[Federal Register Volume 73, Number 20 (Wednesday, January 30, 2008)]
[Notices]
[Pages 5575-5576]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: E8-1550]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
Proposed Collection; Comment Request; Case-Cohort Study of Cancer
and Related Disorders Among Benzene-Exposed Workers in China (OMB No.
0925-0454)
SUMMARY: In compliance with the requirement of Section 3506(c)(2)(A) of
the Paperwork Reduction Act of 1995, for opportunity for public comment
on proposed data collection projects, the National Cancer Institute
(NCI), the National Institutes of Health (NIH) will publish periodic
summaries of proposed projects to be submitted to the Office of
Management and Budget (OMB) for review and approval.
PROPOSED COLLECTION: Title: Case-Cohort Study of Cancer and Related
Disorders Among Benzene-Exposed Workers in China. Type of Information
Collection Request: Emergency Extension. Need and Use of Information
Collection: Since 1987, the National Cancer Institute has collaborated
with the Chinese Academy of Preventive Medicine (currently designated
Chinese Centers for Disease Control) in a factory-based investigation
of cancer mortality and incidence of lymphohematopoietic disorders in a
cohort of 75,000 and 36,000 comparison workers in 12 cities in China.
Our initial study revealed elevated risks of leukemia, myelodysplastic
syndromes, non-Hodgkin lymphoma, benzene poisoning, and lung cancer
among the benzene-exposed workers. During the past five years, data
have been collected to enable more precise quantification of risks of
the malignancies and related disorders with an additional 12 years of
follow-up of the subjects using a case-control study design. Cases
included all workers from the exposed and unexposed groups who were
diagnosed with leukemia, myelodysplastic syndromes, non-Hodgkin
lymphoma and all other hematopoietic disorders; benzene poisoning; and
lung cancer. Controls were frequency matched to cases and selected from
the exposed (N=1200) and unexposed (N=300) cohort members. Data have
been collected from factories, hospitals, and directly from interviews
of all living and next of kin of deceased cases and controls.
Information collected from the interviews focuses on potential
confounding exposures including smoking, non-occupational benzene
exposure, level of education, medical conditions, use of specific
medications, and family cancer history. This study
[[Page 5576]]
will provide better understanding of occupational and environmental
risks from benzene exposure in the United States. It will be important
to complete all data collection for the study to realize the full
scientific benefit of this 20 year international collaboration.
However, due to unexpected and unforeseen personnel problems and
training issues in China, the researchers are requesting an emergency
extension of three months to complete data collection. A detailed plan
has been discussed and developed with the collaborators in China to
complete all remaining data collections in the next three months.
Frequency of Response: One-time study. Affected Public: Individuals
or households.
Type of Respondents: Workers or their next of kin. The annual
reporting burden is reported in the following table:
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Estimated Estimated
Estimated number of Average total annual
Type of respondents number of responses per burden hours burden hours
respondents respondent per response requested
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Workers......................................... 2156 1 \1\.37 317
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Total....................................... .............. .............. .............. 317
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\1\ (22 minutes).
There are no Capital Costs to report. There are also no Operating
and/or Maintenance Costs to report.
Request for Comments: Written comments and/or suggestions from the
public and affected agencies are invited on one or more of the
following points: (1) Whether the proposed collection of information is
necessary for the proper performance of the function of the agency,
including whether the information will have practical utility; (2) The
accuracy of the agency's estimate of the burden of the proposed
collection of information, including the validity of the methodology
and assumptions used; (3) Ways to enhance the quality, utility, and
clarity of the information to be collected; and (4) Ways to minimize
the burden of the collection of information on those who are to
respond, including the use of appropriate automated, electronic,
mechanical, or other technological collection techniques or other forms
of information technology.
FOR FURTHER INFORMATION CONTACT: To request more information on the
proposed project or to obtain a copy of the data collection plans and
instruments, contact: Dr. Richard Hayes, Project Officer, OEB/EBP/DCEG/
NCI 6120 Executive Blvd., EPS Room 8114, Bethesda, MD 20892-7364, or
call non-toll-free number (301) 435-3973 or fax your request to (301)
402-1819 or E-mail your request, including your address to:
[email protected].
Comments Due Date: Comments regarding this information collection
are best assured of having their full effect if received within 60-days
of the date of this publication.
Dated: January 24, 2008.
Vivian Horovitch-Kelley,
NCI Project Clearance Liaison, National Institutes of Health.
[FR Doc. E8-1550 Filed 1-29-08; 8:45 am]
BILLING CODE 4140-01-P