[Federal Register Volume 72, Number 13 (Monday, January 22, 2007)]
[Notices]
[Pages 2756-2761]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: E7-837]



[[Page 2755]]

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Part III





Environmental Protection Agency





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Fifty-Ninth Report of the TSCA Interagency Testing Committee to the 
Administrator of the Environmental Protection Agency; Receipt of Report 
and Request for Comments; Notice

  Federal Register / Vol. 72, No. 13 / Monday, January 22, 2007 / 
Notices  

[[Page 2756]]


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ENVIRONMENTAL PROTECTION AGENCY

[EPA-HQ-OPPT-2006-0961; FRL-8110-2]


Fifty-Ninth Report of the TSCA Interagency Testing Committee to 
the Administrator of the Environmental Protection Agency; Receipt of 
Report and Request for Comments

AGENCY: Environmental Protection Agency (EPA).

ACTION: Notice.

-----------------------------------------------------------------------

SUMMARY: The Toxic Substances Control Act (TSCA) Interagency Testing 
Committee (ITC) transmitted its 59\th\ ITC Report to the Administrator 
of EPA on December 13, 2006. In the 59\th\ ITC Report, which is 
included with this notice, the ITC is revising the TSCA section 4(e) 
Priority Testing List by removing 22 chemicals. Phenol, 4-(1,1-
dimethylethyl)- is being removed because a recently submitted 
reproductive effects study meets ITC's data needs. Five tungsten 
compounds and 16 chemicals with insufficient dermal absorption rate 
data are being removed because their production volumes or worker 
numbers indicate low potential for occupational exposures.

DATES: Comments must be received on or before February 21, 2007.

ADDRESSES: Submit your comments, identified by docket identification 
(ID) number EPA-HQ-OPPT-2006-0961, by one of the following methods:
     Federal eRulemaking Portal: http://www.regulations.gov. 
Follow the on-line instructions for submitting comments.
     Mail: Document Control Office (7407M), Office of Pollution 
Prevention and Toxics (OPPT), Environmental Protection Agency, 1200 
Pennsylvania Ave., NW., Washington, DC 20460-0001.
     Hand Delivery: OPPT Document Control Office (DCO), EPA 
East Bldg., Rm. 6428, 1201 Constitution Ave., NW., Washington, DC. 
Attention: Docket ID Number EPA-HQ-OPPT-2006-0961. The DCO is open from 
8 a.m. to 4 p.m., Monday through Friday, excluding legal holidays. The 
telephone number for the DCO is (202) 564-8930. Such deliveries are 
only accepted during the DCO's normal hours of operation, and special 
arrangements should be made for deliveries of boxed information.
    Instructions: Direct your comments to docket ID number EPA-HQ-OPPT-
2006-0961. EPA's policy is that all comments received will be included 
in the docket without change and may be made available on-line at 
http://www.regulations.gov, including any personal information 
provided, unless the comment includes information claimed to be 
Confidential Business Information (CBI) or other information whose 
disclosure is restricted by statute. Do not submit information that you 
consider to be CBI or otherwise protected through regulations.gov or e-
mail. The regulations.gov website is an ``anonymous access'' system, 
which means EPA will not know your identity or contact information 
unless you provide it in the body of your comment. If you send an e-
mail comment directly to EPA without going through regulations.gov, 
your e-mail address will be automatically captured and included as part 
of the comment that is placed in the docket and made available on the 
Internet. If you submit an electronic comment, EPA recommends that you 
include your name and other contact information in the body of your 
comment and with any disk or CD-ROM you submit. If EPA cannot read your 
comment due to technical difficulties and cannot contact you for 
clarification, EPA may not be able to consider your comment. Electronic 
files should avoid the use of special characters, any form of 
encryption, and be free of any defects or viruses. For additional 
information about EPA's public docket, visit the EPA Docket Center 
homepage at http://www.epa.gov/epahome/dockets.htm.
    Docket: All documents in the docket are listed in the docket's 
index available at http://www.regulations.gov. Although listed in the 
index, some information is not publicly available, e.g., CBI or other 
information whose disclosure is restricted by statute. Certain other 
material, such as copyrighted material, will be publicly available only 
in hard copy. Publicly available docket materials are available 
electronically at http://www.regulations.gov, or, if only available in 
hard copy, at the OPPT Docket. The OPPT Docket is located in the EPA 
Docket Center (EPA/DC) at Rm. 3334, EPA West Bldg., 1301 Constitution 
Ave., NW., Washington, DC. The EPA/DC Public Reading Room hours of 
operation are 8:30 a.m. to 4:30 p.m., Monday through Friday, excluding 
Federal holidays. The telephone number of the EPA/DC Public Reading 
Room is (202) 566-1744, and the telephone number for the OPPT Docket is 
(202) 566-0280. Docket visitors are required to show photographic 
identification, pass through a metal detector, and sign the EPA visitor 
log. All visitor bags are processed through an X-ray machine and 
subject to search. Visitors will be provided an EPA/DC badge that must 
be visible at all times in the building and returned upon departure.
    For submission of studies, see Unit IV.A.1. of the SUPPLEMENTARY 
INFORMATION.

FOR FURTHER INFORMATION CONTACT: Colby Lintner, Regulatory Coordinator, 
Environmental Assistance Division (7408M), Office of Pollution 
Prevention and Toxics, Environmental Protection Agency, 1200 
Pennsylvania Ave., NW., Washington, DC 20460-0001; telephone number: 
(202) 554-1404; e-mail address: [email protected].

