stage
 In vitro data available

    Publication:

Tuchman DP. Implementing infrared determination of quartz 
particulates on novel filters for a prototype dust monitor. J 
Environ Monit. 2008 May;10(5):671-8. [PMID 18449405]

    Intellectual Property: HHS Reference No. E-312-2013/0--U.S. Patent 
No. 7,947,503 issued 24 May 2011.
    Licensing Contact: Whitney Blair, J.D., M.P.H.; 301-435-4937; 
[email protected].

[[Page 14259]]

Computer Controlled Aerosol Generator With Multi-Walled Carbon Nanotube 
Inhalation Testing Capabilities

    Description of Technology: This invention pertains to a CDC-NIOSH 
developed sonic aerosol generator that provides a controllable, stable 
concentration of particulate aerosol over a long period of time for 
aerosol exposure studies. Specifically, in situ testing data indicate 
uniform aerosol stability can be maintainable for greater than 30 hours 
at concentrations of 15 mg/m3 or more. Additionally, the technology was 
specifically developed for, and validated in, animal studies assessing 
exposure to airborne multi-walled carbon nanotubes (MWCNT). It has been 
suggested that workers may be at risk for exposure to nanosized 
particles during the manufacture, handling, and cleanup of engineered 
nanomaterials. Compared to other technologies, this NIOSH aerosol 
generator is particularly helpful when used for generating high testing 
concentrations of MWCNT aerosols that more accurately represent 
particulate levels that may be seen in a workplace environment.
    Potential Commercial Applications:

 Studying the size and shape of the aerosolized particles 
produced from simple vibrations of bulk material
 Toxicological investigations and risk assessment of aerosol 
exposures, especially those related to nanoparticle manufacturing.
 Any aerosolization application where the aggregating ``bird's 
nest'' tendencies of airborne multi-walled carbon nanotubes must be 
overcome

    Competitive Advantages:

 Fully automated system with integrated feedback control for 
optimized stability in testing
 Maintains concentration of aerosols for >30 hours at 
concentrations of 15 mg/cubic meter or more
 Capable of generating high concentrations of aerosols that 
more accurately represent the levels seen in a workplace environment
 System insures that each run produces a constant particle 
concentration, air flow, pressure, temperature and humidity within a 
testing chamber

    Development Stage:
 In vitro data available
 In vivo data available (animal)
 In situ data available (on-site)
 Prototype
    Inventors: Walter G. McKinney, David G. Frazer, Bean Chen (all of 
CDC)

    Publications:

1. McKinney W, et al. Computer controlled multi-walled carbon 
nanotube inhalation exposure system. Inhal Toxicol. 2009 
Oct;21(12):1053-61. [PMID 19555230]
2. Porter DW, et al. Acute pulmonary dose-responses to inhaled 
multi-walled carbon nanotubes. Nanotoxicology. 2013 Nov;7:1179-94. 
[PMID 22881873]
3. Porter DW, et al. Mouse pulmonary dose- and time course-responses 
induced by exposure to multi-walled carbon nanotubes. Toxicology. 
2010 Mar 10;269(2-3):136-47. [PMID 19857541]
4. Chen BT, et al. Multi-walled carbon nanotubes: sampling criteria 
and aerosol characterization. Inhal Toxicol. 2012 Oct;24(12):798-
820. [PMID 23033994]

    Intellectual Property: HHS Reference No. E-156-2013/0--U.S. Patent 
Application No. 12/871,453 filed 30 Aug 2010.
    Licensing Contact: Whitney Blair, J.D., M.P.H.; 301-435-4937; 
[email protected].

    Dated: March 10, 2014.
Richard U. Rodriguez,
Director, Division of Technology Development and Transfer, Office of 
Technology Transfer, National Institutes of Health.
[FR Doc. 2014-05472 Filed 3-12-14; 8:45 am]
BILLING CODE 4140-01-P