[Federal Register Volume 75, Number 61 (Wednesday, March 31, 2010)]
[Notices]
[Pages 16153-16157]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2010-7169]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

Agency for Toxic Substances and Disease Registry

[ATSDR-259]


Proposed Substances To Be Evaluated for Set 24 Toxicological 
Profiles

AGENCY: Agency for Toxic Substances and Disease Registry (ATSDR), 
Department of Health and Human Services (HHS).

ACTION: Request for comments on the proposed substances to be evaluated 
for Set 24 toxicological profiles.

-----------------------------------------------------------------------

SUMMARY: This notice announces the list of proposed substances that 
will be evaluated for Comprehensive Environmental Response, 
Compensation, and Liability Act of 1980 (CERCLA) Set 24 toxicological 
profile development. ATSDR's Division of Toxicology and Environmental 
Medicine is soliciting public comments on the list of proposed 
substances to be evaluated for toxicological profile development. ATSDR 
also will consider the nomination of any additional, substances, not on 
this list, that may have public health implications.

DATES: Nominations must be submitted within 30 days of the publication 
of this notice.

ADDRESSES: Nominations may be submitted electronically. Refer to the 
section Submission of Nominations (following) for the specific address.

FOR FURTHER INFORMATION CONTACT: For further information, contact: 
Commander Jessilynn B. Taylor, Division of Toxicology and Environmental 
Medicine, Agency for Toxic Substances and Disease Registry, 1600 
Clifton Road, F-62, Atlanta, GA, 30333; telephone: (770) 488-3313; or 
e-mail: [email protected].

SUPPLEMENTARY INFORMATION: The Superfund Amendments and Reauthorization 
Act of 1986 (SARA) [42 U.S.C. 9601 et seq.] amended the CERCLA (or 
Superfund) [42 U.S.C. 9601 et seq.] by establishing certain 
requirements for ATSDR and the U.S. Environmental Protection Agency 
(EPA) with regard to hazardous substances most commonly found at 
facilities on the CERCLA NPL. Among these statutory requirements is a 
mandate for the Administrator of ATSDR to prepare toxicological 
profiles for each substance included on the Priority List of Hazardous 
Substances. This identifies 275 hazardous substances that ATSDR and EPA 
have determined pose the most significant potential threat to human 
health (http://www.atsdr.cdc.gov/cercla/07list.html). The availability 
of the revised list of the 275 priority substances was announced in the 
Federal Register on March 6, 2008 (73 FR 12178). For prior versions of 
the list of substances, see Federal Register notices dated April 17, 
1987 (52 FR 12866); October 20, 1988 (53 FR 41280); October 26, 1989 
(54 FR 43619); October 17, 1990 (55 FR 42067); October 17, 1991 (56 FR 
52166); October 28, 1992 (57 FR 48801); February 28, 1994 (59 FR 9486); 
April 29, 1996 (61 FR 18744; November 17, 1997 (62 FR 61332); October 
21, 1999 (64 FR 56792); October 25, 2001 (66 FR 54014); and November 7, 
2003 (68 FR 63098), December 7, 2005 (70 FR 72840).

[[Page 16154]]

Proposed Substances To Be Evaluated for Set 24 Toxicological Profiles

    Each year, ATSDR develops a list of substances to be considered for 
toxicological profile development. This list is compiled from ATSDR's 
Priority List of Hazardous Substances and from previously nominated 
substances of public health concern. The following list of 240 proposed 
substances will be considered for Set 24 Toxicological Profile 
development.

