[Federal Register Volume 76, Number 214 (Friday, November 4, 2011)]
[Pages 68460-68461]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2011-28619]



Office of the Secretary

Findings of Research Misconduct

AGENCY: Office of the Secretary, HHS.

ACTION: Notice.


SUMMARY: Notice is hereby given that the Office of Research Integrity 
(ORI) has taken final action in the following case:
    Jayant Jagannathan, M.D., University of Virginia Medical Center: 
Based on the report of an investigation conducted by the University of 
Virginia (UVA) and additional analysis conducted by ORI in its 
oversight review, ORI found that Dr. Jayant Jagannathan, former 
Resident Physician at UVA Medical Center, engaged in research 
misconduct by plagiarizing research supported by National Institutes of 
Health (NIH) research and training awards and by NIH intramural 
research funds from the National Institute of Neurological Disorders 
and Stroke (NINDS), Surgical Neurosurgery Branch (NSB), and from the 
National Institute of Dental and Craniofacial Research (NIDCR).
    ORI found that the Respondent engaged in research misconduct by 
including, in five publications, large amounts of text and an 
illustration that he plagiarized from publications supported by the 
following NIH grant awards: T32 CA09677, P01 HL024136, R01 HL059157, 
P50 CA090270, M01 RR01346, R01 CA075979, R01 DK064169, R01 NS027544, 
R01 NS052406, and K08 NS002197,\1\ and by intramural funds from the 
Surgical Neurosurgery Branch, NINDS, and from NIDCR.

    \1\ T32 CA09677, Radiation Biology Training Grant,'' A. Kennedy, 
    P01 HL024136, ``Mechanisms of Remodeling in Chronic Airway 
Inflammation,'' G. Caughey, P.I.
    HL059157, ``Angioproteins in Airway Vascular Leak and 
Angiogenesis,'' D. McDonald, P.I.
    P50 CA090270, ``UTMDACC Cancer Center SPORE in prostate 
cancer,'' C. Logothetis, P.I.
    M01 RR01346, ``UTHSC GCRC,'' R. Clark, P.I.
    R01 CA075979, ``Mechanisms for Pituitary Tumorigenesis,'' S. 
Melmed, P.I.
    R01 DK064169, ``Metabolic Consequences of Sccurin Disruption,'' 
S. Melmed, P.I.
    R01 NS027544, ``Loss of Developmental Plasticity after Head 
Injury,'' D.A. Hovda, P.I.
    R01 NS052406, ``Age-dependent Ketone Metabolism after Brain 
Injury,'' M.L. Prims, P.I.
    K08 NS002197, ``NMDA Receptor Dysfunction after Traumatic Brain 
Injury,'' C.C. Christopher, P.I.

    Publications in which Respondent reported plagiarized material 

    1. Jagannathan, J., Li, J., Szerlip, N., Vortmeyer, A.O., 
Lonser, R.R., Oldfied, E.H., Zhuang, Z. ``Application and 
implementation of selective tissue microdissection and proteomic 
profiling in neurological disease.'' Neurosurgery 64:4-14, 2009 (to 
be retracted);
    2. Jagannathan, J., Prevedello, D.M., Dumont, A.S., Laws, E.R. 
``Cellular Signaling Molecules as Therapeutic Targets in the 
Treatment of Glioblastoma Multiforme.'' Neurosurgical Focus 
20(4):E8, 2006 (retracted ``due to plagiarism,'' Neurosurgical Focus 
30(2):E8r, 2011);
    3. Kanter, A.S., Jagannathan, J., Shaffrey, C.I., Ouellet, J.A., 
Mummaneni, P.V. ``Inflammatory and dysplastic lesions involving the 
spine.'' Neurosurgical Clinics of North America 19(1):93-109, 2008;
    4. Jagannathan, J., Dumont, A.S., Prevedello, D.M., Oskouian, 
R.J., Lopes, B., Jane, J.A. Jr, Laws, E.R. Jr. ``Genetics of 
pituitary adenomas: Current theories and future implications.'' 
Neurosurgical Focus 19(5):E4, 2005 (retracted ``due to plagiarism,'' 
Neurosurgical Focus 30(2):E4r, 2011);
    5. Jagannathan, J. ``Role of calcium influx and modulation of 
local neurotransmitters as hallmarks of pediatric traumatic brain 
injury.'' Biomarkers Med. 3:95-97, 2009 (retracted online 9/11/

    Dr. Jagannathan has entered into a Voluntary Settlement Agreement 
(Agreement) and has voluntarily agreed for a period of four (4) years, 
beginning on October 20, 2011:
    (1) To have his research supervised; Respondent agreed to ensure 
that prior to the submission of an application for U.S. Public Health 
Service (PHS) support for a research project on which his participation 
is proposed and prior

[[Page 68461]]

to his participation in any capacity on PHS-supported research, the 
institution employing him must submit a plan for supervision of his 
duties to ORI for approval; the plan for supervision must be designed 
to ensure the scientific integrity of his research contribution; 
Respondent agreed that he will not participate in any PHS-supported 
research after sixty (60) days from the effective date of the Agreement 
until a plan for supervision is submitted to and approved by ORI; 
Respondent agreed to maintain responsibility for compliance with the 
agreed upon supervision plan;
    (2) That any institution employing him must submit, in conjunction 
with each application for PHS funds, or report, manuscript, or abstract 
involving PHS-supported research in which Respondent is involved, a 
certification to ORI that the data provided by Respondent are based on 
actual experiments or are otherwise legitimately derived and that the 
data, procedures, and methodology are accurately reported in the 
application, report, manuscript, or abstract;
    (3) To submit a letter to the journal editor for publication 3 
(Neurosurgical Clinics of North America) listed above, requesting that 
the paper be retracted because Respondent had plagiarized portions of 
text reported in it; the letter must be sent to ORI for approval prior 
to being sent to the editor; and
    (4) To exclude himself from serving in any advisory capacity to PHS 
including, but not limited to, service on any PHS advisory committee, 
board, and/or peer review committee, or as a consultant.

FOR FURTHER INFORMATION CONTACT: Director, Division of Investigative 
Oversight, Office of Research Integrity, 1101 Wootton Parkway, Suite 
750, Rockville, MD 20852, (240) 453-8800.

John Dahlberg,
Director, Division of Investigative Oversight, Office of Research 
[FR Doc. 2011-28619 Filed 11-3-11; 8:45 am]