SUPPLEMENTARY INFORMATION:

I. General Information

A. Does this Action Apply to Me?

    This notice is directed to the public in general. It may, however, 
be of particular interest to you if you manufacture (defined by statute 
to include import) and/or process TSCA-covered chemicals and you may be 
identified by the North American Industrial Classification System 
(NAICS) codes 325 and 32411. Because this notice is directed to the 
general public and other entities may also be interested, the Agency 
has not attempted to describe all the specific entities that may be 
interested in this action. If you have any questions regarding the 
applicability of this action to a particular entity, consult the person 
listed under FOR FURTHER INFORMATION CONTACT.

B. What Should I Consider as I Prepare My Comments for EPA?

    1. Submitting CBI. Do not submit this information to EPA through 
regulations.gov or e-mail. Clearly mark the part or all of the 
information that you claim to be CBI. For CBI information in a disk or 
CD ROM that you mail to EPA, mark the outside of the disk or CD ROM 
that you mail to EPA, mark the outside of the disk or CD ROM as CBI and 
then identify electronically within the disk or CD ROM the specific 
information that is claimed as CBI. In addition to one complete version 
of the comment that includes information claimed as CBI, a copy of the 
comment that does not contain the information claimed as CBI must be 
submitted for inclusion in the public docket. Information so marked 
will not be disclosed except in accordance with procedures set forth in 
40 CFR part 2.
    2. Tips for preparing your comments. When submitting comments, 
remember to:
    i. Identify the document by docket ID number and other identifying 
information (subject heading, Federal Register date and page number).
    ii. Follow directions. The Agency may ask you to respond to 
specific questions

[[Page 2757]]

or organize comments by referencing a Code of Federal Regulations (CFR) 
part or section number.
    iii. Explain why you agree or disagree; suggest alternatives and 
substitute language for your requested changes.
    iv. Describe any assumptions and provide any technical information 
and/or data that you used.
    v. If you estimate potential costs or burdens, explain how you 
arrived at your estimate in sufficient detail to allow for it to be 
reproduced.
    vi. Provide specific examples to illustrate your concerns and 
suggest alternatives.
    vii. Explain your views as clearly as possible, avoiding the use of 
profanity or personal threats.
    viii. Make sure to submit your comments by the comment period 
deadline identified.

II. Background

    The Toxic Substances Control Act (TSCA) (15 U.S.C. 260l et seq.) 
authorizes the Administrator of EPA to promulgate regulations under 
section 4(a) of TSCA requiring testing of chemicals and chemical groups 
in order to develop data relevant to determining the risks that such 
chemicals and chemical groups may present to health or the environment. 
Section 4(e) of TSCA established the ITC to recommend chemicals and 
chemical groups to the Administrator of EPA for priority testing 
consideration. Section 4(e) of TSCA directs the ITC to revise the TSCA 
section 4(e) Priority Testing List at least every 6 months.
    You may access additional information about the ITC at http://www.epa.gov/opptintr/itc.

A. The ITC's 59\th\ Report

    The ITC is revising the TSCA section 4(e) Priority Testing List by 
removing 22 chemicals. Phenol, 4-(1,1-dimethylethyl)- is being removed 
because a recently submitted reproductive effects study meets ITC's 
data needs. Five tungsten compounds and sixteen chemicals with 
insufficient dermal absorption rate data are being removed because 
their production volumes or worker numbers indicate low potential for 
occupational exposures.

B. Status of the Priority Testing List

    The Priority Testing List includes 2 alkylphenols, 5 tungsten 
compounds, 16 chemicals with insufficient dermal absorption rate data 
and 243 High Production Volume (HPV) Challenge Program orphan 
chemicals.

List of Subjects

    Environmental protection, Chemicals, Hazardous substances.


    Dated: January 12, 2007.
Charles M. Auer,
Director, Office of Pollution Prevention and Toxics.

Fifty-Ninth Report of the TSCA Interagency Testing Committee to the 
Administrator, U.S. Environmental Protection Agency

Table of Contents

Summary

I. Background
II. TSCA Section 8 Reporting
A. TSCA Section 8 Reporting Rules
B. ITC's Use of TSCA Section 8 and Other Information
C. Previous Requests to Add Chemicals to the TSCA Section 8(a) PAIR 
Rule and TSCA Section 8(d) HaSDR Rule
III. ITC's Activities During this Reporting Period (June to November 
2006)
IV. Revisions to the TSCA Section 4(e) Priority Testing List: 
Chemicals Removed from the Priority Testing List
1. Chemicals with insufficient dermal absorption rate data.
2. Phenol, 4-(1,1-dimethylethyl)-.
3. Tungsten compounds.
V. References
VI. The TSCA Interagency Testing Committee

Summary

    The ITC is revising the Toxic Substances Control Act (TSCA) 
section 4(e) Priority Testing List by removing 22 chemicals. Phenol, 
4-(1,1-dimethylethyl)- is being removed because a recently submitted 
reproductive effects study meets ITC's data needs. Five tungsten 
compounds and sixteen chemicals with insufficient dermal absorption 
rate data are being removed because their production volumes or 
worker numbers indicate low potential for occupational exposures.
    The TSCA section 4(e) Priority Testing List is Table 1 of this 
unit.

