[Federal Register Volume 75, Number 80 (Tuesday, April 27, 2010)]
[Notices]
[Pages 22148-22150]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2010-9693]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
Centers for Disease Control and Prevention
[Docket Number NIOSH-153-A]
Request for the Technical Review of 22 Draft Skin Notation
Assignments and Skin Notation Profiles
AGENCY: National Institute for Occupational Safety and Health (NIOSH)
of the Centers for Disease Control and Prevention (CDC), Department of
Health and Human Services (HHS).
ACTION: Notice of public comment period.
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SUMMARY: The National Institute for Occupational Safety and Health
(NIOSH) of the Centers for Disease Control and Prevention (CDC) is
conducting a public review of the draft skin notations and support
technical documents entitled ``Skin Notations Profiles, for 22
chemicals.'' NIOSH is requesting technical reviews of the draft Skin
Notation Profiles. To facilitate the review of these documents, NIOSH
requests that the following questions be taken into consideration:
1. Does this document clearly outline the systemic health hazards
associated with exposures of the skin to the chemical? If not, what
specific information is missing from the document?
2. If the SYS or SYS (FATAL) notations are assigned, is the
rationale and logic behind the assignment clear? If not assigned, is
the logic clear why it was not (e.g., insufficient data, no identified
health hazard)?
3. Does this document clearly outline the direct (localized) health
hazards associated with exposures of the skin to the chemical? If not,
what specific information is missing from the document?
4. If the DIR, DIR (IRR), or DIR (COR) notations are assigned, is
the rationale and logic behind the assignment clear? If not assigned,
is the logic clear why it was not (e.g., insufficient data, no
identified health hazard)?
5. Does this document clearly outline the immune-mediated responses
(allergic response) health hazards associated with exposures of the
skin to the chemical? If not, what specific information is missing from
the document?
6. If the SEN notation is assigned, is the rationale and logic
behind the assignment clear? If not assigned, is the logic clear why it
was not (e.g., insufficient data, no identified health hazard)?
7. If the ID\(SK)\ or SK were assigned, is the rationale and logic
outlined within the document?
8. Are the conclusions supported by the data?
9. Are the tables clear and appropriate?
10. Is the document organized appropriately? If not, what
improvements are needed?
11. Is the language of the manuscript acceptable as written? If
not, what improvements are needed?
12. Are you aware of any scientific data reported in governmental
publications, databases, peer-reviewed journals, or other sources that
should be included within this document?
13. What is your final recommendation for this manuscript?
Public Comment Period: Comments must be received by June 11, 2010.
ADDRESSES: You may submit comments, identified by docket number NIOSH-
153-A, by any of the following methods:
Mail: NIOSH Docket Office, Robert A. Taft Laboratories,
MS-C34, 4676 Columbia Parkway, Cincinnati, OH 45226.
[[Page 22149]]
Facsimile: (513) 533-8285.
E-mail: [email protected]. All information received in
response to this notice will be available for public examination and
copying at the NIOSH Docket Office, 4676 Columbia Parkway, Cincinnati,
Ohio 45226. A complete electronic docket containing all comments
submitted will be available on the NIOSH Web page at http://www.cdc.gov/niosh/docket, and comments will be available in writing by
request. NIOSH includes all comments received without change in the
docket, including any personal information provided.
FOR FURTHER INFORMATION CONTACT: G. Scott Dotson, NIOSH, Robert A Taft
Laboratories, MS-C32, 4676 Columbia Parkway, Cincinnati, OH 45226,
telephone (513)533-8540.
SUPPLEMENTARY INFORMATION: In 2009, NIOSH published Current
Intelligence Bulletin (CIB) 61: A Strategy for Assigning New NIOSH Skin
Notations [NIOSH 2009-147; available at http://www.cdc.gov/niosh/docs/2009-147/pdfs/2009-147.pdf]. The CIB presents a strategic framework
that is a form of hazard identification that has been designed to do
the following:
1. Ensure that the assigned skin notations reflect the contemporary
state of scientific knowledge.
2. Provide transparency behind the assignment process.
3. Communicate the hazards of chemical exposures of the skin.
4. Meet the needs of health professionals, employers, and other
interested parties in protecting workers from chemical contact with the
skin.