------------------------------------------------------------------------
                                Substances              CAS Nos.
------------------------------------------------------------------------
1........................  METHANE............  000074-82-8
2........................  BROMODICHLOROETHANE  000683-53-4
3........................  1,2,3-TRICHLOROBENZ  000087-61-6
                            ENE.
4........................  POLONIUM-210.......  013981-52-7
5........................  LEAD-210...........  014255-04-0
6........................  NEPTUNIUM-237......  013994-20-2
7........................  S,S,S-TRIBUTYL       000078-48-8
                            PHOSPHOROTRITHIOAT
                            E.
8........................  BROMINE............  007726-95-6
9........................  DICOLFOL...........  000115-32-2
10.......................  PARATHIION.........  000056-38-2
11.......................  TRICHLOROFLUOROETHA  027154-33-2
                            NE.
12.......................  TRIFLURALIN........  000152-09-8
13.......................  PENTACHLOROBENZENE.  000608-93-5
14.......................  TRICHLOROETHANE....  025323-89-1
15.......................  PALLADIUM..........  007440-05-3
16.......................  DIBENZOFURAN.......  000132-64-9
17.......................  2,4-DIMETHYLPHENOL.  000105-67-9
18.......................  TETRACHLOROETHANE..  025322-20-7
19.......................  BIS(2-               034006-76-3
                            METHOXYETHYL)PHTHA
                            LATE.
20.......................  BUTYL BENZYL         000085-68-7
                            PHTHALATE.
21.......................  1,2,4-               000120-82-1
                            TRICHLOROBENZENE.
22.......................  NITRITE............  014797-65-0
23.......................  NITRATE............  014797-55-8
24.......................  POTASSIUM-40.......  013966-00-2
25.......................  THORIUM-227........  015623-47-9
26.......................  PHORATE............  000298-02-2
27.......................  DIMETHOATE.........  000060-51-5
28.......................  ACTINIUM-227.......  014952-40-0
29.......................  STROBANE...........  008001-50-1
30.......................  4-AMINOBIPHENYL....  000092-67-1
31.......................  ARSINE.............  007784-42-1
32.......................  NALED..............  000300-76-5
33.......................  ETHOPROP...........  013194-48-4
34.......................  CARBOPHENOTHION....  000786-19-6
35.......................  2,4-D ACID.........  000094-75-7
36.......................  DIURON.............  000330-54-1
37.......................  BUTYLATE...........  002008-41-5
38.......................  DIMETHYL FORMAMIDE.  000068-12-2
39.......................  DICHLOROBENZENE....  025321-22-6
40.......................  ETHYL ETHER........  000060-29-7
41.......................  DICHLOROETHANE.....  001300-21-6
42.......................  PHOSPHINE..........  007803-51-2
43.......................  TRICHLOROBENZENE...  012002-48-1
44.......................  PENTAERYTHRITOL      000078-11-5
                            TETRANITRATE.
45.......................  BIS(2-               000103-23-1
                            ETHYLHEXYL)ADIPATE.
46.......................  CARBAZOLE..........  000086-74-8
47.......................  METHYL ISOBUTYL      000108-10-1
                            KETONE.
48.......................  CARBARYL...........  000063-25-2
49.......................  MERCURY............  007439-97-6
50.......................  METHYLMERCURY......  022967-92-6
51.......................  MERCURIC CHLORIDE..  007487-94-7
52.......................  POLYCHLORINATED      001336-36-3
                            BIPHENYLS.
53.......................  AROCLOR 1254.......  011097-69-1
54.......................  AROCLOR 1260.......  011096-82-5
55.......................  AROCLOR 1248.......  012672-29-6
56.......................  AROCLOR 1242.......  053469-21-9
57.......................  AROCLOR............  012767-79-2
58.......................  AROCLOR 1221.......  011104-28-2
59.......................  AROCLOR 1016.......  012674-11-2
60.......................  AROCLOR 1232.......  011141-16-5
61.......................  AROCLOR 1240.......  071328-89-7
62.......................  TETRACHLOROBIPHENYL  026914-33-0
63.......................  POLYCYCLIC AROMATIC  130498-29-2
                            HYDROCARBONS.
64.......................  BENZO(A)PYRENE.....  000050-32-8
65.......................  BENZO(B)FLUORANTHEN  000205-99-2
                            E.
66.......................  DIBENZO(A,H)ANTHRAC  000053-70-3
                            ENE.
67.......................  BENZO(A)ANTHRACENE.  000056-55-3
68.......................  BENZO(K)FLUORANTHEN  000207-08-9
                            E.

[[Page 16155]]

