[Federal Register Volume 71, Number 203 (Friday, October 20, 2006)]
[Notices]
[Pages 62017-62018]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: E6-17523]



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DEPARTMENT OF JUSTICE

Drug Enforcement Administration

[Docket No. DEA-274N]


Solicitation of Information on the Use of Phenethylamine-Related 
Compounds

AGENCY: Drug Enforcement Administration (DEA), Department of Justice.

ACTION: Notice, solicitation of information.

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SUMMARY: The DEA is soliciting information on substances that are 
related in chemical structure to phenethylamine (see supplementary 
information). The Controlled Substances Act (CSA), Title 21 of the 
United States Code (U.S.C.) Sec.  812(c) schedule I (Title 21 of the 
Code of Federal Regulations (CFR) Sec.  1308.11(d)), lists certain 
phenethylamines as schedule I controlled substances. Some 
phenethylamines that are not controlled under the CSA produce central 
nervous system effects that are similar to phenethylamines that are 
controlled under the CSA. DEA is requesting information to help 
determine the impact on business if these substances were to be placed 
under control in the CSA.

DATES: Written comments must be postmarked, and electronic comments 
must be sent, on or before December 19, 2006.

ADDRESSES: To ensure proper handling of comments, please reference 
``Docket No. DEA-274N'' on all written and electronic correspondence. 
Written comments being sent via regular mail should be sent to the 
Deputy Assistant Administrator, Office of Diversion Control, Drug 
Enforcement Administration, Washington, DC 20537, Attention: DEA 
Federal Register Representative/ODL. Written comments sent via express 
mail should be sent to DEA Headquarters, Attention: DEA Federal 
Register Representative/ODL, 2401 Jefferson-Davis Highway, Alexandria, 
VA 22301. Comments may be directly sent to DEA electronically by 
sending an electronic message to [email protected]. DEA 
will accept attachments to electronic comments in Microsoft Word, 
WordPerfect, Adobe PDF, or Excel file formats only. DEA will not accept 
any file format other than those specifically listed here.

FOR FURTHER INFORMATION CONTACT: Christine A. Sannerud, Ph.D., Chief, 
Drug and Chemical Evaluation Section, Office of Diversion Control, Drug 
Enforcement Administration, Washington, DC 20537; Telephone: (202) 307-
7183.

SUPPLEMENTARY INFORMATION:
    Phenethylamine is a compound in which the chemical structure is a 
benzene ring substituted with a 2-aminoethyl chain. Although 
phenethylamine itself is not a controlled substance, its chemical 
structure constitutes the skeletal makeup of phenethylamines listed in 
schedule I of the CSA, which are classified as hallucinogenic 
substances. Phenethylamines are also found in schedule II and IV of the 
CSA.
    Phenethylamine is sometimes substituted on the benzene ring or the 
2-aminoethyl chain or both with various substituents. Title 21 CFR 
1308.11(d) lists specific substituted phenethylamines in schedule I. 
Also included in schedule I are the salts, isomers, and salts of 
isomers of the listed phenethylamines. The term isomer, as used in this 
section, means the optical, geometric, and positional isomers.
    Individuals have published detailed methods of synthesis for 
substituted phenethylamines and have reported pharmacological effects 
based on user experiences. Law enforcement personnel encounter such 
phenethylamines, but because they are substituted differently than 
those listed or described in the CSA, they are not subject to direct 
control in schedule I. However, some of these substances can be treated 
as schedule I controlled substance analogues if intended for human 
consumption (21 U.S.C. 802(32); 813).
    DEA is soliciting information on (1) the commercial uses for 
phenethylamines, (2) activities involving research and development, (3) 
phenethylamines as intermediates or analytical standards, (4) import 
and domestic sources for phenethylamines, and (5) any planned or 
anticipated uses for phenethylamines. DEA invites interested persons to 
provide any information on the uses of phenethylamines in industry, 
academia, research and development, or other applications. Both 
quantitative and qualitative information are sought.
    Although information is requested for all phenethylamine substances 
regardless of substitutions, DEA is particularly interested in 
phenethylamines that meet one or more of the following conditions: any 
compound structurally derived from phenethylamine, or from any N-
alkylphenethylamine, any alpha-alkylphenethylamine, or any N-alkyl-
alpha-alkylphenethylamine, by substitution on the ring to any extent 
with alkyl, cycloalkyl, cycloalkenyl, alkoxy, alkylthio, alkylhalide, 
alkylene-dioxy, acyloxy, or halide substituents, whether or not further 
substituted on the ring by one or more other univalent substituents. 
DEA is especially interested in learning of the uses of the following 
phenethylamines:

