[Federal Register Volume 76, Number 39 (Monday, February 28, 2011)]
[Notices]
[Pages 10906-10907]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2011-4327]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

Agency for Toxic Substances and Disease Registry

[ATSDR-269]


Proposed Substances To Be Evaluated for Set 25 Toxicological 
Profiles

AGENCY: Agency for Toxic Substances and Disease Registry (ATSDR), 
Department of Health and Human Services (HHS).

ACTION: Request for comments on the proposed substances to be evaluated 
for Set 25 toxicological profiles.

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SUMMARY: ATSDR is initiating the development of its 25th set of 
toxicological profiles (CERCLA Set 25). This notice announces the list 
of proposed substances that will be evaluated for CERCLA Set 25 
toxicological profile development. ATSDR's Division of Toxicology and 
Environmental Medicine is soliciting public nominations from the list 
of proposed substances to be evaluated for toxicological profile 
development. ATSDR also will consider the nomination of any additional, 
non-CERCLA substances that may have public health implications, on the 
basis of ATSDR's authority to prepare toxicological profiles for 
substances not found at sites on the National Priorities List. The 
agency will do so in order to ``* * * establish and maintain inventory 
of literature, research, and studies on the health effects of toxic 
substances'' under CERCLA Section 104(i)(1)(B), to respond to requests 
for consultation under section 104(i)(4), and to support the site-
specific response actions conducted by ATSDR, as otherwise necessary.

DATES: Nominations must be submitted within 30 days of the publication 
of this notice.

ADDRESSES: Nominations may be submitted electronically. Refer to the 
section Submission of Nominations (below) for the specific address.

SUPPLEMENTARY INFORMATION: The Superfund Amendments and Reauthorization 
Act of 1986 (SARA) [42 U.S.C. 9601 et seq.] amended the Comprehensive 
Environmental Response, Compensation, and Liability Act of 1980 (CERCLA 
or Superfund) [42 U.S.C. 9601 et seq.] by establishing certain 
requirements for ATSDR and the U.S. Environmental Protection Agency 
(EPA) with regard to hazardous substances most commonly found at 
facilities on the CERCLA National Priorities List (NPL). Among these 
statutory requirements is a mandate for the Administrator of ATSDR to 
prepare toxicological profiles for each substance included on the 
Priority List of Hazardous Substances. This list identifies 275 
hazardous substances that ATSDR and EPA have determined pose the most 
significant current potential threat to human health. The availability 
of the revised list of the 275 priority substances was announced in the 
Federal Register on March 6, 2008 (73 FR 12178). For prior versions of 
the list of substances, see Federal Register notices dated April 17, 
1987 (52 FR 12866); October 20, 1988 (53 FR 41280); October 26, 1989 
(54 FR 43619); October 17, 1990 (55 FR 42067); October 17, 1991 (56 FR 
52166); October 28, 1992 (57 FR 48801); February 28, 1994 (59 FR 9486); 
April 29, 1996 (61 FR 18744); November 17, 1997 (62 FR 61332); October 
21, 1999 (64 FR 56792); October 25, 2001 (66 FR 54014); November 7, 
2003 (68 FR 63098); and November 29, 2005 (70 FR 71506).

Proposed Substances To Be Evaluated for Set 25 Toxicological Profiles

    Each year, ATSDR develops a list of substances to be considered for 
toxicological profile development; this list is compiled from ATSDR's 
Priority List of Hazardous Substances and from previously nominated 
substances of public health concern. The following 74 proposed 
substances will be considered for Set 25 Toxicological Profile 
development:

Candidate Substances for Profile Development

    1. s,s,s-Tributyl phosphorotrithioate (CAS No. 000078-48-8).
    2. 2,4-Dimethylphenol (CAS No. 000105-67-9).
    3. Bromine (CAS No. 007726-95-6).
    4. Bromodichloroethane (CAS No. 0000683-53-4).
    5. Butyl benzyl phthalate (CAS No. 000085-68-7).
    6. Dibenzofuran (CAS No. 000132-64-9).
    7. Dicofol (CAS No. 000115-32-2).
    8. Methane (CAS No. 74-82-8).
    9. Neptunium-237 (CAS No. 013994-20-2).
    10. Palladium (CAS No. 007440-05-3).
    11. Parathion (CAS No. 000056-38-2).
    12. Pentachlorobenzene (CAS No. 000608-93-5).
    13. Polonium-210 (CAS No. 013981-52-7).
    14. Treflan (Trifluralin) (CAS No. 001582-09-8).
    15. Trichlorofluoroethane (CAS No. 027154-33-2).
    16. Fluorides (CAS Nos. 007782-41-4, 007664-39-3, 016984-48-8).
    17. Selenium (CAS No. 007782-49-2).
    18. Aldrin/Dieldrin (CAS Nos. 000309-00-2, 000060-57-1).
    19. Beryllium (CAS No. 007440-41-7).
    20. Creosote/Coal Tar (CAS Nos. 008021-39-4, 008007-45-2, 008001-
58-9, 065996-93-2).
    21. DDT, DDE, DDD (CAS Nos. 000050-29-3, 000072-55-9, 000072-54-8, 
000789-02-6, 000053-19, 003424-82-6).
    22. Di(2-ethylhexyl)phthalate (CAS No. 000117-81-7).
    23. Hexachlorobenzene (CAS No. 000118-74-1).
    24. Methoxychlor (CAS No. 000072-43-5).
    25. 1,2-Dichloroethane (CAS No. 000107-06-2).
    26. Asbestos (CAS Nos. 001332-21-4, 012001-29-5, 012172-73-5).
    27. Benzidine (CAS No. 000092-87-5).
    28. Di-n-butyl phthalate (CAS No. 000084-74-2).
    29. Pentachlorophenol (CAS No. 000087-86-5).
    30. Endosulfan (CAS Nos. 000115-29-7, 001031-07-8, 000959-98-8, 
033213-65-9).
    31. Ethion (CAS No. 000563-12-2).
    32. Methylene chloride (CAS No. 000075-09-2).
    33. Polychlorinated biphenyls (CAS Nos. 001336-36-3, 011097-69-1, 
011096-82-5, 012672-29-6, 053469-21-9, 012767-79-2, 011104-28-2, 
012674-11-2, 011141-16-5, 071328-89-7, 026914-33-0).
    34. Toluene (CAS No. 000108-88-3).
    35. Chlorophenols (CAS Nos. 000088-06-2, 025167-83-3, 000120-83-2, 
000095-95-4, 000095-57-8, 004901-51-3, 000935-95-5, 000058-90-2, 
000106-48-9, 025167-80-0).
    36. Hexachlorocyclopentadiene (CAS No. 000077-47-4).
    37. Mercury (CAS Nos. 007439-97-6, 022967-92-6, 007487-94-7).
    38. 3,3'-Dichlorobenzidine (CAS No. 000091-94-1).
    39. Chlorinated Dibenzodioxin (CDDs) (CAS Nos. 001746-01-6, 034465-
46-8, 037871-00-4, 041903-57-5, 036088-22-9, 035822-46-9, 003268-87-9,

[[Page 10907]]