 
69.......................  BENZOFLUORANTHENE..  056832-73-6
70.......................  FLUORANTHENE.......  000206-44-0
71.......................  CHRYSENE...........  000218-01-9
72.......................  ACENAPHTHENE.......  000083-32-9
73.......................  INDENO(1,2,3-CD)PYR  000193-39-5
                            ENE.
74.......................  BENZOPYRENE........  073467-76-2
75.......................  PHENANTHRENE.......  000085-01-8
76.......................  PYRENE.............  000129-00-0
77.......................  FLUORENE...........  000086-73-7
78.......................  ANTHRACENE.........  000120-12-7
79.......................  BENZO(A)FLUORANTHEN  000203-33-8
                            E.
80.......................  BENZO(GHI)PERYLENE.  000191-24-2
81.......................  ACENAPHTHYLENE.....  000208-96-8
82.......................  BENZO(J)FLUORANTHEN  000205-82-3
                            E.
83.......................  BENZO(E)PYRENE.....  000192-97-2
84.......................  BENZOPERYLENE......  011057-45-7
85.......................  BENZO(B)ANTHRACENE.  000092-24-0
86.......................  DIBENZ(A,J)ANTHRACE  000224-41-9
                            NE.
87.......................  BENZO(GHI)FLUORANTH  000203-12-3
                            ENE.
88.......................  1-METHYLPYRENE.....  002381-21-7
89.......................  CHLOROFORM.........  000067-66-3
90.......................  DDT, P,P'-.........  000050-29-3
91.......................  DDE, P,P'-.........  000072-55-9
92.......................  DDD, P,P'-.........  000072-54-8
93.......................  DDT, O,P'-.........  000789-02-6
94.......................  DDD, O,P'-.........  000053-19-0
95.......................  DDE, O,P'-.........  003424-82-6
96.......................  TRICHLOROETHYLENE..  000079-01-6
97.......................  DIELDRIN...........  000060-57-1
98.......................  ALDRIN.............  000309-00-2
99.......................  CHLORDANE..........  000057-74-9
100......................  CIS-CHLORDANE......  005103-71-9
101......................  TRANS-CHLORDANE....  005103-74-2
102......................  OXYCHLORDANE.......  027304-13-8
103......................  GAMMA-CHLORDENE....  056641-38-4
104......................  CHLORDANE,           012789-03-6
                            TECHNICAL.
105......................  ALPHA-CHLORDENE....  056534-02-2
106......................  NONACHLOR, TRANS-..  039765-80-5
107......................  NONACHLOR, CIS-....  005103-73-1
108......................  CHLORDENE..........  003734-48-3
109......................  HEXACHLOROBUTADIENE  000087-68-3
110......................  COAL TAR CREOSOTE..  008001-58-9
111......................  COAL TARS..........  008007-45-2
112......................  DDD, P,P'-.........  000072-54-8
113......................  COAL TAR PITCH.....  065996-93-2
114......................  BENZIDINE..........  000092-87-5
115......................  TOXAPHENE..........  008001-35-2
116......................  TETRACHLOROETHYLENE  000127-18-4
117......................  1,2-DIBROMOETHANE..  000106-93-4
118......................  DISULFOTON.........  000298-04-4
119......................  3,3'-                000091-94-1
                            DICHLOROBENZIDINE.
120......................  ENDRIN.............  000072-20-8
121......................  ENDRIN KETONE......  053494-70-5
122......................  ENDRIN ALDEHYDE....  007421-93-4
123......................  BERYLLIUM..........  007440-41-7
124......................  1,2-DIBROMO-3-CHLOR  000096-12-8
                            OPROPANE.
125......................  DIBROMOCHLOROPROPAN  067708-83-2
                            E.
126......................  PENTACHLOROPHENOL..  000087-86-5
127......................  DI-N-BUTYL           000084-74-2
                            PHTHALATE.
128......................  ENDOSULFAN.........  000115-29-7
129......................  ENDOSULFAN SULFATE.  001031-07-8
130......................  ENDOSULFAN, ALPHA..  000959-98-8
131......................  ENDOSULFAN, BETA...  033213-65-9
132......................  METHOXYCHLOR.......  000072-43-5
133......................  METHANE............  000074-82-8
134......................  TOLUENE............  000108-88-3
135......................  2-HEXANONE.........  000591-78-6
136......................  2,3,7,8-TETRACHLORO  001746-01-6
                            DIBENZO-P-DIOXIN.
137......................  HEXACHLORODIBENZO-P  034465-46-8
                            -DIOXIN.
138......................  HEPTACHLORODIBENZO-  037871-00-4
                            P-DIOXIN.
139......................  TETRACHLORODIBENZO-  041903-57-5
                            P-DIOXIN.
140......................  PENTACHLORODIBENZO-  036088-22-9
                            P-DIOXIN.
141......................  1,2,3,4,6,7,8-HEPTA  035822-46-9
                            CHLORODIBENZO-P-DI
                            OXIN.
142......................  OCTACHLORODIBENZO-P  003268-87-9
                            -DIOXIN.