                        Table 1.--TSCA Section 4(e) Priority Testing List (November 2006)
----------------------------------------------------------------------------------------------------------------
              ITC Report                         Date             Chemical name/group             Action
----------------------------------------------------------------------------------------------------------------
31                                     January 1993             2 Chemicals with         Designated
                                                                 insufficient dermal
                                                                 absorption rate data
----------------------------------------------------------------------------------------------------------------
32                                     May 1993                 10 Chemicals with        Designated
                                                                 insufficient dermal
                                                                 absorption rate data
----------------------------------------------------------------------------------------------------------------
35                                     November 1994            4 Chemicals with         Designated
                                                                 insufficient dermal
                                                                 absorption rate data
----------------------------------------------------------------------------------------------------------------
37                                     November 1995            Branched 4-nonylphenol   Recommended
                                                                 (mixed isomers)
----------------------------------------------------------------------------------------------------------------
41                                     November 1997            Phenol, 4-(1,1,3,3-      Recommended
                                                                 tetramethylbutyl)-
----------------------------------------------------------------------------------------------------------------
53                                     November 2003            5 Tungsten compounds     Recommended
----------------------------------------------------------------------------------------------------------------
55                                     December 2004            238 High Production      Recommended
                                                                 Volume (HPV) Challenge
                                                                 Program orphan
                                                                 chemicals
----------------------------------------------------------------------------------------------------------------
56                                     August 2005              5 HPV Challenge Program  Recommended
                                                                 orphan chemicals
----------------------------------------------------------------------------------------------------------------

I. Background

    The ITC was established by section 4(e) of TSCA ``to make 
recommendations to the Administrator respecting the chemical 
substances and mixtures to which the Administrator should give 
priority consideration for the promulgation of rules for testing 
under section 4(a).... At least every six months ..., the Committee 
shall make such revisions to the Priority Testing List as it 
determines to be necessary and transmit them to the Administrator 
together with the Committee's reasons for the revisions'' (Public 
Law 94-469, 90 Stat. 2003 et seq., 15

[[Page 2758]]

U.S.C. 2601 et seq.). ITC Reports are available from the ITC's 
website (http://www.epa.gov/opptintr/itc) within a few days of 
submission to the EPA Administrator and from the EPA's website 
(http://www.epa.gov/fedrgstr) after publication in the Federal 
Register. The ITC produces its revisions to the Priority Testing 
List with administrative and technical support from the ITC staff, 
ITC members, and their U.S. Government organizations, and contract 
support provided by EPA. ITC members and staff are listed at the end 
of this report.

II. TSCA Section 8 Reporting

A. TSCA Section 8 Reporting Rules

    Following receipt of the ITC's report (and the revised Priority 
Testing List) by the EPA Administrator, the EPA's Office of 
Pollution Prevention and Toxics (OPPT) may add the chemicals from 
the revised Priority Testing List to the TSCA section 8(a) 
Preliminary Assessment Information Reporting (PAIR) or TSCA section 
8(d) Health and Safety Data Reporting (HaSDR) rules. The PAIR rule 
requires manufacturers (including importers) of chemicals added to 
the Priority Testing List to submit production and exposure reports 
(http://www.epa.gov/opptintr/chemtest/pubs/pairform.pdf). The HaSDR 
rule requires manufacturers (including importers) and can require 
processors of chemicals added to the Priority Testing List to submit 
unpublished health and safety studies under TSCA section 8(d) that 
must be in compliance with the revised HaSDR rule (Ref. 1).

B. ITC's Use of TSCA Section 8 and Other Information

    The ITC's use of TSCA section 8 and other information is 
described in the 52\nd\ ITC Report (http://www.epa.gov/opptintr/itc).

C. Previous Requests to Add Chemicals to the TSCA Section 8(a) PAIR 
Rule and TSCA Section 8(d) HaSDR Rule

    In its 56\th\ ITC Report the ITC requested that EPA add 243 of 
the 251 HPV Challenge Program orphan chemicals on the Priority 
Testing List to TSCA section 8(a) PAIR and 8(d) HaSDR rules (Ref. 
2). In its 58\th\ ITC Report the ITC removed the 8 HPV Challenge 
Program orphan chemicals listed in Tables 2 and 3 of the 56\th\ ITC 
Report from the Priority Testing List and requested that EPA not add 
them to the TSCA section 8(a) PAIR and 8(d) HaSDR rules (Ref. 3). 
Additional information on the HPV Challenge Program orphan chemicals 
and EPA's September 2006 amended Policy Regarding Acceptance of New 
Commitments to Sponsor Chemicals under the HPV Challenge Program is 
available at http://www.epa.gov/hpv/pubs/general/hpvpolcy2.htm.

III. ITC's Activities During this Reporting Period (June to November 
2006)

    In its 56\th\ and 58\th\ ITC Reports, the ITC appended lists of 
new HPV chemicals with 1998 or 2002 Inventory Update Rule (IUR) 
production or importation volume data greater than or equal to 1 
million pounds (Refs. 2 and 3). In response to public comments, the 
ITC made available on its website (http://www.epa.gov/opptintr/itc) 
the sources of publicly available health effects and environmental 
data for new HPV chemicals. The ITC provided these data sources to 
facilitate the efforts of Federal and State agencies, interested 
stakeholders, and members of the public to obtain basic health 
effects and environmental data for new HPV chemicals.
    Despite efforts to provide these data sources for new HPV 
chemicals, appending these lists to the 56\th\ and 58\th\ ITC 
Reports (Refs. 2 and 3) caused confusion. The ITC regrets the 
confusion caused by these efforts and therefore provides the 
following clarifications:

     The ITC intentionally listed these new HPV chemicals in 
appendices and did not add them to the TSCA section 4(e) Priority 
Testing List.
     The EPA promulgates TSCA section 8(a) and TSCA 8(d) 
rules for ITC chemicals only after they have been added to the TSCA 
section 4(e) Priority Testing List.
     The ITC requests comments from readers who found the 
sources of basic health effects and environmental data for new HPV 
chemicals either useful or not useful, and if useful, how the 
sources were used.

