[Federal Register Volume 71, Number 190 (Monday, October 2, 2006)]
[Notices]
[Pages 57946-57955]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: E6-16178]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES


Training and Capacity-Building for the Detection and Monitoring 
of, and Response to, Emerging Infectious Diseases in the Asia-Pacific 
Region

AGENCY: Office of Public Health Emergency Preparedness and the Office 
of Global Health Affairs, Office of the Secretary, DHHS.

ACTION: Notice.

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    Announcement Type: Single Eligibility--FY 2006 Initial 
Announcement.
    Funding Opportunity Number: OGHA 05-019.
    GSA Catalog of Federal Domestic Assistance: 93.283.

DATES: October 2, 2006.
    Application Availability.
    October 10, 2006.
    Optional Letter of Intent due by 5 p.m. ET.
    October 17, 2006--Applications due by 5 p.m. ET
    October 27, 2006--Award date.

SUMMARY: The Office of Public Health Emergency Preparedness (OPHEP) and 
the Office of Global Health Affairs (OGHA) within the U.S. Department 
of Health and Human Services (HHS) announces that up to $2,100,000 in 
fiscal year (FY) 2006 funds is available for a cooperative agreement to 
provide support to develop a cadre of in-country trainers who can 
improve their ongoing hospital infection-control programs to achieve 
better adherence by health-care workers to infection-control and case-
management principles and practices.
    This effort is an undertaking by the Department of Health and Human 
Services (HHS). The project will be approved for up to a program period 
of three (3) years with a budget period of one-year for a total of 
$2,100,000.
    Under certain circumstances especially in support of HHS 
International efforts, OGHA and OPHEP are required to collaborate on 
programs, issues and initiatives regarding international public health 
(i.e. Avian Influenza, disease surveillance, etc.). Normally, OGHA is 
often tasked as to devise, award, and administer international Federal 
assistance actions (grants, cooperative agreements, IAA's, etc.). When 
emergency preparedness issues are to be addressed as part of the 
program plan, OGHA partners with OPHEP to provide assistance in 
ensuring risks mitigation and emergency preparedness elements are 
included.
    The Regional Emerging Diseases Intervention (REDI) Center in 
Singapore will design the program around mentorship principles so 
trainers can gain advice and support for their efforts in teaching 
infection-control and case-management practices in local languages.
    While there is no current pandemic influenza outbreak, there is 
still reason to be concerned about the spread of the H5N1 virus from 
Southeast Asia to countries in Europe, the Middle East, and Africa. In 
the last century, three influenza pandemics have affected the United 
States, and viruses from birds contributed to all of them. Medical 
practitioners have also discovered several other, new, avian viruses 
human beings can transmit among one another. Although the H5N1 virus 
has primarily infected domesticated birds and long-range migratory 
birds, the virus has demonstrated the ability to infect and produce 
fatal illness in humans. Influenza experts believe an avian virus could 
become efficiently transmissible between humans, and result in a 
worldwide outbreak, which would overwhelm health and medical 
capabilities. Furthermore, an influenza pandemic could result in 
hundreds of thousands of deaths, millions of hospitalizations, and 
hundreds of billions of dollars in direct costs in the United States 
alone.
    On November 1, 2005, President Bush announced the National Strategy 
on Pandemic Influenza, and the following day Secretary Michael O. 
Leavitt released the HHS Pandemic Influenza Plan. Building on these 
efforts, President Bush released the Implementation Plan for the 
National Strategy for Pandemic Influenza on May 3, 2006, which 
describes more than 300 critical actions to address the threat of 
pandemic influenza. All relevant Federal Departments and agencies must 
take steps to address the threat of avian and pandemic influenza. 
Drawing on the combined efforts of Government officials and the public-
health, medical, veterinary, and law-enforcement communities, as well 
as the private sector, this strategy is designed to meet three critical 
goals: Detecting human or animal outbreaks that occur anywhere in the 
world; protecting the American people by stockpiling vaccines and 
antiviral drugs, while improving the capacity to produce new vaccines; 
and preparing to respond at the Federal, State, and local levels in the 
event an avian or pandemic influenza reaches the United States. HHS 
technical expertise in applied epidemiology, rapid laboratory 
diagnostics, infection control, virology research, vaccine delivery, 
and other areas is a critical component of both the domestic and the 
international

[[Page 57947]]