[[Page 16156]]

 
143......................  1,2,3,6,7,8-HEXACHL  057653-85-7
                            ORODIBENZO-P-DIOXI
                            N.
144......................  1,2,3,4,7,8-HEXACHL  039227-28-6
                            ORODIBENZO-P-DIOXI
                            N.
145......................  1,2,3,7,8,9-HEXACHL  019408-74-3
                            ORODIBENZO-P-DIOXI
                            N.
146......................  1,2,3,7,8-PENTACHLO  040321-76-4
                            RODIBENZO-P-DIOXIN.
147......................  DI(2-ETHYLHEXYL)PHT  000117-81-7
                            HALATE.
148......................  1,1-DICHLOROETHENE.  000075-35-4
149......................  METHYLENE CHLORIDE.  000075-09-2
150......................  BROMODICHLOROETHANE  000683-53-4
151......................  1,2-DICHLOROETHANE.  000107-06-2
152......................  2,4,6-TRICHLOROPHEN  000088-06-2
                            OL.
153......................  TETRACHLOROPHENOL..  025167-83-3
154......................  2,4-DICHLOROPHENOL.  000120-83-2
155......................  2,4,5-TRICHLOROPHEN  000095-95-4
                            OL.
156......................  2-CHLOROPHENOL.....  000095-57-8
157......................  2,3,4,5-TETRACHLORO  004901-51-3
                            PHENOL.
158......................  2,3,5,6-TETRACHLORO  000935-95-5
                            PHENOL.
159......................  2,3,4,6-TETRACHLORO  000058-90-2
                            PHENOL.
160......................  4-CHLOROPHENOL.....  000106-48-9
161......................  CHLOROPHENOL.......  025167-80-0
162......................  2,4-DINITROPHENOL..  000051-28-5
163......................  BIS(2-CHLOROETHYL)   000111-44-4
                            ETHER.
164......................  ASBESTOS...........  001332-21-4
165......................  CHRYSOTILE ASBESTOS  012001-29-5
166......................  AMOSITE ASBESTOS...  012172-73-5
167......................  HEXACHLOROBENZENE..  000118-74-1
168......................  2,4-DINITROTOLUENE.  000121-14-2
169......................  DINITROTOLUENE.....  025321-14-6
170......................  2,6-DINITROTOLUENE.  000606-20-2
171......................  RADIUM-226.........  013982-63-3
172......................  RADIUM.............  007440-14-4
173......................  RADIUM-228.........  015262-20-1
174......................  RADIUM-224.........  013233-32-4
175......................  ETHION.............  000563-12-2
176......................  THORIUM............  007440-29-1
177......................  THORIUM-230........  014269-63-7
178......................  THORIUM-228........  014274-82-9
179......................  4,6-DINITRO-O-CRESO  000534-52-1
                            L.
180......................  CHLOROBENZENE......  000108-90-7
181......................  N-NITROSODI-N-PROPY  000621-64-7
                            LAMINE.
182......................  1,2,3-TRICHLOROBENZ  000087-61-6
                            ENE.
183......................  POLONIUM-210.......  013981-52-7
184......................  CHLORPYRIFOS.......  002921-88-2
185......................  NEPTUNIUM-237......  013994-20-2
186......................  CHLORDECONE........  000143-50-0
187......................  MIREX..............  002385-85-5
188......................  S,S,S-TRIBUTYL       000078-48-8
                            PHOSPHOROTRITHIOAT
                            E.
189......................  BROMINE............  007726-95-6
190......................  DICOFOL............  000115-32-2
191......................  PARATHION..........  000056-38-2
192......................  SELENIUM...........  007782-49-2
193......................  TRICHLOROFLUOROETHA  027154-33-2
                            NE.
194......................  TRIFLURALIN........  001582-09-8
195......................  4,4'-METHYLENEBIS(2- 000101-14-4
                            CHLOROANILINE).
196......................  PENTACHLOROBENZENE.  000608-93-5
197......................  1,1-DICHLOROETHANE.  000075-34-3
198......................  1,2,3,4,6,7,8,9-OCT  039001-02-0
                            ACHLORODIBENZOFURA
                            N.
199......................  HEPTACHLORODIBENZOF  038998-75-3
                            URAN.
200......................  2,3,4,7,8-PENTACHLO  057117-31-4
                            RODIBENZOFURAN.
201......................  HEXACHLORODIBENZOFU  055684-94-1
                            RAN.
202......................  PENTACHLORODIBENZOF  030402-15-4
                            URAN.
203......................  2,3,7,8-TETRACHLORO  051207-31-9
                            DIBENZOFURAN.
204......................  DIBENZOFURANS,       042934-53-2
                            CHLORINATED.
205......................  1,2,3,4,6,7,8-HEPTA  067562-39-4
                            CHLORODIBENZOFURAN.
206......................  1,2,3,7,8,9-HEXACHL  072918-21-9
                            ORODIBENZOFURAN.
207......................  TETRACHLORODIBENZOF  030402-14-3
                            URAN.
208......................  1,2,3,6,7,8-HEXACHL  057117-44-9
                            ORODIBENZOFURAN.
209......................  1,2,3,4,7,8-HEXACHL  070648-26-9
                            ORODIBENZOFURAN.
210......................  2,3,4,6,7,8-HEXACHL  060851-34-5
                            ORODIBENZOFURAN.
211......................  1,2,3,7,8-PENTACHLO  057117-41-6
                            RODIBENZOFURAN.
212......................  1,2,3,4,7,8,9-HEPTA  055673-89-7
                            CHLORODIBENZOFURAN.
213......................  1,1,2-TRICHLOROETHA  000079-00-5
                            NE.
214......................  HEXACHLOROCYCLOPENT  000077-47-4
                            ADIENE.
215......................  1,2-DIPHENYLHYDRAZI  000122-66-7
                            NE.
216......................  1,2-DICHLOROETHENE,  000156-60-5
                            TRANS-.

