[Federal Register Volume 72, Number 67 (Monday, April 9, 2007)]
[Notices]
[Pages 17553-17554]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: E7-6583]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

Centers for Disease Control and Prevention

[30Day-07-06AX]


Agency Forms Undergoing Paperwork Reduction Act Review

    The Centers for Disease Control and Prevention (CDC) publishes a 
list of information collection requests under review by the Office of 
Management and Budget (OMB) in compliance with the Paperwork Reduction 
Act (44 U.S.C. Chapter 35). To request a copy of these requests, call 
the CDC Reports Clearance Officer at (404) 639-5960 or send an e-mail 
to [email protected]. Send written comments to CDC Desk Officer, Office of 
Management and Budget, Washington, DC or by fax to (202) 395-6974. 
Written comments should be received within 30 days of this notice.

Proposed Project

    Risk Perception, Worry, and Use of Ovarian Cancer Screening Among 
Women At High, Elevated, and Average Risk of Ovarian Cancer--NEW--
National Center for Chronic Disease Prevention and Health Promotion 
(NCCDPHP), Centers for Disease Control and Prevention (CDC).

Background and Brief Description

    Accounting for an estimated 22,220 cases and 16,210 deaths in 2005, 
ovarian cancer is the most frequent cause of death from gynecologic 
malignancy in the United States. In over 80 percent of patients, 
ovarian cancer presents at a late clinical stage, affording a five-year 
survival rate of only 28 percent. For cases where ovarian cancer is 
identified in Stage I, however, the five-year survival rate exceeds 90 
percent.
    Identifying a woman's risk of ovarian cancer plays a large role in 
determining the appropriateness of having her undergo screening. It is 
only for women with a strong family history of ovarian and/or breast 
cancer or women with a

[[Page 17554]]

hereditary genetic risk for ovarian cancer that the currently available 
screening modalities of CA 125 and transvaginal ultrasound are 
recommended.
    Statements from the scientific and medical community regarding 
recommendations for ovarian cancer screening play only a partial role 
in a woman's decision to undergo screening exams. Numerous 
psychological and sociological factors can affect this decision as 
well, including a woman's knowledge, attitudes, beliefs, and 
experiences. For instance, a woman's experience of cancer within her 
family or experience with a friend who has had cancer may influence a 
woman's screening decisions.
    The literature also notes that women with a family history of 
ovarian cancer report increased worry and high levels of perceived 
risk. A positive association has also been shown between screening 
behavior and family history. Recent studies indicate, however, that 
screening is not occurring in proportion to women's levels of risk. 
These findings underscore the need for a better understanding of how 
perceived risk of ovarian cancer may influence worry about cancer and 
ultimately screening behavior.
    To address these issues, the Division of Cancer Prevention and 
Control (DCPC), at the National Center for Chronic Disease Prevention 
and Health Promotion, Centers for Disease Control and Prevention, is 
conducting a study to examine the effects of family history of cancer, 
knowledge about ovarian cancer, worry and/or anxiety, and perceived 
risk of cancer on the likelihood of a woman undergoing screening for 
ovarian cancer. By also examining other psycho-social factors such as a 
woman's closeness to a relative or friend with cancer, coping style, 
cancer worry, use of other cancer screening tests, social support, and 
provider's recommendations, the study will elucidate the causal pathway 
leading from actual risk (as measured by family history) through 
perceived risk to intent to undergo screening and actual screening 
behavior.
    The proposed study will consist of two tasks. In Task 1, a baseline 
survey will be administered through a computer-assisted telephone 
interview (CATI) program. Initially, an estimated 32,000 women will be 
screened to determine eligibility, and then approximately 2000 women 
will be asked a series of questions over a 35-minute time period. 
Questions will cover key variables related to ovarian cancer screening 
including coping, anxiety, perceived risk, worry, personal cancer 
history, family cancer history, closeness with family or friends who 
have had cancer, screening behavior, and knowledge of ovarian cancer.
    In Task 2, a follow-up questionnaire will be administered, also 
using a CATI program, to approximately 1600 of the women included in 
the baseline questionnaire. Each of the women will be contacted one 
year after they complete the baseline survey. The researchers 
anticipate a 15 percent attrition of the sample between baseline and 
follow-up. In the follow-up, women will be asked a series of questions 
over a 15-minute time period. The purpose of this data collection 
effort is to determine if risk perception has changed and to ask about 
screening for ovarian cancer, since the baseline questionnaire was 
administered.
    All data will be collected over a three-year time period. The total 
estimated annualized burden hours are 1,411. There are no costs to the 
respondents other than their time.

                                        Estimated Annualized Burden Hours
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                                                                                      No. of        Avg. burden
                 Group                     Type of respondents        No. of       responses per   per response
                                                                    respondents     respondent      (in hours)
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Eligibility Screener..................  Women 30 and older......          10,667               1            5/60
Baseline Survey.......................  Women 30 and older                   667               1           35/60
                                         (high, elevated or
                                         average risk of ovarian
                                         cancer).
Follow-Up Survey......................  Women who completed the              533               1           15/60
                                         baseline survey.
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    Dated: April 3, 2007.
Joan F. Karr,
Acting Reports Clearance Officer, Centers for Disease Control and 
Prevention.
 [FR Doc. E7-6583 Filed 4-6-07; 8:45 am]
BILLING CODE 4163-18-P