response to the threat of pandemic influenza.
    One of the primary objectives of both the National Strategy and the 
HHS Pandemic Plan is to leverage global partnerships to increase 
preparedness and response capabilities around the world with the intent 
of stopping, slowing, or otherwise limiting the spread of a pandemic to 
the United States.\1\ The U.S. cannot mount an effective response to an 
influenza pandemic without effective worldwide partnerships. As such, 
we are working bilaterally with partner countries, with multilateral 
organizations, and with private, non-profit organizations, to amplify 
our efforts. Our international effort to contain and mitigate the 
effects of an outbreak of pandemic influenza is a central component of 
our overall strategy. In many ways, the character and quality of the 
U.S. response and that of our international partners could play a 
determining role in the severity of a pandemic. Pillars Two and Three 
of the National Strategy set out clear goals for ensuring the rapid 
reporting of outbreaks and containing outbreaks beyond the borders of 
the U.S. by taking the following actions:
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    \1\ National Strategy for Academic Influenza, p. 2.
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    Working through the International Partnership on Avian and Pandemic 
Influenza, as well as through other political and diplomatic channels, 
such as the United Nations and the Asia-Pacific Economic Cooperation 
Forum, to ensure transparency, scientific cooperation, and rapid 
reporting of avian and human influenza cases;
    Supporting the development of proper scientific and epidemiological 
expertise in affected regions to ensure early recognition of changes in 
the pattern of avian or human influenza outbreaks;
    Supporting the development and sustainment of sufficient host-
country laboratory capacities and diagnostic reagents in affected 
regions, to provide rapid confirmation of cases of influenza in animals 
and humans;
    Working through the International Partnership to develop a 
coalition of strong partners to coordinate actions to limit the spread 
of an influenza with pandemic potential beyond the location where it is 
first located; and,
    Providing guidance to all levels of Government in affected nations 
on the range of options for infection control and containment.
    The International Partnership on Avian and Pandemic Influenza, 
launched by President Bush at the United Nations (UN) General Assembly 
in September 2005, stands in support of multinational organizations and 
National Governments. Members of the Partnership have agreed the 
following 10 principles will guide their efforts:
    1. International cooperation to protect the lives and health of our 
people;
    2. Timely, sustained, high-level, global political leadership to 
combat avian and pandemic influenza;
    3. Transparency in reporting of influenza cases in humans and in 
animals caused by viruses strains that have pandemic potential, to 
increase understanding and preparedness and especially to ensure rapid 
and timely response to potential outbreaks;
    4. Immediate sharing of epidemiological data and samples with the 
World Health Organization (WHO) and the international community to 
detect and characterize the nature and evolution of any outbreaks as 
quickly as possible by using, where appropriate, existing networks and 
mechanisms;
    5. Rapid reaction to address the first signs of accelerated 
transmission of H5N1 and other highly pathogenic influenza strains, 
that appropriate international and national resources can be brought to 
bear;
    6. Prevent and contain an incipient epidemic through capacity-
building and in-country collaboration with international partners;
    7. Work in a manner complementary to and supportive of expanded 
cooperation with and appropriate support of key multilateral 
organizations (including the WHO, the UN Food and Agriculture 
Organization and the World Organization for Animal Health);
    8. Timely coordination of bilateral and multilateral resource 
allocations; dedication of domestic resources (human and financial); 
improvements in public awareness; and development of economic and trade 
contingency plans;
    9. Increased coordination and harmonization of preparedness, 
prevention, response, and containment activities among nations, 
complementing domestics, and regional preparedness initiatives, and 
encouraging (where appropriate) the development of strategic regional 
initiatives; and,
    10. Actions based on the best available science.
    Through the Partnership and other bilateral and multilateral 
initiatives, we will promote these principles and support the 
development of an international capacity to prepare for, detect, and 
respond to an influenza pandemic.
    An important international resource for minimizing the global 
impact of avian-influenza and human-influenza pandemics is the REDI 
Center. Announced in 2003 by President Bush and Singaporean Prime 
Minister Goh under the auspices of the Asia-Pacific Economic 
Cooperation forum, the REDI Center is an international organization 
based in Singapore and jointly supported by HHS and the Singaporean 
Ministry of Health. The primary goal of the REDI Center is to establish 
a regional outpost for the United States to improve the detection of 
and the response to new and emerging infectious diseases threats by 
strengthening regional capabilities. These goals are directly related 
to the goals of the President's National Strategy and the HHS Pandemic 
Plan. With funding from this grant, the REDI Center will help extend 
the perimeter of defense for emerging infectious diseases, such as the 
H5N1 strain of avian influenza; increase international collaborative 
research; and translate the findings of research into improved public 
health in the Asia-Pacific region.
    In direct support of the President's National Strategy, this grant 
will finance the REDI Center. Funding support for activities supported 
by the REDI Center is fully consistent with the international component 
of the Fiscal Year 2006 Pandemic Influenza Plan. One of the overarching 
goals of the National Strategy and the HHS Pandemic Plan is to stop, 
slow or limit the spread of disease. Early in a pandemic, before a 
vaccine is available, the ability to limit transmission and delay the 
spread of a pandemic will rely primarily on the appropriate and 
thorough application of infection-control measures in health-care 
facilities, the work place, and community and among individuals at 
home. The education and training of health-care workers in infection-
control measures is imperative for both their protection and for 
limiting the transmission of virus.
    The Implementation Plan directs HHS to educate health-care workers 
in priority countries, and to provide guidance on the range of options 
for infection-control and containment. Current HHS infection-control 
guidance for influenza is based on our knowledge of the routes of 
influenza transmission, the pathogenesis of the virus, and the effects 
of influenza-control measures used for past pandemics and inter-
pandemic periods. Infection-control precautions during patient care in 
health-care settings (e.g., hospitals, nursing homes, outpatient 
offices, emergency transport vehicles) also apply to health-care 
personnel who go into the homes of patients.
    Funding from this grant will focus on hospital infection-control 
training in Indonesia. As of August 22, 2006, 58

[[Page 57948]]

cases of human infection with the H5N1 avian influenza virus, of which 
39 have been fatal. The H5N1 avian influenza virus is now endemic in 
poultry populations throughout Indonesia, and there continues to be 
close contact between humans and poultry across that country. A portion 
of the available funding will support an innovative, integrated animal 
and human disease-control and surveillance pilot project in Tangerang, 
jointly supported by the Governments of Singapore, Indonesia, and the 
United States.
    The National Strategy for Pandemic Influenza and the HHS Pandemic 
Influenza Strategic Plan are available at the following Internet 
address: http://www.pandemicflu.gov.

I. Funding Opportunity Description

    Authority: Sections 301(a) and 307 of the Public Health Service 
Act (42 U.S.C. 241(a) and 42 U.S.C. 2421).

Purpose of the Agreement

    Enhance cooperation between the United States, Singapore, and 
Indonesia, to support and increase influenza-preparedness;
    Provide assistance to the REDI Center for the expansion of in-
country training programs in local languages in infection control and 
case management in Indonesia;
    Institute infection-control procedures in the approximately 40 
infectious disease hospitals throughout Indonesia;
    Develop a cadre of Indonesian trainers who can train additional 
health-care workers, by designing and implementing courses in local 
languages that follow a train-the-trainer model;
    Provide support for a trilateral collaboration between the United 
States, Singapore, and Indonesia, on an innovative and integrated 
disease-control and surveillance pilot program in the Tangerang 
District of Indonesia.
    The program will encourage participants to assess the condition of 
their designated health-care facilities to handle large volumes of 
influenza patients and assess the effectiveness of their current 
training efforts and quality-assurance systems in hospital infection 
control. The goal is to develop a cadre of Indonesian trainers who can 
improve their ongoing hospital infection-control programs to achieve 
better adherence by health-care workers to infection-control and case-
management principles and practices. The REDI Center will design the 
program around mentorship principles so trainers can gain advice and 
support for their efforts in teaching infection-control and case-
management practices in local languages.
    Activities: Awardee activities for this program are as follows:
    Identify infectious-disease hospitals likely to receive influenza 
patients in Indonesia, and conduct needs assessments on current 
hospital infection-control and influenza case-management practices.
    Provide technical support and training for staff who are 
implementing in-country reviews of current hospital infection-control 
and influenza case-management practices in Indonesia.
    Develop and implement local-language training curricula and 
workshops by using a train-the-trainer model. Serve as an ongoing 
technical resource and mentor for trainers and health-care workers in 
Indonesia.
    Develop and implement demonstration projects and table-top 
exercises to complement classroom teaching.
    Providing support to epidemiological investigations and case 
management following confirmed human or animal influenza cases in 
Indonesia.
    Measurable outcomes of the program will be in alignment with the 
President's National Strategy and the principles of the International 
Partnership on Avian and Pandemic Influenza, and one (or more) of the 
following performance goal(s) for HHS pursuant to the President's 
initiative on pandemic-influenza preparedness:
     To detect outbreaks in the Asia/Pacific region before they 
spread to the United States and around the world;
     To educate health-care workers in priority countries, and 
provide guidance on the range of options for infection-control and 
containment.
     To take immediate steps to ensure early warning of an 
avian influenza outbreak among animals or humans in affected regions; 
and
     To strengthen a new international partnership on avian 
influenza.

