[Federal Register Volume 71, Number 193 (Thursday, October 5, 2006)]
[Notices]
[Pages 58865-58866]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: E6-16455]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

Centers for Disease Control and Prevention

[60 Day-06-0425X]


Proposed Data Collections Submitted for Public Comment and 
Recommendations

    In compliance with the requirement of Section 3506(c)(2)(A) of the 
Paperwork Reduction Act of 1995 for opportunity for public comment on 
proposed data collection projects, the Centers for Disease Control and 
Prevention (CDC) will publish periodic summaries of proposed projects. 
To request more information on the proposed projects or to obtain a 
copy of the data collection plans and instruments, call 404-639-5960 
and send comments to Seleda Perryman, CDC Assistant Reports Clearance 
Officer, 1600 Clifton Road, MS-D74, Atlanta, GA 30333 or send an e-mail 
to [email protected].
    Comments are invited on: (a) Whether the proposed collection of 
information is necessary for the proper performance of the functions of 
the agency, including whether the information shall have practical 
utility; (b) the accuracy of the agency's estimate of the burden of the 
proposed collection of information; (c) ways to enhance the quality, 
utility, and clarity of the information to be collected; and (d) ways 
to minimize the burden of the collection of information on respondents, 
including through the use of automated collection techniques or other 
forms of information technology. Written comments should be received 
within 60 days of this notice.

Proposed Project

    The National Centers for Autism and Developmental Disabilities 
Research and Epidemiology (CADDRE) Study--New--National Center on Birth 
Defects and Developmental Disabilities (NCBDDD), Centers for Disease 
Control and Prevention (CDC).

Background and Brief Description

    The Children's Health Act of 2000 mandated CDC to establish autism 
surveillance and research programs to address the number, incidence, 
correlates, and causes of autism and related disabilities. Under the 
provisions of this act, CDC funded 5 CADDRE centers including the 
California Department of Health and Human Services, Colorado Department 
of Public Health and Environment, Johns Hopkins University, the 
University of Pennsylvania, and the University of North Carolina at 
Chapel Hill. CDC National Center on Birth Defects and Developmental 
Disabilities will participate as the 6th site. The multi-site, 
collaborative study will be an epidemiological investigation of 
possible causes for the autism spectrum disorders.
    Study participants will be selected from children born in and 
residing in the following six areas: Atlanta metropolitan area, San 
Francisco Bay area, Denver metropolitan area, Baltimore metropolitan 
area, Philadelphia metropolitan area, and Central North Carolina. 
Children with autism spectrum disorders will be compared to children 
with other developmental problems, referred to as the 
neurodevelopmentally impaired group (NIC), as well as children who do 
not have developmental problems, referred to as the subcohort.
    Data collection methods will consist of the following: (1) Medical 
record review of the child participant; (2) medical record review of 
the biological mother of the child participant; (3) a packet sent to 
the participants with self-administered questionnaires and a buccal 
swab kit; (4) a telephone interview focusing on pregnancy-related 
events and early life history (biological mother and/or primary 
caregiver interview); (5) a child development evaluation (more 
comprehensive for case participants than for the control group 
participants); (6) parent-child development interview (for case 
participants only) administered over the telephone or in-person; (7) a 
physical exam of the child participant; (8) biological sampling of the 
child participant (blood and hair); and (9) biological sampling of the 
biological parents of the child participant (blood only). There is no 
cost to respondents other than their time.

                                        Estimated Annualized Burden Hours
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                                                                Number of      Avg. burden per
                  Form                        Number of       responses per     response (in      Total burden
                                             respondents       respondent          hours)             hours
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1. Initial Contact by Mail..............            17,610                 1              0.17             2,994
2. Invitation Telephone Contact.........             8,922                 1              0.33             2,944
3. Self-administered Questionnaires and              3,456                 1              3.17            10,955
 buccal sample..........................
4. Caregiver Interview by telephone.....             3,282                 1              0.83             2,724
5. Child Clinic Visit (Child Development             3,114
 Evaluation, physical exam, and
 biosamples)............................
    Case................................               810                 1               2.0             1,620
    NIC.................................             1,170                 1              1.33             1,556
    Subcohort...........................             1,134                 1              1.33             1,508
6. Parent-Child Development Interview                  810                 1              3.17             2,568
 (Case participants only)...............
7. Parent biosamples....................             3,114                 1              0.25               779
                                                                                               -----------------
        Total...........................  ................  ................  ................            27,648
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[[Page 58866]]

    Dated: September 29, 2006.
Joan F. Karr,
Acting Reports Clearance Officer, Centers for Disease Control and 
Prevention.
[FR Doc. E6-16455 Filed 10-4-06; 8:45 am]
BILLING CODE 4163-18-P