[Federal Register Volume 71, Number 188 (Thursday, September 28, 2006)]
[Notices]
[Page 56987]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: E6-15946]


-----------------------------------------------------------------------

DEPARTMENT OF HEALTH AND HUMAN SERVICES

Agency for Toxic Substances and Disease Registry

[ATSDR-224]


Availability of Two Interaction Profiles [Final Documents] at 
http://www.atsdr.cdc.gov

AGENCY: Agency for Toxic Substances and Disease Registry (ATSDR), 
Department of Health and Human Services (DHHS).

ACTION: Notice of availability.

-----------------------------------------------------------------------

SUMMARY: This notice announces the availability of two interaction 
profiles prepared by ATSDR [final documents].

DATES: The interaction profiles will be available to the public on or 
about, October 1, 2006.

ADDRESSES: The documents will also be available on ATSDR's Web site at 
http://www.atsdr.cdc.gov.

FOR FURTHER INFORMATION CONTACT: Please submit questions regarding 
information contained in the profiles to Dr. Hana Pohl, Division of 
Toxicology and Environmental Medicine, Agency for Toxic Substances and 
Disease Registry, Mailstop F-32, 1600 Clifton Road, NE., Atlanta, 
Georgia 30333, telephone (888) 422-8737.

SUPPLEMENTARY INFORMATION: The interaction profiles were developed by 
ATSDR for hazardous substances at National Priority List (NPL) sites 
under sections 104(i)(3) and (5) of the Comprehensive Environmental 
Response, Compensation, and Liability Act of 1980 (CERCLA or 
Superfund), as amended by the Superfund Amendments and Reauthorization 
Act of 1986 (SARA). This public law mandates that ATSDR shall assess 
whether adequate information on health effects is available for the 
priority hazardous substances. Where such information is not available 
or under development, ATSDR shall, in cooperation with the National 
Toxicology Program, initiate a program of research to determine these 
health effects. The Act further directs that where feasible, ATSDR 
shall develop methods to determine the health effects of substances in 
combination with other substances with which they are commonly found.
    To carry out these legislative mandates, ATSDR has developed a 
chemical mixtures program. As part of the mixtures program, ATSDR 
developed a guidance manual that outlines the latest methods for 
mixtures health assessment. In addition, a series of documents called 
interaction profiles are being developed for certain priority mixtures 
that are of special concern to ATSDR. The purpose of an interaction 
profile is to evaluate data on the toxicology of the ``whole'' priority 
mixture (if available) and on the joint toxic action of the chemicals 
in the mixture in order to recommend approaches for the exposure-based 
assessment of the potential hazard to public health.
    The documents were submitted to both the peer-review and the public 
review processes. Changes in the documents reflect those addressing the 
comments.
    The following documents will be available to the public on or 
about, October 1, 2006.

Document 1

    Interaction profile for atrazine deethylatrazine, diazinon, 
simazine, and nitrate.

Document 2

    Interaction profile for chlorpyrifos, lead, mercury, and 
methylmercury.

    Dated: September 21, 2006.
Kenneth Rose,
Acting Director, Office of Policy, Planning and Evaluation, National 
Center for Environmental Health/Agency for Toxic Substances and Disease 
Registry.
 [FR Doc. E6-15946 Filed 9-27-06; 8:45 am]
BILLING CODE 4163-70-P