II. Award Information

    The administrative and funding instrument for this program will be 
the cooperative agreement, in which HHS/OGHA will have scientific and/
or programmatic involvement is anticipated during the performance of 
the project. Under the cooperative agreement, HHS/OGHA will support 
and/or stimulate activities of the awardee by working with it in a non-
directive partnership role. HHS staff is substantially involved in the 
program activities, above and beyond routine monitoring. Through this 
cooperative agreement, HHS will collaborate in an advisory capacity 
with the award recipient, especially during the development and 
implementation of a mutually agreed-upon work plan. HHS will actively 
participate in periodic progress reviews and in a final evaluation of 
the program.
    Approximately $2,100,000 in FY 2006 funds is available to support 
this agreement under the Department of Defense, Emergency Supplemental 
Appropriations to Address Hurricanes in the Gulf of Mexico, and 
Pandemic Influenza Act, 2006 which provides funds to combat a potential 
influenza pandemic both domestically and internationally.
    The anticipated start date is October 27, 2006. There will only be 
one (1), single award made from this announcement. The program period 
is three (3) years for this agreement and the budget period is for 12 
months.
    Although the financial plans of HHS/OGHA provide for this program, 
the award pursuant to this Request for Applications (RFA) is contingent 
upon the availability of funds for this purpose.
    The award recipient must comply with all HHS management 
requirements for meeting progress against milestones and for financial 
reporting for this cooperative agreement. (Please see HHS Activities 
and Program Evaluation sections below.)
    HHS/OGHA activities for this program are as follows:
     Organize an orientation meeting with the award recipient 
after the award is made to brief it on applicable U.S. Government 
expectations, regulations, policies and key management requirements, as 
well as report formats and contents.
     Review and approve the award recipient's annual work plan 
and detailed budget.
     Review and approve the award recipient's monitoring-and-
evaluation plan.
     Conference on a monthly basis with the award recipient to 
assess monthly expenditures in relation to the approved work plan, and 
modify plans as necessary.
     Meet on an annual basis with the award recipient to review 
its annual progress report for each U.S. Government Fiscal Year, and to 
review annual work plans and budgets for the subsequent year.
     Assure experienced HHS or other subject-matter experts 
from other relevant U.S. Government Departments and agencies will 
participate in the planning, development, implementation, and 
evaluation of all phases of this project.
     Assist in establishing and maintaining U.S. Government, 
Singaporean and Indonesian

[[Page 57949]]

Governments, and non-governmental organizations (NGOs) contracts and 
agreements necessary to carry out the program.
    Program Evaluation Criteria: The application must have a 
comprehensive evaluation plan consistent with the scope, stated goals 
and objectives and funding level of the project. The evaluation plan 
should include both a process evaluation to track the implementation of 
project activities and outcome evaluation criteria.
    In addition to conducting internal evaluations, successful 
applicants must be prepared to participate in external evaluations 
supported by Singaporean and Indonesian Governments and HHS.
    In addition to routine communications with the Ministry of Health 
of Singapore and HHS within 30 days following the end of each quarter, 
the grantee will submit a written quarterly performance and financial 
status report of no more than ten pages in length to the Ministry of 
Health and HHS. At a minimum, quarterly performance reports will 
include the following:
     A concise summary of the most significant achievements and 
problems encountered during the reporting period, e.g. a comparison of 
work progress with objectives established for the quarter against the 
award recipient's implementation schedule. Where the awardee did not 
meet objectives were not met, the report must include a statement of 
cause and a summary of corrective actions.
     Specific action(s) HHS and/or the Singaporean and/or 
Indonesian Governments need to undertake to alleviate obstacles to 
progress.
     Other pertinent information that will permit oversight and 
evaluation of project operations.
    Within 90 days following the end of the project period the awardee 
must submit a final report that contain all required information and 
data to HHS and the Singaporean Ministry of Health. At minimum, the 
report will contain the following:
     A summary of the major activities supported under the 
grant; and the major accomplishments that resulted from activities to 
improve performance.
     An analysis of the project, based on the challenges 
described in the ``Background'' Section of the RFA performed prior to 
or during the project period, including a description of the specific 
objectives stated in the grant application and the accomplishments and 
failures that resulted from activities during the grant agreement 
period. Awardees should place emphasis on indicators and measures of 
operational efficiency and effectiveness.