    During this reporting period, the ITC discussed:

     Chemicals with insufficient dermal absorption rate 
data.
     Alkylphenols.
     Tungsten compounds.
     Brominated flame retardants.
     Health-based screening levels.
     Tetrahydrofuran.
     Methyl iodide.
     Chlorine dioxide.

IV. Revisions to the TSCA Section 4(e) Priority Testing List: Chemicals 
Removed from the Priority Testing List

    1. Chemicals with insufficient dermal absorption rate data. In 
its 31\st\, 32\nd\, and 35\th\ ITC Reports, the ITC added 24, 34, 
and 25 chemicals, respectively, to the Priority Testing List and 
designated them for testing to develop dermal absorption rate data 
(Refs. 4, 5, and 6). The ITC removed methyl methacrylate and diethyl 
phthalate from the Priority Testing List in its 34\th\ ITC Report 
(Ref. 7) and cyclohexanone from the Priority Testing List in its 
36\th\ ITC Report (Ref. 8). Methyl methacrylate, diethyl phthalate, 
and cyclohexanone were removed from the Priority Testing List 
because dermal absorption rate data were identified after these 
chemicals were added to the Priority Testing List. In its 45\th\ ITC 
Report (Ref. 9), the ITC removed an additional 47 chemicals 
(designated for dermal absorption rate testing) from the Priority 
Testing List, because the EPA published a rule proposing dermal 
absorption rate testing for these chemicals (Ref. 10). In 2004, the 
EPA reviewed more recent production volume, exposure, and dermal 
absorption rate data and promulgated a rule requiring dermal 
absorption rate testing for 34 of these chemicals (Ref. 11). The 
rationales for EPA's decision not to finalize testing requirements 
for the other 13 chemicals in the proposed rule are described in 
reference 11. At this time, dermal absorption rate data have been 
developed for 32 of the 34 chemicals. Dimethyl sulfate (CAS No. 77-
78-1) was dropped from consideration because it was considered too 
corrosive to test. Nonane (CAS No. 111-84-2) has been referred to 
EPA's compliance staff because a letter of intent to commence 
testing has not been received. In this 59\th\ ITC Report, the ITC is 
removing 16 chemicals with insufficient dermal absorption rate data 
from the Priority Testing List (See Table 2 of this unit.).

 Table 2.--Chemicals with insufficient dermal absorption rate data being
                 removed from the Priority Testing List
------------------------------------------------------------------------
                                    TSCA Inventory
             CAS No.                     Name             ITC Report
------------------------------------------------------------------------
61-82-5                           1H-1,2,4-Triazol-3- 32
                                   amine
------------------------------------------------------------------------
75-25-2                           Methane, tribromo-  32
------------------------------------------------------------------------
75-34-3                           Ethane, 1,1-        32
                                   dichloro-
------------------------------------------------------------------------
76-22-2                           Bicyclo[2.2.1]hept  31
                                   an-2-one, 1,7,7-
                                   trimethyl-
------------------------------------------------------------------------
99-65-0                           Benzene, 1,3-       32
                                   dinitro-
------------------------------------------------------------------------
100-25-4                          Benzene, 1,4-       31
                                   dinitro-
------------------------------------------------------------------------
105-46-4                          Acetic acid, 1-     31
                                   methylpropyl
                                   ester
------------------------------------------------------------------------
107-66-4                          Phosphoric acid,    31
                                   dibutyl ester
------------------------------------------------------------------------
110-83-8                          Cyclohexene         31
------------------------------------------------------------------------
123-92-2                          1-Butanol, 3-       31
                                   methyl-, acetate
------------------------------------------------------------------------
532-27-4                          Ethanone, 2-chloro- 31
                                   1-phenyl-
------------------------------------------------------------------------
540-88-5                          Acetic acid, 1,1-   31
                                   dimethylethyl
                                   ester
------------------------------------------------------------------------
1300-73-8                         Benzenamine, ar,ar- 32
                                   dimethyl-
------------------------------------------------------------------------
6423-43-4                         1,2-Propanediol,    32
                                   dinitrate
------------------------------------------------------------------------
7631-90-5                         Sulfurous acid,     31
                                   monosodium salt
------------------------------------------------------------------------
7681-57-4                         Disulfurous acid,   31
                                   disodium salt
------------------------------------------------------------------------

    Five of these chemicals had reported production volumes of < 
500,000 pounds and 11 had no production volumes reported to EPA in 
response to the 2002 IUR (Ref. 12). Further, 8 of the 11 chemicals 
with no 2002 IUR data had no production volumes reported to EPA in 
response to the 1994 or 1998 IURs (Refs. 13 and 14). The ITC is 
removing these 16 chemicals because their

[[Page 2759]]

production volumes indicate low potential for occupational 
exposures.
    There are 16 chemicals with insufficient dermal absorption rate 
data remaining on the Priority Testing List (See Table 3 of this 
unit.).