057653-85-7, 039227-28-6, 019408-74-3, 040321-76-4).
    40. Chloroethane (CAS No. 000075-00-3).
    41. Chloromethane (CAS No. 000074-87-3).
    42. Dinitrotoluene (CAS Nos. 025321-14-6, 000121-14-2, 000606-20-
2).
    43. Chloroform (CAS No. 000067-66-3).
    44. Chlorpyrifos (CAS No. 002921-88-2).
    45. Endrin (CAS Nos. 000072-20-8, 053494-70-5, 007421-93-4).
    46. Tetrachloroethylene (CAS No. 000127-18-4).
    47. Trichloroethylene (CAS No. 000079-01-6).
    48. 1,2-Dichloroethene (CAS Nos. 000540-59-0, 000156-60-5, 000156-
59-2).
    49. Carbon disulfide (CAS No. 000075-15-0).
    50. 1,1-Dichloroethene (CAS No. 000075-35-4).
    51. 2,4-Dinitrophenol (CAS No. 000051-28-5).
    52. 4,6-Dinitro-o-cresol (CAS No. 000534-52-1).
    53. Disulfoton (CAS No. 000298-04-4).
    54. Hexachlorobutadiene (CAS No. 000087-68-3).
    55. Polycyclic aromatic hydrocarbons (CAS No. 130498-29-2).
    56. Acetone (CAS No. 000067-64-1).
    57. Chlordane (CAS Nos. 000057-74-9, 005103-71-9, 005103-74-2, 
027304-13-8, 056641-38-4, 12789-03-6, 056534-02-2, 039765-80-5, 005103-
73-1, 003734-48-3).
    58. Chlordecone/Mirex (CAS Nos. 000143-50-0, 002385-85-5).
    59. Chlorinated Dibenzofurans (CDFs) (CAS Nos. 042934-53-2, 039001-
02-0, 038998-75-3, 057117-31-4, 055684-94-1, 030402-15-4, 051207-31-9, 
067562-39-4, 072918-21-9, 030402-14-3, 057117-44-9, 070648-26-9, 
060851-34-5, 057117-41-6, 055673-89-7).
    60. 1,2-Dibromo-3-chloropropane (CAS Nos. 000096-12-8, 067708-83-
2).
    61. 1,2-Dibromoethane (CAS No. 000106-93-4).
    62. 2-Hexanone (CAS No. 000591-78-6).
    63. 4,4'-Methylene bis(2-chloroaniline) (CAS No. 000101-14-4).
    64. N-Nitrosodiphenylamine (CAS No. 000086-30-6).
    65. 2-Butanone (CAS No. 000078-93-3).
    66. 1,1-Dichloroethane (CAS No. 000075-34-3).
    67. 1,2-Diphenylhydrazine (CAS No. 000122-66-7).
    68. Bis(2-chloroethyl) ether (CAS No. 000111-44-4).
    69. Chlorobenzene (CAS No. 000108-90-7).
    70. Radium (CAS Nos. 007440-14-4, 013982-63-3, 015262-20-1, 013233-
32-4).
    71. Thorium (CAS Nos. 007440-29-1, 014269-63-7, 014274-82-9).
    72. 1,1,2-Trichloroethane (CAS No. 000079-00-5).
    73. N-Nitrosodimethylamine (CAS No. 000062-75-9).
    74. N-Nitrosodi-n-propylamine (CAS No. 000621-64-7).
    Submission of Nominations for the Evaluation Set 25 Proposed 
Substances: Today's notice invites voluntary public nominations for 
substances not listed in this notice. Nominations are most useful if 
they include the full name of the nominator, title, affiliation, e-mail 
address, and telephone number.
    ATSDR will evaluate all data and information associated with 
nominated substances and will determine the final list of substances to 
be chosen for toxicological profile development. Substances will be 
chosen according to ATSDR's specific guidelines for selection. These 
guidelines can be found in the Selection Criteria announced in the 
Federal Register on May 7, 1993 (85FR27286). Please submit nominations 
by any of the following methods:
    E-mail: [email protected].
    Fax: 770.488.4178.
    Mail: CDR Jessilynn Taylor, 1600 Clifton Rd., NE., MS F-62, 
Atlanta, GA 30333.

FOR FURTHER INFORMATION CONTACT: For further information, please 
contact Commander Jessilynn B. Taylor by e-mail at [email protected] or by 
phone at 770-488-3313.
    Please ensure that your comments are submitted within the specified 
nomination period. Nominations received after the closing date will be 
marked as late and may be considered only if time and resources permit.

Ken Rose,
Director, Office of Policy, Planning and Evaluation, National Center 
for Environmental Health/Agency for Toxic Substances and Disease 
Registry.
[FR Doc. 2011-4327 Filed 2-25-11; 8:45 am]
BILLING CODE 4163-70-P