[Federal Register Volume 73, Number 232 (Tuesday, December 2, 2008)]
[Notices]
[Pages 73329-73332]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: E8-28551]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

Agency for Toxic Substances and Disease Registry

[ATSDR-248]


Proposed Substances To Be Evaluated for Set 23 Toxicological 
Profiles

AGENCY: Agency for Toxic Substances and Disease Registry (ATSDR), 
Department of Health and Human Services (HHS).

ACTION: Request for comments on the proposed substances to be evaluated 
for Set 23 toxicological profiles.

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SUMMARY: This notice announces the list of proposed substances that 
will be evaluated for CERCLA Set 23 toxicological profile development. 
ATSDR's Division of Toxicology and Environmental Medicine is soliciting 
public nominations from the list of proposed substances to be evaluated 
for toxicological profile development. ATSDR also will consider the 
evaluation of any additional substances that may have public health 
implications.

DATES: Nominations must be submitted by December 24th, 2008.

ADDRESSES: Nominations may be submitted electronically, by mail, or by 
facsimile. Refer to the section Submission of Nominations (below) for 
specific addresses and/or the facsimile number.

FOR FURTHER INFORMATION: Contact Commander Jessilynn B. Taylor, 
Division of Toxicology and Environmental Medicine, Agency for Toxic 
Substances and Disease Registry, Mailstop F-32, 1600 Clifton Road, NE., 
Atlanta, Georgia 30333, telephone (770) 488-3313.

SUPPLEMENTARY INFORMATION: The Superfund Amendments and Reauthorization 
Act of 1986 (SARA) [42 U.S.C. 9601 et seq.] amended the Comprehensive 
Environmental Response, Compensation, and Liability Act of 1980 (CERCLA 
or Superfund) [42 U.S.C. 9601 et seq.] by establishing certain 
requirements for ATSDR and the U.S. Environmental Protection Agency 
(EPA) with regard to hazardous substances that are most commonly found 
at facilities on the CERCLA National Priorities List (NPL). Among these 
statutory requirements is a mandate for the Administrator of ATSDR to 
prepare toxicological profiles for each substance included on the 
Priority List of Hazardous Substances. This list has identified 275 
hazardous substances that ATSDR and EPA determined pose the most 
significant potential threat to human health. The availability of the 
revised list of the 275 priority substances was announced in the 
Federal Register on March 6, 2008 (73 FR 12178). For previous versions 
of the list of substances, see Federal Register notices dated April 17, 
1987 (52 FR 12866); October 20, 1988 (53 FR 41280); October 26, 1989 
(54 FR 43619); October 17, 1990 (55 FR 42067); October 17, 1991 (56 FR 
52166); October 28, 1992 (57 FR 48801); February 28, 1994 (59 FR 9486); 
April 29, 1996 (61 FR 18744; November 17, 1997 (62 FR 61332); October 
21, 1999 (64 FR 56792); October 25, 2001 (66 FR 54014); November 7, 
2003 (68 FR 63098); and December 7, 2005 (70 FR 70284).

Proposed Substances To Be Evaluated for Set 23 Toxicological Profiles

    Each year, ATSDR develops a list of priority substances that will 
be evaluated for toxicological profile development. This list was 
compiled, on the basis of ATSDR's Priority List of Hazardous 
Substances, with consideration of the amount of relevance of newly 
published scientific

[[Page 73330]]

literature. The following 80 substances will be evaluated:

----------------------------------------------------------------------------------------------------------------
                                                                     Name                             CAS
----------------------------------------------------------------------------------------------------------------
1..............................................  MERCURY.....................................        007439-97-6
                                                 METHYLMERCURY...............................        022967-92-6
                                                 MERCURIC CHLORIDE...........................        007487-94-7
2..............................................  POLYCHLORINATED BIPHENYLS...................        001336-36-3
                                                 AROCLOR 1254................................        011097-69-1
                                                 AROCLOR 1260................................        011096-82-5
                                                 AROCLOR 1248................................        012672-29-6
                                                 AROCLOR 1242................................        053469-21-9
                                                 AROCLOR.....................................        012767-79-2
                                                 AROCLOR 1221................................        011104-28-2
                                                 AROCLOR 1016................................        012674-11-2
                                                 AROCLOR 1232................................        011141-16-5
                                                 AROCLOR 1240................................        071328-89-7
                                                 TETRACHLOROBIPHENYL.........................        026914-33-0
3..............................................  POLYCYCLIC AROMATIC HYDROCARBONS............        130498-29-2
                                                  BENZO(A)PYRENE.............................        000050-32-8
                                                 BENZO(B)FLUORANTHENE........................        000205-99-2
                                                 DIBENZO(A,H)ANTHRACENE......................        000053-70-3
                                                 BENZO(A)ANTHRACENE..........................        000056-55-3
                                                 BENZO(K)FLUORANTHENE........................        000207-08-9
                                                 BENZOFLUORANTHENE...........................        056832-73-6
                                                 FLUORANTHENE................................        000206-44-0
                                                 CHRYSENE....................................        000218-01-9
                                                 ACENAPHTHENE................................        000083-32-9
                                                 INDENO(1,2,3-CD)PYRENE......................        000193-39-5
                                                 BENZOPYRENE.................................        073467-76-2
                                                 PHENANTHRENE................................        000085-01-8
                                                 PYRENE......................................        000129-00-0
                                                 FLUORENE....................................        000086-73-7
                                                 ANTHRACENE..................................        000120-12-7
                                                 BENZO(A)FLUORANTHENE........................        000203-33-8
                                                 BENZO(GHI)PERYLENE..........................        000191-24-2
                                                 ACENAPHTHYLENE..............................        000208-96-8
                                                 BENZO(J)FLUORANTHENE........................        000205-82-3
                                                 BENZO(E)PYRENE..............................        000192-97-2
                                                 BENZOPERYLENE...............................        011057-45-7
                                                 BENZO(B)ANTHRACENE..........................        000092-24-0
                                                 DIBENZ(A,J)ANTHRACENE.......................        000224-41-9
                                                 BENZO(GHI)FLUORANTHENE......................        000203-12-3
                                                 1-METHYLPYRENE..............................        002381-21-7
4..............................................  CHLOROFORM..................................        000067-66-3
5..............................................  DDT, P,P'-..................................        000050-29-3
                                                 DDE, P,P'-..................................        000072-55-9
                                                 DDD, P,P'-..................................        000072-54-8
                                                 DDT, O,P'-..................................        000789-02-6
                                                 DDD, O,P'...................................       -000053-19-0
                                                 DDE, O,P'-..................................        003424-82-6
6..............................................  TRICHLOROETHYLENE...........................        000079-01-6
7..............................................  DIELDRIN....................................        000060-57-1
                                                 ALDRIN......................................        000309-00-2
8..............................................  CHLORDANE...................................        000057-74-9
                                                 CIS-CHLORDANE...............................        005103-71-9
                                                 TRANS-CHLORDANE.............................        005103-74-2
                                                 OXYCHLORDANE................................        027304-13-8
                                                 GAMMA-CHLORDENE.............................        056641-38-4
                                                 CHLORDANE, TECHNICAL........................        012789-03-6
                                                 ALPHA-CHLORDENE.............................        056534-02-2
                                                 NONACHLOR, TRANS-...........................        039765-80-5
                                                 NONACHLOR, CIS-.............................        005103-73-1
                                                 CHLORDENE...................................        003734-48-3
9..............................................  HEXACHLOROBUTADIENE.........................        000087-68-3
10.............................................  COAL TAR CREOSOTE...........................        008001-58-9
                                                 COAL TARS...................................        008007-45-2
                                                 COAL TAR PITCH..............................        065996-93-2
11.............................................  BENZIDINE...................................        000092-87-5
12.............................................  TOXAPHENE...................................        008001-35-2
13.............................................  TETRACHLOROETHYLENE.........................        000127-18-4
14.............................................  1,2-DIBROMOETHANE...........................        000106-93-4
15.............................................  DISULFOTON..................................        000298-04-4
16.............................................  3,3'-DICHLOROBENZIDINE......................        000091-94-1
17.............................................  ENDRIN......................................        000072-20-8

[[Page 73331]]