    Table 3.--Chemicals with insufficient dermal absorption rate data remaining on the Priority Testing List
----------------------------------------------------------------------------------------------------------------
               CAS No.                   TSCA Inventory Name           ITC Report                 Status
----------------------------------------------------------------------------------------------------------------
75-12-7                                Formamide                35                       Screening Information
                                                                                          Data Set (SIDS) &
                                                                                          International Council
                                                                                          of Chemical
                                                                                          Associations (ICCA)
----------------------------------------------------------------------------------------------------------------
88-72-2                                Benzene, 1-methyl-2-     32                       SIDS
                                        nitro-
----------------------------------------------------------------------------------------------------------------
89-72-5                                Phenol, 2-(1-            32                       SIDS & HPV Challenge
                                        methylpropyl)-                                    Program
----------------------------------------------------------------------------------------------------------------
90-04-0                                Benzenamine, 2-methoxy-  32                       SIDS
----------------------------------------------------------------------------------------------------------------
95-13-6                                1H-Indene                32                       American Chemistry
                                                                                          Council (ACC), Soap
                                                                                          and Detergent
                                                                                          Association (SDA) &
                                                                                          Synthetic Organic
                                                                                          Chemical Manufacturers
                                                                                          Association (SOCMA)
                                                                                          Extended (E) HPV
                                                                                          Challenge Program
----------------------------------------------------------------------------------------------------------------
96-18-4                                Propane, 1,2,3-          35                       SIDS & ICCA
                                        trichloro-
----------------------------------------------------------------------------------------------------------------
99-08-1                                Benzene, 1-methyl-3-     35                       Sponsored HPV chemical
                                        nitro-
----------------------------------------------------------------------------------------------------------------
100-63-0                               Hydrazine, phenyl-       32                       Appendix A, 58\th\ ITC
                                                                                          Report
----------------------------------------------------------------------------------------------------------------
106-49-0                               Benzenamine, 4-methyl-   32                       SIDS & ICCA
----------------------------------------------------------------------------------------------------------------
108-44-1                               Benzenamine, 3-methyl-   32                       SIDS
----------------------------------------------------------------------------------------------------------------
108-87-2                               Cyclohexane, methyl-     31                       Moderate production
                                                                                          volume (MPV) 2002
                                                                                          chemical
----------------------------------------------------------------------------------------------------------------
121-14-2                               Benzene, 1-methyl-2,4-   32                       SIDS
                                        dinitro-
----------------------------------------------------------------------------------------------------------------
287-92-3                               Cyclopentane             31                       SIDS, ICCA, & HPV
                                                                                          Challenge Program
----------------------------------------------------------------------------------------------------------------
540-59-0                               Ethene, 1,2-dichloro-    32                       MPV 1998 & 2002
----------------------------------------------------------------------------------------------------------------
542-92-7                               1,3-Cyclopentadiene      35                       HPV orphan chemical
----------------------------------------------------------------------------------------------------------------
626-17-5                               1,3-                     32                       Sponsored HPV chemical
                                        Benzenedicarbonitrile
----------------------------------------------------------------------------------------------------------------

    Twelve of the sixteen chemicals with insufficient dermal 
absorption rate data remaining on the Priority Testing List are 
included in EPA's HPV Challenge Program, the Organization for 
Economic Cooperation and Development (OECD) SIDS Program, ICCA HPV 
Initiative, or the ACC, SDA, and SOCMA EHPV Program.
    Two of the sixteen chemicals with insufficient dermal absorption 
rate data remaining on the Priority Testing List are MPV chemicals 
(production or importation volumes ranging from 500,000 to 999,999 
pounds). One of the 16 chemicals, phenylhydrazine, was listed in 
Appendix A of the 58\th\ ITC Report (Ref. 3) because it was a new 
HPV chemical in 2002. The last chemical, 1,3-cyclopentadiene is a 
HPV Challenge Program orphan chemical that remains on the Priority 
Testing List to provide potential sponsors the opportunity to 
voluntarily submit or develop data, including dermal absorption rate 
data.
    The ITC encourages the manufacturers or sponsors of the 16 
chemicals in Table 3 of this unit to voluntarily develop dermal 
absorption rate data using the methods discussed in reference 11 and 
submit studies using one of the following methods:

     Hand Delivery: John D. Walker, OPPT/ITC (7401M), EPA, 
EPA East Bldg., Rm. 5353, 1201 Constitution Ave., NW., Washington, 
DC. Attention: FYI-ITC.
     Mail: Document Control Office (7407M), Office of 
Pollution Prevention and Toxics (OPPT), Environmental Protection 
Agency, 1200 Pennsylvania Ave., NW., Washington, DC 20460-0001. 
Attention: FYI-ITC.

    2. Phenol, 4-(1,1-dimethylethyl)-. Eighty-eight alkylphenols, 
polyalkylphenols, alkylphenol ethoxylates, and alkylphenol 
polyethoxylates were added to the Priority Testing List in the 
37\th\, 39\th\, 41\st\, and 46\th\ ITC Reports (Refs. 18-21). Fifty 
of these chemicals were removed from the Priority Testing List in 
the 43\rd\, 46\th\, and 48\th\ ITC Reports (Refs. 21-23) because:

    a. No domestic production or importation volumes were reported 
to the EPA in response to 1986, 1990, 1994, or 1998 IURs (Refs. 13, 
14, 24, and 25),
    b. No domestic production or importation volumes were reported 
to the EPA in response to the February 28, 1996 PAIR rule (Ref. 26),
    c. No TSCA section 8(d) studies were submitted to the EPA in 
response to the February 28, 1996 HaSDR rule (Ref. 26),
    d. No domestic production or importation volumes were reported 
to the EPA in response to the January 11, 2000 PAIR rule (Ref. 27),
    e. No domestic production or importation volumes were reported 
to the EPA in response to the July 5, 2000 PAIR rule (Ref. 28),
    f. No TSCA section 8(e) or FYI studies were available for these 
chemicals as of September 1998, or
    g. Use and health and safety data were voluntarily submitted to 
the ITC by the Chemical Manufacturers Association Alkylphenols and 
Ethoxylates Panel.

    Thirty-five of these chemicals were removed from the Priority 
Testing List in the 50\th\ and 51\st\ ITC Reports (Refs. 29 and 30) 
because:

     No domestic production or importation volumes were 
reported to the EPA in response to 1986, 1990, 1994, and 1998 IURs 
(Refs. 13, 14, 24, and 25) or reported to the EPA in response to the 
July 5, 2000 PAIR rule (Ref. 28).
     Data developed in response to the EPA's HPV Challenge 
Program could be used to predict toxicity, or
     The Alkyl Phenol Ethoxylates Research Consortium 
(http://www.aperc.org) provided information to meet the ITC's data 
needs.