III. Eligibility Information

    1. Eligible Applicants: This is a single-source, cooperative 
agreement with the Regional Emerging Diseases Intervention (REDI) 
Center for approximately a total of $2,100,000 in FY 2006 funds for a 
project period of three years with the anticipated start date of 
October 27, 2006. The REDI Center is a joint venture by the United 
States and the Republic of Singapore, announced under the auspices of 
the Asia-Pacific Economic Cooperation forum and incorporated in 
Singapore as an International Organization. Senior political and 
scientific leadership in the United States and Singapore, the World 
Health Organization, countries in the Asia-Pacific region, and other 
partners support the REDI center's objectives and mission. The REDI 
Center is specifically designed to serve as a base of training for 
regional public-health officials, researchers, clinicians and other 
health professionals, with an emphasis on the surveillance of and rapid 
response to emerging disease threats, such as a human pandemic 
influenza.
    There is no other organization in the Asia-Pacific region with the 
REDI Center's unique ability to serve as a regional center of 
excellence for influenza-related training in public health, biomedical 
research, and public-health emergency preparedness. The REDI Center is 
already working to catalyze regional collaboration in research into and 
surveillance of infectious diseases, including the H5N1 strain of avian 
influenza and other diseases directly relevant to the security of the 
United States and the Asia-Pacific region. The REDI Center is uniquely 
positioned to leverage existing networks, training infrastructure, and 
scientific expertise for influenza preparedness and response 
activities.
    The REDI Center has and will continue to carry out activities in 
Southeast Asia of high relevance to the U.S. Government's planning and 
preparedness for a potential human influenza pandemic. The REDI Center 
is organizing in-country training of hospital workers throughout 
Southeast Asia in infection control and case management of influenza, 
has organized training courses in infectious disease epidemiology and 
in public-health emergency preparedness for trainees from throughout 
the region, and has as facilitated international research 
collaborations in influenza and related illnesses. The REDI Center has 
demonstrated experience in organizing committees of world-renowned 
infectious-disease experts from HHS, Singaporean centers of excellence, 
and other leading public-health and medical-research institutions.
    2. Cost-Sharing or Matching: Although cost-sharing, matching funds, 
and cost participation are not a requirement of this agreement, 
preference may go to organizations that can leverage additional funds 
to contribute to program goals. If applicants receive funding from 
other sources to underwrite the same or similar activities, or 
anticipate receiving such funding in the next 12 months, they must 
detail how the disparate streams of financing complement each other.
    3. Other--(If Applicable): If an applicant requests a funding 
amount greater than the ceiling of the award range, HHS will consider 
the application non-responsive, and it will not enter into the review 
process. HHS will notify the applicant that the application did not 
meet the submission requirements.

IV. Application and Submission Information

    1. Address to Request Application Package:
    This Cooperative Agreement project uses the Application Form HHS/
OPHS-1, Revised 8/2004, enclosed in the application packet. Many 
different programs funded through the HHS Public Health Service (PHS) 
use this generic form. Some parts of it are not required; applicants 
must fill out other sections in a fashion specific to the program. 
Instructions for filling out HHS OPHS-1, Revised 8/2004 will accompany 
the application packet. Applicants may also obtain these forms by 
downloading them from the following Internet address: https://egrants.osophs.dhhs.gov and clicking on Grant Announcements; from 
http://www.grants.gov/; or by writing to Ms. Karen Campbell, Director, 
Office of Grants Management, Office of Public Health and Science, U.S. 
Department of Health and Human Services, Tower Building, 1101 Wootton 
Parkway, Suite 550, Rockville, MD 20852; or contact the HHS/OPHS/Office 
of Grants Management, at (240) 453-8822. Please specify the HHS/OGHA 
program(s) for which you are requesting an application kit.

ADDRESSES: Application kits may be requested from, and submit to: Ms. 
Karen Campbell, Director, Office of Grants Management, Office of Public 
Health and Science, Department of Health and Human Services, Tower 
Building, 1101 Wootton Parkway, Suite 550, Rockville, MD 20852.

[[Page 57950]]

    2. Content and Form of Application Submission:
    Application Materials:
    A separate budget page is required for each budget year. Applicant 
must submit with their proposal a line-item budget (SF 424A) with 
coinciding justification to support each of the budget years. These 
forms will represent the full project period of Federal assistance 
requested. HHS/OGHA will reject proposals submitted without a budget 
and justification for each budget year requested in the application.
    All applicants must include in their applications by a Project 
Abstract, submitted on a 3.5-inch floppy disk. The abstract must be 
typed, single-spaced, and not exceed two pages. Reviewers and staff 
will refer frequently to the information contained in the abstract, and 
therefore it should contain substantive information about the proposed 
projects in summary form. A list of suggested keywords and a format 
sheet for your use in preparing the abstract will accompany the 
application packet.
    All applicants must include a Project Narrative in their grant 
applications. Format requirements are the same as for the ``Project 
Abstract'' Section; margins should be one-inch at the top and one-inch 
at the bottom and both sides; and typeset must be no smaller than 12 
cpi, unreduced. Applicants should type biographical sketches either on 
the appropriate form or on plain paper and they should not exceed two 
pages; list only with publications directly relevant to this project.

Application Format Requirements

    If an applicant is applying on paper, the entire application may 
not exceed 80 pages in length, including the abstract, project and 
budget narratives, face page, attachments, any appendices and letters 
of commitment and support. Applicants must number pages consecutively.
a. Number of Copies
    If submitting in hard-copy, please submit one (1) original and two 
(2) unbound copies of the application. Please do not bind or staple the 
application. Application must be single-sided.
b. Font
    Please use an easily readable serif typeface, such as Times Roman, 
Courier, or CG Times. Applicants must submit the text and table 
portions of the application in not less than 12-point and 1.0 line 
spacing. HHS/OGHA will return applications that do not adhere to 12-
point font requirements.
c. Paper Size and Margins
    For scanning purposes, please submit the application on 8\1/2\ x 11 
white paper. Margins must be at least one (1) inch at the top, bottom, 
left and right of the paper. Please left-align text.
d. Numbering
    Please number the pages of the application sequentially from page 
one (face page) to the end of the application, including charts, 
figures, tables, and appendices.
e. Names
    Please include the name of the applicant on each page.
f. Section Headings
    Please put all section headings flush left in bold type.
    Application Format: An application for funding must consist of the 
following documents, in the following order:
    i. Application Face Page. HHS/PHS Application Form HHS/OPHS-1, 
provided with the application package. Prepare this page according to 
instructions provided in the form itself.

