[Federal Register Volume 74, Number 241 (Thursday, December 17, 2009)]
[Notices]
[Pages 66978-66979]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: E9-29345]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

Agency for Toxic Substances and Disease Registry

[ATSDR-256]


Availability of Draft Toxicological Profiles

AGENCY: Agency for Toxic Substances and Disease Registry (ATSDR), 
Department of Health and Human Services (HHS).

ACTION: Notice of availability.

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SUMMARY: The Comprehensive Environmental Response, Compensation, and 
Liability Act of 1980 (CERCLA), as amended by the Superfund Amendments 
and Reauthorization Act of 1986 (SARA), Sec.  104(i)(3) [42 U.S.C. 
9604(i)(3)], directs the ATSDR Administrator to prepare toxicological 
profiles of priority hazardous substances and, as necessary, to revise 
and publish each updated toxicological profile. This notice announces 
the availability of the 23rd set of toxicological profiles, which 
consists of three new and two updated drafts prepared by ATSDR for 
review and comment.

DATES: To be considered, comments on these draft toxicological profiles 
must be received on or before February 26, 2010. Comments received 
after the public comment period will be considered at the discretion of 
ATSDR, based on what it deems in the best interest of the general 
public.

ADDRESSES: Send requests for printed copies of the draft toxicological 
profiles to the attention of Ms. Olga Dawkins, [email protected], 
Division of Toxicology and Environmental Medicine, Agency for Toxic 
Substances and Disease Registry, Mailstop F-62, 1600 Clifton Road, NE., 
Atlanta, Georgia 30333. Electronic access to these documents is also 
available at the ATSDR Web site: http://www.atsdr.cdc.gov/toxpro2.html.
    Requests for printed copies of the draft toxicological profiles 
must be in writing and must specifically identify the hazardous 
substance(s) profile(s) you wish to receive. ATSDR reserves the right 
to provide free of charge only one copy of each requested profile. 
Requestors will be notified in the event of extended distribution 
delays.
    Written comments and other data submitted in response to this 
notice and in response to the draft toxicological profiles should bear 
the docket control number ATSDR-256. Send one copy of all comments and 
three copies of all supporting documents to the attention of Ms. 
Nickolette Roney, Division of Toxicology and Environmental Medicine, 
Agency for Toxic Substances and Disease Registry, Mailstop F-62, 1600 
Clifton Road, NE., Atlanta, Georgia 30333, no later than the end of the 
comment period. Electronic comments may be sent via e-mail to 
[email protected] and should contain the docket control number 
ATSDR-256 in the subject line.
    Because all public comments regarding ATSDR toxicological profiles 
are available for public inspection, do not submit confidential 
information in response to this notice.

FOR FURTHER INFORMATION CONTACT: Ms. Olga Dawkins, Division of 
Toxicology and Environmental Medicine, Agency for Toxic Substances and 
Disease Registry, Mailstop F-62, 1600 Clifton Road, NE., Atlanta, 
Georgia 30333; telephone number (800) 232-4636 or (770) 488-3315.

SUPPLEMENTARY INFORMATION: The Superfund Amendments and Reauthorization 
Act (SARA) (Pub. L. 99-499) amends the Comprehensive Environmental 
Response, Compensation, and Liability Act (CERCLA or Superfund) (42 
U.S.C. 9601 et seq.) by establishing certain responsibilities for ATSDR 
and the U.S. Environmental Protection Agency (U.S. EPA) with regard to 
hazardous substances most commonly found at facilities on the CERCLA 
National Priorities List (NPL). As part of these responsibilities, the 
ATSDR Administrator must prepare toxicological profiles for substances 
enumerated on the priority list of hazardous substances. This list 
identifies 275 hazardous substances

[[Page 66979]]

which, according to ATSDR and U.S. EPA, pose the most significant 
potential threat to human health. The availability of the revised 
priority list of 275 hazardous substances was announced in the Federal 
Register on March 6, 2008 (73 FR 12178). In addition, ATSDR has the 
authority to prepare toxicological profiles for substances not found at 
sites on the National Priorities List, in an effort to ``* * * 
establish and maintain inventory of literature, research, and studies 
on the health effects of toxic substances'' under CERCLA Section 
104(i)(1)(B), to respond to requests for consultation under section 
104(i)(4), and as otherwise necessary to support the site-specific 
response actions conducted by ATSDR.
    For previous versions of the list of substances, see Federal 
Register notices dated April 17, 1987 (52 FR 12866); October 20, 1988 
(53 FR 41280); October 26, 1989 (54 FR 43619); October 17, 1990 (55 FR 
42067); October 17, 1991 (56 FR 52166); October 28, 1992 (57 FR 48801); 
February 28, 1994 (59 FR 9486); April 29, 1996 (61 FR 18744); November 
17, 1997 (62 FR 61332); October 21, 1999 (64 FR 56792); October 25, 
2001 (66 FR 54014); November 7, 2003 (68 FR 63098); and December 7, 
2005 (70 FR 72840). [CERCLA also requires that ATSDR initiate a 
research program to fill data needs associated with the substances.] 
Section 104(i)(3) of CERCLA [42 U.S.C. 9604(i)(3)] outlines the content 
of these profiles. Each profile will include an examination, a summary, 
and an interpretation of available toxicological information and 
epidemiological evaluations. This information and these data identify 
the levels of significant human exposure for the substance and for the 
associated health effects. The profiles must also include a 
determination of whether adequate information on the health effects of 
each substance is available or is in the process of development. If 
adequate information is not available, ATSDR, in cooperation with the 
National Toxicology Program (NTP), is required to ensure the initiation 
of research to determine such health effects.
    Although during the profile development process ATSDR considered 
key studies for each of the substances, this Federal Register notice 
solicits any relevant, additional studies, particularly unpublished 
data and ongoing studies. ATSDR will evaluate such data or studies for 
possible addition to the profiles, now or in the future.
    The following draft toxicological profiles have been made available 
to the public:

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                  Toxicological profile                     CAS Number
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1. Acrylamide...........................................         79-06-1
2. Carbon Monoxide......................................        630-08-0
3. 1,3-Butadiene........................................        106-99-0
4. Phosphate Ester Flame Retardants.....................         78-51-3
                                                                126-73-8
                                                                126-71-6
                                                                115-86-6
                                                              13674-84-5
                                                              13674-87-8
                                                                115-96-8
5. Vanadium.............................................       7440-62-2
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    All profiles issued as ``Drafts for Public Comment'' represent 
ATSDR's best efforts to provide important toxicological information on 
priority hazardous substances. We seek public comment and additional 
information that may supplement these profiles. ATSDR remains committed 
to providing a public comment period for these documents as the best 
means to serve public health and our clients.

    Dated: December 4, 2009.
Ken Rose,
Director, Office of Policy, Planning and Evaluation, National Center 
for Environmental Health/Agency for Toxic Substances and Disease 
Registry.
[FR Doc. E9-29345 Filed 12-16-09; 8:45 am]
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