[[Page 16157]]

 
217......................  1,2-DICHLOROETHYLEN  000540-59-0
                            E.
218......................  1,2-DICHLOROETHENE,  000156-59-2
                            CIS-.
219......................  CARBON DISULFIDE...  000075-15-0
220......................  PALLADIUM..........  007440-05-3
221......................  CHLOROETHANE.......  000075-00-3
222......................  ACETONE............  000067-64-1
223......................  DIBENZOFURAN.......  000132-64-9
224......................  2,4-DIMETHYLPHENOL.  000105-67-9
225......................  CHLOROMETHANE......  000074-87-3
226......................  BIS(2-METHOXYETHYL)  034006-76-3
                            PHTHALATE.
227......................  BUTYL BENZYL         000085-68-7
                            PHTHALATE.
228......................  N-NITROSODIMETHYLAM  000062-75-9
                            INE.
229......................  1,2,4-TRICHLOROBENZ  000120-82-1
                            ENE.
230......................  N-NITROSODIPHENYLAM  000086-30-6
                            INE.
231......................  2-BUTANONE.........  000078-93-3
232......................  FLUORINE...........  007782-41-4
233......................  HYDROGEN FLUORIDE..  007664-39-3
234......................  FLUORIDE ION.......  016984-48-8
235......................  AMMONIA............  007664-41-7
236......................  COPPER.............  065357-62-2
237......................  CHLORINE DIOXIDE...  010049-04-4
238......................  PBBs...............  059536-65-1
239......................  PBDEs..............  001163-19-5
240......................  SYNTHETIC VITREOUS   NONE
                            FIBERS.
------------------------------------------------------------------------

    Submission of Nominations for the Evaluation Set 24 Proposed 
Substances: Today's notice also invites voluntary public nominations 
for substances not listed in this notice. Nominations are most useful 
if they include the nominator, including full name, title, affiliation, 
e-mail address, and telephone number.
    ATSDR will evaluate all data and information associated with 
nominated substances and will determine the final list of substances to 
be chosen for toxicological profile development. Substances will be 
chosen according to ATSDR's specific guidelines for selection, found in 
the Selection Criteria announced in the Federal Register on May 7, 1993 
(87 FR 27288).
    Submission of Comments: Submit comments via e-mail at: 
[email protected]. Please include ``Set 24'' in the subject 
line of the e-mail. Or, mail to: Commander Jessilynn B. Taylor, 
Division of Toxicology and Environmental Medicine, 1600 Clifton Road, 
MS F-62, Atlanta, GA 30333; e-mail: [email protected].
    Please ensure that your comments are submitted within the specified 
nomination period. Nominations received after the closing date will be 
marked as late and may be considered only if time and resources permit.

    Dated: March 26, 2010.
Ken Rose,
Associate Director, Office of Policy, Planning and Evaluation, National 
Center for Environmental Health/Agency for Toxic Substances and Disease 
Registry.
[FR Doc. 2010-7169 Filed 3-30-10; 8:45 am]
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