    The three remaining alkyphenols on the Priority Testing List 
are: Phenol, 4-(1,1-dimethylethyl)- (CAS No. 98-54-4); phenol, 4-
(1,1,3,3-tetramethylbutyl)- (CAS No. 140-66-9); and phenol, 4-nonyl-
, branched (CAS No. 84852-15-3) (Ref. 30). For phenol, 4-(1,1-
dimethylethyl)-, the ITC anticipated receiving the ongoing 
reproductive effects study. For phenol, 4-(1,1,3,3-

[[Page 2760]]

tetramethylbutyl)- and phenol, 4-nonyl-, branched, the ITC 
anticipated receiving amphibian toxicity data, avian reproductive 
effects data, and fish reproductive effects data.
    The ITC received the recently completed 2-generation 
reproductive effects study in rats for phenol, 4-(1,1-
dimethylethyl)-, more commonly referred to as 4-tert-butylphenol 
(Ref. 31). The ITC is removing 4-tert-butylphenol from the Priority 
Testing List because the reproductive effects study meets the ITC's 
data needs.
    There are amphibian toxicity data for phenol, 4-(1,1,3,3-
tetramethylbutyl)- and phenol, 4-nonyl-, branched. In an amphibian 
toxicity study of phenol, 4-nonyl-, branched, the 96 hour 
LC50 for toad (Bufo boreas) tadpoles was 120 microgram/
Liter ([mu]g/L) (Ref. 32). Two amphibian toxicity studies of phenol, 
4-(1,1,3,3-tetramethylbutyl)- were discussed in a recent review 
(Ref. 33). One was categorized as ``not valid'' (Ref. 34) and the 
other as ``use with care'' (Ref. 35). These studies may be 
sufficient to meet the ITC's amphibian toxicity data needs for 
phenol, 4-(1,1,3,3-tetramethylbutyl)- and phenol, 4-nonyl-, 
branched. However, the ITC is leaving phenol, 4-(1,1,3,3-
tetramethylbutyl)- and phenol, 4-nonyl-, branched on the Priority 
Testing List because it needs time to:

     Determine if the existing fish reproductive effects 
data are sufficient to meet the ITC's data needs.
     Review the EPA's Safer Detergents Stewardship 
Initiative (http://www.epa.gov/dfe/pubs/projects/formulat/sdsi.htm).
     Determine if phenol, 4-(1,1,3,3-tetramethylbutyl)- or 
phenol, 4-nonyl-, branched should be tested for avian reproductive 
effects.

    3. Tungsten compounds. Of the 22 tungsten compounds added to the 
Priority Testing List in the 53\rd\ ITC Report (Ref. 36) and 56\th\ 
ITC Report (Ref. 2), 12 were removed in the 58\th\ ITC Report (Ref. 
3). At this time the ITC is removing 5 additional tungsten compounds 
from the Priority Testing List (See Table 4 of this unit.).

  Table 4.--Tungsten compounds being removed from the Priority Testing
                                  List
------------------------------------------------------------------------
                  CAS No.                           Chemical name
------------------------------------------------------------------------
7783-03-1                                   Tungstate (WO4\2\-),
                                             dihydrogen, (T-4)-
------------------------------------------------------------------------
7783-82-6                                   Tungsten fluoride (WF6), (OC-
                                             6-11)-
------------------------------------------------------------------------
12028-48-7                                  Tungstate (W12(OH)2O38\6\-),
                                             hexaammonium
------------------------------------------------------------------------
12036-22-5                                  Tungsten oxide (WO2)
------------------------------------------------------------------------
12138-09-9                                  Tungsten sulfide (WS2)
------------------------------------------------------------------------

    The ITC is removing these five tungsten compounds from the 
Priority Testing List because production volume and worker numbers 
data submitted in response to the December 7, 2004 PAIR rule (Ref. 
37) indicate low potential for occupational exposure.
    Table 5 of this unit lists the tungsten compounds remaining on 
the Priority Testing List.

   Table 5.--Tungsten Compounds Remaining on the Priority Testing List
------------------------------------------------------------------------
                  CAS No.                           Chemical name
------------------------------------------------------------------------
1314-35-8                                   Tungsten oxide (WO3)
------------------------------------------------------------------------
7440-33-7                                   Tungsten
------------------------------------------------------------------------
10213-10-2                                  Tungstate (WO4\2\-),
                                             disodium, dihydrate, (T-4)-
------------------------------------------------------------------------
11120-25-5                                  Tungstate (W12(OH)2O40\10\-
                                             ), decaammonium
------------------------------------------------------------------------
13472-45-2                                  Tungstate (WO4\2\-),
                                             disodium, (T-4)-
------------------------------------------------------------------------