This strategy involves the assignment of multiple skin notations
for distinguishing systemic (SYS), direct (DIR), and sensitizing (SEN)
effects caused by exposure of skin (SK) to chemicals. Chemicals that
are highly or extremely toxic and may be potentially lethal or life-
threatening following exposures of the skin are designated with the
systemic subnotation (FATAL). Potential irritants and corrosive
chemicals are indicated by the direct effects subnotations (IRR) and
(COR), respectively. Thus with the new strategy, chemicals labeled as
SK: SYS are recognized to contribute to systemic toxicity through
dermal absorption. Chemicals assigned the notation SK: SYS (FATAL) have
been identified as highly or extremely toxic and have the potential to
be lethal or life-threatening following acute contact with the skin.
Substances identified to cause direct effects (i.e., damage or
destruction) to the skin limited to or near the point of contact are
labeled SK: DIR, and those resulting in skin irritation and corrosion
at the point of contact are labeled as SK: DIR (IRR) and SK: DIR (COR),
respectively. The SK: SEN notation is used for substances identified as
causing or contributing to allergic contact dermatitis (ACD) or other
immune-mediated responses, such as airway hyper reactivity (asthma).
Candidate chemicals may be assigned more than one skin notation when
they are identified to cause multiple effects resulting from skin
exposure. For example, if a chemical is identified as corrosive and
also contributes to systemic toxicity, it will be labeled as SK: SYS-
DIR (COR). When scientific data for a chemical indicate that skin
exposure does not produce systemic, direct, or sensitizing effects, the
compound will be assigned the notation (SK). The ID(SK)
notation is assigned to indicate that insufficient data on the health
hazards associated with skin exposure to a substance exist at the time
of the review to determine whether the chemical has the potential to
act as a systemic, direct, or sensitizing agent. The ND notation
indicates that a chemical has not been evaluated by the strategy
outlined in this CIB and that the health hazards associated with skin
exposure are unknown.
Historically, skin notations have been published in the NIOSH
Pocket Guide to Chemical Hazards [NIOSH 2005-149]. This practice will
continue with the NIOSH skin notation assignments for each evaluated
chemical being integrated as they become available. A support document
called a Skin Notation Profile has been developed for each evaluated
chemical. The Skin Notation Profile for a chemical is intended to
provide information supplemental to the skin notation, including a
summary of all relevant data used to aid in determining the hazards
associated with skin exposures.
NIOSH seeks comments on the draft skin notation assignments and
Skin Notation Profiles for 22 chemicals. The draft Skin Notation
Profiles were developed to provide the scientific rationale behind the
hazard-specific skin notation (SK) assignments for the following
chemicals:
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Document Substance(s)
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A-01......................... 1,3-Dichloropropene (CAS 542-75-
6).
A-02......................... Phenol (CAS 108-95-2).
A-03......................... Hydrogen fluoride/hydrofluoric acid
(CAS 7664-39-3).
A-04......................... Dinitrotoluene, (CAS 25321-14-
6); 2,4-.
Dinitrotoluene (CAS 121-14-2);
2,6-.
Dinitrotoluene (CAS 606-20-2).
A-05......................... Acrylamide (CAS 79-06-1).
A-06......................... Acrylonitrile (CAS 107-13-1).
A-07......................... Metallic Chromium and other Substances
containing Hexavalent Chromium [Cr(VI)]
CAS 7440-47-3; 18540-29-9).
A-08......................... m,p,o-Dinitrobenzene (CAS 99-65-
0; CAS 528-29-0; CAS
100-25-4).
A-09......................... Epichlorohydrin (CAS 106-89-8).
A-10......................... Ethylene glycol dinitrate (CAS
628-96-6).
A-11......................... Bisphenol A (CAS 80-05-7).
A-12......................... Formaldehyde (CAS 50-00-0).
A-13......................... Hydrazine (CAS 302-01-2).
A-14......................... Nitroglycerin (CAS 55-63-0).
A-15......................... Nonane (CAS 111-84-2).
A-16......................... Glutaraldehyde (CAS 111-30-8).
A-17......................... Sodium hydroxide (CAS 1310-73-
2).
A-18......................... Trichloroethylene (CAS 79-01-6).
A-19......................... Methyl cellosolve (CAS 109-86-
4).
A-20......................... 2-Butoxyethanol (CAS 111-76-2).
A-21......................... 2-Ethoxyethanol (CAS 110-80-5).
A-22......................... p-Phenylenediamine (CAS 106-50-
3).
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[[Page 22150]]
Each Skin Notation Profile provides a detailed summary of the
health hazards of skin contact and rationale for the proposed SK
assignment with the chemical(s)-of-interest.
Dated: April 19, 2010.
John Howard,
Director, National Institute for Occupational Safety and Health,
Centers for Disease Control and Prevention.
[FR Doc. 2010-9693 Filed 4-26-10; 8:45 am]
BILLING CODE 4163-19-P