[Federal Register Volume 75, Number 90 (Tuesday, May 11, 2010)]
[Pages 26257-26258]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2010-11180]



Centers for Disease Control and Prevention


Agency Forms Undergoing Paperwork Reduction Act Review

    The Centers for Disease Control and Prevention (CDC) publishes a 
list of information collection requests under review by the Office of 
Management and Budget (OMB) in compliance with the Paperwork Reduction 
Act (44 U.S.C. Chapter 35). To request a copy of these requests, call 
the CDC Reports Clearance Officer at (404) 639-5960 or send an e-mail 
to [email protected]. Send written comments to CDC Desk Officer, Office of 
Management and Budget, Washington, DC or by fax to (202) 395-5806. 
Written comments should be received within 30 days of this notice.

Proposed Project

    Examining In-vehicle Exposures to Air Pollutants and Corresponding 
Health Outcomes of Commuters--New--National Center for Environmental 
Health, (NCEH) and Agency for Toxic Substances and Disease Registry 
(ATSDR), Centers for Disease Control and Prevention, (CDC).

Background and Brief Description

    Numerous studies have found associations between ambient fine 
particulate matter (PM2.5) and adverse cardiovascular 
outcomes. Several recent epidemiologic studies suggest that vehicle-
related emissions, in particular, may be linked to many of the these 
adverse effects and that specific sub-populations may be more 
susceptible to health risks due to their enhanced exposures to vehicle-
related PM2.5 sources. Commuters are a potentially 
susceptible, yet poorly characterized, sub-population. Importantly, 
recent epidemiologic studies indicate that specific sub-groups, 
including those with asthma, may be at risk to cardio respiratory 
health effects due to their pre-existing health condition. A more 
complete understanding of in-vehicle exposures for the commuter 
population, especially those with asthma, is therefore becoming 
increasingly necessary as commuting durations and roadway congestion 
have steadily increased throughout the U.S. during the last 20 years. 
The National Center for Environmental Health (NCEH), Centers for 
Disease Control and Prevention (CDC) will conduct this study to 
characterize in-vehicle exposures to traffic-related air pollutants 
among commuters, with and without asthma, and any health impacts that 
these exposures may have on the commuter.
    A total of 40 participants (20 adults with physician-diagnosed 
asthma and 20 healthy adults) living in the Atlanta metro area will be 
recruited for participation in this study. Participants will be 
excluded if they meet specific criteria including: ever being diagnosed 
with severe asthma, ever suffering a myocardial infarction, smoking 
tobacco products, or ever being diagnosed with a pulmonary disease such 
as emphysema, chronic obstructive pulmonary disorder (COPD), or any 
type of lung cancer, will be excluded.
    Prior to their scheduled commute, participants will complete a one-
time baseline questionnaire to assess medical history and general 
exposures. Additionally, a short symptom diary recording any 
respiratory symptoms will be completed by the participant prior to the 
commute and health measurements for lung function, lung inflammatory 
markers, heart rate, and biomarkers of systemic inflammation will be 
conducted by a trained field technician. In-vehicle exposures to 
particulate matter and other air pollutants will then be measured for 
all participants during their commute. After the commute, the symptom 
diary and health measurements will be conducted again to assess any 
potential changes in respiratory and cardiovascular health effects. 
Each participant will conduct the commute two times during the study 
year. The information learned from the health measurements and diary 
entries before and after the commute will be important in better 
understanding the potential acute health impacts associated with 
exposures to in-vehicle traffic pollutants and respiratory and 
cardiovascular health, and whether urban commuters--especially those 
with asthma--should be viewed as a susceptible sub-population given 
their enhanced exposures to PM2.5 and gas-phase pollutants.
    There is no cost to participants other than their time. The 
estimated annual burden hours are 180 hours.

[[Page 26258]]

                                        Estimated Annualized Burden Hours
                                                                      No. of          No. of        burden per
            Respondents                    Instrument type          respondents    responses per  respondent (in
                                                                                    respondent        hours)
Eligible participants..............  Baseline questionnaire.....              40               1           20/60
                                     Symptom survey.............              40               5            2/60
                                     Scripted commute data                    40               2               2

    Dated: May 5, 2010.
Maryam I. Daneshvar,
Reports Clearance Officer, Centers for Disease Control and Prevention.
[FR Doc. 2010-11180 Filed 5-10-10; 8:45 am]