V. References

    1. EPA. 1998. Revisions to Reporting Regulations under TSCA 
Section 8(d). Federal Register (63 FR 15765, April 1, 1998) (FRL-
5750-4). Available on-line at: http://www.epa.gov/fedrgstr.
    2. ITC. 2005. Fifty-Sixth Report of the ITC. Federal Register 
(70 FR 61520, October 24, 2005) (FRL-7739-9). Available on-line at: 
http://www.epa.gov/fedrgstr.
    3. ITC. 2006. Fifty-Eighth Report of the ITC. Federal Register 
(70 FR 39187, July 11, 2006) (FRL-8073-7). Available on-line at: 
http://www.epa.gov/fedrgstr.
    4. ITC. 1993. Thirty-First Report of the ITC. Federal Register 
(58 FR 26898, May 5, 1993) (FRL-4583-4). Available on-line at: 
http://www.regulations.gov, EPA-HQ-OPPT-2006-0961.
    5. ITC. 1993. Thirty-Second Report of the ITC. Federal Register 
(58 FR 38490, July 16, 1993) (FRL-4630-2). Available on-line at: 
http://www.regulations.gov, EPA-HQ-OPPT-2006-0961.
    6. ITC. 1994. Thirty-Fifth Report of the ITC. Federal Register 
(59 FR 67596, December 29, 1994) (FRL-4923-2). Available on-line at: 
http://www.regulations.gov, EPA-HQ-OPPT-2006-0961.
    7. ITC. 1994. Thirty-Fourth Report of the ITC. Federal Register 
(59 FR 35720, July 13, 1994) (FRL-4870-4). Available online at 
http://www.regulations.gov, EPA-HQ-OPPT-2006-0961.
    8. ITC. 1995. Thirty-Sixth Report of the ITC. Federal Register 
(60 FR 42982, August 17, 1995) (FRL-4965-6). Available on-line at: 
http://www.epa.gov/fedrgstr.
    9. ITC. 2000. Forty-Fifth Report of the ITC. Federal Register 
(65 FR 75544, December 1, 2000) (FRL-6399-5). Available on-line at: 
http://www.epa.gov/fedrgstr.
    10. EPA. 1999. Proposed Test Rule for In Vitro Dermal Absorption 
Rate Testing of Certain Chemicals of Interest to Occupational Safety 
and Health Administration. Federal Register (64 FR 31074, June 9, 
1999) (FRL-5760-3). Available on-line at: http://www.epa.gov/fedrgstr.
    11. EPA. 2004. Final Test Rule for In Vitro Dermal Absorption 
Rate Testing of Certain Chemicals of Interest to Occupational Safety 
and Health Administration. Federal Register (69 FR 22402, April 26, 
2004) (FRL-7312-2). Available on-line at: http://www.epa.gov/fedrgstr.
    12. EPA. 2002 Reporting Notice; 2002. Partial Updating of TSCA 
Inventory Data Base; Production and Site Reports; Federal Register 
(67 FR 18615, April 16, 2002) (FRL-6826-5). Available on-line at: 
http://www.epa.gov/fedrgstr.
    13. EPA. 1994. Partial Updating of TSCA Inventory Data Base; 
Production and Site Reports; Technical Amendment. Federal Register 
(59 FR 30652, June 14, 1994) (FRL-4869-7). Available on-line at: 
http://www.regulations.gov, EPA-HQ-OPPT-2006-0961.
    14. EPA. 1998. Partial Updating of TSCA Inventory Data Base; 
Production and Site Reports; Technical Amendment. Federal Register 
(63 FR 459503, August 28, 1998) (FRL-6028-3). Available on-line at: 
http://www.epa.gov/fedrgstr.
    15. EPA. 2006. Preliminary Assessment Information Reporting; 
Addition of Certain Chemicals. Federal Register (71 FR 47122, August 
16, 2006) (FRL-7764-9). Available on-line at: http://www.epa.gov/fedrgstr.
    16. EPA. 2006. Health and Safety Data Reporting; Addition of 
Certain Chemicals. Federal Register (71 FR 47130, August 16, 2006) 
(FRL-7764-7). Available on-line at: http://www.epa.gov/fedrgstr.
    17. EPA. 2006. Withdrawal of Certain Chemicals from Preliminary 
Assessment Information Reporting and Health and Safety Data 
Reporting Rules. Federal Register (71 FR 57439, September 29, 2006) 
(FRL-8096-5). Available on-line at: http://www.epa.gov/fedrgstr.
    18. ITC. 1995. Thirty-Seventh Report of the ITC. Federal 
Register (61 FR. 4188, February 2, 1996) (FRL-4991-6). Available on-
line at: http://www.epa.gov/fedrgstr.
    19. ITC. 1996. Thirty-Ninth Report of the ITC. Federal Register 
(62 FR 8578, February 25, 1997) (FRL-5580-9). Available on-line at: 
http://www.epa.gov/fedrgstr.
    20. ITC. 1997. Forty-First Report of the ITC. Federal Register 
(63 FR 17658, April 9, 1998) (FRL-5773-5). Available on-line at: 
http://www.epa.gov/fedrgstr.
    21. ITC. 2000. Forty-Sixth Report of the ITC. Federal Register 
(65 FR 75552, December 1, 2000) (FRL-6594-7). Available on-line at: 
http://www.epa.gov/fedrgstr.
    22. ITC. 2000. Forty-Third Report of the ITC. Federal Register 
(65 FR 65234, October 31, 2000) (FRL-6049-5). Available on-line at: 
http://www.epa.gov/fedrgstr.
    23. ITC. 2001. Forty-Eighth Report of the ITC. Federal Register 
(66 FR 51276, October 5, 2001) (FRL-6786-7). Available on-line at: 
http://www.epa.gov/fedrgstr.
    24. EPA. 1986. Partial Updating of TSCA Inventory Data Base; 
Production and Site Reports. Federal Register (51 FR 21438, June 12, 
1986). Available on-line at: http://www.regulations.gov, EPA-HQ-
OPPT-2006-0961.
    25. EPA. 1990. Partial Updating of TSCA Inventory Data Base; 
Production and Site

[[Page 2761]]