DUNS Number

    An applicant organization must have a Data Universal Numbering 
System (DUNS) number to apply for a grant from the Federal Government. 
The DUNS number is a unique, nine-character identification number 
provided by the commercial company Dun and Bradstreet. There is no 
charge to obtain a DUNS number. Information about obtaining a DUNS 
number is available at the following Internet address: https://www.dnb.com/product/eupdate/requestOptions.html or by calling 1-866-
705-5711. Please include the DUNS number next to the Office of 
Management and Budget (OMB) Approval Number on the application face 
page. HHS/OGHA will not review an application that does not have a DUNS 
number.
    Additionally, the applicant organization must register with the 
Federal Government's Central Contractor Registry (CCR) to do electronic 
business with the Federal Government. Information about registering 
with the CCR is available at the following Internet address: http://www.hrsa.gov/grants/ccr.htm.
    Finally, applicants that are applying electronically through 
Grants.gov must register with the Credential Provider for Grants.gov. 
Information about this requirement is available at the following 
Internet address: http://www.grants.gov/CredentialProvider.
    Applicants that are applying electronically through the HHS/OPHS E-
Grants System must register with the provider. Information about this 
requirement is available at the following Internet address: https://egrants.osophs.dhhs.gov.
    ii. Table of Contents. Provide a Table of Contents for the 
remainder of the application (including appendices), with page numbers.
    iii. Application Checklist. Application Form HHS/OPHS-1, provided 
with the application package.
    iv. Budget. Application Form HHS/OPHS-1, provided with the 
application package.
    v. Budget Justification. Applicants must enter the amount of 
financial support (direct costs) they are requesting from the Federal 
granting agency for the first year on the Face Sheet of Application 
Form HHS/PHS 5161-1, Line 15a. The application should include funds for 
electronic-mail capability, unless access to the Internet is already 
available. The amount of financial support (direct costs) entered on 
the SF 424 is the amount an applicant is requesting from the Federal 
granting agency for the project year.
    Personnel Costs: Applicants should explain their personnel costs by 
listing each staff member supported from Federal funds, name (if 
possible), position title, percent full-time equivalency, annual 
salary, and the exact amount requested.
    Fringe Benefits: List the components that comprise the fringe 
benefit rate, for example, health insurance, taxes, unemployment 
insurance, life insurance, retirement plan, and tuition reimbursement. 
The fringe benefits should be directly proportional to that portion of 
personnel costs allocated for the project.
    Travel: Applicants must list travel costs according to local and 
long-distance travel. For local travel, the applicants should outline 
the mileage rate, number of miles, reason for the travel and the staff 
member/consumers who will be completing the travel. The budget should 
also reflect the travel expenses associated with participating in 
meetings and other proposed training or workshops.
    Equipment: Applicants must list equipment costs, and provide 
justification for the need of the equipment to carry out the program's 
goals. Applicants must provide an extensive justification and a 
detailed status of current equipment when they request funds for the 
purchase of computers and furniture items.
    Supplies: Applicants must list the items the project will use. In 
this

[[Page 57951]]

category, separate office supplies from medical and educational 
purchases. ``Office supplies'' could include paper, pencils, and the 
like; ``medical supplies'' are syringes, blood tubes, plastic gloves, 
etc., and ``educational supplies'' can be pamphlets and educational 
videotapes. Applicants must list these categories separately.
    Subcontracts: To the extent possible, applicants should standardize 
all subcontract budgets and justifications, and should present contract 
budgets by using the same object-class categories contained in the 
Standard Form 424A. Applicants must provide a clear explanation as to 
the purpose of each contract, how organization estimated the costs, and 
the specific contract deliverables.
    Other: Applicants must put all costs that do not fit into any other 
category into this category, and provide an explanation of each cost in 
this category. In some cases, grantee rent, utilities and insurance 
fall under this category if they are not included in an approved 
indirect cost rate.)
    vi. Staffing Plan and Personnel Requirements. Applicants must 
present a staffing plan, and provide a justification for the plan that 
includes education and experience qualifications and the rationale for 
the amount of time being requested for each staff position. Applicants 
must include in Appendix B position descriptions that include the 
roles, responsibilities, and qualifications of proposed project staff. 
Applicants must include in Appendix C copies of biographical sketches 
for any key employed personnel that will be assigned to work on the 
proposed project.
    vii. Project Abstract. Applicants must provide a summary of the 
application. Because HHS/OGHA often distributes the abstract to provide 
information to the American public and to the U.S. Congress, applicants 
should prepare this so it is clear, accurate, concise, and without 
reference to other parts of the application. It must include a brief 
description of the proposed grant project, including the needs 
addressed, the proposed work, and the population group(s) served.
    Applicants must place the following at the top of the abstract:
     Project Title;
     Applicant Name;
     Address;
     Contact Phone Numbers (Voice, Fax);
     E-Mail Address; and
     Web Site Address, if applicable
    The project abstract must be single-spaced and limited to two pages 
in length.
    viii. Program Narrative. This section provides a comprehensive 
framework and description of all aspects of the proposed program. It 
should be succinct, self-explanatory and well-organized, so reviewers 
can understand the proposed project.
    Applicants should use the following section headers for the 
Narrative:
     Introduction
    This section should briefly describe the purpose of the proposed 
project.
     Work Plan
    Applicants should describe the activities or steps to achieve each 
of the activities proposed in the methodology section and use a time 
line that includes each activity and identifies responsible staff.
     Resolution of Challenges
    Applicants should discuss likely challenges in designing and 
implementing the activities described in the Work Plan, and approaches 
to resolve such challenges.
     Evaluation and Technical Support Capacity
    Applicants should describe their current experience, skills, and 
knowledge, including individuals on staff, materials published, and 
previous work of a similar nature.
     Organizational Information
    Applicants should provide information on their current mission and 
structure, scope of current activities, and an organizational chart, 
and describe how these all contribute to the ability of the 
organization to conduct the program requirements and meet program 
expectations.
    ix. Appendices. Applicants must provide the following items to 
complete the content of their application(s). Please note that these 
are supplementary in nature, and are not a continuation of the project 
narrative. Applicants should label each appendix clearly.
    (1) Appendix A: Tables, Charts, etc.
    To give further details about the proposal.
    (2) Appendix B: Job Descriptions for Key Personnel
    Applicants should keep each to one page in length as much as 
possible. Item 6 in the Program Narrative Section of the HHS/PHS 5161-1 
Form provides some guidance on items to include in a job description.
    (3) Appendix C: Biographical Sketches of Key Personnel
    Applicants should include biographical sketches for persons who are 
occupying the key positions described in Appendix B, not to exceed two 
pages in length. In the event an applicant includes a biographical 
sketch for an identified individual who is not yet hired, it must 
include a letter of commitment from that person with the biographical 
sketch.
    (4) Appendix D: Letters of Agreement and/or Description(s) of 
Proposed/Existing Contracts (project specific). Applicants must provide 
any documents that describe working relationships between the applicant 
agency and other agencies and programs cited in the proposal. Documents 
that confirm actual or pending contractual agreements should clearly 
describe the roles of the subcontractors and any deliverable. Letters 
of agreement must be dated.
    (5) Appendix E: Organizational Chart for the Project. Applicants 
must provide a one-page figure that depicts the organizational 
structure of the project, including subcontractors and other 
significant collaborators.
    (6) Appendix F: Other Relevant Documents. Applicants should include 
here any other documents relevant to the application, including letters 
of support. Letters of support must be dated.
    3. Submission Dates and Times: Application Submission.
    HHS/OPHS provides multiple mechanisms for the submission of 
applications, as described in the following sections. Applicants will 
receive notification via mail from the HHS/OPHS Office of Grants 
Management to confirm receipt of applications submitted by using any of 
these mechanisms. The HHS/OPHS Office of Grants Management will not 
accept for review applications submitted after the deadlines described 
below. HHS will not accept for review applications that do not conform 
to the requirements of the grant announcement and will return them to 
the applicant.
    Applicants may only submit electronically via the electronic 
submission mechanisms specified below. HHS will accept for review any 
applications submitted via any other means of electronic communication, 
including facsimile or electronic mail. While HHS will accept 
applications in hard copy, we encourage the use of the electronic 
application submission capabilities provided by the HHS/OPHS eGrants 
system or the Grants.gov Web site Portal.
    Applicants must submit electronic grant application submissions no 
later than 5 p.m. Eastern Time on the deadline date specified in the 
DATES section of the announcement using one of the electronic 
submission mechanisms specified below. The HHS/OPHS Office of Grants 
Management must receive all required hardcopy original signatures and 
mail-in items no

