[Federal Register Volume 74, Number 27 (Wednesday, February 11, 2009)]
[Notices]
[Pages 6909-6910]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: E9-2821]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Government-Owned Inventions; Availability for Licensing

AGENCY: National Institutes of Health, Public Health Service, HHS.

ACTION: Notice.

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SUMMARY: The inventions listed below are owned by an agency of the U.S. 
Government and are available for licensing in the U.S. in accordance 
with 35 U.S.C. 207 to achieve expeditious commercialization of results 
of federally-funded research and development. Foreign patent 
applications are filed on selected inventions to extend market coverage 
for companies and may also be available for licensing.

ADDRESSES: Licensing information and copies of any U.S. patent 
applications listed below may be obtained by writing to the indicated 
licensing contact at the Office of Technology Transfer, National 
Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville, 
Maryland 20852-3804; telephone: 301/496-7057; fax: 301/402-0220. A 
signed Confidential Disclosure Agreement will be required to receive 
copies of the patent applications.

Constructs for Measuring Activated Arf5 in Cells

    Description of Technology: Scientists at the National Institutes of 
Health have developed a series of fusion protein constructs that can 
quantify the levels of activated Arf5 in cells. Arf5 is a member of the 
Arf family of GTP binding proteins and is an important regulator of 
intracellular trafficking and actin-mediated cell motility. Arf family 
members have been implicated to play a role in the spread of cancer 
(metastasis) and in the movement of cancer cells into healthy tissues 
(invasion). The constructs are DNA sequences of various portions of the 
carboxyl-terminal end of the Rab11-

[[Page 6910]]

family interacting protein 3 (FIP3) expressed in the pGEX2T vector.
    Application: Research tool to detect and quantify activated Arf5 in 
various laboratory procedures to analyze intracellular trafficking and 
cellular motility.
    Advantages: To the best of our knowledge, this technology 
represents the first reported assay for the detection of activated 
Arf5.
    Inventors: Paul A. Randazzo and Vi L. Ha (NCI).
    Publications:
    1. H Inoue et al. Arf GTPase-activating protein ASAP1 interacts 
with Rab11 effector FIP3 and regulates pericentrosomal localization of 
transferrin receptor-positive recycling endosome. Mol Biol Cell. 2008 
Oct;19(10):4224-4237.
    2. HY Yoon et al. In vitro assays of Arf1 interaction with GGA 
proteins. Methods Enzymol. 2005;404:316-332.
    Patent Status: HHS Reference No. E-064-2009/0--Research Tool. 
Patent protection is not being pursued for this technology.
    Related Technologies: Antibodies and Antisera Recognizing Members 
of the ArfGap Family of Proteins:
     HHS Reference No. E-220-2008/0--Research Tool.
     HHS Reference No. E-220-2008/1--Research Tool.
     HHS Reference No. E-220-2008/2--Research Tool.
     HHS Reference No. E-221-2008/0--Research Tool.
     HHS Reference No. E-221-2008/1--Research Tool.
     HHS Reference No. E-221-2008/2--Research Tool.
     HHS Reference No. E-222-2008/0--Research Tool.
     HHS Reference No. E-242-2008/0--Research Tool.
     HHS Reference No. E-243-2008/0--Research Tool.
     HHS Reference No. E-244-2008/0--Research Tool.
     HHS Reference No. E-245-2008/0--Research Tool.
     HHS Reference No. E-245-2008/1--Research Tool.
     HHS Reference No. E-252-2008/0--Research Tool.
    Licensing Status: Available for licensing under a Biological 
Materials License Agreement.
    Licensing Contact: Samuel E. Bish, PhD; 301-435-5282; 
[email protected].

Mouse Monoclonal Antibodies to MAD1, a Human Spindle Assembly 
Checkpoint Protein for Maintaining Chromosomal Segregation

    Description of Technology: Scientists at the National Institutes of 
Health have developed mouse monoclonal antibodies against the human 
spindle assembly checkpoint protein, MAD1. The spindle assembly 
checkpoint in mitotic cell division regulates the fidelity of 
chromosome segregation during cell division. MAD1 is an important 
component of this checkpoint control, which if compromised, can lead to 
the initiation of cancer cell growth. These monoclonal antibodies are 
the first available antibodies against MAD1 and can be used in 
laboratory research and diagnostics.
    Applications:
     Research tool in various laboratory procedures to identify 
and detect MAD1.
     Diagnostic tool for aneuploidy, the condition of having an 
abnormal number of chromosomes, which results in birth and 
developmental defects, such as Down syndrome.
    Inventor: Kuan-Teh Jeang (NIAID).
    Publication: K Haller et al. The N-terminus of rodent and human 
MAD1 confers species-specific stringency to spindle assembly 
checkpoint. Oncogene 2006 Apr 6;25(15):2137-2147.
    Patent Status: HHS Reference No. E-119-2003/0--Research Tool. 
Patent protection is not being pursued for this technology.
    Licensing Status: Available for licensing under a Biological 
Materials License Agreement.
    Licensing Contact: Samuel E. Bish, PhD; 301-435-5282; 
[email protected].
    Collaborative Research Opportunity: The NIAID Office of Technology 
Development is seeking statements of capability or interest from 
parties interested in collaborative research to further develop, 
evaluate, or commercialize reagents for studying cell cycle checkpoint 
factors. Please contact Agnes Rooke at [email protected] or by 
phone at 301-594-1697 for more information.

    Dated: January 30, 2009.
Richard U. Rodriguez,
Director, Division of Technology Development and Transfer, Office of 
Technology Transfer, National Institutes of Health.
 [FR Doc. E9-2821 Filed 2-10-09; 8:45 am]
BILLING CODE 4140-01-P