[Federal Register Volume 72, Number 246 (Wednesday, December 26, 2007)]
[Notices]
[Pages 73021-73022]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: E7-24929]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

Centers for Disease Control and Prevention

[30 Day-08-07AW]


Agency Forms Undergoing Paperwork Reduction Act Review

    The Centers for Disease Control and Prevention (CDC) publishes a 
list of information collection requests under review by the Office of 
Management and Budget (OMB) in compliance with the Paperwork Reduction 
Act (44 U.S.C. Chapter 35). To request a copy of these requests, call 
the CDC Reports Clearance Officer at (404) 639-5960 or send an e-mail 
to [email protected]. Send written comments to CDC Desk Officer, Office of 
Management and Budget, Washington, DC or by fax to (202) 395-6974. 
Written comments should be received within 30 days of this notice.

Proposed Project

    Experimental and Theoretical Study of Early Detection and Isolation 
of Influenza--New--The National Institute for Occupational Safety and 
Health (NIOSH), Centers for Disease Control and Prevention (CDC).

Background and Brief Description

    The Federal Occupational Safety and Health Act of 1970, section 
501, enables NIOSH to carry out research relevant to the health and 
safety of workers. Some diseases like influenza and Severe Acute 
Respiratory Syndrome (SARS) can be spread when people produce clouds of 
droplets (called aerosols) by coughing or sneezing. Aerosol 
transmission of infectious diseases is of particular interest today 
because of increased concern over a possible global influenza pandemic. 
The possible airborne spread of influenza is especially important to 
health-care workers and emergency responders, who face a much greater 
risk of exposure than does the general public. However, substantial 
gaps exist in our understanding of the generation and spread of 
infectious aerosols containing influenza. This lack of information 
hampers the ability of health scientists to model and predict the 
transmission of influenza by airborne particles and to understand 
whether or not aerosols are likely to be an important route of 
transmission of influenza during a pandemic.
    The purpose of this study is to gain a better understanding of the 
production and dissemination of aerosols containing the influenza 
virus. The results of this research will give

[[Page 73022]]

scientists and health professionals greater insight into the airborne 
transmission of influenza and allow them to better assess the potential 
effectiveness of preventive measures.
    The first part of this study will measure the quantity and size 
distribution of aerosol droplets produced by people with influenza when 
they cough. To accomplish this, volunteers with influenza-like illness 
will be asked to provide an oral swab for influenza testing, and then 
will cough into a spirometer. The aerosol produced by each person will 
be measured using commercially-available instrumentation. The oral 
swabs will be processed after the aerosol experiments are completed.
    The second part of this study will determine the amount and size of 
airborne particles containing influenza virus that are present in a 
hospital emergency department during influenza season. Health care 
workers will be recruited to wear small aerosol collection devices as 
they go about their normal duties. The collected samples will then be 
analyzed for influenza virus. Adult patients in the emergency 
department with influenza-like illness will be asked to provide an oral 
swab to test for the flu virus in order to estimate the number of 
potential sources of viral-laden airborne particles. There will be no 
costs to study participants. The total estimated annualized burden 
hours are 35.

                                     Total Estimated Annualized Burden Table
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                                                                                         Number of     Average
                                                                            Number of    responses    burden per
            Type of respondent                           Form              respondents      per        response
                                                                                         respondent   (in hours)
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Specific Aim 1: Volunteers with influenza
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Initial participants......................  Health questionnaire.........           42            1         5/60
Qualified participants....................  Consent form.................           40            1        20/60
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Specific Aim 2: Health care workers
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Initial participants......................  Health questionnaire.........           32            1         5/60
Qualified participants....................  Consent form.................           30            1        20/60
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Specific Aim 2: Emergency Department patients
----------------------------------------------------------------------------------------------------------------
Participants..............................  Consent form.................           15            1        20/60
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    Dated: December 14, 2007.
Maryam I. Daneshvar,
Acting Reports Clearance Officer, Centers for Disease Control and 
Prevention.
[FR Doc. E7-24929 Filed 12-21-07; 8:45 am]
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