[[Page 57952]]

later than 5 p.m. Eastern Time on the next business day after the 
deadline date specified in the DATES section of the announcement.
    HHS will not consider applications valid until the HHS/OPHS Office 
of Grants Management has received all electronic application 
components, hard-copy original signatures, and mail-in items according 
to the deadlines specified above. HHS will consider application 
submissions that do not adhere to the due date requirements and will 
deem them ineligible.
    Applicants should initiate electronic applications early in the 
application development process and should submit early on the due date 
or before to aid in addressing any problems with submissions prior to 
the application deadline.
    Electronic Submissions via the Grants.gov Web site Portal. The 
Grants.gov Web site Portal provides organizations with the ability to 
submit applications for HHS grant opportunities. Organizations must 
successfully complete the necessary registration processes in order to 
submit an application. Information about this system is available on 
the Grants.gov Web site at the following Internet address: http://www.grants.gov.
    In addition to electronically submitted materials, applicants may 
be required to submit hard-copy signatures for certain Program-related 
forms, or original materials, as required by the announcement. 
Applicants must review both the grant announcement, as well as the 
application guidance provided within the Grants.gov application 
package, to determine such requirements. Applicants must submit any 
required hard-copy materials, or documents that require a signature, 
separately via mail to the HHS/OPHS Office of Grants Management, which, 
if required, must contain the original signature of an individual 
authorized to act for the applicant agency and the obligations imposed 
by the terms and conditions of the grant award.
    Electronic applications submitted via the Grants.gov Web site 
Portal must contain all completed online forms required by the 
application kit, the Program Narrative, Budget Narrative and any 
appendices or exhibits. HHS must receive all required mail-in items by 
the due date requirements specified above. Mail-in items may only 
include publications, r[eacute]sum[eacute]s, or organizational 
documentation.
    Upon completion of a successful electronic application submission 
via the Grants.gov Web site Portal the applicant will receive a 
confirmation page from Grants.gov to indicate the date and time 
(Eastern Time) of the electronic application submission, as well as the 
Grants.gov Receipt Number. Applicants must print and retain this 
confirmation for their records, as well as a copy of the entire 
application package.
    Grants.gov will validate all applications submitted via the 
Grants.gov Web site Portal. Any applications deemed ``Invalid'' by the 
Grants.gov Web site Portal will not proceed to the HHS/OPHS eGrants 
system, and HHS/OPHS has no responsibility for any application that is 
not validated and transferred to HHS/OPHS from the Grants.gov Web site 
Portal. Grants.gov will notify the applicant regarding the application 
validation status. Once the Grants.gov Web site Portal has successfully 
validated the application, applicants should immediately mail all 
required hard-copy materials to the HHS/OPHS Office of Grants 
Management by the deadlines specified above. Applicants must clearly 
identify their Organization's name and Grants.gov Application Receipt 
Number on all hard-copy materials.
    Once the Grants.gov has validated an application, it will 
electronically proceed to the HHS/OPHS eGrants system for processing. 
Upon receipt of both the electronic application from the Grants.gov Web 
site Portal, and the required hard-copy mail-in items, applicants will 
receive notification via mail from the HHS/OPHS Office of Grants 
Management to confirm the receipt of the application submitted by using 
the Grants.gov Web site Portal.
    Applicants should contact Grants.gov regarding any questions or 
concerns regarding the electronic application process conducted through 
the Grants.gov Web site Portal.
    Electronic Submissions via the HHS/OPHS eGrants System. The HHS/
OPHS electronic grants management system, eGrants, provides for 
applications to be submitted electronically. Information about this 
system is available on the HHS/OPHS eGrants Web site, https://egrants.osophs.dhhs.gov, or may be requested from the HHS/OPHS Office 
of Grants Management at (240) 453-8822.
    When submitting applications via the HHS/OPHS eGrants system, 
applicants are required to submit a hard copy of the application face 
page (Standard Form 424) with the original signature of an individual 
authorized to act for the applicant agency and assume the obligations 
imposed by the terms and conditions of the grant award. If required, 
applicants will also need to submit a hard copy of the Standard Form 
LLL and/or certain Program-related forms (e.g., Program Certifications) 
with the original signature of an individual authorized to act for the 
applicant agency.
    Electronic applications submitted via the HHS/OPHS eGrants system 
must contain all completed online forms required by the application 
kit, the Program Narrative, Budget Narrative and any appendices or 
exhibits. The applicant may identify specific mail-in items to send to 
the HHS/OPHS Office of Grants Management separate from the electronic 
submission; however, applicants must enter these mail-in items on the 
eGrants Application Checklist at the time of electronic submission, and 
HHS must receive them by the due date requirements specified above. 
Mail-in items may only include publications, resumes, or organizational 
documentation.
    Upon completion of a successful electronic application submission, 
the HHS/OPHS eGrants system will provide the applicant with a 
confirmation page to indicate the date and time (Eastern Time) of the 
electronic application submission. This confirmation page will also 
provide a listing of all items that constitute the final application 
submission, including all electronic application components, required 
hard-copy original signatures, and mail-in items, as well as the 
mailing address of the HHS/OPHS Office of Grants Management, to which 
applicants must submit all required hard copy materials.
    As items the HHS/OPHS Office of Grants Management receives items, 
the electronic application status will be updated to reflect the 
receipt of mail-in items. We recommend applicants monitor the status of 
their applications in the HHS/OPHS eGrants system to ensure that the 
receipt of all signatures and mail-in items.
    Mailed or Hand-Delivered Hard-Copy Applications. Applicants who 
submit applications in hard copy (via mail or hand-delivered) must 
submit an original and two copies of the application. An individual 
authorized to act for the applicant agency or organization and to 
assume for the organization the obligations imposed by the terms and 
conditions of the grant award must sign the original application.
    HHS will consider mailed or hand-delivered applications as having 
met the deadline if the HHS/OPHS Office of Grant Management receives 
them on or before 5 p.m. Eastern Time on the deadline date specified in 
the DATES section of the announcement. The application deadline date 
requirement specified in this announcement supersedes the instructions 
in the HHS/OPHS-1. HHS will return unread