1,4-Dimethoxynaphthyl-2-ethylamine
1,4-Dimethoxynaphthyl-2-isopropylamine
2-(2,5-Dimethoxy-4-methylphenyl)-cyclopropylamine
2,3,4,5-Tetramethoxyamphetamine
2,3,4-Trimethoxyamphetamine
2,3,4-Trimethoxyphenethylamine
2,3,5-Trimethoxyamphetamine
2,3,6-Trimethoxyamphetamine
2,3-Dimethoxy-4,5-methylenedioxyamphetamine
2,4,5-Triethoxyamphetamine
2,4,5-Trimethoxyamphetamine
2,4,5-Trimethoxyphenethylamine
2,4,6-Trimethoxyamphetamine
2,4-Diethoxy-5-methoxyamphetamine
2,4-Dimethoxy-5-ethoxyamphetamine
2,4-Dimethoxyamphetamine
2,5,beta-Trimethoxy-4-methylphenethylamine
2,5-Bismethylthio-4-methylamphetamine
2,5-Diethoxy-4-methoxyamphetamine
2,5-Dimethoxy-3,4-methylenedioxyamphetamine
2,5-Dimethoxy-4,N-dimethylamphetamine
2,5-Dimethoxy-4-ethoxyamphetamine
2,5-Dimethoxy-4-propoxyamphetamine
2,5-Dimethoxy-alpha-ethyl-4-methylphenethylamine
2,5-Dimethoxy-beta-hydroxy-4-methylphenethylamine
2,5-Dimethoxy-N,N-dimethyl-4-iodoamphetamine
2,5-Dimethoxy-N-hydroxy-4-(n)-propylthiophenethylamine
2,5-Dimethoxy-N-hydroxy-4-(sec)-butylthiophenethylamine
2,5-Dimethoxy-N-hydroxy-4-ethylthiophenethylamine
2,5-Dimethoxyphenethylamine
2,N-Dimethyl-4,5-methylenedioxyamphetamine
2-Bromo-4,5-methylenedioxyamphetamine
2-Ethoxy-4,5-dimethoxyamphetamine
2-Methoxy-3,4-methylenedioxyamphetamine
2-Methoxy-4,5-diethoxyamphetamine
2-Methoxy-4,5-methylenedioxyamphetamine
2-Methoxy-4-methyl-5-methylsulfinylamphetamine
2-Methoxy-4-methyl-5-methylthioamphetamine
2-Methylthio-3,4-dimethoxyphenethylamine
2-Methylthio-3,4-methylenedioxyamphetamine
2-Methylthio-4,5-dimethoxyamphetamine
3,4,5,beta-Tetramethoxyphenethylamine
3,4,5-Triethoxyphenethylamine
3,4,5-Trimethoxyphenethylamine
3,4-Diethoxy-5-methoxyphenethylamine
3,4-Diethoxy-5-methylthiophenethylamine
3,4-Dimethoxy-5-ethoxyphenethylamine
3,4-Dimethoxy-5-propoxyphenethylamine
3,4-Dimethoxyamphetamine
3,4-Dimethoxy-beta-hydroxyphenethylamine
3,4-Dimethoxyphenethylamine