 
                                                 ENDRIN KETONE...............................        053494-70-5
                                                 ENDRIN ALDEHYDE.............................        007421-93-4
18.............................................  BERYLLIUM...................................        007440-41-7
19.............................................  1,2-DIBROMO-3-CHLOROPROPANE.................        000096-12-8
                                                 DIBROMOCHLOROPROPANE........................        067708-83-2
20.............................................  PENTACHLOROPHENOL...........................        000087-86-5
21.............................................  DI-N-BUTYL PHTHALATE........................        000084-74-2
22.............................................  ENDOSULFAN..................................        000115-29-7
                                                 ENDOSULFAN SULFATE..........................        001031-07-8
                                                 ENDOSULFAN, ALPHA...........................        000959-98-8
                                                 ENDOSULFAN, BETA............................        033213-65-9
23.............................................  METHOXYCHLOR................................        000072-43-5
24.............................................  METHANE.....................................        000074-82-8
25.............................................  TOLUENE.....................................        000108-88-3
26.............................................  2-HEXANONE..................................        000591-78-6
27.............................................  2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN.........        001746-01-6
                                                 HEXACHLORODIBENZO-P-DIOXIN..................        034465-46-8
                                                 HEPTACHLORODIBENZO-P-DIOXIN.................        037871-00-4
                                                 TETRACHLORODIBENZO-P-DIOXIN.................        041903-57-5
                                                 PENTACHLORODIBENZO-P-DIOXIN.................        036088-22-9
                                                 1,2,3,4,6,7,8-HEPTACHLORODIBENZO-P-DIOXIN...        035822-46-9
                                                 OCTACHLORODIBENZO-P-DIOXIN..................        003268-87-9
                                                 1,2,3,6,7,8-HEXACHLORODIBENZO-P-DIOXIN......        057653-85-7
                                                 1,2,3,4,7,8-HEXACHLORODIBENZO-P-DIOXIN......        039227-28-6
                                                 1,2,3,7,8,9-HEXACHLORODIBENZO-P-DIOXIN......        019408-74-3
                                                 1,2,3,7,8-PENTACHLORODIBENZO-P-DIOXIN.......        040321-76-4
28.............................................  DI(2-ETHYLHEXYL)PHTHALATE...................        000117-81-7
29.............................................  1,1-DICHLOROETHENE..........................        000075-35-4
30.............................................  METHYLENE CHLORIDE..........................        000075-09-2
31.............................................  BROMODICHLOROETHANE.........................        000683-53-4
32.............................................  1,2-DICHLOROETHANE..........................        000107-06-2
33.............................................  2,4,6-TRICHLOROPHENOL.......................        000088-06-2
                                                  TETRACHLOROPHENOL..........................        025167-83-3
                                                 2,4-DICHLOROPHENOL..........................        000120-83-2
                                                 2,4,5-TRICHLOROPHENOL.......................        000095-95-4
                                                 2-CHLOROPHENOL..............................        000095-57-8
                                                 2,3,4,5-TETRACHLOROPHENOL...................        004901-51-3
                                                 2,3,5,6-TETRACHLOROPHENOL...................        000935-95-5
                                                 2,3,4,6-TETRACHLOROPHENOL...................        000058-90-2
                                                 4-CHLOROPHENOL..............................        000106-48-9
                                                 CHLOROPHENOL................................        025167-80-0
34.............................................  2,4-DINITROPHENOL...........................        000051-28-5
35.............................................  BIS(2-CHLOROETHYL) ETHER....................        000111-44-4
36.............................................  ASBESTOS....................................        001332-21-4
                                                 CHRYSOTILE ASBESTOS.........................        012001-29-5
                                                 AMOSITE ASBESTOS............................        012172-73-5
37.............................................  HEXACHLOROBENZENE...........................        000118-74-1
38.............................................  2,4-DINITROTOLUENE..........................        000121-14-2
                                                 DINITROTOLUENE..............................        025321-14-6
                                                 2,6-DINITROTOLUENE..........................        000606-20-2
39.............................................  RADIUM-226..................................        013982-63-3
                                                 RADIUM......................................        007440-14-4
                                                 RADIUM-228..................................        015262-20-1
                                                 RADIUM-224..................................        013233-32-4
40.............................................  ETHION......................................        000563-12-2
41.............................................  THORIUM.....................................        007440-29-1
                                                 THORIUM-230.................................        014269-63-7
                                                 THORIUM-228.................................        014274-82-9
42.............................................  4,6-DINITRO-O-CRESOL........................        000534-52-1
42.............................................  CHLOROBENZENE...............................        000108-90-7
44.............................................  N-NITROSODI-N-PROPYLAMINE...................        000621-64-7
45.............................................  1,2,3-TRICHLOROBENZENE......................        000087-61-6
46.............................................  POLONIUM-210................................        013981-52-7
47.............................................  CHLORPYRIFOS................................        002921-88-2
48.............................................  NEPTUNIUM-237...............................        013994-20-2
49.............................................  CHLORDECONE.................................        000143-50-0
                                                 MIREX.......................................        002385-85-5
50.............................................  S,S,S-TRIBUTYL PHOSPHOROTRITHIOATE..........        000078-48-8
51.............................................  BROMINE.....................................        007726-95-6
52.............................................  DICOFOL.....................................        000115-32-2
53.............................................  PARATHION...................................        000056-38-2
54.............................................  SELENIUM....................................        007782-49-2
55.............................................  TRICHLOROFLUOROETHANE.......................        027154-33-2
56.............................................  TRIFLURALIN.................................        001582-09-8

[[Page 73332]]

