[Federal Register Volume 76, Number 210 (Monday, October 31, 2011)]
[Notices]
[Pages 67200-67201]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2011-28131]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Prospective Grant of Exclusive License: Electron Paramagnetic 
Resonance Devices and Systems for Oximetry

AGENCY: National Institutes of Health, Public Health Service, HHS.

ACTION: Notice.

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SUMMARY: This is notice, in accordance with 35 U.S.C. 209(c)(1) and 37 
CFR 404.7(a)(1)(i), that the National Institutes of Health (NIH), 
Department of Health and Human Services (HHS), is contemplating the 
grant of an exclusive worldwide license to practice the invention 
embodied in: HHS Ref. No. E-175-1995/0 and/1;

[[Page 67201]]



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        Patent/Application No.                  Territory                 Filing date               Status
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5,678,548.............................  US.......................  July 20, 1995...........  Issued.
5,828,216.............................  US.......................  August 19, 1996.........  Issued.
5,865,146.............................  US.......................  July 29, 1997...........  Issued.
PCT/US1996/11879......................  WIPO.....................  July 18, 1996...........  Expired.
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and HHS Ref. No. E-250-2008/0;

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        Patent/Application No.                  Territory                 Filing date               Status
----------------------------------------------------------------------------------------------------------------
61/200,579............................  US.......................  November 29, 2008.......  Expired.
PCT/US2009/65956......................  WIPO.....................  November 25, 2009.......  Expired.
13/131,165............................  US.......................  May 25, 2011............  Pending.
09829806.0............................  EP.......................  November 25, 2009.......  Pending.
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to Resonance Research, Inc., a company incorporated under the laws of 
the Commonwealth of Massachusetts having its headquarters in Billerica, 
Massachusetts. The United States of America is the assignee of the 
rights of the above inventions. The contemplated exclusive license may 
be granted in a field of use limited to electron paramagnetic resonance 
devices and systems for oximetry.

DATES: Only written comments and/or applications for a license received 
by the NIH Office of Technology Transfer on or before November 15, 2011 
will be considered.

ADDRESSES: Requests for a copy of the patent application, inquiries, 
comments and other materials relating to the contemplated license 
should be directed to: Michael A. Shmilovich, Esq., Office of 
Technology Transfer, National Institutes of Health, 6011 Executive 
Boulevard, Suite 325, Rockville, MD 20852-3804; Telephone: (301) 435-
5019; Facsimile: (301) 402-0220; Email: [email protected]. A signed 
confidentiality nondisclosure agreement will be required to receive 
copies of any patent applications that have not been published by the 
United States Patent and Trademark Office or the World Intellectual 
Property Organization.

SUPPLEMENTARY INFORMATION: The patents and patent applications intended 
for licensure disclose or cover devices and systems for in vivo 
quantitative oximetry using low frequency time-domain EPR imaging in 
the frequency range of 250-300 MHz. The systems developed use a time-
domain spectroscopic EPR imaging approach that is a unique combination 
of: (1) multi-gradient Single Point Imaging involving global phase 
encoding and (2) conventional 90[deg]-[tau]-180[deg] Spin-Echo pulse 
sequence well-known in MRI where the images are obtained by the 
filtered back-projection after FT of the echoes collected under 
frequency-encoding gradients. The combination approach of single point 
imaging with the spin-echo signal detection procedure to take advantage 
of T2 (and not T2*) dependent contrast and the 
enhanced spatial resolution associated with the constant-time pure 
phase-encoding approach. This approach has become feasible because of 
the availability of non-toxic water-soluble trityl and deuterated 
trityl based spin probes which have reasonable T1 and 
T2 in the range 5-10 [mu]s.
    The prospective exclusive license will be royalty bearing and will 
comply with the terms and conditions of 35 U.S.C. 209 and 37 CFR 404.7. 
The prospective exclusive license may be granted unless, within fifteen 
(15) days from the date of this published notice, NIH receives written 
evidence and argument that establishes that the grant of the license 
would not be consistent with the requirements of 35 U.S.C. 209 and 37 
CFR 404.7.
    Properly filed competing applications for a license filed in 
response to this notice will be treated as objections to the 
contemplated license. Comments and objections submitted in response to 
this notice will not be made available for public inspection, and, to 
the extent permitted by law, will not be released under the Freedom of 
Information Act, 5 U.S.C. 552.

    Dated: October 25, 2011.
Richard U. Rodriguez,
Director, Division of Technology Development and Transfer, Office of 
Technology Transfer, National Institutes of Health.
[FR Doc. 2011-28131 Filed 10-28-11; 8:45 am]
BILLING CODE 4140-01-P