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3,4-Dimethyl-2,5-dimethoxyamphetamine
3,4-Dimethyl-2,5-dimethoxyphenethylamine
3,4-Ethylenedioxy-5-methoxyamphetamine
3,4-Methylenedioxyphenethylamine
3,4-Norbornyl-2,5-dimethoxyamphetamine
3,4-Norbornyl-2,5-dimethoxyphenethylamine
3,4-Tetramethylene-2,5-dimethoxyamphetamine
3,4-Tetramethylene-2,5-dimethoxyphenethylamine
3,4-Trimethylene-2,5-dimethoxyamphetamine
3,4-Trimethylene-2,5-dimethoxyphenethylamine
3,5-Diethoxy-4-ethylthiophenethylamine
3,5-Diethoxy-4-methoxyphenethylamine
3,5-Diethoxy-4-methylthiophenethylamine
3,5-Dimethoxy-4-ethylthiophenethylamine
3,5-Dimethoxy-4-isopropoxyphenethylamine
3,5-Dimethoxy-4-methallyloxyphenethylamine
3,5-Dimethoxy-4-phenethyloxyphenethylamine
3,5-Dimethoxy-4-propoxyphenethylamine
3-Ethoxy-4-ethylthio-5-methoxyphenethylamine
3-Ethoxy-4-methoxy-5-methylthiophenethylamine
3-Ethoxy-5-ethylthio-4-methoxyphenethylamine
3-Ethoxy-5-methoxy-4-methylthiophenethylamine
3-Methoxy-4,5-methylenedioxyphenethylamine
3-Methoxy-4-ethoxyphenethylamine
3-Methylthio-2,4-dimethoxyphenethylamine
3-Methylthio-4,5-dimethoxyphenethylamine
4-(2-Fluoroethyl)-2,5-dimethoxyamphetamine
4-(2-Fluoroethylthio)-2,5-dimethoxyphenethylamine
4-(2-Methoxyethylthio)-2,5-dimethoxyphenethylamine
4-(sec)-Butylthio-2,5-dimethoxyphenethylamine
4-(tert)-Butylthio-2,5-dimethoxyphenethylamine
4,5-Diethoxy-3-ethylthiophenethylamine
4,5-Dimethoxy-3-ethylthiophenethylamine
4,5-Thiomethyleneoxy-2-methoxyamphetamine
4-Allyloxy-3,5-dimethoxyphenethylamine
4-Amyl-2,5-dimethoxyamphetamine
4-Benzyloxy-3,5-dimethoxyamphetamine
4-Bromo-2,5,beta-trimethoxyphenethylamine
4-Bromo-2,5-dimethoxy-N-methylamphetamine
4-Bromo-3,5-dimethoxyamphetamine
4-Butoxy-3,5-dimethoxyphenethylamine
4-Butyl-2,5-dimethoxyamphetamine
4-Chloro-2,5-dimethoxyamphetamine
4-Chloro-2,5-dimethoxyphenethylamine
4-Cyclopropylmethoxy-3,5-dimethoxyphenethylamine
4-Cyclopropylmethylthio-2,5-dimethoxyphenethylamine
4-Cyclopropylthio-2,5-dimethoxyphenethylamine
4-Ethoxy-3,5-dimethoxyamphetamine
4-Ethoxy-3,5-dimethoxyphenethylamine
4-Ethoxy-3-ethylthio-5-methoxyphenethylamine
4-Ethoxy-5-methoxy-3-methylthiophenethylamine
4-Ethyl-2,5-dimethoxyphenethylamine
4-Ethyl-2-methoxy-5-methylthioamphetamine
4-Ethyl-5-methoxy-2-methylthioamphetamine
4-Ethylthio-2,5-dimethoxyamphetamine
4-Ethylthio-2,5-dimethoxyphenethylamine
4-Fluoro-2,5-dimethoxyphenethylamine
4-Iodo-2,5-dimethoxyamphetamine
4-Iodo-2,5-dimethoxyphenethylamine
4-Isopropoxy-2,5-dimethoxyphenethylamine
4-Isopropylthio-2,5-dimethoxyamphetamine
4-Isopropylthio-2,5-dimethoxyphenethylamine
4-Isopropylthio-2,6-dimethoxyphenethylamine
4-Methoxy-2,3-methylenedioxyamphetamine
4-Methyl-2,5-dimethoxyphenethylamine
4-Methyl-2,6-dimethoxyamphetamine