[[Page 57953]]

applications that do not meet the deadline.
    Applicants should submit their applications to the following 
address: Director, Office of Grants Management, Office of Public Health 
and Science, Department of Health and Human Services, 1101 Wootten 
Parkway, Suite 550, Rockville, MD 20852
    4. Intergovernmental Review: This program is not subject to the 
review requirements of Executive Order 12372, Intergovernmental Review 
of Federal Programs.
    5. Funding Restrictions: Allowability, allocability, 
reasonableness, and necessity of direct costs applicants may charge 
appear in the following documents: OMB-21 (Institutes of Higher 
Education); OMB Circular A-122 (Nonprofit Organizations); and 45 CFR 
part 74, Appendix E (Hospitals). Copies of these circulars are 
available at the following Internet address: http://www.whitehouse.gov/omb. No pre-award costs are allowed.
    6. Other Submission Requirements: N/A.

V. Application Review Information

    1. Criteria: HHS/OGHA staff will screen applications for 
completeness and for responsiveness to the program guidance. Applicant 
should pay strict attention to addressing these criteria, as they are 
the basis upon which the application will be judged. An application 
judged to be non-responsive or incomplete will be returned to the 
applicant without review.
    An application that is complete and responsive to the guidance will 
undergo an evaluation for scientific and technical merit by an 
appropriate peer-review group specifically convened for this 
solicitation and in accordance with HHS policies and procedures. The 
panel may contain both Federal and non-Federal representatives. As part 
of the initial merit review, the application will receive a written 
critique. The ad hoc peer review group will discuss fully all 
applications recommended for approval and will assign a priority score 
for funding. HHS/OGHA will assess an eligible application according the 
following criteria:
    (1) Technical Approach (40 points):
     The applicant's presentation of a sound and practical 
technical approach for executing the requirements with adequate 
explanation, substantiation and justification for methods for handling 
the projected needs of Indonesian health-care institutions.
     The successful applicant must demonstrate a clear 
understanding of the scope and objectives of the President's National 
Strategy and Implementation Plan and the HHS Pandemic Influenza Plan, a 
recognition of potential difficulties that could arise in performing 
the work required, and an understanding of the close coordination 
necessary between the Singaporean and Indonesian Governments, the U.S. 
Agency for International Development, and other organizations, such as 
the World Health Organization and the United Nations Children's Fund.
     Applicants must submit a strategic plan that outlines the 
schedule of activities and expected products of the Group's work, with 
benchmarks at months six and 12.
    (2) Personnel Qualifications and Experience (20 points):
     Project Leadership--For the technical and administrative 
leadership of the project requirements, successful applicants must 
demonstrate documented training, expertise, relevant experiences, 
local-language skills, leadership/management skills, and the 
availability of a suitable overall project manager and surrounding 
management structure to successfully plan and manage the project. The 
successful applicant will provide documented history of leadership in 
the establishment and management of training programs that involve 
training of health care professionals in countries other than the 
United States. Applicants should show documented managerial ability to 
achieve delivery or performance requirements as demonstrated by the 
proposed use of management and other personnel resources and to 
successfully manage the project, including subcontractor and/or 
consultant efforts, if applicable, as evidenced by the management plan 
and demonstrated by previous relevant experience.
     Partner Institutions and other Personnel-Applicants should 
provide documented evidence of the availability, training, 
qualifications, expertise, relevant experience, local-language skills, 
education and competence of the scientific, clinical, analytical, 
technical and administrative staff and any other proposed personnel 
(including from partner institutions, subcontractors and consultants), 
to perform the requirements of the work activities, as evidenced by 
r[eacute]sum[eacute]s, endorsements and explanations of previous 
efforts.
     Staffing Plan--Applicants should submit a staffing plan 
for the conduct of the project, including the appropriateness of the 
time commitment of all staff and partner institutions, the clarity and 
appropriateness of assigned roles, and lines of authority. Applicants 
should also provide an organizational chart for each partner 
institution named in the application to show the relationships among 
the key personnel.
     Administrative and Organizational Framework--Applicants 
must demonstrate the adequacy of their administrative and 
organizational framework, with lines of authority and responsibility 
clearly drawn, and the adequacy of the project plan, with a proposed 
time schedule for achieving the objectives and maintaining quality 
control over the implementation and operation of the project. 
Applicants must show the adequacy of back-up staffing and the evidence 
they will be able to function as a team. The framework should identify 
the institution that will assume legal and financial responsibility and 
accountability for the use and disposition of funds awarded on the 
basis of this RFA.
    (3) Experience and Capabilities of the Organization (30 Points):
     Applicants should submit documented relevant experience of 
their organization in managing projects of similar complexity and scope 
of activities in the developing world.
     Applicants should show the clarity and appropriateness of 
their lines of communication and authority for coordination and 
management of the project. Adequacy and feasibility of plans to ensure 
successful coordination of multiple-partner collaboration.
     Applicants must document their experience in recruiting 
qualified medical personnel for projects of similar complexity and 
scope in the developing world.
    (4) Facilities and Resources (10 Points):
    Applicants must document the availability and adequacy of 
facilities, equipment and resources necessary to carry out the 
activities specified under the ``Program Requirements'' Section of the 
announcement.
    2. Review and Selection Process:
    A panel of peer reviewers will review the application. The 
reviewers will address and consider each of the above criteria will in 
assigning the overall score. The Deputy Director for Operations of the 
HHS/Office of Global Health Affairs will make the award on the basis of 
score, program relevance, and availability of funds.