 
57.............................................  4,4'-METHYLENEBIS(2-CHLOROANILINE)..........        000101-14-4
58.............................................  PENTACHLOROBENZENE..........................        000608-93-5
59.............................................  1,3-BUTADIENE...............................        000106-99-0
60.............................................  1,1-DICHLOROETHANE..........................        000075-34-3
61.............................................  1,2,3,4,6,7,8,9-OCTACHLORODIBENZOFURAN......        039001-02-0
                                                 HEPTACHLORODIBENZOFURAN.....................        038998-75-3
                                                 2,3,4,7,8-PENTACHLORODIBENZOFURAN...........        057117-31-4
                                                 HEXACHLORODIBENZOFURAN......................        055684-94-1
                                                 PENTACHLORODIBENZOFURAN.....................        030402-15-4
                                                 2,3,7,8-TETRACHLORODIBENZOFURAN.............        051207-31-9
                                                 DIBENZOFURANS, CHLORINATED..................        042934-53-2
                                                 1,2,3,4,6,7,8-HEPTACHLORODIBENZOFURAN.......        067562-39-4
                                                 1,2,3,7,8,9-HEXACHLORODIBENZOFURAN..........        072918-21-9
                                                 TETRACHLORODIBENZOFURAN.....................        030402-14-3
                                                 1,2,3,6,7,8-HEXACHLORODIBENZOFURAN..........        057117-44-9
                                                 1,2,3,4,7,8-HEXACHLORODIBENZOFURAN..........        070648-26-9
                                                 2,3,4,6,7,8-HEXACHLORODIBENZOFURAN..........        060851-34-5
                                                 1,2,3,7,8-PENTACHLORODIBENZOFURAN...........        057117-41-6
                                                 1,2,3,4,7,8,9-HEPTACHLORODIBENZOFURAN.......        055673-89-7
62.............................................  1,1,2-TRICHLOROETHANE.......................        000079-00-5
63.............................................  HEXACHLOROCYCLOPENTADIENE...................        000077-47-4
64.............................................  1,2-DIPHENYLHYDRAZINE.......................        000122-66-7
65.............................................  1,2-DICHLOROETHENE, TRANS-..................        000156-60-5
                                                 1,2-DICHLOROETHYLENE........................        000540-59-0
                                                 1,2-DICHLOROETHENE, CIS-....................        000156-59-2
66.............................................  CARBON DISULFIDE............................        000075-15-0
67.............................................  PALLADIUM...................................        007440-05-3
68.............................................  CHLOROETHANE................................        000075-00-3
98.............................................  ACETONE.....................................        000067-64-1
70.............................................  DIBENZOFURAN................................        000132-64-9
71.............................................  2,4-DIMETHYLPHENOL..........................        000105-67-9
72.............................................  CARBON MONOXIDE.............................        000630-08-0
73.............................................  CHLOROMETHANE...............................        000074-87-3
74.............................................  BUTYL BENZYL PHTHALATE......................        000085-68-7
75.............................................  VANADIUM....................................        007440-62-2
76.............................................  N-NITROSODIMETHYLAMINE......................        000062-75-9
77.............................................  1,2,4-TRICHLOROBENZENE......................        000120-82-1
78.............................................  N-NITROSODIPHENYLAMINE......................        000086-30-6
79.............................................  2-BUTANONE..................................        000078-93-3
80.............................................  FLUORINE....................................        007782-41-4
                                                 HYDROGEN FLUORIDE...........................        007664-39-3
                                                 FLUORIDE ION................................        016984-48-8
----------------------------------------------------------------------------------------------------------------

    Submission of Nominations for the Evaluation Set 23 Proposed 
Substances: Today's notice also invites voluntary public nominations 
for substances not listed in this notice. Nominations are most useful 
if they include the full name, title, affiliation, e-mail address and 
telephone number of the nominator.
    ATSDR will evaluate all data and information associated with 
nominated substances and will determine the final list of substances 
that will be chosen for toxicological profile development. Substances 
will be chosen according to ATSDR's specific guidelines for selection, 
found in the Selection Criteria announced in the Federal Register on 
May 7th, 1993 (87 FR 27288).
    Please submit nominations by one of the following methods:
     E-mail [email protected].
     Fax 770.488.4178.
     Mail CDR Jessilynn Taylor, 1600 Clifton Rd, NE., MS F32, 
Atlanta, GA 30333.
    Please ensure that your comments are submitted within the specified 
nomination period. Nominations received after the closing date will be 
marked as late and may be considered only if time permits.

    Dated: November 26, 2008.
Ken Rose,
Director, Office of Policy, Planning, and Evaluation National Center 
for Environmental Health/Agency for Toxic Substances and Disease 
Registry.
[FR Doc. E8-28551 Filed 12-1-08; 8:45 am]
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