4-Methyl-3,5-Dimethoxyphenethylamine
4-Methylseleno-2,5-dimethoxyphenethylamine
4-Methylthio-2,3-dimethoxyphenethylamine
4-Methylthio-2,5-dimethoxyamphetamine
4-Methylthio-2,5-dimethoxyphenethylamine
4-Methylthio-3,5-dimethoxyphenethylamine
4-Nitro-2,5-dimethoxyamphetamine
4-Nitro-2,5-dimethoxyphenethylamine
4-Phenylthio-2,5-dimethoxyamphetamine
4-Propyl-2,5-dimethoxyamphetamine
4-Propyl-2,5-dimethoxyphenethylamine
4-Propylthio-2,5-dimethoxyamphetamine
4-Propylthio-3,5-dimethoxyphenethylamine
4-Propynyloxy-3,5-dimethoxyphenethylamine
4-Thiobutoxy-3,5-dimethoxyphenethylamine
4-Trideuteromethyl-3,5-dimethoxyphenethylamine
5-Bromo-2,4-dimethoxyamphetamine
5-Ethoxy-2-methoxy-4-methylamphetamine
5-Methoxy-4-methyl-2-methylthioamphetamine
5-Methylthio-2,4-dimethoxyamphetamine
alpha,alpha,N-Trimethyl-3,4-methylenedioxyphenethylamine
alpha,alpha-Dimethyl-3,4-methylenedioxyphenethylamine
alpha-Ethyl-3,4,5-trimethoxyphenethylamine
alpha-Ethyl-3,4-methylenedioxyphenethylamine
Benzofuran-2,2-dimethyl-5-methoxy-6-(2-aminopropane)
Benzofuran-2-methyl-5-methoxy-6-(2-aminopropane)
beta,beta-Dideutero-3,4,5-trimethoxyphenethylamine
beta-Methoxy-3,4-methylenedioxyphenethylamine
N-(2-Hydroxyethyl)-3,4-methylenedioxyamphetamine
N-(2-Methoxyethyl)-3,4-methylenedioxyamphetamine
N,alpha-diethyl-3,4-methylenedioxyphenethylamine
N,N-Dimethyl-3,4-methylenedioxyamphetamine
N-Allyl-3,4-methylenedioxyamphetamine
N-Benzyl-3,4-methylenedioxyamphetamine
N-Butyl-3,4-methylenedioxyamphetamine
N-Cyclopropylmethyl-3,4-methylenedioxyamphetamine
N-Ethyl-alpha-propyl-3,4-methylenedioxyphenethylamine
N-Hydroxy-N-methyl-3,4-methylenedioxyamphetamine
N-Isopropyl-3,4-methylenedioxyamphetamine
N-Methoxy-3,4-methylenedioxyamphetamine
N-Methyl-2,5-dimethoxyamphetamine
N-Methyl-2-methoxy-4,5-methylenedioxyamphetamine
N-Methyl-3,4-ethylenedioxyamphetamine
N-Methyl-4-methoxyamphetamine
N-Methyl-alpha-ethyl-3,4-methylenedioxyphenethylamine
N-Methyl-alpha-propyl-3,4-methylenedioxyphenethylamine
N-Propargyl-3,4-methylenedioxyamphetamine
N-Propyl-3,4-methylenedioxyamphetamine

    Such information may be submitted to the Drug Enforcement 
Administration using the information in the ADDRESSES section above. 
Such information is requested on or before December 19, 2006. 
Information designated as confidential or proprietary will be treated 
accordingly. Confidential business information is protected from 
disclosure under Exemption 4 of the Freedom of Information Act, 5 
U.S.C. 552(b)(4)(FOIA) and the Department of Justice procedures set 
forth in 28 CFR 16.8.

    Dated: October 11, 2006.
Joseph T. Rannazzisi,
Deputy Assistant Administrator, Office of Diversion Control.
[FR Doc. E6-17523 Filed 10-19-06; 8:45 am]
BILLING CODE 4410-09-P