Reports; Technical Amendment. Federal Register (55 FR 39586, 
September 27, 1990) (FRL-3770-4). Available on-line at: http://www.regulations.gov, EPA-HQ-OPPT-2006-0961.
    26. EPA. 1996. Preliminary Assessment Information and Health and 
Safety Data Reporting; Addition of Certain Chemicals. Federal 
Register (61 FR 7421, February 28, 1996) (FRL-4996-9). Available on-
line at: http://www.epa.gov/fedrgstr.
    27. EPA. 2000. Preliminary Assessment Information and Health and 
Safety Data Reporting; Addition of Certain Chemicals. Federal 
Register (65 FR 1548, January 11, 2000) (FRL-5777-2). Available on-
line at: http://www.epa.gov/fedrgstr.
    28. EPA. 2000. Preliminary Assessment Information and Health and 
Safety Data Reporting; Addition of Certain Chemicals. Federal 
Register (65 FR 41371, July 5, 2000) (FRL-6589-1). Available on-line 
at: http://www.epa.gov/fedrgstr.
    29. ITC. 2002. Fiftieth Report of the ITC. Federal Register (67 
FR 49530, July 30, 2002) (FRL-7183-7). Available on-line at: http://www.epa.gov/fedrgstr.
    30. ITC. 2003. Fifty-First Report of the ITC. Federal Register 
(68 FR 8976, February 26, 2003) (FRL-7285-7). Available on-line at: 
http://www.epa.gov/fedrgstr.
    31. Charles Rivers Laboratories, Edinburgh, Scotland. Final 
Report: p-tert-butylphenol Two Generation Reproduction Study in Rats 
Study No. 493595 Report No. 24804. Unpublished report sponsored by 
SASOL GmbH (Germany) and SI Group-Switzerland GmbH (Formerly 
Schenectady Pratteln GmbH, Switzerland). February 2006.
    32. Dwyer, F.J.; Mayer, F.L.; Sappington, L.C.; Buckler, D.R.; 
Bridges, C.M.; Greer, I.E.; Hardesty, D.K.; Henke, C.E.; Ingersoll, 
C.G.; Kunz, J.L.; Whites, D.W.; Augspurger, T.; Mount, D.R.; 
Hattala, K.; and Neuderfer, G. 2005. Assessing contaminant 
sensitivity of endangered and threatened aquatic species: Part I. 
Acute toxicity of five chemicals. Archives Environmental 
Contamination Toxicology. 48:143-154.
    33. Van Miller, J.P. Staples CA. 2005. Review of the potential 
environmental and human health-related hazards and risks from long-
term exposure to p-tert-octylphenol. Human and Ecological Risk 
Assessment. 11:319-351.
    34. Kloas, W.; Lutz, I.; Einspanier, R. 1999. Amphibians as a 
model to study endocrine disruptors: II. Estrogenic activity of 
environmental chemicals in vitro and in vivo. Science of the Total 
Environment. 225:59-68.
    35. Crump, D.; Lean, D.; and Trudeau, V.L. 2002. Octylphenol and 
UV-B radiation alter larval development and hypothalamic gene 
expression in the Leopard Frog (Rana pipiens). Environmental Health 
Perspectives. 110:277-284.
    36. ITC. 2004. Fifty-Third Report of the ITC. Federal Register 
(69 FR 2467, January 15, 2004) (FRL-7335-2). Available on-line at: 
http://www.epa.gov/fedrgstr.
    37. EPA. 2004. Preliminary Assessment Information Reporting; 
Addition of Certain Chemicals. Federal Register (69 FR 70552, 
December 7, 2004) (FRL-7366-8). Available on-line at: http://www.epa.gov/fedrgstr.

VI. The TSCA Interagency Testing Committee

    Statutory Organizations and Their Representatives

    Council on Environmental Quality
     Vacant

    Department of Commerce

     National Institute of Standards and Technology
     Dianne Poster, Member, Vice Chair

     National Oceanographic and AtmosphericAdministration
     Tony Pait, Member

    Environmental Protection Agency
     John Schaeffer, Member
     Gerry Brown, Alternate

    National Cancer Institute
     Alan Poland, Alternate

    National Institute of Environmental Health Sciences
     John Bucher, Member
     Scott Masten, Alternate

    National Institute for Occupational Safety and Health
     Dennis W. Lynch, Member
     Mark Toraason, Alternate

    National Science Foundation
     Cindy Lee, Member
     Marge Cavanaugh, Alternate

    Occupational Safety and Health Administration
     Maureen Ruskin, Member, Chair
     Thomas Nerad, Alternate

    Liaison Organizations and Their Representatives

    Agency for Toxic Substances and Disease Registry
     Daphne Moffett, Member
     Glenn D. Todd, Alternate

    Consumer Product Safety Commission
     Jacqueline Ferrante, Member

    Department of Agriculture
     Clifford P. Rice, Member
     Laura L. McConnell, Alternate

    Department of Defense
     Laurie Roszell, Member

    Department of the Interior
     Barnett A. Rattner, Member

    Food and Drug Administration
     Kirk Arvidson, Alternate
     Ronald F. Chanderbhan, Alternate

    National Library of Medicine
     Vera W. Hudson, Member

    National Toxicology Program
     NIEHS, FDA, and NIOSH, Members

    Technical Support Contractor
     Syracuse Research Corporation

    ITC Staff
     John D. Walker, Director
     Carol Savage, Administrative Assistant

TSCA Interagency Testing Committee (7401), Office of Pollution 
Prevention and Toxics, Environmental Protection Agency, 1200 
Pennsylvania Ave., NW., Washington, DC 20460-0001; e-mail address: 
[email protected]; url: http://www.epa.gov/opptintr/itc.
[FR Doc. E7-837 Filed 1-19-07; 8:45 am]
BILLING CODE 6560-50-S