VI. Award Administration Information

    1. Award Notices: HHS/OGHA does not release information about 
individual applications during the review process until it has made 
final funding decisions. When HHS/OGHA has made these decisions, it 
will notify applicants by letter regarding the outcome of their

[[Page 57954]]

applications. The official document to notify an applicant HHS has 
approved and funded an application is the Notice of Award, which 
specifies to the awardee the amount of money awarded, the purpose of 
the agreement, the terms and conditions of the agreement, and the 
amount of funding, if any, by the awardee will contribute to the 
project costs.
    2. Administrative and National Policy Requirements:
    The regulations set out at 45 CFR parts 74 and 92 are the HHS rules 
and requirements that govern the administration of grants. Part 74 is 
applicable to all recipients, except those covered by part 92, which 
governs awards to U.S. State and local Governments. Applicants funded 
under this announcement must be aware of and comply with these 
regulations. The CFR volume that includes parts 74 and 92 is available 
at the following Internet address: http://www.access.gpo.gov/nara/cfr/waisidx_03/45cfrv1_03.html.
    3. Reporting: The projects must have an evaluation plan, consistent 
with the scope of the proposed project and funding level, that conforms 
to the project's stated goals and objectives. The evaluation plan 
should include both a process evaluation to track the implementation of 
project activities, and an outcome evaluation to measure changes in 
knowledge and skills attributable to the project. Project funds may 
support evaluation activities.
    In addition to conducting its own evaluation of projects, the 
successful applicant must be prepared to participate in an external 
evaluation, supported by HHS/OGHA and conducted by an independent 
entity, to assess the efficiency and effectiveness of the project 
funded under this announcement.
    Within 30 days following the end of each of quarter, awardees must 
submit a performance report no more than ten pages in length to HHS/
OGHA. HHS/OGHA will forward a sample monthly performance report will be 
provided at the time of notification of award. At a minimum, monthly 
performance reports should include the following:
     A concise summary of the most significant achievements and 
problems encountered during the reporting period, e.g., number of 
training courses held and number of trainees.
     A comparison of work progress with objectives established 
against the quarter using the grantee's implementation schedule, and 
where the grantee did not meet such objectives, a statement of why.
     Specific action(s) the grantee would like HHS/OGHA to 
undertake to alleviate a problem.
     Other pertinent information that will permit the 
monitoring and oversight of project operations.
     A quarterly financial report to describe the current 
financial status of the funds used under this award. The awardee and 
HHS/OGHA will agree at the time of award on the format of this portion 
of the report.
    Within 90 days following the end of the project period, the awardee 
must submit a final report containing information and data of interest 
to HHS, the U.S. Congress, and other countries. HHS/OGHA will send to 
successful applicants the specifics as to the format and content of the 
final report and the summary. At minimum, the report should contain the 
following:
     A summary of the major activities supported under the 
agreement and the major accomplishments resulting from activities to 
improve influenza preparedness in Indonesia.
     An analysis of the project based on the problem(s) 
described in the application and needs assessments, performed prior to 
or during the project period, including a description of the specific 
objectives stated in the grant application and the accomplishments and 
failures resulting from activities during the grant period.
    Awardees must submit quarterly performance reports and the final 
report may be submitted to: Mr. Dewayne Wynn, Grants Management 
Specialist, Office of Grants Management, HHS/OPHS, 1101 Wootton 
Parkway, Suite 550, Rockville, MD 20852, phone +1 (240) 453-8822.
    A Financial Status Report (FSR) SF-269 is due 90 days after the 
close of each 12-month budget period to HHS/OPHS Office of Grants 
Management.

VII. Agency Contacts

    For assistance on administrative and budgetary requirements, please 
contact: Mr. DeWayne Wynn, Grants Management Specialist, Office of 
Grants Management, HHS/OPHS, 1101 Wootton Parkway, Suite 550, 
Rockville, MD 20852, phone +1 (240) 453-8822.
    For assistance with questions regarding program requirements, 
please contact:Amar Bhat, PhD, Director, Office of Asia and the 
PacificOffice of Global Health Affairs,U.S. Department of Health and 
Human Services,5600 Fishers Lane, Suite 18-101,Rockville, MD 
20857,Phone Number: 301-443-1774.

VIII. Tips for Writing a Strong Application

    Include DUNS Number. You must include a DUNS Number to have your 
application reviewed. HHS will not review applications without a DUNS 
number. To obtain a DUNS number, go to www.dunandbradstreet.com or call 
1-866-705-5711. Please include the DUNS number next to the OMB Approval 
Number on the application face page.
    Keep your audience in mind. Reviewers will use only the information 
contained in the application to assess the application. Please be sure 
the application and responses to the program requirements and 
expectations are complete and clearly written. Do not assume reviewers 
are familiar with the applicant organization. Keep the review criteria 
in mind when writing the application.
    Start preparing the application early. Allow plenty of time to 
gather required information from various sources.
    Follow the instructions in this guidance carefully. Place all 
information in the order requested in the guidance. If you do not place 
the information in the requested order, you could receive a lower 
score.
    Be brief, concise, and clear. Make your points understandable. 
Provide accurate and honest information, including candid accounts of 
problems and realistic plans to address them. If you are omitting any 
required information or data, explain why. Make sure the information 
provided in each table, chart, attachment, etc., is consistent with the 
proposal narrative and information in other tables.
    Be organized and logical. Many applications fail to receive a high 
score because the reviewers cannot follow the thought process of the 
applicant, or because parts of the application do not fit together.
    Be careful in the use of appendices. Do not use the appendices for 
information required in the body of the application. Be sure to cross-
reference all tables and attachments located in the appendices to the 
appropriate text in the application.
    Carefully proofread the application. Misspellings and grammatical 
errors will impede reviewers in understanding the application. Be sure 
pages are numbered (including appendices), and you follow page limits. 
Limit the use of abbreviations and acronyms, and define each one at its 
first use and periodically throughout application.


[[Page 57955]]


     Dated: September 26, 2006.
Sandra R. Manning,
Deputy Director for Operations,Office of Global Health Affairs,U.S. 
Department of Health and Human Services.
[FR Doc. E6-16178 Filed 9-29-06; 8:45 am]
BILLING CODE 4150-38-P